UniProtKB - Q9P2J5 (SYLC_HUMAN)
Protein
Leucine--tRNA ligase, cytoplasmic
Gene
LARS1
Organism
Homo sapiens (Human)
Status
Functioni
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs.1 Publication
Catalytic activityi
- EC:6.1.1.4
Activity regulationi
5-fluoro-1,3-dihydro-1-hydroxy-1,2-benzoxaborole inhibits LARS1 by forming a covalent adduct with the 3' adenosine of tRNA(Leu) at the editing site, thus locking the enzyme in an inactive conformation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 719 | ATPBy similarity | 1 |
GO - Molecular functioni
- aminoacyl-tRNA editing activity Source: InterPro
- ATP binding Source: UniProtKB-KW
- glutamine-tRNA ligase activity Source: UniProtKB
- GTPase activator activity Source: CAFA
- leucine-tRNA ligase activity Source: GO_Central
GO - Biological processi
- cellular response to amino acid starvation Source: CAFA
- cellular response to amino acid stimulus Source: CAFA
- cellular response to leucine Source: CAFA
- cellular response to leucine starvation Source: CAFA
- glutaminyl-tRNA aminoacylation Source: UniProtKB
- leucyl-tRNA aminoacylation Source: GO_Central
- positive regulation of GTPase activity Source: CAFA
- positive regulation of TORC1 signaling Source: CAFA
- positive regulation of TOR signaling Source: CAFA
- regulation of cell size Source: CAFA
- tRNA aminoacylation for protein translation Source: Reactome
Keywordsi
Molecular function | Aminoacyl-tRNA synthetase, Ligase |
Biological process | Protein biosynthesis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 6.1.1.4, 2681 |
PathwayCommonsi | Q9P2J5 |
Reactomei | R-HSA-2408522, Selenoamino acid metabolism R-HSA-379716, Cytosolic tRNA aminoacylation |
SABIO-RKi | Q9P2J5 |
Protein family/group databases
MoonProti | Q9P2J5 |
Names & Taxonomyi
Protein namesi | Recommended name: Leucine--tRNA ligase, cytoplasmic (EC:6.1.1.4)Alternative name(s): Leucyl-tRNA synthetase Short name: LeuRS |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000133706.17 |
HGNCi | HGNC:6512, LARS1 |
MIMi | 151350, gene |
neXtProti | NX_Q9P2J5 |
Subcellular locationi
Other locations
- Cytoplasm By similarity
Cytosol
- cytosol Source: UniProtKB
Endoplasmic reticulum
- endoplasmic reticulum Source: CAFA
Lysosome
- lysosome Source: CAFA
Nucleus
- nuclear body Source: HPA
Other locations
- aminoacyl-tRNA synthetase multienzyme complex Source: UniProtKB
- cytoplasm Source: CAFA
- endomembrane system Source: CAFA
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Involvement in diseasei
Infantile liver failure syndrome 1 (ILFS1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA life-threatening disorder of hepatic function that manifests with acute liver failure in the first few months of life. Clinical features include anemia, renal tubulopathy, developmental delay, seizures, failure to thrive, and liver steatosis and fibrosis.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_070438 | 373 | Y → C in ILFS1. 1 PublicationCorresponds to variant dbSNP:rs201861847EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease mutationOrganism-specific databases
DisGeNETi | 51520 |
