Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q9P2F8 (SI1L2_HUMAN)

Entry version 163 (10 Feb 2021)
Sequence version 2 (10 Jan 2006)
Previous versions | rss
Add a publicationFeedback
Protein

Signal-induced proliferation-associated 1-like protein 2

Gene

SIPA1L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9P2F8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Signal-induced proliferation-associated 1-like protein 2
Short name:
SIPA1-like protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SIPA1L2
Synonyms:KIAA1389
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:23800, SIPA1L2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611609, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9P2F8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000116991.10

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		57568

Open Targets

More...OpenTargetsi		ENSG00000116991

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134933243

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9P2F8, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SIPA1L2

Domain mapping of disease mutations (DMDM)

More...DMDMi		85681894

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000567491 – 1722Signal-induced proliferation-associated 1-like protein 2Add BLAST1722

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei148PhosphoserineCombined sources1
Modified residuei379PhosphoserineBy similarity1
Modified residuei383PhosphoserineBy similarity1
Modified residuei1029PhosphoserineCombined sources1
Modified residuei1244PhosphoserineBy similarity1
Modified residuei1461PhosphoserineCombined sources1
Modified residuei1472PhosphoserineBy similarity1
Modified residuei1478PhosphoserineCombined sources1
Modified residuei1488PhosphoserineCombined sources1
Modified residuei1549PhosphoserineCombined sources1
Modified residuei1552PhosphoserineCombined sources1
Modified residuei1591PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9P2F8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9P2F8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9P2F8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9P2F8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9P2F8

PeptideAtlas

More...PeptideAtlasi		Q9P2F8

PRoteomics IDEntifications database

More...PRIDEi		Q9P2F8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		83807 [Q9P2F8-1]
83808 [Q9P2F8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9P2F8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9P2F8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000116991, Expressed in left ventricle myocardium and 213 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9P2F8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000116991, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121621, 53 interactors

Protein interaction database and analysis system

More...IntActi		Q9P2F8, 42 interactors

Molecular INTeraction database

More...MINTi		Q9P2F8

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000355589

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9P2F8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9P2F8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini595 – 812Rap-GAPPROSITE-ProRule annotationAdd BLAST218
Domaini950 – 1026PDZPROSITE-ProRule annotationAdd BLAST77

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1654 – 1712Sequence analysisAdd BLAST59

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi60 – 63Poly-Gly4
Compositional biasi1125 – 1128Poly-Ser4
Compositional biasi1321 – 1384Ser-richAdd BLAST64

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3686, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157388

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002127_0_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9P2F8

Identification of Orthologs from Complete Genome Data

More...OMAi		GSRSMIH

Database of Orthologous Groups

More...OrthoDBi		28453at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9P2F8

TreeFam database of animal gene trees

More...TreeFami		TF318626

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.42.10, 1 hit
3.40.50.11210, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001478, PDZ
IPR036034, PDZ_sf
IPR035974, Rap/Ran-GAP_sf
IPR000331, Rap_GAP_dom
IPR031203, SIPA1L2
IPR021818, SIPA1L_C

