SIPA1L2

Functionⁱ

GO - Molecular functionⁱ

GTPase activator activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of small GTPase mediated signal transduction Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	GTPase activation

Molecular function

GTPase activation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Signal-induced proliferation-associated 1-like protein 2 Short name: SIPA1-like protein 2
Gene namesⁱ	Name:SIPA1L2 Synonyms:KIAA1389
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000116991.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23800 SIPA1L2
MIMⁱ	611609 gene
neXtProtⁱ	NX_Q9P2F8

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	57568
Open Targets More...OpenTargetsⁱ	ENSG00000116991
PharmGKBⁱ	PA134933243

Polymorphism and mutation databases

BioMutaⁱ	SIPA1L2
DMDMⁱ	85681894

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000056749	1 – 1722	Signal-induced proliferation-associated 1-like protein 2Add BLAST		1722

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	148	PhosphoserineCombined sources	1
Modified residueⁱ	379	PhosphoserineBy similarity	1
Modified residueⁱ	383	PhosphoserineBy similarity	1
Modified residueⁱ	1029	PhosphoserineCombined sources	1
Modified residueⁱ	1244	PhosphoserineBy similarity	1
Modified residueⁱ	1461	PhosphoserineCombined sources	1
Modified residueⁱ	1472	PhosphoserineBy similarity	1
Modified residueⁱ	1478	PhosphoserineCombined sources	1
Modified residueⁱ	1488	PhosphoserineCombined sources	1
Modified residueⁱ	1549	PhosphoserineCombined sources	1
Modified residueⁱ	1552	PhosphoserineCombined sources	1
Modified residueⁱ	1591	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9P2F8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9P2F8
PaxDbⁱ	Q9P2F8
PeptideAtlas More...PeptideAtlasⁱ	Q9P2F8
PRIDEⁱ	Q9P2F8
ProteomicsDBⁱ	83807 83808 [Q9P2F8-2]

PTM databases

iPTMnetⁱ	Q9P2F8
PhosphoSitePlusⁱ	Q9P2F8

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000116991 Expressed in 199 organ(s), highest expression level in left ventricle myocardium
CleanExⁱ	HS_SIPA1L2
Genevisibleⁱ	Q9P2F8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA024181 HPA027224

HPAⁱ

HPA024181
HPA027224

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
AP3M1	Q9Y2T2	5	EBI-10326741,EBI-2371151
DDX6	P26196	4	EBI-10326741,EBI-351257

Protein-protein interaction databases

BioGridⁱ	121621, 37 interactors
IntActⁱ	Q9P2F8, 27 interactors
Molecular INTeraction database More...MINTⁱ	Q9P2F8
STRINGⁱ	9606.ENSP00000262861

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9P2F8
SMRⁱ	Q9P2F8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	595 – 812	Rap-GAPPROSITE-ProRule annotationAdd BLAST		218
Domainⁱ	950 – 1026	PDZPROSITE-ProRule annotationAdd BLAST		77

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	1654 – 1712	Sequence analysisAdd BLAST		59

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	60 – 63	Poly-Gly	4
Compositional biasⁱ	1125 – 1128	Poly-Ser	4
Compositional biasⁱ	1321 – 1384	Ser-richAdd BLAST	64

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	KOG3686 Eukaryota ENOG410XTIX LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119182
HOVERGENⁱ	HBG056135
InParanoidⁱ	Q9P2F8
KEGG Orthology (KO) More...KOⁱ	K17702
OMAⁱ	MWHVIAR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G016P
PhylomeDBⁱ	Q9P2F8
TreeFamⁱ	TF318626

