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UniProtKB - Q9P2K3 (RCOR3_HUMAN)
Protein
REST corepressor 3
Gene
RCOR3
Organism
Homo sapiens (Human)
Status
Functioni
May act as a component of a corepressor complex that represses transcription.
CuratedGO - Molecular functioni
- transcription corepressor activity Source: GO_Central
GO - Biological processi
- histone deacetylation Source: GO_Central
- negative regulation of transcription, DNA-templated Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q9P2K3 |
SignaLinki | Q9P2K3 |
Names & Taxonomyi
Protein namesi | Recommended name: REST corepressor 3 |
Gene namesi | Name:RCOR3 Synonyms:KIAA1343 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25594, RCOR3 |
neXtProti | NX_Q9P2K3 |
VEuPathDBi | HostDB:ENSG00000117625 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Cytosol
- cytosol Source: HPA
Nucleus
- histone deacetylase complex Source: GO_Central
- nucleoplasm Source: HPA
Other locations
- transcription regulator complex Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 55758 |
OpenTargetsi | ENSG00000117625 |
PharmGKBi | PA134917623 |
Miscellaneous databases
Pharosi | Q9P2K3, Tdark |
Chemistry databases
ChEMBLi | CHEMBL4296112 CHEMBL4296114 |
Genetic variation databases
BioMutai | RCOR3 |
DMDMi | 90103520 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000226781 | 1 – 495 | REST corepressor 3Add BLAST | 495 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 20 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 156 | PhosphoserineCombined sources | 1 | |
Modified residuei | 171 | PhosphoserineCombined sources | 1 | |
Cross-linki | 193 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 285 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 376 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 445 | Asymmetric dimethylarginineCombined sources | 1 | |
Modified residuei | 457 | Asymmetric dimethylarginineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9P2K3 |
jPOSTi | Q9P2K3 |
MassIVEi | Q9P2K3 |
MaxQBi | Q9P2K3 |
PaxDbi | Q9P2K3 |
PeptideAtlasi | Q9P2K3 |
PRIDEi | Q9P2K3 |
ProteomicsDBi | 83829 [Q9P2K3-1] 83830 [Q9P2K3-2] 83831 [Q9P2K3-3] 83832 [Q9P2K3-4] |
PTM databases
iPTMneti | Q9P2K3 |
PhosphoSitePlusi | Q9P2K3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000117625, Expressed in testis and 235 other tissues |
ExpressionAtlasi | Q9P2K3, baseline and differential |
Genevisiblei | Q9P2K3, HS |
Organism-specific databases
HPAi | ENSG00000117625, Low tissue specificity |
Interactioni
Binary interactionsi
Q9P2K3
Isoform 2 [Q9P2K3-2]
Protein-protein interaction databases
BioGRIDi | 120876, 140 interactors |
CORUMi | Q9P2K3 |
IntActi | Q9P2K3, 110 interactors |
MINTi | Q9P2K3 |
STRINGi | 9606.ENSP00000413929 |
Chemistry databases
BindingDBi | Q9P2K3 |
Miscellaneous databases
RNActi | Q9P2K3, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9P2K3 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 83 | ELM2PROSITE-ProRule annotationAdd BLAST | 83 | |
Domaini | 84 – 135 | SANT 1PROSITE-ProRule annotationAdd BLAST | 52 | |
Domaini | 285 – 336 | SANT 2PROSITE-ProRule annotationAdd BLAST | 52 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 147 – 219 | DisorderedSequence analysisAdd BLAST | 73 | |
Regioni | 346 – 495 | DisorderedSequence analysisAdd BLAST | 150 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 237 – 273 | Sequence analysisAdd BLAST | 37 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 166 – 184 | Basic and acidic residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 346 – 373 | Polar residuesSequence analysisAdd BLAST | 28 | |
Compositional biasi | 389 – 430 | Pro residuesSequence analysisAdd BLAST | 42 | |
Compositional biasi | 446 – 465 | Pro residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 472 – 495 | Polar residuesSequence analysisAdd BLAST | 24 |
Sequence similaritiesi
Belongs to the CoREST family.Curated
Keywords - Domaini
Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG1194, Eukaryota |
GeneTreei | ENSGT00940000154196 |
HOGENOMi | CLU_026741_1_0_1 |
InParanoidi | Q9P2K3 |
OMAi | XSNQKIN |
OrthoDBi | 641792at2759 |
PhylomeDBi | Q9P2K3 |
TreeFami | TF106450 |
Family and domain databases
CDDi | cd00167, SANT, 1 hit |
DisProti | DP02408 [Q9P2K3-3] |
IDEALi | IID00589 |
InterProi | View protein in InterPro IPR000949, ELM2_dom IPR009057, Homeobox-like_sf IPR017930, Myb_dom IPR001005, SANT/Myb IPR017884, SANT_dom |
Pfami | View protein in Pfam PF01448, ELM2, 1 hit PF00249, Myb_DNA-binding, 1 hit |
SMARTi | View protein in SMART SM01189, ELM2, 1 hit SM00717, SANT, 2 hits |
SUPFAMi | SSF46689, SSF46689, 2 hits |
PROSITEi | View protein in PROSITE PS51156, ELM2, 1 hit PS51293, SANT, 2 hits |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9P2K3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRVGAEYQAR IPEFDPGATK YTDKDNGGML VWSPYHSIPD AKLDEYIAIA
60 70 80 90 100
KEKHGYNVEQ ALGMLFWHKH NIEKSLADLP NFTPFPDEWT VEDKVLFEQA
110 120 130 140 150
FSFHGKSFHR IQQMLPDKTI ASLVKYYYSW KKTRSRTSLM DRQARKLANR
160 170 180 190 200
HNQGDSDDDV EETHPMDGND SDYDPKKEAK KEGNTEQPVQ TSKIGLGRRE
210 220 230 240 250
YQSLQHRHHS QRSKCRPPKG MYLTQEDVVA VSCSPNAANT ILRQLDMELI
260 270 280 290 300
SLKRQVQNAK QVNSALKQKM EGGIEEFKPP ESNQKINARW TTEEQLLAVQ
310 320 330 340 350
GVRKYGKDFQ AIADVIGNKT VGQVKNFFVN YRRRFNLEEV LQEWEAEQGT
360 370 380 390 400
QASNGDASTL GEETKSASNV PSGKSTDEEE EAQTPQAPRT LGPSPPAPSS
410 420 430 440 450
TPTPTAPIAT LNQPPPLLRP TLPAAPALHR QPPPLQQQAR FIQPRPTLNQ
460 470 480 490
PPPPLIRPAN SMPPRLNPRP VLSTVGGQQP PSLIGIQTDS QSSLH
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YF22 | H0YF22_HUMAN | REST corepressor 3 | RCOR3 | 240 | Annotation score: | ||
B4DV59 | B4DV59_HUMAN | REST corepressor 3 | RCOR3 | 374 | Annotation score: | ||
H0YDD7 | H0YDD7_HUMAN | REST corepressor 3 | RCOR3 | 143 | Annotation score: | ||
H0YDR8 | H0YDR8_HUMAN | REST corepressor 3 | RCOR3 | 74 | Annotation score: | ||
