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Protein

Kelch-like protein 9

Gene

KLHL9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.3 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • post-translational protein modification Source: Reactome
  • protein ubiquitination Source: UniProtKB
  • regulation of cytokinesis Source: UniProtKB

Keywordsi

Biological processCell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 9
Gene namesi
Name:KLHL9
Synonyms:KIAA1354
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000198642.6
HGNCiHGNC:18732 KLHL9
MIMi611201 gene
neXtProtiNX_Q9P2J3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi55958
MalaCardsiKLHL9
OpenTargetsiENSG00000198642
Orphaneti399081 KLHL9-related childhood-onset distal myopathy
PharmGKBiPA38662

Polymorphism and mutation databases

BioMutaiKLHL9
DMDMi51338828

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001191101 – 617Kelch-like protein 9Add BLAST617

Proteomic databases

EPDiQ9P2J3
MaxQBiQ9P2J3
PaxDbiQ9P2J3
PeptideAtlasiQ9P2J3
PRIDEiQ9P2J3
ProteomicsDBi83821

PTM databases

iPTMnetiQ9P2J3
PhosphoSitePlusiQ9P2J3

Expressioni

Gene expression databases

BgeeiENSG00000198642
CleanExiHS_KLHL9
ExpressionAtlasiQ9P2J3 baseline and differential
GenevisibleiQ9P2J3 HS

Organism-specific databases

HPAiHPA046039
HPA059901

Interactioni

Subunit structurei

Component of the BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL9, KLHL13 and RBX1. Interacts with AURKB.2 Publications

Protein-protein interaction databases

BioGridi121009, 29 interactors
DIPiDIP-53514N
IntActiQ9P2J3, 8 interactors
STRINGi9606.ENSP00000351933

Structurei

3D structure databases

ProteinModelPortaliQ9P2J3
SMRiQ9P2J3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 119BTBPROSITE-ProRule annotationAdd BLAST70
Domaini154 – 255BACKAdd BLAST102
Repeati300 – 347Kelch 1Add BLAST48
Repeati348 – 399Kelch 2Add BLAST52
Repeati400 – 446Kelch 3Add BLAST47
Repeati448 – 493Kelch 4Add BLAST46
Repeati495 – 545Kelch 5Add BLAST51
Repeati546 – 595Kelch 6Add BLAST50

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441 Eukaryota
ENOG410XNX8 LUCA
GeneTreeiENSGT00760000118825
HOGENOMiHOG000231583
HOVERGENiHBG106526
InParanoidiQ9P2J3
KOiK10447
OMAiDDAHMKV
OrthoDBiEOG091G039V
PhylomeDBiQ9P2J3
TreeFamiTF328485

Family and domain databases

Gene3Di2.120.10.80, 1 hit
InterProiView protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 5 hits
PIRSFiPIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 6 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

Sequencei

Sequence statusi: Complete.

Q9P2J3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSLGNGEM GVSAHLQPCK AGTTRFFTSN THSSVVLQGF DQLRIEGLLC
60 70 80 90 100
DVTLVPGDGD EIFPVHRAMM ASASDYFKAM FTGGMKEQDL MCIKLHGVNK
110 120 130 140 150
VGLKKIIDFI YTAKLSLNMD NLQDTLEAAS FLQILPVLDF CKVFLISGVS
160 170 180 190 200
LDNCVEVGRI ANTYNLIEVD KYVNNFILKN FPALLSTGEF LKLPFERLAF
210 220 230 240 250
VLSSNSLKHC TELELFKAAC RWLRLEDPRM DYAAKLMKNI RFPLMTPQDL
260 270 280 290 300
INYVQTVDFM RTDNTCVNLL LEASNYQMMP YMQPVMQSDR TAIRSDSTHL
310 320 330 340 350
VTLGGVLRQQ LVVSKELRMY DERAQEWRSL APMDAPRYQH GIAVIGNFLY
360 370 380 390 400
VVGGQSNYDT KGKTAVDTVF RFDPRYNKWM QVASLNEKRT FFHLSALKGH
410 420 430 440 450
LYAVGGRSAA GELATVECYN PRMNEWSYVA KMSEPHYGHA GTVYGGLMYI
460 470 480 490 500
SGGITHDTFQ NELMCFDPDT DKWMQKAPMT TVRGLHCMCT VGDKLYVIGG
510 520 530 540 550
NHFRGTSDYD DVLSCEYYSP TLDQWTPIAA MLRGQSDVGV AVFENKIYVV
560 570 580 590 600
GGYSWNNRCM VEIVQKYDPE KDEWHKVFDL PESLGGIRAC TLTVFPPEEN
610
PGSPSRESPL SAPSDHS
Length:617
Mass (Da):69,429
Last modified:August 16, 2004 - v2
Checksum:iB74232F28ABF7C82
GO

Sequence cautioni

The sequence BAA92592 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037775 mRNA Translation: BAA92592.1 Different initiation.
AL713669 mRNA Translation: CAD28475.1
CCDSiCCDS6503.1
RefSeqiNP_061335.1, NM_018847.3
UniGeneiHs.701778
Hs.710126
Hs.744736

Genome annotation databases

EnsembliENST00000359039; ENSP00000351933; ENSG00000198642
GeneIDi55958
KEGGihsa:55958
UCSCiuc003zoy.4 human

Similar proteinsi

Entry informationi

Entry nameiKLHL9_HUMAN
AccessioniPrimary (citable) accession number: Q9P2J3
Secondary accession number(s): Q8TCQ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 16, 2004
Last modified: July 18, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways

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