Family and domain databases

Gene3Dⁱ	3.40.50.11210, 1 hit
InterProⁱ	View protein in InterPro IPR001478 PDZ IPR036034 PDZ_sf IPR035974 Rap/Ran-GAP_sf IPR000331 Rap_GAP_dom IPR031203 SIPA1L2 IPR021818 SIPA1L_C
PANTHERⁱ	PTHR15711:SF7 PTHR15711:SF7, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02145 Rap_GAP, 1 hit PF11881 SPAR_C, 1 hit
SMARTⁱ	View protein in SMART SM00228 PDZ, 1 hit
SUPFAMⁱ	SSF111347 SSF111347, 1 hit SSF50156 SSF50156, 1 hit
PROSITEⁱ	View protein in PROSITE PS50106 PDZ, 1 hit PS50085 RAPGAP, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q9P2F8-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDPRQSQEE KHKLGRASSK FKDPPRIMQS DDYFARKFKA INGNMGPTTS 
        60         70         80         90        100
LNASNSNETG GGGPANGTPA VPKMGVRARV SEWPPKKDCS KELTCKALWE 
       110        120        130        140        150
SRSQTSYESI TSVLQNGQSD QSEGQQDEQL DLDFVEAKYT IGDIFVHSPQ 
       160        170        180        190        200
RGLHPIRQRS NSDVTISDID AEDVLDQNAV NPNTGAALHR EYGSTSSIDR 
       210        220        230        240        250
QGLSGENFFA MLRGYRVENY DHKAMVPFGF PEFFRCDPAI SPSLHAAAQI 
       260        270        280        290        300
SRGEFVRISG LDYVDSALLM GRDRDKPFKR RLKSESVETS LFRKLRTVKS 
       310        320        330        340        350
EHETFKFTSE LEESRLERGI RPWNCQRCFA HYDVQSILFN INEAMATRAN 
       360        370        380        390        400
VGKRKNITTG ASAASQTQMP TGQTGNCESP LGSKEDLNSK ENLDADEGDG 
       410        420        430        440        450
KSNDLVLSCP YFRNETGGEG DRRIALSRAN SSSFSSGESC SFESSLSSHC 
       460        470        480        490        500
TNAGVSVLEV PRENQPIHRE KVKRYIIEHI DLGAYYYRKF FYGKEHQNYF 
       510        520        530        540        550
GIDENLGPVA VSIRREKVED AKEKEGSQFN YRVAFRTSEL TTLRGAILED 
       560        570        580        590        600
AIPSTARHGT ARGLPLKEVL EYVIPELSIQ CLRQASNSPK VSEQLLKLDE 
       610        620        630        640        650
QGLSFQHKIG ILYCKAGQST EEEMYNNETA GPAFEEFLDL LGQRVRLKGF 
       660        670        680        690        700
SKYRAQLDNK TDSTGTHSLY TTYKDYELMF HVSTLLPYMP NNRQQLLRKR 
       710        720        730        740        750
HIGNDIVTIV FQEPGALPFT PKSIRSHFQH VFVIVKVHNP CTENVCYSVG 
       760        770        780        790        800
VSRSKDVPPF GPPIPKGVTF PKSAVFRDFL LAKVINAENA AHKSEKFRAM 
       810        820        830        840        850
ATRTRQEYLK DLAENFVTTA TVDTSVKFSF ITLGAKKKEK VKPRKDAHLF 
       860        870        880        890        900
SIGAIMWHVI ARDFGQSADI ECLLGISNEF IMLIEKDSKN VVFNCSCRDV 
       910        920        930        940        950
IGWTSGLVSI KVFYERGECV LLSSVDNCAE DIREIVQRLV IVTRGCETVE 
       960        970        980        990       1000
MTLRRNGLGQ LGFHVNFEGI VADVEPFGFA WKAGLRQGSR LVEICKVAVA 
      1010       1020       1030       1040       1050
TLTHEQMIDL LRTSVTVKVV IIQPHDDGSP RRGCSELCRI PMVEYKLDSE 
      1060       1070       1080       1090       1100
GTPCEYKTPF RRNTTWHRVP TPALQPLSRA SPIPGTPDRL PCQQLLQQAQ 
      1110       1120       1130       1140       1150
AAIPRSTSFD RKLPDGTRSS PSNQSSSSDP GPGGSGPWRP QVGYDGCQSP 
      1160       1170       1180       1190       1200
LLLEHQGSGP LECDGARERE DTMEASRHPE TKWHGPPSKV LGSYKERALQ 
      1210       1220       1230       1240       1250
KDGSCKDSPN KLSHIGDKSC SSHSSSNTLS SNTSSNSDDK HFGSGDLMDP 
      1260       1270       1280       1290       1300
ELLGLTYIKG ASTDSGIDTA PCMPATILGP VHLAGSRSLI HSRAEQWADA 
      1310       1320       1330       1340       1350
ADVSGPDDEP AKLYSVHGYA STISAGSAAE GSMGDLSEIS SHSSGSHHSG 
      1360       1370       1380       1390       1400
SPSAHCSKSS GSLDSSKVYI VSHSSGQQVP GSMSKPYHRQ GAVNKYVIGW 
      1410       1420       1430       1440       1450
KKSEGSPPPE EPEVTECPGM YSEMDVMSTA TQHQTVVGDA VAETQHVLSK 
      1460       1470       1480       1490       1500
EDFLKLMLPD SPLVEEGRRK FSFYGNLSPR RSLYRTLSDE SICSNRRGSS 
      1510       1520       1530       1540       1550
FGSSRSSVLD QALPNDILFS TTPPYHSTLP PRAHPAPSMG SLRNEFWFSD 
      1560       1570       1580       1590       1600
GSLSDKSKCA DPGLMPLPDT ATGLDWTHLV DAARAFEGLD SDEELGLLCH 
      1610       1620       1630       1640       1650
HTSYLDQRVA SFCTLTDMQH GQDLEGAQEL PLCVDPGSGK EFMDTTGERS 
      1660       1670       1680       1690       1700
PSPLTGKVNQ LELILRQLQT DLRKEKQDKA VLQAEVQHLR QDNMRLQEES 
      1710       1720 
QTATAQLRKF TEWFFTTIDK KS