E9PQE5 | E9PQE5_HUMAN | REST corepressor 3 | RCOR3 | 149 | Annotation score: | ||
E9PR63 | E9PR63_HUMAN | REST corepressor 3 | RCOR3 | 86 | Annotation score: | ||
E9PPC5 | E9PPC5_HUMAN | REST corepressor 3 | RCOR3 | 44 | Annotation score: |
Sequence cautioni
The sequence BAA92581 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_025517 | 42 | K → R1 PublicationCorresponds to variant dbSNP:rs17856928Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_017460 | 1 | M → MPGMMEKGPELLGKNRSANG SAKSPAGGGGSGASSTNGGL HYSEPESGCSSDDEHDVGM in isoform 2, isoform 3 and isoform 4. 2 Publications | 1 | |
Alternative sequenceiVSP_017461 | 302 – 378 | VRKYG…KSTDE → TDPTGSSDTGSITSCPIIHS NTNSPYCHSEPASTTSSSNT ACCPGSSPAASSTPAAGSVH PAPANFKSASTTSYSPC in isoform 2. 1 PublicationAdd BLAST | 77 | |
Alternative sequenceiVSP_017462 | 379 – 495 | Missing in isoform 2. 1 PublicationAdd BLAST | 117 | |
Alternative sequenceiVSP_041465 | 382 – 391 | AQTPQAPRTL → VCLCMEFELI in isoform 4. 1 Publication | 10 | |
Alternative sequenceiVSP_041466 | 392 – 495 | Missing in isoform 4. 1 PublicationAdd BLAST | 104 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB037764 mRNA Translation: BAA92581.1 Different initiation. AK131312 mRNA Translation: BAG54764.1 AK302664 mRNA Translation: BAG63899.1 AK001738 mRNA Translation: BAA91872.1 AL590101 Genomic DNA No translation available. AL611964 Genomic DNA No translation available. BC031608 mRNA Translation: AAH31608.1 |
CCDSi | CCDS31016.1 [Q9P2K3-1] CCDS44312.1 [Q9P2K3-3] CCDS44313.1 [Q9P2K3-2] CCDS44314.1 [Q9P2K3-4] |
RefSeqi | NP_001129695.1, NM_001136223.1 [Q9P2K3-3] NP_001129696.2, NM_001136224.2 [Q9P2K3-2] NP_001129697.1, NM_001136225.1 [Q9P2K3-4] NP_060724.1, NM_018254.3 [Q9P2K3-1] |
Genome annotation databases
Ensembli | ENST00000367005; ENSP00000355972; ENSG00000117625 ENST00000367006; ENSP00000355973; ENSG00000117625 [Q9P2K3-2] ENST00000419091; ENSP00000413929; ENSG00000117625 [Q9P2K3-3] ENST00000452621; ENSP00000398558; ENSG00000117625 [Q9P2K3-4] |
GeneIDi | 55758 |
KEGGi | hsa:55758 |
MANE-Selecti | ENST00000419091.7; ENSP00000413929.2; NM_001136223.3; NP_001129695.1 [Q9P2K3-3] |
UCSCi | uc001hie.4, human [Q9P2K3-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB037764 mRNA Translation: BAA92581.1 Different initiation. AK131312 mRNA Translation: BAG54764.1 AK302664 mRNA Translation: BAG63899.1 AK001738 mRNA Translation: BAA91872.1 AL590101 Genomic DNA No translation available. AL611964 Genomic DNA No translation available. BC031608 mRNA Translation: AAH31608.1 |
CCDSi | CCDS31016.1 [Q9P2K3-1] CCDS44312.1 [Q9P2K3-3] CCDS44313.1 [Q9P2K3-2] CCDS44314.1 [Q9P2K3-4] |
RefSeqi | NP_001129695.1, NM_001136223.1 [Q9P2K3-3] NP_001129696.2, NM_001136224.2 [Q9P2K3-2] NP_001129697.1, NM_001136225.1 [Q9P2K3-4] NP_060724.1, NM_018254.3 [Q9P2K3-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4CZZ | X-ray | 3.00 | B | 1-495 | [»] | |
SMRi | Q9P2K3 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120876, 140 interactors |
CORUMi | Q9P2K3 |
