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UniProtKB - Q9P2J5 (SYLC_HUMAN)

Entry version 185 (02 Jun 2021)
Sequence version 2 (07 Jun 2004)
Previous versions | rss
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Protein

Leucine--tRNA ligase, cytoplasmic

Gene

LARS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

5-fluoro-1,3-dihydro-1-hydroxy-1,2-benzoxaborole inhibits LARS1 by forming a covalent adduct with the 3' adenosine of tRNA(Leu) at the editing site, thus locking the enzyme in an inactive conformation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei719ATPBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		6.1.1.4, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9P2J5

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2408522, Selenoamino acid metabolism
R-HSA-379716, Cytosolic tRNA aminoacylation

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		Q9P2J5

Protein family/group databases

MoonProt database of moonlighting proteins

More...MoonProti		Q9P2J5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine--tRNA ligase, cytoplasmic (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LARS1Imported
Synonyms:KIAA1352, LARS
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6512, LARS1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		151350, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9P2J5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000133706.17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Infantile liver failure syndrome 1 (ILFS1)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA life-threatening disorder of hepatic function that manifests with acute liver failure in the first few months of life. Clinical features include anemia, renal tubulopathy, developmental delay, seizures, failure to thrive, and liver steatosis and fibrosis.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_070438373Y → C in ILFS1. 1 PublicationCorresponds to variant dbSNP:rs201861847EnsemblClinVar.1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		51520

MalaCards human disease database

More...MalaCardsi		LARS1
MIMi615438, phenotype

Open Targets

More...OpenTargetsi		ENSG00000133706

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		370088, Acute infantile liver failure-multisystemic involvement syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30297

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9P2J5, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3258

Drug and drug target database

More...DrugBanki		DB00149, Leucine

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LARS

Domain mapping of disease mutations (DMDM)

More...DMDMi		48428689

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001521501 – 1176Leucine--tRNA ligase, cytoplasmicAdd BLAST1176

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei167PhosphoserineCombined sources1
Modified residuei720PhosphoserineCombined sources1
Modified residuei970N6-acetyllysineBy similarity1
Modified residuei1047N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9P2J5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9P2J5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9P2J5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9P2J5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9P2J5

PeptideAtlas

More...PeptideAtlasi		Q9P2J5

PRoteomics IDEntifications database

More...PRIDEi		Q9P2J5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		4339
61500
83822 [Q9P2J5-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9P2J5

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9P2J5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9P2J5

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9P2J5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000133706, Expressed in kidney and 237 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9P2J5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9P2J5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000133706, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119584, 249 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9P2J5

Protein interaction database and analysis system

More...IntActi		Q9P2J5, 56 interactors

Molecular INTeraction database

More...MINTi		Q9P2J5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000377954

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9P2J5

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9P2J5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11176
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9P2J5

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9P2J5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni260 – 509Editing domainAdd BLAST250

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi53 – 63'HIGH' regionAdd BLAST11
Motifi716 – 720'KMSKS' region5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0437, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000012163

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004174_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9P2J5

Identification of Orthologs from Complete Genome Data

More...OMAi		KFIEWQF

Database of Orthologous Groups

More...OrthoDBi		75155at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9P2J5

TreeFam database of animal gene trees

More...TreeFami		TF105718

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001412, aa-tRNA-synth_I_CS
IPR002300, aa-tRNA-synth_Ia
IPR004493, Leu-tRNA-synth_Ia_arc/euk
IPR013155, M/V/L/I-tRNA-synth_anticd-bd
IPR009080, tRNAsynth_Ia_anticodon-bd
IPR009008, Val/Leu/Ile-tRNA-synth_edit

