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Entry version 138 (08 May 2019)
Sequence version 3 (18 May 2010)
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Protein

Myelin expression factor 2

Gene

MYEF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor, RNA-binding
Biological processTranscription

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myelin expression factor 2
Short name:
MEF-2
Short name:
MyEF-2
Alternative name(s):
MST156
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYEF2
Synonyms:KIAA1341
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:17940 MYEF2

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9P2K5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
50804

Open Targets

More...
OpenTargetsi
ENSG00000104177

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134877084

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MYEF2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439294

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000816551 – 600Myelin expression factor 2Add BLAST600

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei13PhosphothreonineCombined sources1
Modified residuei17PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki53Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei406Omega-N-methylarginineBy similarity1
Modified residuei431PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9P2K5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9P2K5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9P2K5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9P2K5

PeptideAtlas

More...
PeptideAtlasi
Q9P2K5

PRoteomics IDEntifications database

More...
PRIDEi
Q9P2K5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
83833
83834 [Q9P2K5-2]
83835 [Q9P2K5-3]
83836 [Q9P2K5-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9P2K5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9P2K5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000104177 Expressed in 191 organ(s), highest expression level in esophagus

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9P2K5 baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA004883

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
119124, 81 interactors

Protein interaction database and analysis system

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IntActi
Q9P2K5, 34 interactors

Molecular INTeraction database

More...
MINTi
Q9P2K5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000316950

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9P2K5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini100 – 178RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini233 – 310RRM 2PROSITE-ProRule annotationAdd BLAST78
Domaini523 – 599RRM 3PROSITE-ProRule annotationAdd BLAST77

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi330 – 522Gly-richAdd BLAST193

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IKNU Eukaryota
ENOG4110PAX LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157397

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9P2K5

Database of Orthologous Groups

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OrthoDBi
1174365at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9P2K5

TreeFam database of animal gene trees

More...
TreeFami
TF313406

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12658 RRM1_MYEF2, 1 hit
cd12662 RRM3_MYEF2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.70.330, 3 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR034632 MYEF2
IPR034630 MYEF2_RRM1
IPR034631 MYEF2_RRM3
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom

The PANTHER Classification System

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PANTHERi
PTHR23003:SF15 PTHR23003:SF15, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00076 RRM_1, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00360 RRM, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928 SSF54928, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102 RRM, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9P2K5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADANKAEVP GATGGDSPHL QPAEPPGEPR REPHPAEAEK QQPQHSSSSN
60 70 80 90 100
GVKMENDESA KEEKSDLKEK STGSKKANRF HPYSKDKNSG AGEKKGPNRN
110 120 130 140 150
RVFISNIPYD MKWQAIKDLM REKVGEVTYV ELFKDAEGKS RGCGVVEFKD
160 170 180 190 200
EEFVKKALET MNKYDLSGRP LNIKEDPDGE NARRALQRTG GSFPGGHVPD
210 220 230 240 250
MGSGLMNLPP SILNNPNIPP EVISNLQAGR LGSTIFVANL DFKVGWKKLK
260 270 280 290 300
EVFSIAGTVK RADIKEDKDG KSRGMGTVTF EQAIEAVQAI SMFNGQFLFD
310 320 330 340 350
RPMHVKMDDK SVPHEEYRSH DGKTPQLPRG LGGIGMGLGP GGQPISASQL
360 370 380 390 400
NIGGVMGNLG PGGMGMDGPG FGGMNRIGGG IGFGGLEAMN SMGGFGGVGR
410 420 430 440 450
MGELYRGAMT SSMERDFGRG DIGINQGFGD SFGRLGSAMI GGFAGRIGSS
460 470 480 490 500
NMGPVGSGIS GGMGSMNSVT GGMGMGLDRM SSSFDRMGPG IGAILERSID
510 520 530 540 550
MDRGFLSGPM GSGMRERIGS KGNQIFVRNL PFDLTWQKLK EKFSQCGHVM
560 570 580 590 600
FAEIKMENGK SKGCGTVRFD SPESAEKACR IMNGIKISGR EIDVRLDRNA
Length:600
Mass (Da):64,122
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC965138A61B62DC3
GO
Isoform 2 (identifier: Q9P2K5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     437-460: Missing.

Show »
Length:576
Mass (Da):61,929
Checksum:i5A3A9D34B084ABC7
GO
Isoform 3 (identifier: Q9P2K5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-388: Missing.
     437-460: Missing.

Show »
Length:188
Mass (Da):20,266
Checksum:i40BBBBDDA769E353
GO
Isoform 4 (identifier: Q9P2K5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-128: VGEVT → GLWCG
     129-600: Missing.