IntActi | Q9P2K3, 110 interactors |
MINTi | Q9P2K3 |
STRINGi | 9606.ENSP00000413929 |
Chemistry databases
BindingDBi | Q9P2K3 |
ChEMBLi | CHEMBL4296112 CHEMBL4296114 |
PTM databases
iPTMneti | Q9P2K3 |
PhosphoSitePlusi | Q9P2K3 |
Genetic variation databases
BioMutai | RCOR3 |
DMDMi | 90103520 |
Proteomic databases
EPDi | Q9P2K3 |
jPOSTi | Q9P2K3 |
MassIVEi | Q9P2K3 |
MaxQBi | Q9P2K3 |
PaxDbi | Q9P2K3 |
PeptideAtlasi | Q9P2K3 |
PRIDEi | Q9P2K3 |
ProteomicsDBi | 83829 [Q9P2K3-1] 83830 [Q9P2K3-2] 83831 [Q9P2K3-3] 83832 [Q9P2K3-4] |
Protocols and materials databases
Antibodypediai | 2380, 104 antibodies from 20 providers |
DNASUi | 55758 |
Genome annotation databases
Ensembli | ENST00000367005; ENSP00000355972; ENSG00000117625 ENST00000367006; ENSP00000355973; ENSG00000117625 [Q9P2K3-2] ENST00000419091; ENSP00000413929; ENSG00000117625 [Q9P2K3-3] ENST00000452621; ENSP00000398558; ENSG00000117625 [Q9P2K3-4] |
GeneIDi | 55758 |
KEGGi | hsa:55758 |
MANE-Selecti | ENST00000419091.7; ENSP00000413929.2; NM_001136223.3; NP_001129695.1 [Q9P2K3-3] |
UCSCi | uc001hie.4, human [Q9P2K3-1] |
Organism-specific databases
CTDi | 55758 |
DisGeNETi | 55758 |
GeneCardsi | RCOR3 |
HGNCi | HGNC:25594, RCOR3 |
HPAi | ENSG00000117625, Low tissue specificity |
neXtProti | NX_Q9P2K3 |
OpenTargetsi | ENSG00000117625 |
PharmGKBi | PA134917623 |
VEuPathDBi | HostDB:ENSG00000117625 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1194, Eukaryota |
GeneTreei | ENSGT00940000154196 |
HOGENOMi | CLU_026741_1_0_1 |
InParanoidi | Q9P2K3 |
OMAi | XSNQKIN |
OrthoDBi | 641792at2759 |
PhylomeDBi | Q9P2K3 |
TreeFami | TF106450 |
Enzyme and pathway databases
PathwayCommonsi | Q9P2K3 |
SignaLinki | Q9P2K3 |
Miscellaneous databases
BioGRID-ORCSi | 55758, 8 hits in 1070 CRISPR screens |
ChiTaRSi | RCOR3, human |
GenomeRNAii | 55758 |
Pharosi | Q9P2K3, Tdark |
PROi | PR:Q9P2K3 |
RNActi | Q9P2K3, protein |
Gene expression databases
Bgeei | ENSG00000117625, Expressed in testis and 235 other tissues |
ExpressionAtlasi | Q9P2K3, baseline and differential |
Genevisiblei | Q9P2K3, HS |
Family and domain databases
CDDi | cd00167, SANT, 1 hit |
DisProti | DP02408 [Q9P2K3-3] |
IDEALi | IID00589 |
InterProi | View protein in InterPro IPR000949, ELM2_dom IPR009057, Homeobox-like_sf IPR017930, Myb_dom IPR001005, SANT/Myb IPR017884, SANT_dom |
Pfami | View protein in Pfam PF01448, ELM2, 1 hit PF00249, Myb_DNA-binding, 1 hit |
SMARTi | View protein in SMART SM01189, ELM2, 1 hit SM00717, SANT, 2 hits |
SUPFAMi | SSF46689, SSF46689, 2 hits |
PROSITEi | View protein in PROSITE PS51156, ELM2, 1 hit PS51293, SANT, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | RCOR3_HUMAN | |
Accessioni | Q9P2K3Primary (citable) accession number: Q9P2K3 Secondary accession number(s): B3KYA2 Q9NV83 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 7, 2006 |
Last sequence update: | March 7, 2006 | |
Last modified: | February 23, 2022 | |
This is version 169 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families