MalaCardsi | LARS1 |
MIMi | 615438, phenotype |
OpenTargetsi | ENSG00000133706 |
Orphaneti | 370088, Acute infantile liver failure-multisystemic involvement syndrome |
PharmGKBi | PA30297 |
Miscellaneous databases
Pharosi | Q9P2J5, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3258 |
DrugBanki | DB00149, Leucine |
Polymorphism and mutation databases
BioMutai | LARS |
DMDMi | 48428689 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000152150 | 1 – 1176 | Leucine--tRNA ligase, cytoplasmicAdd BLAST | 1176 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 167 | PhosphoserineCombined sources | 1 | |
Modified residuei | 720 | PhosphoserineCombined sources | 1 | |
Modified residuei | 970 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 1047 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9P2J5 |
jPOSTi | Q9P2J5 |
MassIVEi | Q9P2J5 |
MaxQBi | Q9P2J5 |
PaxDbi | Q9P2J5 |
PeptideAtlasi | Q9P2J5 |
PRIDEi | Q9P2J5 |
ProteomicsDBi | 4339 61500 83822 [Q9P2J5-1] |
PTM databases
iPTMneti | Q9P2J5 |
MetOSitei | Q9P2J5 |
PhosphoSitePlusi | Q9P2J5 |
SwissPalmi | Q9P2J5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000133706, Expressed in kidney and 236 other tissues |
ExpressionAtlasi | Q9P2J5, baseline and differential |
Genevisiblei | Q9P2J5, HS |
Organism-specific databases
HPAi | ENSG00000133706, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ9P2J5
With | #Exp. | IntAct |
---|---|---|
RARS1 [P54136] | 4 | EBI-356077,EBI-355482 |
RPTOR [Q8N122] | 3 | EBI-356077,EBI-1567928 |
RRAGD [Q9NQL2] | 13 | EBI-356077,EBI-992949 |
Protein-protein interaction databases
BioGRIDi | 119584, 232 interactors |
CORUMi | Q9P2J5 |
IntActi | Q9P2J5, 51 interactors |
MINTi | Q9P2J5 |
STRINGi | 9606.ENSP00000377954 |
Chemistry databases
BindingDBi | Q9P2J5 |
Miscellaneous databases
RNActi | Q9P2J5, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9P2J5 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9P2J5 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 260 – 509 | Editing domainAdd BLAST | 250 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 53 – 63 | 'HIGH' regionAdd BLAST | 11 | |
Motifi | 716 – 720 | 'KMSKS' region | 5 |
Sequence similaritiesi
Belongs to the class-I aminoacyl-tRNA synthetase family.Curated
Phylogenomic databases
eggNOGi | KOG0437, Eukaryota |
GeneTreei | ENSGT00390000012163 |
HOGENOMi | CLU_004174_2_1_1 |
InParanoidi | Q9P2J5 |
OMAi | KFIEWQF |
OrthoDBi | 75155at2759 |
PhylomeDBi | Q9P2J5 |
TreeFami | TF105718 |
Family and domain databases
InterProi | View protein in InterPro IPR001412, aa-tRNA-synth_I_CS IPR002300, aa-tRNA-synth_Ia IPR004493, Leu-tRNA-synth_Ia_arc/euk IPR013155, M/V/L/I-tRNA-synth_anticd-bd IPR009080, tRNAsynth_Ia_anticodon-bd IPR009008, Val/Leu/Ile-tRNA-synth_edit |
PANTHERi | PTHR45794, PTHR45794, 1 hit |
Pfami | View protein in Pfam PF08264, Anticodon_1, 1 hit PF00133, tRNA-synt_1, 2 hits |
SUPFAMi | SSF47323, SSF47323, 1 hit SSF50677, SSF50677, 1 hit |
TIGRFAMsi | TIGR00395, leuS_arch, 1 hit |
