UniProtKB - Q9P2F8 (SI1L2_HUMAN)
Protein
Signal-induced proliferation-associated 1-like protein 2
Gene
SIPA1L2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- GTPase activator activity Source: UniProtKB-KW
GO - Biological processi
- regulation of small GTPase mediated signal transduction Source: InterPro
Keywordsi
Molecular function | GTPase activation |
Enzyme and pathway databases
PathwayCommonsi | Q9P2F8 |
Names & Taxonomyi
Protein namesi | Recommended name: Signal-induced proliferation-associated 1-like protein 2Short name: SIPA1-like protein 2 |
Gene namesi | Name:SIPA1L2 Synonyms:KIAA1389 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23800, SIPA1L2 |
MIMi | 611609, gene |
neXtProti | NX_Q9P2F8 |
VEuPathDBi | HostDB:ENSG00000116991.10 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 57568 |
OpenTargetsi | ENSG00000116991 |
PharmGKBi | PA134933243 |
Miscellaneous databases
Pharosi | Q9P2F8, Tdark |
Genetic variation databases
BioMutai | SIPA1L2 |
DMDMi | 85681894 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000056749 | 1 – 1722 | Signal-induced proliferation-associated 1-like protein 2Add BLAST | 1722 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 148 | PhosphoserineCombined sources | 1 | |
Modified residuei | 379 | PhosphoserineBy similarity | 1 | |
Modified residuei | 383 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1029 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1244 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1461 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1472 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1478 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1488 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1549 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1552 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1591 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9P2F8 |
jPOSTi | Q9P2F8 |
MassIVEi | Q9P2F8 |
MaxQBi | Q9P2F8 |
PaxDbi | Q9P2F8 |
PeptideAtlasi | Q9P2F8 |
PRIDEi | Q9P2F8 |
ProteomicsDBi | 83807 [Q9P2F8-1] 83808 [Q9P2F8-2] |
PTM databases
iPTMneti | Q9P2F8 |
PhosphoSitePlusi | Q9P2F8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000116991, Expressed in left ventricle myocardium and 213 other tissues |
Genevisiblei | Q9P2F8, HS |
Organism-specific databases
HPAi | ENSG00000116991, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsIsoform 2 [Q9P2F8-2]
With | #Exp. | IntAct |
---|---|---|
AP3M1 [Q9Y2T2] | 6 | EBI-10326741,EBI-2371151 |
DDX6 [P26196] | 5 | EBI-10326741,EBI-351257 |
TCEANC - isoform 2 [Q8N8B7-2] | 3 | EBI-10326741,EBI-11955057 |
Protein-protein interaction databases
BioGRIDi | 121621, 53 interactors |
IntActi | Q9P2F8, 42 interactors |
MINTi | Q9P2F8 |
STRINGi | 9606.ENSP00000355589 |
Miscellaneous databases
RNActi | Q9P2F8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 595 – 812 | Rap-GAPPROSITE-ProRule annotationAdd BLAST | 218 | |
Domaini | 950 – 1026 | PDZPROSITE-ProRule annotationAdd BLAST | 77 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1654 – 1712 | Sequence analysisAdd BLAST | 59 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 60 – 63 | Poly-Gly | 4 | |
Compositional biasi | 1125 – 1128 | Poly-Ser | 4 | |