Show »
Length:128
Mass (Da):14,125
Checksum:i7322C827DC690A50
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MR39A0A0A0MR39_HUMAN
Myelin expression factor 2
MYEF2 hCG_40072
600Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WUT0A0A087WUT0_HUMAN
Myelin expression factor 2
MYEF2
547Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MQW0A0A0A0MQW0_HUMAN
Myelin expression factor 2
MYEF2 hCG_40072
576Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WWC8A0A087WWC8_HUMAN
Myelin expression factor 2
MYEF2
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YN19H0YN19_HUMAN
Myelin expression factor 2
MYEF2
290Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKS1H0YKS1_HUMAN
Myelin expression factor 2
MYEF2
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGV1A0A0C4DGV1_HUMAN
Myelin expression factor 2
MYEF2
211Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH14533 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAQ13703 differs from that shown. Reason: Frameshift at position 344.Curated
The sequence BAA92579 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti186L → S in BAB14421 (PubMed:14702039).Curated1
Sequence conflicti364M → G in AAH14533 (PubMed:15489334).Curated1
Sequence conflicti578A → T in AAQ13703 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05220991A → T4 PublicationsCorresponds to variant dbSNP:rs8023906Ensembl.1
Natural variantiVAR_061829426Q → R4 PublicationsCorresponds to variant dbSNP:rs2470103Ensembl.1
Natural variantiVAR_052210465S → G2 PublicationsCorresponds to variant dbSNP:rs36075490Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0134511 – 388Missing in isoform 3. 1 PublicationAdd BLAST388
Alternative sequenceiVSP_013452124 – 128VGEVT → GLWCG in isoform 4. 1 Publication5
Alternative sequenceiVSP_013453129 – 600Missing in isoform 4. 1 PublicationAdd BLAST472
Alternative sequenceiVSP_013454437 – 460Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST24

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB037762 mRNA Translation: BAA92579.1 Different initiation.
AK002075 mRNA Translation: BAA92070.1
AK023133 mRNA Translation: BAB14421.1
AC066612 Genomic DNA No translation available.
AC090526 Genomic DNA No translation available.
BC014533 mRNA Translation: AAH14533.3 Different initiation.
BC068523 mRNA Translation: AAH68523.1
BC152420 mRNA Translation: AAI52421.1
BC152451 mRNA Translation: AAI52452.1
AF190159 mRNA Translation: AAQ13703.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32230.1 [Q9P2K5-1]
CCDS73722.1 [Q9P2K5-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001288139.1, NM_001301210.1
NP_057216.2, NM_016132.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000561151; ENSP00000452913; ENSG00000104177 [Q9P2K5-4]
ENST00000561351; ENSP00000453125; ENSG00000104177 [Q9P2K5-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
50804

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:50804

UCSC genome browser

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UCSCi
uc059iwz.1 human [Q9P2K5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037762 mRNA Translation: BAA92579.1 Different initiation.
AK002075 mRNA Translation: BAA92070.1
AK023133 mRNA Translation: BAB14421.1
AC066612 Genomic DNA No translation available.
AC090526 Genomic DNA No translation available.
BC014533 mRNA Translation: AAH14533.3 Different initiation.
BC068523 mRNA Translation: AAH68523.1
BC152420 mRNA Translation: AAI52421.1
BC152451 mRNA Translation: AAI52452.1
AF190159 mRNA Translation: AAQ13703.1 Frameshift.
CCDSiCCDS32230.1 [Q9P2K5-1]
CCDS73722.1 [Q9P2K5-2]
RefSeqiNP_001288139.1, NM_001301210.1
NP_057216.2, NM_016132.4

3D structure databases

SMRiQ9P2K5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119124, 81 interactors
IntActiQ9P2K5, 34 interactors
MINTiQ9P2K5
STRINGi9606.ENSP00000316950

PTM databases

iPTMnetiQ9P2K5
PhosphoSitePlusiQ9P2K5

Polymorphism and mutation databases

BioMutaiMYEF2
DMDMi296439294

Proteomic databases

EPDiQ9P2K5
jPOSTiQ9P2K5
MaxQBiQ9P2K5
PaxDbiQ9P2K5
PeptideAtlasiQ9P2K5
PRIDEiQ9P2K5
ProteomicsDBi83833
83834 [Q9P2K5-2]
83835 [Q9P2K5-3]
83836 [Q9P2K5-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
50804
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000561151; ENSP00000452913; ENSG00000104177 [Q9P2K5-4]
ENST00000561351; ENSP00000453125; ENSG00000104177 [Q9P2K5-4]
GeneIDi50804
KEGGihsa:50804
UCSCiuc059iwz.1 human [Q9P2K5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
50804
DisGeNETi50804

GeneCards: human genes, protein and diseases

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GeneCardsi
MYEF2
HGNCiHGNC:17940 MYEF2
HPAiHPA004883
neXtProtiNX_Q9P2K5
OpenTargetsiENSG00000104177
PharmGKBiPA134877084

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IKNU Eukaryota
ENOG4110PAX LUCA
GeneTreeiENSGT00940000157397
InParanoidiQ9P2K5
OrthoDBi1174365at2759
PhylomeDBiQ9P2K5
TreeFamiTF313406

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
50804

Protein Ontology

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PROi
PR:Q9P2K5

Gene expression databases

BgeeiENSG00000104177 Expressed in 191 organ(s), highest expression level in esophagus
ExpressionAtlasiQ9P2K5 baseline and differential

Family and domain databases

CDDicd12658 RRM1_MYEF2, 1 hit
cd12662 RRM3_MYEF2, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR034632 MYEF2
IPR034630 MYEF2_RRM1
IPR034631 MYEF2_RRM3
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR23003:SF15 PTHR23003:SF15, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 3 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYEF2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P2K5
Secondary accession number(s): A7MCZ9
, C9J921, C9K0J4, Q6NUM5, Q7L388, Q7Z4B7, Q9H922, Q9NUQ1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: May 18, 2010
Last modified: May 8, 2019
This is version 138 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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