PROSITEi | View protein in PROSITE PS00178, AA_TRNA_LIGASE_I, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9P2J5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAERKGTAKV DFLKKIEKEI QQKWDTERVF EVNASNLEKQ TSKGKYFVTF
60 70 80 90 100
PYPYMNGRLH LGHTFSLSKC EFAVGYQRLK GKCCLFPFGL HCTGMPIKAC
110 120 130 140 150
ADKLKREIEL YGCPPDFPDE EEEEEETSVK TEDIIIKDKA KGKKSKAAAK
160 170 180 190 200
AGSSKYQWGI MKSLGLSDEE IVKFSEAEHW LDYFPPLAIQ DLKRMGLKVD
210 220 230 240 250
WRRSFITTDV NPYYDSFVRW QFLTLRERNK IKFGKRYTIY SPKDGQPCMD
260 270 280 290 300
HDRQTGEGVG PQEYTLLKLK VLEPYPSKLS GLKGKNIFLV AATLRPETMF
310 320 330 340 350
GQTNCWVRPD MKYIGFETVN GDIFICTQKA ARNMSYQGFT KDNGVVPVVK
360 370 380 390 400
ELMGEEILGA SLSAPLTSYK VIYVLPMLTI KEDKGTGVVT SVPSDSPDDI
410 420 430 440 450
AALRDLKKKQ ALRAKYGIRD DMVLPFEPVP VIEIPGFGNL SAVTICDELK
460 470 480 490 500
IQSQNDREKL AEAKEKIYLK GFYEGIMLVD GFKGQKVQDV KKTIQKKMID
510 520 530 540 550
AGDALIYMEP EKQVMSRSSD ECVVALCDQW YLDYGEENWK KQTSQCLKNL
560 570 580 590 600
ETFCEETRRN FEATLGWLQE HACSRTYGLG THLPWDEQWL IESLSDSTIY
610 620 630 640 650
MAFYTVAHLL QGGNLHGQAE SPLGIRPQQM TKEVWDYVFF KEAPFPKTQI
660 670 680 690 700
AKEKLDQLKQ EFEFWYPVDL RVSGKDLVPN HLSYYLYNHV AMWPEQSDKW
710 720 730 740 750
PTAVRANGHL LLNSEKMSKS TGNFLTLTQA IDKFSADGMR LALADAGDTV
760 770 780 790 800
EDANFVEAMA DAGILRLYTW VEWVKEMVAN WDSLRSGPAS TFNDRVFASE
810 820 830 840 850
LNAGIIKTDQ NYEKMMFKEA LKTGFFEFQA AKDKYRELAV EGMHRELVFR
860 870 880 890 900
FIEVQTLLLA PFCPHLCEHI WTLLGKPDSI MNASWPVAGP VNEVLIHSSQ
910 920 930 940 950
YLMEVTHDLR LRLKNYMMPA KGKKTDKQPL QKPSHCTIYV AKNYPPWQHT
960 970 980 990 1000
TLSVLRKHFE ANNGKLPDNK VIASELGSMP ELKKYMKKVM PFVAMIKENL
1010 1020 1030 1040 1050
EKMGPRILDL QLEFDEKAVL MENIVYLTNS LELEHIEVKF ASEAEDKIRE
1060 1070 1080 1090 1100
DCCPGKPLNV FRIEPGVSVS LVNPQPSNGH FSTKIEIRQG DNCDSIIRRL
1110 1120 1130 1140 1150
MKMNRGIKDL SKVKLMRFDD PLLGPRRVPV LGKEYTEKTP ISEHAVFNVD
1160 1170
LMSKKIHLTE NGIRVDIGDT IIYLVH
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB4DER1 | B4DER1_HUMAN | Leucyl-tRNA synthetase | LARS1 | 1,149 | Annotation score: | ||
A0A6I8PL42 | A0A6I8PL42_HUMAN | Leucyl-tRNA synthetase | LARS1 | 1,130 | Annotation score: | ||
A0A6I8PIP7 | A0A6I8PIP7_HUMAN | Leucyl-tRNA synthetase | LARS1 | 850 | Annotation score: | ||
A0A6I8PIT3 | A0A6I8PIT3_HUMAN | Leucyl-tRNA synthetase | LARS1 | 1,164 | Annotation score: | ||
A0A6I8PIV1 | A0A6I8PIV1_HUMAN | Leucyl-tRNA synthetase | LARS1 | 1,175 | Annotation score: | ||
A0A6I8PLB8 | A0A6I8PLB8_HUMAN | Leucyl-tRNA synthetase | LARS1 | 1,112 | Annotation score: | ||
A0A6I8PRS0 | A0A6I8PRS0_HUMAN | Leucyl-tRNA synthetase | LARS1 | 1,121 | Annotation score: | ||
A0A6I8PRU9 | A0A6I8PRU9_HUMAN | Leucyl-tRNA synthetase | LARS1 | 543 | Annotation score: | ||
A0A6I8PS05 | A0A6I8PS05_HUMAN | Leucyl-tRNA synthetase | LARS1 | 1,049 | Annotation score: | ||
A0A6I8PTV8 | A0A6I8PTV8_HUMAN | Leucyl-tRNA synthetase | LARS1 | 697 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
The sequence BAA92590 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 271 | V → A in BAA95667 (Ref. 1) Curated | 1 | |
Sequence conflicti | 892 | N → D in BAA95667 (Ref. 1) Curated | 1 | |