Length:1,722

Mass (Da):190,438

Last modified:January 10, 2006 - v2

Checksum:ⁱC99E808CD6B156B1

GO

Isoform 2 (identifier: Q9P2F8-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-926: Missing.
     927-940: NCAEDIREIVQRLV → MSPCFSFIGCKLCS
     1588-1605: Missing.

« Hide

        10         20         30         40         50
MSPCFSFIGC KLCSIVTRGC ETVEMTLRRN GLGQLGFHVN FEGIVADVEP 
        60         70         80         90        100
FGFAWKAGLR QGSRLVEICK VAVATLTHEQ MIDLLRTSVT VKVVIIQPHD 
       110        120        130        140        150
DGSPRRGCSE LCRIPMVEYK LDSEGTPCEY KTPFRRNTTW HRVPTPALQP 
       160        170        180        190        200
LSRASPIPGT PDRLPCQQLL QQAQAAIPRS TSFDRKLPDG TRSSPSNQSS 
       210        220        230        240        250
SSDPGPGGSG PWRPQVGYDG CQSPLLLEHQ GSGPLECDGA REREDTMEAS 
       260        270        280        290        300
RHPETKWHGP PSKVLGSYKE RALQKDGSCK DSPNKLSHIG DKSCSSHSSS 
       310        320        330        340        350
NTLSSNTSSN SDDKHFGSGD LMDPELLGLT YIKGASTDSG IDTAPCMPAT 
       360        370        380        390        400
ILGPVHLAGS RSLIHSRAEQ WADAADVSGP DDEPAKLYSV HGYASTISAG 
       410        420        430        440        450
SAAEGSMGDL SEISSHSSGS HHSGSPSAHC SKSSGSLDSS KVYIVSHSSG 
       460        470        480        490        500
QQVPGSMSKP YHRQGAVNKY VIGWKKSEGS PPPEEPEVTE CPGMYSEMDV 
       510        520        530        540        550
MSTATQHQTV VGDAVAETQH VLSKEDFLKL MLPDSPLVEE GRRKFSFYGN 
       560        570        580        590        600
LSPRRSLYRT LSDESICSNR RGSSFGSSRS SVLDQALPND ILFSTTPPYH 
       610        620        630        640        650
STLPPRAHPA PSMGSLRNEF WFSDGSLSDK SKCADPGLMP LPDTATGLDW 
       660        670        680        690        700
THLVDAARAF EDQRVASFCT LTDMQHGQDL EGAQELPLCV DPGSGKEFMD 
       710        720        730        740        750
TTGERSPSPL TGKVNQLELI LRQLQTDLRK EKQDKAVLQA EVQHLRQDNM 
       760        770 
RLQEESQTAT AQLRKFTEWF FTTIDKKS

Show »