The PANTHER Classification System

More...PANTHERi		PTHR15711:SF7, PTHR15711:SF7, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00595, PDZ, 1 hit
PF02145, Rap_GAP, 1 hit
PF11881, SPAR_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00228, PDZ, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF111347, SSF111347, 1 hit
SSF50156, SSF50156, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50106, PDZ, 1 hit
PS50085, RAPGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9P2F8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDPRQSQEE KHKLGRASSK FKDPPRIMQS DDYFARKFKA INGNMGPTTS 
        60         70         80         90        100
LNASNSNETG GGGPANGTPA VPKMGVRARV SEWPPKKDCS KELTCKALWE 
       110        120        130        140        150
SRSQTSYESI TSVLQNGQSD QSEGQQDEQL DLDFVEAKYT IGDIFVHSPQ 
       160        170        180        190        200
RGLHPIRQRS NSDVTISDID AEDVLDQNAV NPNTGAALHR EYGSTSSIDR 
       210        220        230        240        250
QGLSGENFFA MLRGYRVENY DHKAMVPFGF PEFFRCDPAI SPSLHAAAQI 
       260        270        280        290        300
SRGEFVRISG LDYVDSALLM GRDRDKPFKR RLKSESVETS LFRKLRTVKS 
       310        320        330        340        350
EHETFKFTSE LEESRLERGI RPWNCQRCFA HYDVQSILFN INEAMATRAN 
       360        370        380        390        400
VGKRKNITTG ASAASQTQMP TGQTGNCESP LGSKEDLNSK ENLDADEGDG 
       410        420        430        440        450
KSNDLVLSCP YFRNETGGEG DRRIALSRAN SSSFSSGESC SFESSLSSHC 
       460        470        480        490        500
TNAGVSVLEV PRENQPIHRE KVKRYIIEHI DLGAYYYRKF FYGKEHQNYF 
       510        520        530        540        550
GIDENLGPVA VSIRREKVED AKEKEGSQFN YRVAFRTSEL TTLRGAILED 
       560        570        580        590        600
AIPSTARHGT ARGLPLKEVL EYVIPELSIQ CLRQASNSPK VSEQLLKLDE 
       610        620        630        640        650
QGLSFQHKIG ILYCKAGQST EEEMYNNETA GPAFEEFLDL LGQRVRLKGF 
       660        670        680        690        700
SKYRAQLDNK TDSTGTHSLY TTYKDYELMF HVSTLLPYMP NNRQQLLRKR 
       710        720        730        740        750
HIGNDIVTIV FQEPGALPFT PKSIRSHFQH VFVIVKVHNP CTENVCYSVG 
       760        770        780        790        800
VSRSKDVPPF GPPIPKGVTF PKSAVFRDFL LAKVINAENA AHKSEKFRAM 
       810        820        830        840        850
ATRTRQEYLK DLAENFVTTA TVDTSVKFSF ITLGAKKKEK VKPRKDAHLF 
       860        870        880        890        900
SIGAIMWHVI ARDFGQSADI ECLLGISNEF IMLIEKDSKN VVFNCSCRDV 
       910        920        930        940        950
IGWTSGLVSI KVFYERGECV LLSSVDNCAE DIREIVQRLV IVTRGCETVE 
       960        970        980        990       1000
MTLRRNGLGQ LGFHVNFEGI VADVEPFGFA WKAGLRQGSR LVEICKVAVA 
      1010       1020       1030       1040       1050
TLTHEQMIDL LRTSVTVKVV IIQPHDDGSP RRGCSELCRI PMVEYKLDSE 
      1060       1070       1080       1090       1100
GTPCEYKTPF RRNTTWHRVP TPALQPLSRA SPIPGTPDRL PCQQLLQQAQ 
      1110       1120       1130       1140       1150
AAIPRSTSFD RKLPDGTRSS PSNQSSSSDP GPGGSGPWRP QVGYDGCQSP 
      1160       1170       1180       1190       1200
LLLEHQGSGP LECDGARERE DTMEASRHPE TKWHGPPSKV LGSYKERALQ 
      1210       1220       1230       1240       1250
KDGSCKDSPN KLSHIGDKSC SSHSSSNTLS SNTSSNSDDK HFGSGDLMDP 
      1260       1270       1280       1290       1300
ELLGLTYIKG ASTDSGIDTA PCMPATILGP VHLAGSRSLI HSRAEQWADA 
      1310       1320       1330       1340       1350
ADVSGPDDEP AKLYSVHGYA STISAGSAAE GSMGDLSEIS SHSSGSHHSG 
      1360       1370       1380       1390       1400
SPSAHCSKSS GSLDSSKVYI VSHSSGQQVP GSMSKPYHRQ GAVNKYVIGW 
      1410       1420       1430       1440       1450
KKSEGSPPPE EPEVTECPGM YSEMDVMSTA TQHQTVVGDA VAETQHVLSK 
      1460       1470       1480       1490       1500
EDFLKLMLPD SPLVEEGRRK FSFYGNLSPR RSLYRTLSDE SICSNRRGSS 
      1510       1520       1530       1540       1550
FGSSRSSVLD QALPNDILFS TTPPYHSTLP PRAHPAPSMG SLRNEFWFSD 
      1560       1570       1580       1590       1600
GSLSDKSKCA DPGLMPLPDT ATGLDWTHLV DAARAFEGLD SDEELGLLCH 
      1610       1620       1630       1640       1650
HTSYLDQRVA SFCTLTDMQH GQDLEGAQEL PLCVDPGSGK EFMDTTGERS 
      1660       1670       1680       1690       1700
PSPLTGKVNQ LELILRQLQT DLRKEKQDKA VLQAEVQHLR QDNMRLQEES 
      1710       1720 
QTATAQLRKF TEWFFTTIDK KS
Length:1,722
Mass (Da):190,438
Last modified:January 10, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC99E808CD6B156B1
GO
Isoform 2 (identifier: Q9P2F8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-926: Missing.
     927-940: NCAEDIREIVQRLV → MSPCFSFIGCKLCS
     1588-1605: Missing.

Show »
Length:778
Mass (Da):84,536
Checksum:iBAB3E9A97733DBCB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A6Q8PH54A0A6Q8PH54_HUMAN
Signal-induced proliferation-associ...
SIPA1L2
1,704Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PFQ0A0A6Q8PFQ0_HUMAN
Signal-induced proliferation-associ...
SIPA1L2
1,773Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PGD5A0A6Q8PGD5_HUMAN
Signal-induced proliferation-associ...
SIPA1L2
739Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA92627 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14273 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1288S → P in BAB14273 (PubMed:14702039).Curated1
Sequence conflicti1308D → V in BAB14273 (PubMed:14702039).Curated1
Sequence conflicti1702T → I in BAB14273 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04915349T → A. Corresponds to variant dbSNP:rs16857502Ensembl.1
Natural variantiVAR_0491541322T → A4 PublicationsCorresponds to variant dbSNP:rs2275307Ensembl.1
Natural variantiVAR_0491551403S → L. Corresponds to variant dbSNP:rs1547742Ensembl.1
Natural variantiVAR_0611831424M → L. Corresponds to variant dbSNP:rs3210731Ensembl.1
Natural variantiVAR_0491561639G → S. Corresponds to variant dbSNP:rs2275303Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0109201 – 926Missing in isoform 2. 2 PublicationsAdd BLAST926
Alternative sequenceiVSP_010921927 – 940NCAED…VQRLV → MSPCFSFIGCKLCS in isoform 2. 2 PublicationsAdd BLAST14
Alternative sequenceiVSP_0109221588 – 1605Missing in isoform 2. 2 PublicationsAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY168879 mRNA Translation: AAO12530.1
AK022852 mRNA Translation: BAB14273.1 Different initiation.
AK093191 mRNA Translation: BAC04090.1
AL356965 Genomic DNA No translation available.
AL157409 Genomic DNA No translation available.
AB037810 mRNA Translation: BAA92627.1 Different initiation.
CH471098 Genomic DNA Translation: EAW69972.1
BC013119 mRNA Translation: AAH13119.2
BC082251 mRNA Translation: AAH82251.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41474.1 [Q9P2F8-1]

NCBI Reference Sequences

More...RefSeqi		NP_065859.3, NM_020808.4 [Q9P2F8-1]
XP_005273268.1, XM_005273211.2
XP_005273269.1, XM_005273212.4 [Q9P2F8-1]
XP_005273270.1, XM_005273213.4 [Q9P2F8-1]
XP_011542545.1, XM_011544243.2 [Q9P2F8-1]
XP_016857385.1, XM_017001896.1 [Q9P2F8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000262861; ENSP00000262861; ENSG00000116991 [Q9P2F8-1]
ENST00000308942; ENSP00000309102; ENSG00000116991 [Q9P2F8-2]
ENST00000366630; ENSP00000355589; ENSG00000116991 [Q9P2F8-1]
ENST00000674635; ENSP00000502693; ENSG00000116991 [Q9P2F8-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57568

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:57568

UCSC genome browser

More...UCSCi		uc001hvf.4, human [Q9P2F8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY168879 mRNA Translation: AAO12530.1
AK022852 mRNA Translation: BAB14273.1 Different initiation.
AK093191 mRNA Translation: BAC04090.1
AL356965 Genomic DNA No translation available.
AL157409 Genomic DNA No translation available.
AB037810 mRNA Translation: BAA92627.1 Different initiation.
CH471098 Genomic DNA Translation: EAW69972.1
BC013119 mRNA Translation: AAH13119.2
BC082251 mRNA Translation: AAH82251.1
CCDSiCCDS41474.1 [Q9P2F8-1]
RefSeqiNP_065859.3, NM_020808.4 [Q9P2F8-1]
XP_005273268.1, XM_005273211.2
XP_005273269.1, XM_005273212.4 [Q9P2F8-1]
XP_005273270.1, XM_005273213.4 [Q9P2F8-1]
XP_011542545.1, XM_011544243.2 [Q9P2F8-1]
XP_016857385.1, XM_017001896.1 [Q9P2F8-1]

3D structure databases

SMRiQ9P2F8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121621, 53 interactors
IntActiQ9P2F8, 42 interactors
MINTiQ9P2F8
STRINGi9606.ENSP00000355589

PTM databases

iPTMnetiQ9P2F8
PhosphoSitePlusiQ9P2F8

Genetic variation databases

BioMutaiSIPA1L2
DMDMi85681894

Proteomic databases

EPDiQ9P2F8
jPOSTiQ9P2F8
MassIVEiQ9P2F8
MaxQBiQ9P2F8
PaxDbiQ9P2F8
PeptideAtlasiQ9P2F8
PRIDEiQ9P2F8
ProteomicsDBi83807 [Q9P2F8-1]
83808 [Q9P2F8-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		11728, 126 antibodies

The DNASU plasmid repository

More...DNASUi		57568

Genome annotation databases

EnsembliENST00000262861; ENSP00000262861; ENSG00000116991 [Q9P2F8-1]
ENST00000308942; ENSP00000309102; ENSG00000116991 [Q9P2F8-2]
ENST00000366630; ENSP00000355589; ENSG00000116991 [Q9P2F8-1]
ENST00000674635; ENSP00000502693; ENSG00000116991 [Q9P2F8-1]
GeneIDi57568
KEGGihsa:57568
UCSCiuc001hvf.4, human [Q9P2F8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57568
DisGeNETi57568

GeneCards: human genes, protein and diseases

More...GeneCardsi		SIPA1L2
HGNCiHGNC:23800, SIPA1L2
HPAiENSG00000116991, Low tissue specificity
MIMi611609, gene
neXtProtiNX_Q9P2F8
OpenTargetsiENSG00000116991
PharmGKBiPA134933243
VEuPathDBiHostDB:ENSG00000116991.10

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3686, Eukaryota
GeneTreeiENSGT00940000157388
HOGENOMiCLU_002127_0_2_1
InParanoidiQ9P2F8
OMAiGSRSMIH
OrthoDBi28453at2759
PhylomeDBiQ9P2F8
TreeFamiTF318626

Enzyme and pathway databases

PathwayCommonsiQ9P2F8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		57568, 2 hits in 870 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SIPA1L2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SIPA1L2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		57568
PharosiQ9P2F8, Tdark

Protein Ontology

More...PROi		PR:Q9P2F8
RNActiQ9P2F8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000116991, Expressed in left ventricle myocardium and 213 other tissues
GenevisibleiQ9P2F8, HS

Family and domain databases

Gene3Di2.30.42.10, 1 hit
3.40.50.11210, 1 hit
InterProiView protein in InterPro
IPR001478, PDZ
IPR036034, PDZ_sf
IPR035974, Rap/Ran-GAP_sf
IPR000331, Rap_GAP_dom
IPR031203, SIPA1L2
IPR021818, SIPA1L_C
PANTHERiPTHR15711:SF7, PTHR15711:SF7, 1 hit
PfamiView protein in Pfam
PF00595, PDZ, 1 hit
PF02145, Rap_GAP, 1 hit
PF11881, SPAR_C, 1 hit
SMARTiView protein in SMART
SM00228, PDZ, 1 hit
SUPFAMiSSF111347, SSF111347, 1 hit
SSF50156, SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106, PDZ, 1 hit
PS50085, RAPGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSI1L2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P2F8
Secondary accession number(s): Q2TV88
, Q5VXR7, Q5VXR8, Q641Q4, Q8NA38, Q96DZ3, Q9H9F6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 10, 2006
Last modified: February 10, 2021
This is version 163 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again