Sequence conflicti | 1026 | Y → C in AAI31799 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_070437 | 82 | K → R1 PublicationCorresponds to variant dbSNP:rs112954500EnsemblClinVar. | 1 | |
Natural variantiVAR_070438 | 373 | Y → C in ILFS1. 1 PublicationCorresponds to variant dbSNP:rs201861847EnsemblClinVar. | 1 | |
Natural variantiVAR_052637 | 1088 | R → K1 PublicationCorresponds to variant dbSNP:rs10988EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_057204 | 1 – 691 | Missing in isoform 3. 2 PublicationsAdd BLAST | 691 | |
Alternative sequenceiVSP_057205 | 1 – 54 | Missing in isoform 2. 1 PublicationAdd BLAST | 54 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D84223 mRNA Translation: BAA95667.1 AB037773 mRNA Translation: BAA92590.1 Different initiation. AY513284 mRNA Translation: AAT08037.1 AY926480 mRNA Translation: AAX10025.1 AK295874 mRNA Translation: BAG58672.1 AC091887 Genomic DNA No translation available. AC091959 Genomic DNA No translation available. CH471062 Genomic DNA Translation: EAW61848.1 BC131798 mRNA Translation: AAI31799.1 BC150213 mRNA Translation: AAI50214.1 BC151214 mRNA Translation: AAI51215.1 BC152422 mRNA Translation: AAI52423.1 |
CCDSi | CCDS34265.1 [Q9P2J5-1] CCDS83029.1 [Q9P2J5-2] |
RefSeqi | NP_001304893.1, NM_001317964.1 NP_001304894.1, NM_001317965.1 [Q9P2J5-2] NP_057544.2, NM_016460.3 NP_064502.9, NM_020117.10 [Q9P2J5-1] XP_011535958.1, XM_011537656.2 [Q9P2J5-2] |
Genome annotation databases
Ensembli | ENST00000274562; ENSP00000274562; ENSG00000133706 [Q9P2J5-3] ENST00000394434; ENSP00000377954; ENSG00000133706 [Q9P2J5-1] ENST00000510191; ENSP00000426005; ENSG00000133706 [Q9P2J5-2] ENST00000674174; ENSP00000501434; ENSG00000133706 [Q9P2J5-2] |
GeneIDi | 51520 |
KEGGi | hsa:51520 |
UCSCi | uc003lnx.2, human [Q9P2J5-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D84223 mRNA Translation: BAA95667.1 AB037773 mRNA Translation: BAA92590.1 Different initiation. AY513284 mRNA Translation: AAT08037.1 AY926480 mRNA Translation: AAX10025.1 AK295874 mRNA Translation: BAG58672.1 AC091887 Genomic DNA No translation available. AC091959 Genomic DNA No translation available. CH471062 Genomic DNA Translation: EAW61848.1 BC131798 mRNA Translation: AAI31799.1 BC150213 mRNA Translation: AAI50214.1 BC151214 mRNA Translation: AAI51215.1 BC152422 mRNA Translation: AAI52423.1 |
CCDSi | CCDS34265.1 [Q9P2J5-1] CCDS83029.1 [Q9P2J5-2] |
RefSeqi | NP_001304893.1, NM_001317964.1 NP_001304894.1, NM_001317965.1 [Q9P2J5-2] NP_057544.2, NM_016460.3 NP_064502.9, NM_020117.10 [Q9P2J5-1] XP_011535958.1, XM_011537656.2 [Q9P2J5-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2WFD | X-ray | 3.25 | A/B | 260-509 | [»] | |
6LPF | X-ray | 2.49 | A/B | 1-1070 | [»] | |
6LR6 | X-ray | 3.01 | A/B | 1-1070 | [»] | |
SMRi | Q9P2J5 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119584, 232 interactors |
CORUMi | Q9P2J5 |
IntActi | Q9P2J5, 51 interactors |
MINTi | Q9P2J5 |
STRINGi | 9606.ENSP00000377954 |
Chemistry databases
BindingDBi | Q9P2J5 |
ChEMBLi | CHEMBL3258 |
DrugBanki | DB00149, Leucine |
Protein family/group databases
MoonProti | Q9P2J5 |
PTM databases
iPTMneti | Q9P2J5 |
MetOSitei | Q9P2J5 |