Length:778

Mass (Da):84,536

Checksum:ⁱBAB3E9A97733DBCB

GO

Sequence cautionⁱ

The sequence BAA92627 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAB14273 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	1288	S → P in BAB14273 (PubMed:14702039).Curated	1
Sequence conflictⁱ	1308	D → V in BAB14273 (PubMed:14702039).Curated	1
Sequence conflictⁱ	1702	T → I in BAB14273 (PubMed:14702039).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_049153	49	T → A. Corresponds to variant dbSNP:rs16857502Ensembl.	1
Natural variantⁱVAR_049154	1322	T → A4 PublicationsCorresponds to variant dbSNP:rs2275307Ensembl.	1
Natural variantⁱVAR_049155	1403	S → L. Corresponds to variant dbSNP:rs1547742Ensembl.	1
Natural variantⁱVAR_061183	1424	M → L. Corresponds to variant dbSNP:rs3210731Ensembl.	1
Natural variantⁱVAR_049156	1639	G → S. Corresponds to variant dbSNP:rs2275303Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_010920	1 – 926	Missing in isoform 2. 2 PublicationsAdd BLAST	926
Alternative sequenceⁱVSP_010921	927 – 940	NCAED…VQRLV → MSPCFSFIGCKLCS in isoform 2. 2 PublicationsAdd BLAST	14
Alternative sequenceⁱVSP_010922	1588 – 1605	Missing in isoform 2. 2 PublicationsAdd BLAST	18

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY168879 mRNA Translation: AAO12530.1 AK022852 mRNA Translation: BAB14273.1 Different initiation. AK093191 mRNA Translation: BAC04090.1 AL356965 Genomic DNA No translation available. AL157409 Genomic DNA No translation available. AB037810 mRNA Translation: BAA92627.1 Different initiation. CH471098 Genomic DNA Translation: EAW69972.1 BC013119 mRNA Translation: AAH13119.2 BC082251 mRNA Translation: AAH82251.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS41474.1 [Q9P2F8-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_065859.3, NM_020808.4 [Q9P2F8-1] XP_005273268.1, XM_005273211.2 [Q9P2F8-1] XP_005273269.1, XM_005273212.4 [Q9P2F8-1] XP_005273270.1, XM_005273213.4 [Q9P2F8-1] XP_011542545.1, XM_011544243.2 [Q9P2F8-1] XP_016857385.1, XM_017001896.1 [Q9P2F8-1]
UniGeneⁱ	Hs.745009

Genome annotation databases

Ensemblⁱ	ENST00000262861; ENSP00000262861; ENSG00000116991 [Q9P2F8-1] ENST00000308942; ENSP00000309102; ENSG00000116991 [Q9P2F8-2] ENST00000366630; ENSP00000355589; ENSG00000116991 [Q9P2F8-1]
GeneIDⁱ	57568
KEGGⁱ	hsa:57568
UCSC genome browser More...UCSCⁱ	uc001hvf.4 human [Q9P2F8-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q9P2F8	Signal-induced proliferation-associated 1-like protein 2		MOUSE		1722	UniRef90_Q9P2F8
SIPA1L2 isoform 4		PANTR		1802
Signal-induced proliferation-associated 1-like 2 (Fragment)		MACMU		112
Uncharacterized protein		CALJA		1745
Uncharacterized protein		RHIBE		1733
+185
Q9P2F8-2	SIPA1L2 isoform 3		PANTR		778	UniRef90_Q9P2F8-2
Signal induced proliferation associated 1 like 2		SAIBB		778
Uncharacterized protein		PROCO		778
Uncharacterized protein		CALJA		778
Uncharacterized protein		MACMU		778
+12

Protein	Similar proteins		Species	Score	Length	Source
Q9P2F8	Signal-induced proliferation-associated 1-like protein 2		MOUSE		1722	UniRef50_Q9P2F8
Signal-induced proliferation-associated 1-like protein 2		RAT		1722
SIPA1L2 isoform 4		PANTR		1802
Signal-induced proliferation-associated 1-like 2 (Fragment)		MACMU		112
Uncharacterized protein		CALJA		1745
+594
Q9P2F8-2	SIPA1L2 isoform 3		PANTR		778	UniRef50_Q9P2F8-2
Signal induced proliferation associated 1 like 2		GORGO		778
Uncharacterized protein		COLAP		778
Signal induced proliferation associated 1 like 2		SAIBB		778
Uncharacterized protein		Cebus capucinus imitator		778
+16

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY168879 mRNA Translation: AAO12530.1 AK022852 mRNA Translation: BAB14273.1 Different initiation. AK093191 mRNA Translation: BAC04090.1 AL356965 Genomic DNA No translation available. AL157409 Genomic DNA No translation available. AB037810 mRNA Translation: BAA92627.1 Different initiation. CH471098 Genomic DNA Translation: EAW69972.1 BC013119 mRNA Translation: AAH13119.2 BC082251 mRNA Translation: AAH82251.1
CCDSⁱ	CCDS41474.1 [Q9P2F8-1]
RefSeqⁱ	NP_065859.3, NM_020808.4 [Q9P2F8-1] XP_005273268.1, XM_005273211.2 [Q9P2F8-1] XP_005273269.1, XM_005273212.4 [Q9P2F8-1] XP_005273270.1, XM_005273213.4 [Q9P2F8-1] XP_011542545.1, XM_011544243.2 [Q9P2F8-1] XP_016857385.1, XM_017001896.1 [Q9P2F8-1]
UniGeneⁱ	Hs.745009