Compositional biasi | 1321 – 1384 | Ser-richAdd BLAST | 64 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG3686, Eukaryota |
GeneTreei | ENSGT00940000157388 |
HOGENOMi | CLU_002127_0_2_1 |
InParanoidi | Q9P2F8 |
OMAi | GSRSMIH |
OrthoDBi | 28453at2759 |
PhylomeDBi | Q9P2F8 |
TreeFami | TF318626 |
Family and domain databases
Gene3Di | 2.30.42.10, 1 hit 3.40.50.11210, 1 hit |
InterProi | View protein in InterPro IPR001478, PDZ IPR036034, PDZ_sf IPR035974, Rap/Ran-GAP_sf IPR000331, Rap_GAP_dom IPR031203, SIPA1L2 IPR021818, SIPA1L_C |
PANTHERi | PTHR15711:SF7, PTHR15711:SF7, 1 hit |
Pfami | View protein in Pfam PF00595, PDZ, 1 hit PF02145, Rap_GAP, 1 hit PF11881, SPAR_C, 1 hit |
SMARTi | View protein in SMART SM00228, PDZ, 1 hit |
SUPFAMi | SSF111347, SSF111347, 1 hit SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS50106, PDZ, 1 hit PS50085, RAPGAP, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9P2F8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSDPRQSQEE KHKLGRASSK FKDPPRIMQS DDYFARKFKA INGNMGPTTS
60 70 80 90 100
LNASNSNETG GGGPANGTPA VPKMGVRARV SEWPPKKDCS KELTCKALWE
110 120 130 140 150
SRSQTSYESI TSVLQNGQSD QSEGQQDEQL DLDFVEAKYT IGDIFVHSPQ
160 170 180 190 200
RGLHPIRQRS NSDVTISDID AEDVLDQNAV NPNTGAALHR EYGSTSSIDR
210 220 230 240 250
QGLSGENFFA MLRGYRVENY DHKAMVPFGF PEFFRCDPAI SPSLHAAAQI
260 270 280 290 300
SRGEFVRISG LDYVDSALLM GRDRDKPFKR RLKSESVETS LFRKLRTVKS
310 320 330 340 350
EHETFKFTSE LEESRLERGI RPWNCQRCFA HYDVQSILFN INEAMATRAN
360 370 380 390 400
VGKRKNITTG ASAASQTQMP TGQTGNCESP LGSKEDLNSK ENLDADEGDG
410 420 430 440 450
KSNDLVLSCP YFRNETGGEG DRRIALSRAN SSSFSSGESC SFESSLSSHC
460 470 480 490 500
TNAGVSVLEV PRENQPIHRE KVKRYIIEHI DLGAYYYRKF FYGKEHQNYF
510 520 530 540 550
GIDENLGPVA VSIRREKVED AKEKEGSQFN YRVAFRTSEL TTLRGAILED
560 570 580 590 600
AIPSTARHGT ARGLPLKEVL EYVIPELSIQ CLRQASNSPK VSEQLLKLDE
610 620 630 640 650
QGLSFQHKIG ILYCKAGQST EEEMYNNETA GPAFEEFLDL LGQRVRLKGF
660 670 680 690 700
SKYRAQLDNK TDSTGTHSLY TTYKDYELMF HVSTLLPYMP NNRQQLLRKR
710 720 730 740 750
HIGNDIVTIV FQEPGALPFT PKSIRSHFQH VFVIVKVHNP CTENVCYSVG
760 770 780 790 800
VSRSKDVPPF GPPIPKGVTF PKSAVFRDFL LAKVINAENA AHKSEKFRAM
810 820 830 840 850
ATRTRQEYLK DLAENFVTTA TVDTSVKFSF ITLGAKKKEK VKPRKDAHLF
860 870 880 890 900
SIGAIMWHVI ARDFGQSADI ECLLGISNEF IMLIEKDSKN VVFNCSCRDV
910 920 930 940 950
IGWTSGLVSI KVFYERGECV LLSSVDNCAE DIREIVQRLV IVTRGCETVE
960 970 980 990 1000
MTLRRNGLGQ LGFHVNFEGI VADVEPFGFA WKAGLRQGSR LVEICKVAVA
1010 1020 1030 1040 1050
TLTHEQMIDL LRTSVTVKVV IIQPHDDGSP RRGCSELCRI PMVEYKLDSE
1060 1070 1080 1090 1100
GTPCEYKTPF RRNTTWHRVP TPALQPLSRA SPIPGTPDRL PCQQLLQQAQ
1110 1120 1130 1140 1150
AAIPRSTSFD RKLPDGTRSS PSNQSSSSDP GPGGSGPWRP QVGYDGCQSP
1160 1170 1180 1190 1200
LLLEHQGSGP LECDGARERE DTMEASRHPE TKWHGPPSKV LGSYKERALQ
1210 1220 1230 1240 1250
KDGSCKDSPN KLSHIGDKSC SSHSSSNTLS SNTSSNSDDK HFGSGDLMDP
1260 1270 1280 1290 1300
ELLGLTYIKG ASTDSGIDTA PCMPATILGP VHLAGSRSLI HSRAEQWADA
1310 1320 1330 1340 1350
ADVSGPDDEP AKLYSVHGYA STISAGSAAE GSMGDLSEIS SHSSGSHHSG
1360 1370 1380 1390 1400
SPSAHCSKSS GSLDSSKVYI VSHSSGQQVP GSMSKPYHRQ GAVNKYVIGW
1410 1420 1430 1440 1450
KKSEGSPPPE EPEVTECPGM YSEMDVMSTA TQHQTVVGDA VAETQHVLSK
1460 1470 1480 1490 1500
EDFLKLMLPD SPLVEEGRRK FSFYGNLSPR RSLYRTLSDE SICSNRRGSS
1510 1520 1530 1540 1550
FGSSRSSVLD QALPNDILFS TTPPYHSTLP PRAHPAPSMG SLRNEFWFSD
1560 1570 1580 1590 1600