PhosphoSitePlusi | Q9P2J5 |
SwissPalmi | Q9P2J5 |
Polymorphism and mutation databases
BioMutai | LARS |
DMDMi | 48428689 |
Proteomic databases
EPDi | Q9P2J5 |
jPOSTi | Q9P2J5 |
MassIVEi | Q9P2J5 |
MaxQBi | Q9P2J5 |
PaxDbi | Q9P2J5 |
PeptideAtlasi | Q9P2J5 |
PRIDEi | Q9P2J5 |
ProteomicsDBi | 4339 61500 83822 [Q9P2J5-1] |
Protocols and materials databases
ABCDi | Q9P2J5, 2 sequenced antibodies |
Antibodypediai | 45640, 107 antibodies |
Genome annotation databases
Ensembli | ENST00000274562; ENSP00000274562; ENSG00000133706 [Q9P2J5-3] ENST00000394434; ENSP00000377954; ENSG00000133706 [Q9P2J5-1] ENST00000510191; ENSP00000426005; ENSG00000133706 [Q9P2J5-2] ENST00000674174; ENSP00000501434; ENSG00000133706 [Q9P2J5-2] |
GeneIDi | 51520 |
KEGGi | hsa:51520 |
UCSCi | uc003lnx.2, human [Q9P2J5-1] |
Organism-specific databases
CTDi | 51520 |
DisGeNETi | 51520 |
EuPathDBi | HostDB:ENSG00000133706.17 |
GeneCardsi | LARS1 |
HGNCi | HGNC:6512, LARS1 |
HPAi | ENSG00000133706, Low tissue specificity |
MalaCardsi | LARS1 |
MIMi | 151350, gene 615438, phenotype |
neXtProti | NX_Q9P2J5 |
OpenTargetsi | ENSG00000133706 |
Orphaneti | 370088, Acute infantile liver failure-multisystemic involvement syndrome |
PharmGKBi | PA30297 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0437, Eukaryota |
GeneTreei | ENSGT00390000012163 |
HOGENOMi | CLU_004174_2_1_1 |
InParanoidi | Q9P2J5 |
OMAi | KFIEWQF |
OrthoDBi | 75155at2759 |
PhylomeDBi | Q9P2J5 |
TreeFami | TF105718 |
Enzyme and pathway databases
BRENDAi | 6.1.1.4, 2681 |
PathwayCommonsi | Q9P2J5 |
Reactomei | R-HSA-2408522, Selenoamino acid metabolism R-HSA-379716, Cytosolic tRNA aminoacylation |
SABIO-RKi | Q9P2J5 |
Miscellaneous databases
BioGRID-ORCSi | 51520, 732 hits in 843 CRISPR screens |
ChiTaRSi | LARS, human |
EvolutionaryTracei | Q9P2J5 |
GeneWikii | Leucyl-tRNA_synthetase |
GenomeRNAii | 51520 |
Pharosi | Q9P2J5, Tchem |
PROi | PR:Q9P2J5 |
RNActi | Q9P2J5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000133706, Expressed in kidney and 236 other tissues |
ExpressionAtlasi | Q9P2J5, baseline and differential |
Genevisiblei | Q9P2J5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR001412, aa-tRNA-synth_I_CS IPR002300, aa-tRNA-synth_Ia IPR004493, Leu-tRNA-synth_Ia_arc/euk IPR013155, M/V/L/I-tRNA-synth_anticd-bd IPR009080, tRNAsynth_Ia_anticodon-bd IPR009008, Val/Leu/Ile-tRNA-synth_edit |
PANTHERi | PTHR45794, PTHR45794, 1 hit |
Pfami | View protein in Pfam PF08264, Anticodon_1, 1 hit PF00133, tRNA-synt_1, 2 hits |
SUPFAMi | SSF47323, SSF47323, 1 hit SSF50677, SSF50677, 1 hit |
TIGRFAMsi | TIGR00395, leuS_arch, 1 hit |
PROSITEi | View protein in PROSITE PS00178, AA_TRNA_LIGASE_I, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SYLC_HUMAN | |
Accessioni | Q9P2J5Primary (citable) accession number: Q9P2J5 Secondary accession number(s): A2RRR4 Q9NSE1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2004 |
Last sequence update: | June 7, 2004 | |
Last modified: | December 2, 2020 | |
This is version 182 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Aminoacyl-tRNA synthetases
List of aminoacyl-tRNA synthetase entries