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Entry version 121 (26 Feb 2020)
Sequence version 2 (01 Jun 2001)
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Protein

Microtubule-associated protein 10

Gene

MAP10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Microtubule-associated protein (MAP) that plays a role in the regulation of cell division; promotes microtubule stability and participates in the organization of the spindle midzone and normal progress of cytokinesis.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Microtubule-associated protein 10
Alternative name(s):
Microtubule regulator of 120 KDa
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAP10
Synonyms:KIAA1383, MTR120
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29265 MAP10

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
618551 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9P2G4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54627

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671610

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9P2G4 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MAP10

Domain mapping of disease mutations (DMDM)

More...
DMDMi
14286071

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000507941 – 905Microtubule-associated protein 10Add BLAST905

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9P2G4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9P2G4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9P2G4

PeptideAtlas

More...
PeptideAtlasi
Q9P2G4

PRoteomics IDEntifications database

More...
PRIDEi
Q9P2G4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
83813

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1514

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9P2G4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9P2G4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in different cell lines (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000212916 Expressed in heart and 90 other tissues

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA052496

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via middle region) with microtubules.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120084, 30 interactors

Protein interaction database and analysis system

More...
IntActi
Q9P2G4, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000403208

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9P2G4 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi701 – 870Ser-richAdd BLAST170

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEFV Eukaryota
ENOG4111RUV LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_014844_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9P2G4

Database of Orthologous Groups

More...
OrthoDBi
486802at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9P2G4

TreeFam database of animal gene trees

More...
TreeFami
TF338644

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039302 MAP10
IPR026679 MAP10_C-term

The PANTHER Classification System

More...
PANTHERi
PTHR21831 PTHR21831, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14925 HPHLAWLY, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9P2G4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAASLSERLF SLELLVDWVR LEARLLPSPA AAVEQEEEEE EKEQGEASSP
60 70 80 90 100
RGLCPAVAFR LLDFPTLLVY PPDGPGAPAA EPWPGVIRFG RGKSCLFRLQ
110 120 130 140 150
PATLHCRLLR TPLATLLLQL PPGRPTPTPQ LLGACDISLA TAAHRVVGPA
160 170 180 190 200
ASGCSHRHRG RFPLHNRVGE RTGDIALAYR LTDLGSRLLS QLERPLTFTR
210 220 230 240 250
TGGGAEVSPQ TQQERQQLQQ PASQPSPKEA DKPLGELEIP EAQKDLKEMV
260 270 280 290 300
KSKAECDNVG SVENGKTNSV VTCSGAGNGR NVSSLNEEVT ELDMETNIFC
310 320 330 340 350
PPPLYYTNLT QEKPPPAQAK ITIEPQMNAP EEMDDASPEK KRVNPPAHRS
360 370 380 390 400
CLKHPSSAAH EHPPMLVNPP HIQNIGATNQ TCQTEQNRIN TIRQLPLLNA
410 420 430 440 450
LLVELSLLYD QPVTSPAHIH PHLAWLYRTE DKKSPESSAK STCRSEAKKD
460 470 480 490 500
KRSVGGCEKS VSLQYKKNQI ENYKEDKYSE KSSGALHKRV PKGRLLYGLT
510 520 530 540 550
NTLRLRLKLT NPDMLVVHEK RELYRKRQSQ MLGTKFRIPS SKVKLLSSAE
560 570 580 590 600
QSQKPQLPED KYLDSDASFT ENSDTSRQIS GVFDEPSTSK ETKLKYATEK
610 620 630 640 650
KTVDCSKNRI NNVSLEEVVS PANSIIPERL TPTNILGGNV EMKIQSPCVF
660 670 680 690 700
QQDAVVDRIV DKEIDIRQVK TTDNDILMAD ISDKRTGKNS CYENISELKY
710 720 730 740 750
SDDLSSPCYS EDFCTSEDTS RSFKAHDSSS RTENPKHSQY TSKSSDTGVS
760 770 780 790 800
KKKNSSDRSS ILSPPFSAGS PVHSYRKFHI SKTQDKSLEE ASSISASDLS
810 820 830 840 850
STHWTEQKEN QIDQNSMHNS EITKRAQDIS VKTRSSWKSL EKSQSPQTSQ
860 870 880 890 900
VSSYLPSNVS ELNVLDSSTS DHFEEGNDDV GSLNISKQCK DICELVINKL

PGYTM
Length:905
Mass (Da):100,345
Last modified:June 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB02FBD0EDAD78491
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA92621 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB037804 mRNA Translation: BAA92621.1 Different initiation.
AK290216 mRNA Translation: BAF82905.1
AL451083 Genomic DNA No translation available.
BC036663 mRNA Translation: AAH36663.1
BC109122 mRNA Translation: AAI09123.2

NCBI Reference Sequences

More...
RefSeqi
NP_061963.2, NM_019090.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000418460; ENSP00000403208; ENSG00000212916

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54627

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54627

UCSC genome browser

More...
UCSCi
uc001hvh.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037804 mRNA Translation: BAA92621.1 Different initiation.
AK290216 mRNA Translation: BAF82905.1
AL451083 Genomic DNA No translation available.
BC036663 mRNA Translation: AAH36663.1
BC109122 mRNA Translation: AAI09123.2
RefSeqiNP_061963.2, NM_019090.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi120084, 30 interactors
IntActiQ9P2G4, 1 interactor
STRINGi9606.ENSP00000403208

PTM databases

GlyConnecti1514
iPTMnetiQ9P2G4
PhosphoSitePlusiQ9P2G4

Polymorphism and mutation databases

BioMutaiMAP10
DMDMi14286071

Proteomic databases

EPDiQ9P2G4
jPOSTiQ9P2G4
PaxDbiQ9P2G4
PeptideAtlasiQ9P2G4
PRIDEiQ9P2G4
ProteomicsDBi83813

Genome annotation databases

EnsembliENST00000418460; ENSP00000403208; ENSG00000212916
GeneIDi54627
KEGGihsa:54627
UCSCiuc001hvh.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54627
DisGeNETi54627

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MAP10
HGNCiHGNC:29265 MAP10
HPAiHPA052496
MIMi618551 gene
neXtProtiNX_Q9P2G4
PharmGKBiPA142671610

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEFV Eukaryota
ENOG4111RUV LUCA
HOGENOMiCLU_014844_0_0_1
InParanoidiQ9P2G4
OrthoDBi486802at2759
PhylomeDBiQ9P2G4
TreeFamiTF338644

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MAP10 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
54627
PharosiQ9P2G4 Tbio

Protein Ontology

More...
PROi
PR:Q9P2G4
RNActiQ9P2G4 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000212916 Expressed in heart and 90 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR039302 MAP10
IPR026679 MAP10_C-term
PANTHERiPTHR21831 PTHR21831, 1 hit
PfamiView protein in Pfam
PF14925 HPHLAWLY, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMAP10_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P2G4
Secondary accession number(s): A8K2F1
, Q32MI1, Q58EZ9, Q5VV83
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: February 26, 2020
This is version 121 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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