The PANTHER Classification System

More...PANTHERi		PTHR45794, PTHR45794, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08264, Anticodon_1, 1 hit
PF00133, tRNA-synt_1, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47323, SSF47323, 1 hit
SSF50677, SSF50677, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00395, leuS_arch, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00178, AA_TRNA_LIGASE_I, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9P2J5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAERKGTAKV DFLKKIEKEI QQKWDTERVF EVNASNLEKQ TSKGKYFVTF 
        60         70         80         90        100
PYPYMNGRLH LGHTFSLSKC EFAVGYQRLK GKCCLFPFGL HCTGMPIKAC 
       110        120        130        140        150
ADKLKREIEL YGCPPDFPDE EEEEEETSVK TEDIIIKDKA KGKKSKAAAK 
       160        170        180        190        200
AGSSKYQWGI MKSLGLSDEE IVKFSEAEHW LDYFPPLAIQ DLKRMGLKVD 
       210        220        230        240        250
WRRSFITTDV NPYYDSFVRW QFLTLRERNK IKFGKRYTIY SPKDGQPCMD 
       260        270        280        290        300
HDRQTGEGVG PQEYTLLKLK VLEPYPSKLS GLKGKNIFLV AATLRPETMF 
       310        320        330        340        350
GQTNCWVRPD MKYIGFETVN GDIFICTQKA ARNMSYQGFT KDNGVVPVVK 
       360        370        380        390        400
ELMGEEILGA SLSAPLTSYK VIYVLPMLTI KEDKGTGVVT SVPSDSPDDI 
       410        420        430        440        450
AALRDLKKKQ ALRAKYGIRD DMVLPFEPVP VIEIPGFGNL SAVTICDELK 
       460        470        480        490        500
IQSQNDREKL AEAKEKIYLK GFYEGIMLVD GFKGQKVQDV KKTIQKKMID 
       510        520        530        540        550
AGDALIYMEP EKQVMSRSSD ECVVALCDQW YLDYGEENWK KQTSQCLKNL 
       560        570        580        590        600
ETFCEETRRN FEATLGWLQE HACSRTYGLG THLPWDEQWL IESLSDSTIY 
       610        620        630        640        650
MAFYTVAHLL QGGNLHGQAE SPLGIRPQQM TKEVWDYVFF KEAPFPKTQI 
       660        670        680        690        700
AKEKLDQLKQ EFEFWYPVDL RVSGKDLVPN HLSYYLYNHV AMWPEQSDKW 
       710        720        730        740        750
PTAVRANGHL LLNSEKMSKS TGNFLTLTQA IDKFSADGMR LALADAGDTV 
       760        770        780        790        800
EDANFVEAMA DAGILRLYTW VEWVKEMVAN WDSLRSGPAS TFNDRVFASE 
       810        820        830        840        850
LNAGIIKTDQ NYEKMMFKEA LKTGFFEFQA AKDKYRELAV EGMHRELVFR 
       860        870        880        890        900
FIEVQTLLLA PFCPHLCEHI WTLLGKPDSI MNASWPVAGP VNEVLIHSSQ 
       910        920        930        940        950
YLMEVTHDLR LRLKNYMMPA KGKKTDKQPL QKPSHCTIYV AKNYPPWQHT 
       960        970        980        990       1000
TLSVLRKHFE ANNGKLPDNK VIASELGSMP ELKKYMKKVM PFVAMIKENL 
      1010       1020       1030       1040       1050
EKMGPRILDL QLEFDEKAVL MENIVYLTNS LELEHIEVKF ASEAEDKIRE 
      1060       1070       1080       1090       1100
DCCPGKPLNV FRIEPGVSVS LVNPQPSNGH FSTKIEIRQG DNCDSIIRRL 
      1110       1120       1130       1140       1150
MKMNRGIKDL SKVKLMRFDD PLLGPRRVPV LGKEYTEKTP ISEHAVFNVD 
      1160       1170 
LMSKKIHLTE NGIRVDIGDT IIYLVH
Length:1,176
Mass (Da):134,466
Last modified:June 7, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i44A4D1A1EF31634A
GO
Isoform 2 (identifier: Q9P2J5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: Missing.

Show »
Length:1,122
Mass (Da):128,038
Checksum:i87D1D1210F7A2252
GO
Isoform 3 (identifier: Q9P2J5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-691: Missing.

Show »
Length:485
Mass (Da):55,295
Checksum:iE4C99F943B951653
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DER1B4DER1_HUMAN
Leucyl-tRNA synthetase
LARS1
1,149Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8PL42A0A6I8PL42_HUMAN
Leucyl-tRNA synthetase
LARS1
1,130Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8PIP7A0A6I8PIP7_HUMAN
Leucyl-tRNA synthetase
LARS1
850Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8PIT3A0A6I8PIT3_HUMAN
Leucyl-tRNA synthetase
LARS1
1,164Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8PIV1A0A6I8PIV1_HUMAN
Leucyl-tRNA synthetase
LARS1
1,175Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8PLB8A0A6I8PLB8_HUMAN
Leucyl-tRNA synthetase
LARS1
1,112Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8PRS0A0A6I8PRS0_HUMAN
Leucyl-tRNA synthetase
LARS1
1,121Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8PRU9A0A6I8PRU9_HUMAN
Leucyl-tRNA synthetase
LARS1
543Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8PS05A0A6I8PS05_HUMAN
Leucyl-tRNA synthetase
LARS1
1,049Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8PTV8A0A6I8PTV8_HUMAN
Leucyl-tRNA synthetase
LARS1
697Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA92590 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti271V → A in BAA95667 (Ref. 1) Curated1
Sequence conflicti892N → D in BAA95667 (Ref. 1) Curated1
Sequence conflicti1026Y → C in AAI31799 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07043782K → R1 PublicationCorresponds to variant dbSNP:rs112954500EnsemblClinVar.1
Natural variantiVAR_070438373Y → C in ILFS1. 1 PublicationCorresponds to variant dbSNP:rs201861847EnsemblClinVar.1
Natural variantiVAR_0526371088R → K1 PublicationCorresponds to variant dbSNP:rs10988EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0572041 – 691Missing in isoform 3. 2 PublicationsAdd BLAST691
Alternative sequenceiVSP_0572051 – 54Missing in isoform 2. 1 PublicationAdd BLAST54

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D84223 mRNA Translation: BAA95667.1
AB037773 mRNA Translation: BAA92590.1 Different initiation.
AY513284 mRNA Translation: AAT08037.1
AY926480 mRNA Translation: AAX10025.1
AK295874 mRNA Translation: BAG58672.1
AC091887 Genomic DNA No translation available.
AC091959 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61848.1
BC131798 mRNA Translation: AAI31799.1
BC150213 mRNA Translation: AAI50214.1
BC151214 mRNA Translation: AAI51215.1
BC152422 mRNA Translation: AAI52423.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34265.1 [Q9P2J5-1]
CCDS83029.1 [Q9P2J5-2]

NCBI Reference Sequences

More...RefSeqi		NP_001304893.1, NM_001317964.1
NP_001304894.1, NM_001317965.1 [Q9P2J5-2]
NP_057544.2, NM_016460.3
NP_064502.9, NM_020117.10 [Q9P2J5-1]
XP_011535958.1, XM_011537656.2 [Q9P2J5-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000274562; ENSP00000274562; ENSG00000133706 [Q9P2J5-3]
ENST00000394434; ENSP00000377954; ENSG00000133706 [Q9P2J5-1]
ENST00000510191; ENSP00000426005; ENSG00000133706 [Q9P2J5-2]
ENST00000674174; ENSP00000501434; ENSG00000133706 [Q9P2J5-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51520

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51520

UCSC genome browser

More...UCSCi		uc003lnx.2, human [Q9P2J5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84223 mRNA Translation: BAA95667.1
AB037773 mRNA Translation: BAA92590.1 Different initiation.
AY513284 mRNA Translation: AAT08037.1
AY926480 mRNA Translation: AAX10025.1
AK295874 mRNA Translation: BAG58672.1
AC091887 Genomic DNA No translation available.
AC091959 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61848.1
BC131798 mRNA Translation: AAI31799.1
BC150213 mRNA Translation: AAI50214.1
BC151214 mRNA Translation: AAI51215.1
BC152422 mRNA Translation: AAI52423.1
CCDSiCCDS34265.1 [Q9P2J5-1]
CCDS83029.1 [Q9P2J5-2]
RefSeqiNP_001304893.1, NM_001317964.1
NP_001304894.1, NM_001317965.1 [Q9P2J5-2]
NP_057544.2, NM_016460.3
NP_064502.9, NM_020117.10 [Q9P2J5-1]
XP_011535958.1, XM_011537656.2 [Q9P2J5-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WFDX-ray3.25A/B260-509[»]
6KIDX-ray3.15A1-1176[»]
6KIEX-ray3.15A1-1061[»]
6KQYX-ray3.30A1-1176[»]
6KR7X-ray4.00A1-1176[»]
6LPFX-ray2.49A/B1-1070[»]
6LR6X-ray3.01A/B1-1070[»]
SMRiQ9P2J5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi119584, 249 interactors
CORUMiQ9P2J5
IntActiQ9P2J5, 56 interactors
MINTiQ9P2J5
STRINGi9606.ENSP00000377954

Chemistry databases

BindingDBiQ9P2J5
ChEMBLiCHEMBL3258
DrugBankiDB00149, Leucine

Protein family/group databases

MoonProtiQ9P2J5

PTM databases

iPTMnetiQ9P2J5
MetOSiteiQ9P2J5
PhosphoSitePlusiQ9P2J5
SwissPalmiQ9P2J5

Genetic variation databases

BioMutaiLARS
DMDMi48428689

Proteomic databases

EPDiQ9P2J5
jPOSTiQ9P2J5
MassIVEiQ9P2J5
MaxQBiQ9P2J5
PaxDbiQ9P2J5
PeptideAtlasiQ9P2J5
PRIDEiQ9P2J5
ProteomicsDBi4339
61500
83822 [Q9P2J5-1]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q9P2J5, 2 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		45640, 108 antibodies

The DNASU plasmid repository

More...DNASUi		51520

Genome annotation databases

EnsembliENST00000274562; ENSP00000274562; ENSG00000133706 [Q9P2J5-3]
ENST00000394434; ENSP00000377954; ENSG00000133706 [Q9P2J5-1]
ENST00000510191; ENSP00000426005; ENSG00000133706 [Q9P2J5-2]
ENST00000674174; ENSP00000501434; ENSG00000133706 [Q9P2J5-2]
GeneIDi51520
KEGGihsa:51520
UCSCiuc003lnx.2, human [Q9P2J5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51520
DisGeNETi51520

GeneCards: human genes, protein and diseases

More...GeneCardsi		LARS1
HGNCiHGNC:6512, LARS1
HPAiENSG00000133706, Low tissue specificity
MalaCardsiLARS1
MIMi151350, gene
615438, phenotype
neXtProtiNX_Q9P2J5
OpenTargetsiENSG00000133706
Orphaneti370088, Acute infantile liver failure-multisystemic involvement syndrome
PharmGKBiPA30297
VEuPathDBiHostDB:ENSG00000133706.17

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0437, Eukaryota
GeneTreeiENSGT00390000012163
HOGENOMiCLU_004174_2_1_1
InParanoidiQ9P2J5
OMAiKFIEWQF
OrthoDBi75155at2759
PhylomeDBiQ9P2J5
TreeFamiTF105718

Enzyme and pathway databases

BRENDAi6.1.1.4, 2681
PathwayCommonsiQ9P2J5
ReactomeiR-HSA-2408522, Selenoamino acid metabolism
R-HSA-379716, Cytosolic tRNA aminoacylation
SABIO-RKiQ9P2J5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		51520, 757 hits in 994 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LARS, human
EvolutionaryTraceiQ9P2J5

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Leucyl-tRNA_synthetase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51520
PharosiQ9P2J5, Tchem

Protein Ontology

More...PROi		PR:Q9P2J5
RNActiQ9P2J5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000133706, Expressed in kidney and 237 other tissues
ExpressionAtlasiQ9P2J5, baseline and differential
GenevisibleiQ9P2J5, HS

Family and domain databases

InterProiView protein in InterPro
IPR001412, aa-tRNA-synth_I_CS
IPR002300, aa-tRNA-synth_Ia
IPR004493, Leu-tRNA-synth_Ia_arc/euk
IPR013155, M/V/L/I-tRNA-synth_anticd-bd
IPR009080, tRNAsynth_Ia_anticodon-bd
IPR009008, Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR45794, PTHR45794, 1 hit
PfamiView protein in Pfam
PF08264, Anticodon_1, 1 hit
PF00133, tRNA-synt_1, 2 hits
SUPFAMiSSF47323, SSF47323, 1 hit
SSF50677, SSF50677, 1 hit
TIGRFAMsiTIGR00395, leuS_arch, 1 hit
PROSITEiView protein in PROSITE
PS00178, AA_TRNA_LIGASE_I, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYLC_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P2J5
Secondary accession number(s): A2RRR4
, A7E266, B4DJ10, Q2TU79, Q9NSE1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: June 2, 2021
This is version 185 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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