GSLSDKSKCA DPGLMPLPDT ATGLDWTHLV DAARAFEGLD SDEELGLLCH
1610 1620 1630 1640 1650
HTSYLDQRVA SFCTLTDMQH GQDLEGAQEL PLCVDPGSGK EFMDTTGERS
1660 1670 1680 1690 1700
PSPLTGKVNQ LELILRQLQT DLRKEKQDKA VLQAEVQHLR QDNMRLQEES
1710 1720
QTATAQLRKF TEWFFTTIDK KS
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A6Q8PH54 | A0A6Q8PH54_HUMAN | Signal-induced proliferation-associ... | SIPA1L2 | 1,704 | Annotation score: | ||
A0A6Q8PFQ0 | A0A6Q8PFQ0_HUMAN | Signal-induced proliferation-associ... | SIPA1L2 | 1,773 | Annotation score: | ||
A0A6Q8PGD5 | A0A6Q8PGD5_HUMAN | Signal-induced proliferation-associ... | SIPA1L2 | 739 | Annotation score: |
Sequence cautioni
The sequence BAA92627 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14273 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1288 | S → P in BAB14273 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1308 | D → V in BAB14273 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1702 | T → I in BAB14273 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049153 | 49 | T → A. Corresponds to variant dbSNP:rs16857502Ensembl. | 1 | |
Natural variantiVAR_049154 | 1322 | T → A4 PublicationsCorresponds to variant dbSNP:rs2275307Ensembl. | 1 | |
Natural variantiVAR_049155 | 1403 | S → L. Corresponds to variant dbSNP:rs1547742Ensembl. | 1 | |
Natural variantiVAR_061183 | 1424 | M → L. Corresponds to variant dbSNP:rs3210731Ensembl. | 1 | |
Natural variantiVAR_049156 | 1639 | G → S. Corresponds to variant dbSNP:rs2275303Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010920 | 1 – 926 | Missing in isoform 2. 2 PublicationsAdd BLAST | 926 | |
Alternative sequenceiVSP_010921 | 927 – 940 | NCAED…VQRLV → MSPCFSFIGCKLCS in isoform 2. 2 PublicationsAdd BLAST | 14 | |
Alternative sequenceiVSP_010922 | 1588 – 1605 | Missing in isoform 2. 2 PublicationsAdd BLAST | 18 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY168879 mRNA Translation: AAO12530.1 AK022852 mRNA Translation: BAB14273.1 Different initiation. AK093191 mRNA Translation: BAC04090.1 AL356965 Genomic DNA No translation available. AL157409 Genomic DNA No translation available. AB037810 mRNA Translation: BAA92627.1 Different initiation. CH471098 Genomic DNA Translation: EAW69972.1 BC013119 mRNA Translation: AAH13119.2 BC082251 mRNA Translation: AAH82251.1 |
CCDSi | CCDS41474.1 [Q9P2F8-1] |
RefSeqi | NP_065859.3, NM_020808.4 [Q9P2F8-1] XP_005273268.1, XM_005273211.2 XP_005273269.1, XM_005273212.4 [Q9P2F8-1] XP_005273270.1, XM_005273213.4 [Q9P2F8-1] XP_011542545.1, XM_011544243.2 [Q9P2F8-1] XP_016857385.1, XM_017001896.1 [Q9P2F8-1] |
Genome annotation databases
Ensembli | ENST00000262861; ENSP00000262861; ENSG00000116991 [Q9P2F8-1] ENST00000308942; ENSP00000309102; ENSG00000116991 [Q9P2F8-2] ENST00000366630; ENSP00000355589; ENSG00000116991 [Q9P2F8-1] ENST00000674635; ENSP00000502693; ENSG00000116991 [Q9P2F8-1] |
GeneIDi | 57568 |
KEGGi | hsa:57568 |
UCSCi | uc001hvf.4, human [Q9P2F8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY168879 mRNA Translation: AAO12530.1 AK022852 mRNA Translation: BAB14273.1 Different initiation. AK093191 mRNA Translation: BAC04090.1 AL356965 Genomic DNA No translation available. AL157409 Genomic DNA No translation available. AB037810 mRNA Translation: BAA92627.1 Different initiation. CH471098 Genomic DNA Translation: EAW69972.1 BC013119 mRNA Translation: AAH13119.2 BC082251 mRNA Translation: AAH82251.1 |
