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Protein

[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

Gene

PDP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex.By similarity

Catalytic activityi

[Pyruvate dehydrogenase (acetyl-transferring)] phosphate + H2O = [pyruvate dehydrogenase (acetyl-transferring)] + phosphate.

Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi141Manganese 1By similarity1
Metal bindingi141Manganese 2By similarity1
Metal bindingi142Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi412Manganese 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandMagnesium, Manganese, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.3.43 2681
ReactomeiR-HSA-204174 Regulation of pyruvate dehydrogenase (PDH) complex
SIGNORiQ9P2J9

Names & Taxonomyi

Protein namesi
Recommended name:
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial (EC:3.1.3.43)
Short name:
PDP 2
Alternative name(s):
Pyruvate dehydrogenase phosphatase catalytic subunit 2
Short name:
PDPC 2
Gene namesi
Name:PDP2
Synonyms:KIAA1348
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000172840.6
HGNCiHGNC:30263 PDP2
MIMi615499 gene
neXtProtiNX_Q9P2J9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi57546
OpenTargetsiENSG00000172840
PharmGKBiPA165450460

Polymorphism and mutation databases

BioMutaiPDP2
DMDMi12585321

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 66MitochondrionSequence analysisAdd BLAST66
ChainiPRO_000002542167 – 529[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrialAdd BLAST463

Proteomic databases

EPDiQ9P2J9
MaxQBiQ9P2J9
PaxDbiQ9P2J9
PeptideAtlasiQ9P2J9
PRIDEiQ9P2J9
ProteomicsDBi83825

PTM databases

DEPODiQ9P2J9
iPTMnetiQ9P2J9
PhosphoSitePlusiQ9P2J9

Expressioni

Gene expression databases

BgeeiENSG00000172840
ExpressionAtlasiQ9P2J9 baseline and differential
GenevisibleiQ9P2J9 HS

Organism-specific databases

HPAiHPA019950
HPA062059

Interactioni

Subunit structurei

Heterodimer of a catalytic subunit and a FAD protein of unknown function.By similarity

Protein-protein interaction databases

BioGridi121604, 11 interactors
IntActiQ9P2J9, 1 interactor
STRINGi9606.ENSP00000309548

Structurei

3D structure databases

ProteinModelPortaliQ9P2J9
SMRiQ9P2J9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini106 – 517PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST412

Sequence similaritiesi

Belongs to the PP2C family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0700 Eukaryota
COG0631 LUCA
GeneTreeiENSGT00390000006874
HOGENOMiHOG000220821
HOVERGENiHBG008162
InParanoidiQ9P2J9
KOiK01102
OMAiQEDNGMW
OrthoDBiEOG091G05XU
PhylomeDBiQ9P2J9
TreeFamiTF313505

Family and domain databases

CDDicd00143 PP2Cc, 1 hit
Gene3Di3.60.40.10, 1 hit
InterProiView protein in InterPro
IPR015655 PP2C
IPR000222 PP2C_BS
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
PANTHERiPTHR13832 PTHR13832, 1 hit
PfamiView protein in Pfam
PF00481 PP2C, 1 hit
SMARTiView protein in SMART
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81606 SSF81606, 3 hits
PROSITEiView protein in PROSITE
PS01032 PPM_1, 1 hit
PS51746 PPM_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P2J9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTVSYWIL NSTRNSIATL QGGRRLYSRY VSNRNKLKWR LFSRVPPTLN
60 70 80 90 100
SSPCGGFTLC KAYRHTSTEE DDFHLQLSPE QINEVLRAGE TTHKILDLES
110 120 130 140 150
RVPNSVLRFE SNQLAANSPV EDRRGVASCL QTNGLMFGIF DGHGGHACAQ
160 170 180 190 200
AVSERLFYYV AVSLMSHQTL EHMEGAMESM KPLLPILHWL KHPGDSIYKD
210 220 230 240 250
VTSVHLDHLR VYWQELLDLH MEMGLSIEEA LMYSFQRLDS DISLEIQAPL
260 270 280 290 300
EDEVTRNLSL QVAFSGATAC MAHVDGIHLH VANAGDCRAI LGVQEDNGMW
310 320 330 340 350
SCLPLTRDHN AWNQAELSRL KREHPESEDR TIIMEDRLLG VLIPCRAFGD
360 370 380 390 400
VQLKWSKELQ RSILERGFNT EALNIYQFTP PHYYTPPYLT AEPEVTYHRL
410 420 430 440 450
RPQDKFLVLA SDGLWDMLSN EDVVRLVVGH LAEADWHKTD LAQRPANLGL
460 470 480 490 500
MQSLLLQRKA SGLHEADQNA ATRLIRHAIG NNEYGEMEAE RLAAMLTLPE
510 520
DLARMYRDDI TVTVVYFNSE SIGAYYKGG
Length:529
Mass (Da):59,978
Last modified:January 24, 2001 - v2
Checksum:i252CAEBCDAF61A5C
GO

Sequence cautioni

The sequence BAA92586 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037769 mRNA Translation: BAA92586.1 Different initiation.
AK292539 mRNA Translation: BAF85228.1
CH471092 Genomic DNA Translation: EAW83048.1
BC028030 mRNA Translation: AAH28030.1
CCDSiCCDS10822.1
RefSeqiNP_001316857.1, NM_001329928.1
NP_001316858.1, NM_001329929.1
NP_001316859.1, NM_001329930.1
NP_001316860.1, NM_001329931.1
NP_001316861.1, NM_001329932.1
NP_001316862.1, NM_001329933.1
NP_001316863.1, NM_001329934.1
NP_065837.1, NM_020786.3
UniGeneiHs.632214

Genome annotation databases

EnsembliENST00000311765; ENSP00000309548; ENSG00000172840
GeneIDi57546
KEGGihsa:57546
UCSCiuc002eqk.3 human

Entry informationi

Entry nameiPDP2_HUMAN
AccessioniPrimary (citable) accession number: Q9P2J9
Secondary accession number(s): A8K924
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: January 24, 2001
Last modified: June 20, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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