3D structure databases

ProteinModelPortalⁱ	Q9P2F8
SMRⁱ	Q9P2F8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121621, 37 interactors
IntActⁱ	Q9P2F8, 27 interactors
MINTⁱ	Q9P2F8
STRINGⁱ	9606.ENSP00000262861

PTM databases

iPTMnetⁱ	Q9P2F8
PhosphoSitePlusⁱ	Q9P2F8

Polymorphism and mutation databases

BioMutaⁱ	SIPA1L2
DMDMⁱ	85681894

Proteomic databases

EPDⁱ	Q9P2F8
MaxQBⁱ	Q9P2F8
PaxDbⁱ	Q9P2F8
PeptideAtlasⁱ	Q9P2F8
PRIDEⁱ	Q9P2F8
ProteomicsDBⁱ	83807 83808 [Q9P2F8-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	57568
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000262861; ENSP00000262861; ENSG00000116991 [Q9P2F8-1] ENST00000308942; ENSP00000309102; ENSG00000116991 [Q9P2F8-2] ENST00000366630; ENSP00000355589; ENSG00000116991 [Q9P2F8-1]
GeneIDⁱ	57568
KEGGⁱ	hsa:57568
UCSCⁱ	uc001hvf.4 human [Q9P2F8-1]

Organism-specific databases

CTDⁱ	57568
DisGeNETⁱ	57568
EuPathDBⁱ	HostDB:ENSG00000116991.10
GeneCardsⁱ	SIPA1L2
HGNCⁱ	HGNC:23800 SIPA1L2
HPAⁱ	HPA024181 HPA027224
MIMⁱ	611609 gene
neXtProtⁱ	NX_Q9P2F8
OpenTargetsⁱ	ENSG00000116991
PharmGKBⁱ	PA134933243
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3686 Eukaryota ENOG410XTIX LUCA
GeneTreeⁱ	ENSGT00760000119182
HOVERGENⁱ	HBG056135
InParanoidⁱ	Q9P2F8
KOⁱ	K17702
OMAⁱ	MWHVIAR
OrthoDBⁱ	EOG091G016P
PhylomeDBⁱ	Q9P2F8
TreeFamⁱ	TF318626

Miscellaneous databases

ChiTaRSⁱ	SIPA1L2 human
GeneWikiⁱ	SIPA1L2
GenomeRNAiⁱ	57568
Protein Ontology More...PROⁱ	PR:Q9P2F8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000116991 Expressed in 199 organ(s), highest expression level in left ventricle myocardium
CleanExⁱ	HS_SIPA1L2
Genevisibleⁱ	Q9P2F8 HS

Family and domain databases

Gene3Dⁱ	3.40.50.11210, 1 hit
InterProⁱ	View protein in InterPro IPR001478 PDZ IPR036034 PDZ_sf IPR035974 Rap/Ran-GAP_sf IPR000331 Rap_GAP_dom IPR031203 SIPA1L2 IPR021818 SIPA1L_C
PANTHERⁱ	PTHR15711:SF7 PTHR15711:SF7, 1 hit
Pfamⁱ	View protein in Pfam PF02145 Rap_GAP, 1 hit PF11881 SPAR_C, 1 hit
SMARTⁱ	View protein in SMART SM00228 PDZ, 1 hit
SUPFAMⁱ	SSF111347 SSF111347, 1 hit SSF50156 SSF50156, 1 hit
PROSITEⁱ	View protein in PROSITE PS50106 PDZ, 1 hit PS50085 RAPGAP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SI1L2_HUMAN
Accessionⁱ	Q9P2F8Primary (citable) accession number: Q9P2F8 Secondary accession number(s): Q2TV88 Q9H9F6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
	Last sequence update:	January 10, 2006
	Last modified:	November 7, 2018
	This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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Supporting data

UniProtKB - Q9P2F8 (SI1L2_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Signal-induced proliferation-associated 1-like protein 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