CCDSi | CCDS41474.1 [Q9P2F8-1] |
RefSeqi | NP_065859.3, NM_020808.4 [Q9P2F8-1] XP_005273268.1, XM_005273211.2 XP_005273269.1, XM_005273212.4 [Q9P2F8-1] XP_005273270.1, XM_005273213.4 [Q9P2F8-1] XP_011542545.1, XM_011544243.2 [Q9P2F8-1] XP_016857385.1, XM_017001896.1 [Q9P2F8-1] |
3D structure databases
SMRi | Q9P2F8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121621, 53 interactors |
IntActi | Q9P2F8, 42 interactors |
MINTi | Q9P2F8 |
STRINGi | 9606.ENSP00000355589 |
PTM databases
iPTMneti | Q9P2F8 |
PhosphoSitePlusi | Q9P2F8 |
Genetic variation databases
BioMutai | SIPA1L2 |
DMDMi | 85681894 |
Proteomic databases
EPDi | Q9P2F8 |
jPOSTi | Q9P2F8 |
MassIVEi | Q9P2F8 |
MaxQBi | Q9P2F8 |
PaxDbi | Q9P2F8 |
PeptideAtlasi | Q9P2F8 |
PRIDEi | Q9P2F8 |
ProteomicsDBi | 83807 [Q9P2F8-1] 83808 [Q9P2F8-2] |
Protocols and materials databases
Antibodypediai | 11728, 126 antibodies |
DNASUi | 57568 |
Genome annotation databases
Ensembli | ENST00000262861; ENSP00000262861; ENSG00000116991 [Q9P2F8-1] ENST00000308942; ENSP00000309102; ENSG00000116991 [Q9P2F8-2] ENST00000366630; ENSP00000355589; ENSG00000116991 [Q9P2F8-1] ENST00000674635; ENSP00000502693; ENSG00000116991 [Q9P2F8-1] |
GeneIDi | 57568 |
KEGGi | hsa:57568 |
UCSCi | uc001hvf.4, human [Q9P2F8-1] |
Organism-specific databases
CTDi | 57568 |
DisGeNETi | 57568 |
GeneCardsi | SIPA1L2 |
HGNCi | HGNC:23800, SIPA1L2 |
HPAi | ENSG00000116991, Low tissue specificity |
MIMi | 611609, gene |
neXtProti | NX_Q9P2F8 |
OpenTargetsi | ENSG00000116991 |
PharmGKBi | PA134933243 |
VEuPathDBi | HostDB:ENSG00000116991.10 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3686, Eukaryota |
GeneTreei | ENSGT00940000157388 |
HOGENOMi | CLU_002127_0_2_1 |
InParanoidi | Q9P2F8 |
OMAi | GSRSMIH |
OrthoDBi | 28453at2759 |
PhylomeDBi | Q9P2F8 |
TreeFami | TF318626 |
Enzyme and pathway databases
PathwayCommonsi | Q9P2F8 |
Miscellaneous databases
BioGRID-ORCSi | 57568, 2 hits in 870 CRISPR screens |
ChiTaRSi | SIPA1L2, human |
GeneWikii | SIPA1L2 |
GenomeRNAii | 57568 |
Pharosi | Q9P2F8, Tdark |
PROi | PR:Q9P2F8 |
RNActi | Q9P2F8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000116991, Expressed in left ventricle myocardium and 213 other tissues |
Genevisiblei | Q9P2F8, HS |
Family and domain databases
Gene3Di | 2.30.42.10, 1 hit 3.40.50.11210, 1 hit |
InterProi | View protein in InterPro IPR001478, PDZ IPR036034, PDZ_sf IPR035974, Rap/Ran-GAP_sf IPR000331, Rap_GAP_dom IPR031203, SIPA1L2 IPR021818, SIPA1L_C |
PANTHERi | PTHR15711:SF7, PTHR15711:SF7, 1 hit |
Pfami | View protein in Pfam PF00595, PDZ, 1 hit PF02145, Rap_GAP, 1 hit PF11881, SPAR_C, 1 hit |
SMARTi | View protein in SMART SM00228, PDZ, 1 hit |
SUPFAMi | SSF111347, SSF111347, 1 hit SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS50106, PDZ, 1 hit PS50085, RAPGAP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SI1L2_HUMAN | |
Accessioni | Q9P2F8Primary (citable) accession number: Q9P2F8 Secondary accession number(s): Q2TV88 Q9H9F6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | January 10, 2006 | |
Last modified: | February 10, 2021 | |
This is version 163 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot