UniProtKB - Q9P2F6 (RHG20_HUMAN)

>sp|Q9P2F6|RHG20_HUMAN Rho GTPase-activating protein 20 OS=Homo sapiens OX=9606 GN=ARHGAP20 PE=1 SV=2
MEAMSPQQETLGGQPGRSSSLTGVSRLAGGSCTKKKMKTLAERRRSAPSLILDKALQKRP
TTRDSPSASVDTCTFLSSLVCSNRTLLIDGRAELKRGLQRQERHLFLFNDLFVVAKIKYN
NNFKIKNKIKLTDMWTASCVDEVGEGNTNAMKSFVLGWPTVNFVATFSSPEQKDKWLSLL
QRYINLEKEKDYPKSIPLKIFAKDIGNCAYSKTITVMNSDTANEVINMSLPMLGITGSER
DYQLWVNSGKEEAPYPLIGHEYPYGIKMSHLRDSALLTPGSKDSTTPFNLQEPFLMEQLP
REMQCQFILKPSRLAAAQQLSDSGHKTFKRRRSIINWAFWRGSSTHLDNLPSSPTSPMPG
QLFGISLPNICENDNLPKPVLDMLFFLNQKGPLTKGIFRQSANVKSCRELKEKLNSGVEV
HLDCESIFVIASVLKDFLRNIPGSIFSSDLYDHWVSVMDQGNDEEKINTVQRLLDQLPRA
NVVLLRYLFGVLHNIEQHSSSNQMTAFNLAVCVAPSILWPPASSSPELENEFTKKVSLLI
QFLIENCLRIFGEEITSLFREVSVRCDTRENASDISCFQLNDSSYDSLENELNEDVDAPC
SDLVKKLGQGSRSMDSVLTLSDYDLDQPEVEGLLTLSDFDLAHSKDEDVQMKRPLESKPV
NILVYTKIPLRDHARAPSAMCTPSYLSTAAANAAKSLRRHRRCSEPSIDYLDSKLSYLRE
FYQKKLRKSSCDAILSQKDEDYLKQNQPLQEEGKTCFKQSLVTGTDVSKKNATTQNTKKK
SLSGSEGNHVKLFPKSKPVAISVASYSPMSSQDHSKNQPFDVNTSGYSPPHTADALKGPR
THRRCSEPNIEDQNRKLTYLRGIYSKKQHKTSCEAGLLHGEEDYLKRHKSLQMEGQKLIN
QSLVMGIEVGKSSATNQNTEKVLPPRLNLCPRTSYSSLSSPGTSPSGSSVSSQDSAFSQI
SEHSVFTPTETSSPIDCTFQAQRKREDLSPDFSNASHVSGMPGPSSGQACSRPAYTKKDT
MEWHSQMHSVTLHPSTWLRNGVASLKNWSLKKKAKAARPEEEKIASPKGPLEPPPHASGV
PEANSLQEEQKDLPLRAAEGLSPVQSAQRCSSSPFQDSERHCSSPFSLVESRLKLCMKSH
EEIEPGSQSSSGSLPWERASASSWTLEDATSPDSGPTVVCDIEDRYLTKDI

Entry version 143 (02 Dec 2020)
Sequence version 2 (03 Apr 2007)
Previous versions | rss

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Protein

Rho GTPase-activating protein 20

Gene

ARHGAP20

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.By similarity

Caution

The translocation involving this gene was originally published as t(X;11)(q13;23), but BRWD3 is localized to Xq21 and not to Xq13.1 Publication

GO - Molecular functionⁱ

GTPase activator activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of small GTPase mediated signal transduction Source: Reactome
signal transduction Source: InterPro

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	GTPase activation

Molecular function

GTPase activation

Enzyme and pathway databases

PathwayCommonsⁱ	Q9P2F6
Reactomeⁱ	R-HSA-194840, Rho GTPase cycle
SIGNORⁱ	Q9P2F6

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Rho GTPase-activating protein 20 Alternative name(s): Rho-type GTPase-activating protein 20
Gene namesⁱ	Name:ARHGAP20 Synonyms:KIAA1391
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000137727.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18357, ARHGAP20
MIMⁱ	609568, gene
neXtProtⁱ	NX_Q9P2F6

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Involvement in diseaseⁱ

A chromosomal aberration involving ARHGAP20 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL) (PubMed:15543602). Translocation t(X;11)(q21;q23) with BRWD3 does not result in fusion transcripts but disrupts both genes (PubMed:15543602).1 Publication

Keywords - Diseaseⁱ

Tumor suppressor

Organism-specific databases

DisGeNET More...DisGeNETⁱ	57569
Open Targets More...OpenTargetsⁱ	ENSG00000137727
PharmGKBⁱ	PA134963885

Miscellaneous databases

Pharosⁱ	Q9P2F6, Tbio

Pharosⁱ

Q9P2F6, Tbio

Polymorphism and mutation databases

BioMutaⁱ	ARHGAP20
DMDMⁱ	143458429

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000283086	1 – 1191	Rho GTPase-activating protein 20Add BLAST		1191

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	46	PhosphoserineBy similarity	1
Modified residueⁱ	704	PhosphoserineBy similarity	1
Modified residueⁱ	730	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

jPOSTⁱ	Q9P2F6
PaxDbⁱ	Q9P2F6
PeptideAtlas More...PeptideAtlasⁱ	Q9P2F6
PRIDEⁱ	Q9P2F6
ProteomicsDBⁱ	83803 [Q9P2F6-1] 83804 [Q9P2F6-2] 83805 [Q9P2F6-3] 83806 [Q9P2F6-4]

PTM databases

iPTMnetⁱ	Q9P2F6
PhosphoSitePlusⁱ	Q9P2F6

Expressionⁱ

Tissue specificityⁱ

Expressed predominantly in the brain. Lower expression is found in lymph nodes.1 Publication

Developmental stageⁱ

Low expression is found in fetal liver.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000137727, Expressed in caudate nucleus and 193 other tissues
ExpressionAtlasⁱ	Q9P2F6, baseline and differential
Genevisibleⁱ	Q9P2F6, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000137727, Low tissue specificity

HPAⁱ

ENSG00000137727, Low tissue specificity

Interactionⁱ

Protein-protein interaction databases

BioGRIDⁱ	121622, 5 interactors
IntActⁱ	Q9P2F6, 12 interactors
STRINGⁱ	9606.ENSP00000260283

Miscellaneous databases

RNActⁱ	Q9P2F6, protein

RNActⁱ

Q9P2F6, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	367 – 370	Combined sources	4
Helixⁱ	372 – 374	Combined sources	3
Helixⁱ	378 – 390	Combined sources	13
Helixⁱ	391 – 393	Combined sources	3
Turnⁱ	395 – 399	Combined sources	5
Helixⁱ	404 – 415	Combined sources	12
Helixⁱ	427 – 439	Combined sources	13
Turnⁱ	442 – 447	Combined sources	6
Helixⁱ	448 – 450	Combined sources	3
Helixⁱ	451 – 456	Combined sources	6
Helixⁱ	457 – 459	Combined sources	3
Beta strandⁱ	460 – 462	Combined sources	3
Helixⁱ	463 – 474	Combined sources	12
Helixⁱ	479 – 496	Combined sources	18
Helixⁱ	499 – 502	Combined sources	4
Helixⁱ	506 – 517	Combined sources	12
Helixⁱ	526 – 550	Combined sources	25

Show more details

3D structure databases

SMRⁱ	Q9P2F6
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9P2F6

EvolutionaryTraceⁱ

Q9P2F6

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	78 – 180	PHAdd BLAST	103
Domainⁱ	194 – 295	Ras-associatingPROSITE-ProRule annotationAdd BLAST	102
Domainⁱ	365 – 551	Rho-GAPPROSITE-ProRule annotationAdd BLAST	187

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	934 – 973	Ser-richAdd BLAST		40

Phylogenomic databases

eggNOGⁱ	KOG4724, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000154633
HOGENOMⁱ	CLU_008526_0_0_1
InParanoidⁱ	Q9P2F6
OMAⁱ	MWTANCV
Database of Orthologous Groups More...OrthoDBⁱ	148399at2759
PhylomeDBⁱ	Q9P2F6
TreeFamⁱ	TF331062

Family and domain databases

Gene3Dⁱ	1.10.555.10, 1 hit 2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR000159, RA_dom IPR008936, Rho_GTPase_activation_prot IPR000198, RhoGAP_dom IPR029071, Ubiquitin-like_domsf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00788, RA, 1 hit PF00620, RhoGAP, 1 hit
SMARTⁱ	View protein in SMART SM00233, PH, 1 hit SM00324, RhoGAP, 1 hit
SUPFAMⁱ	SSF48350, SSF48350, 1 hit SSF54236, SSF54236, 1 hit
PROSITEⁱ	View protein in PROSITE PS50200, RA, 1 hit PS50238, RHOGAP, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q9P2F6-1) [UniParc]FASTA Add to basket

Also known as: 1ad

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MEAMSPQQET LGGQPGRSSS LTGVSRLAGG SCTKKKMKTL AERRRSAPSL 
        60         70         80         90        100
ILDKALQKRP TTRDSPSASV DTCTFLSSLV CSNRTLLIDG RAELKRGLQR 
       110        120        130        140        150
QERHLFLFND LFVVAKIKYN NNFKIKNKIK LTDMWTASCV DEVGEGNTNA 
       160        170        180        190        200
MKSFVLGWPT VNFVATFSSP EQKDKWLSLL QRYINLEKEK DYPKSIPLKI 
       210        220        230        240        250
FAKDIGNCAY SKTITVMNSD TANEVINMSL PMLGITGSER DYQLWVNSGK 
       260        270        280        290        300
EEAPYPLIGH EYPYGIKMSH LRDSALLTPG SKDSTTPFNL QEPFLMEQLP 
       310        320        330        340        350
REMQCQFILK PSRLAAAQQL SDSGHKTFKR RRSIINWAFW RGSSTHLDNL 
       360        370        380        390        400
PSSPTSPMPG QLFGISLPNI CENDNLPKPV LDMLFFLNQK GPLTKGIFRQ 
       410        420        430        440        450
SANVKSCREL KEKLNSGVEV HLDCESIFVI ASVLKDFLRN IPGSIFSSDL 
       460        470        480        490        500
YDHWVSVMDQ GNDEEKINTV QRLLDQLPRA NVVLLRYLFG VLHNIEQHSS 
       510        520        530        540        550
SNQMTAFNLA VCVAPSILWP PASSSPELEN EFTKKVSLLI QFLIENCLRI 
       560        570        580        590        600
FGEEITSLFR EVSVRCDTRE NASDISCFQL NDSSYDSLEN ELNEDVDAPC 
       610        620        630        640        650
SDLVKKLGQG SRSMDSVLTL SDYDLDQPEV EGLLTLSDFD LAHSKDEDVQ 
       660        670        680        690        700
MKRPLESKPV NILVYTKIPL RDHARAPSAM CTPSYLSTAA ANAAKSLRRH 
       710        720        730        740        750
RRCSEPSIDY LDSKLSYLRE FYQKKLRKSS CDAILSQKDE DYLKQNQPLQ 
       760        770        780        790        800
EEGKTCFKQS LVTGTDVSKK NATTQNTKKK SLSGSEGNHV KLFPKSKPVA 
       810        820        830        840        850
ISVASYSPMS SQDHSKNQPF DVNTSGYSPP HTADALKGPR THRRCSEPNI 
       860        870        880        890        900
EDQNRKLTYL RGIYSKKQHK TSCEAGLLHG EEDYLKRHKS LQMEGQKLIN 
       910        920        930        940        950
QSLVMGIEVG KSSATNQNTE KVLPPRLNLC PRTSYSSLSS PGTSPSGSSV 
       960        970        980        990       1000
SSQDSAFSQI SEHSVFTPTE TSSPIDCTFQ AQRKREDLSP DFSNASHVSG 
      1010       1020       1030       1040       1050
MPGPSSGQAC SRPAYTKKDT MEWHSQMHSV TLHPSTWLRN GVASLKNWSL 
      1060       1070       1080       1090       1100
KKKAKAARPE EEKIASPKGP LEPPPHASGV PEANSLQEEQ KDLPLRAAEG 
      1110       1120       1130       1140       1150
LSPVQSAQRC SSSPFQDSER HCSSPFSLVE SRLKLCMKSH EEIEPGSQSS 
      1160       1170       1180       1190 
SGSLPWERAS ASSWTLEDAT SPDSGPTVVC DIEDRYLTKD I

Length:1,191

Mass (Da):132,608

Last modified:April 3, 2007 - v2

Checksum:ⁱ1837B9DF0655AF41

Isoform 2 (identifier: Q9P2F6-2) [UniParc]FASTA Add to basket

Also known as: 1be

The sequence of this isoform differs from the canonical sequence as follows:
1-34: MEAMSPQQETLGGQPGRSSSLTGVSRLAGGSCTK → MTFWIIIN

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        10         20         30         40         50
MTFWIIINKK MKTLAERRRS APSLILDKAL QKRPTTRDSP SASVDTCTFL 
        60         70         80         90        100
SSLVCSNRTL LIDGRAELKR GLQRQERHLF LFNDLFVVAK IKYNNNFKIK 
       110        120        130        140        150
NKIKLTDMWT ASCVDEVGEG NTNAMKSFVL GWPTVNFVAT FSSPEQKDKW 
       160        170        180        190        200
LSLLQRYINL EKEKDYPKSI PLKIFAKDIG NCAYSKTITV MNSDTANEVI 
       210        220        230        240        250
NMSLPMLGIT GSERDYQLWV NSGKEEAPYP LIGHEYPYGI KMSHLRDSAL 
       260        270        280        290        300
LTPGSKDSTT PFNLQEPFLM EQLPREMQCQ FILKPSRLAA AQQLSDSGHK 
       310        320        330        340        350
TFKRRRSIIN WAFWRGSSTH LDNLPSSPTS PMPGQLFGIS LPNICENDNL 
       360        370        380        390        400
PKPVLDMLFF LNQKGPLTKG IFRQSANVKS CRELKEKLNS GVEVHLDCES 
       410        420        430        440        450
IFVIASVLKD FLRNIPGSIF SSDLYDHWVS VMDQGNDEEK INTVQRLLDQ 
       460        470        480        490        500
LPRANVVLLR YLFGVLHNIE QHSSSNQMTA FNLAVCVAPS ILWPPASSSP 
       510        520        530        540        550
ELENEFTKKV SLLIQFLIEN CLRIFGEEIT SLFREVSVRC DTRENASDIS 
       560        570        580        590        600
CFQLNDSSYD SLENELNEDV DAPCSDLVKK LGQGSRSMDS VLTLSDYDLD 
       610        620        630        640        650
QPEVEGLLTL SDFDLAHSKD EDVQMKRPLE SKPVNILVYT KIPLRDHARA 
       660        670        680        690        700
PSAMCTPSYL STAAANAAKS LRRHRRCSEP SIDYLDSKLS YLREFYQKKL 
       710        720        730        740        750
RKSSCDAILS QKDEDYLKQN QPLQEEGKTC FKQSLVTGTD VSKKNATTQN 
       760        770        780        790        800
TKKKSLSGSE GNHVKLFPKS KPVAISVASY SPMSSQDHSK NQPFDVNTSG 
       810        820        830        840        850
YSPPHTADAL KGPRTHRRCS EPNIEDQNRK LTYLRGIYSK KQHKTSCEAG 
       860        870        880        890        900
LLHGEEDYLK RHKSLQMEGQ KLINQSLVMG IEVGKSSATN QNTEKVLPPR 
       910        920        930        940        950
LNLCPRTSYS SLSSPGTSPS GSSVSSQDSA FSQISEHSVF TPTETSSPID 
       960        970        980        990       1000
CTFQAQRKRE DLSPDFSNAS HVSGMPGPSS GQACSRPAYT KKDTMEWHSQ 
      1010       1020       1030       1040       1050
MHSVTLHPST WLRNGVASLK NWSLKKKAKA ARPEEEKIAS PKGPLEPPPH 
      1060       1070       1080       1090       1100
ASGVPEANSL QEEQKDLPLR AAEGLSPVQS AQRCSSSPFQ DSERHCSSPF 
      1110       1120       1130       1140       1150
SLVESRLKLC MKSHEEIEPG SQSSSGSLPW ERASASSWTL EDATSPDSGP 
      1160 
TVVCDIEDRY LTKDI

Show »

Length:1,165

Mass (Da):130,235

Checksum:ⁱDFAA6B800B24583C

Isoform 3 (identifier: Q9P2F6-3) [UniParc]FASTA Add to basket

Also known as: 1c

The sequence of this isoform differs from the canonical sequence as follows:
1-33: MEAMSPQQETLGGQPGRSSSLTGVSRLAGGSCT → MSARERQPAL

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        10         20         30         40         50
MSARERQPAL KKKMKTLAER RRSAPSLILD KALQKRPTTR DSPSASVDTC 
        60         70         80         90        100
TFLSSLVCSN RTLLIDGRAE LKRGLQRQER HLFLFNDLFV VAKIKYNNNF 
       110        120        130        140        150
KIKNKIKLTD MWTASCVDEV GEGNTNAMKS FVLGWPTVNF VATFSSPEQK 
       160        170        180        190        200
DKWLSLLQRY INLEKEKDYP KSIPLKIFAK DIGNCAYSKT ITVMNSDTAN 
       210        220        230        240        250
EVINMSLPML GITGSERDYQ LWVNSGKEEA PYPLIGHEYP YGIKMSHLRD 
       260        270        280        290        300
SALLTPGSKD STTPFNLQEP FLMEQLPREM QCQFILKPSR LAAAQQLSDS 
       310        320        330        340        350
GHKTFKRRRS IINWAFWRGS STHLDNLPSS PTSPMPGQLF GISLPNICEN 
       360        370        380        390        400
DNLPKPVLDM LFFLNQKGPL TKGIFRQSAN VKSCRELKEK LNSGVEVHLD 
       410        420        430        440        450
CESIFVIASV LKDFLRNIPG SIFSSDLYDH WVSVMDQGND EEKINTVQRL 
       460        470        480        490        500
LDQLPRANVV LLRYLFGVLH NIEQHSSSNQ MTAFNLAVCV APSILWPPAS 
       510        520        530        540        550
SSPELENEFT KKVSLLIQFL IENCLRIFGE EITSLFREVS VRCDTRENAS 
       560        570        580        590        600
DISCFQLNDS SYDSLENELN EDVDAPCSDL VKKLGQGSRS MDSVLTLSDY 
       610        620        630        640        650
DLDQPEVEGL LTLSDFDLAH SKDEDVQMKR PLESKPVNIL VYTKIPLRDH 
       660        670        680        690        700
ARAPSAMCTP SYLSTAAANA AKSLRRHRRC SEPSIDYLDS KLSYLREFYQ 
       710        720        730        740        750
KKLRKSSCDA ILSQKDEDYL KQNQPLQEEG KTCFKQSLVT GTDVSKKNAT 
       760        770        780        790        800
TQNTKKKSLS GSEGNHVKLF PKSKPVAISV ASYSPMSSQD HSKNQPFDVN 
       810        820        830        840        850
TSGYSPPHTA DALKGPRTHR RCSEPNIEDQ NRKLTYLRGI YSKKQHKTSC 
       860        870        880        890        900
EAGLLHGEED YLKRHKSLQM EGQKLINQSL VMGIEVGKSS ATNQNTEKVL 
       910        920        930        940        950
PPRLNLCPRT SYSSLSSPGT SPSGSSVSSQ DSAFSQISEH SVFTPTETSS 
       960        970        980        990       1000
PIDCTFQAQR KREDLSPDFS NASHVSGMPG PSSGQACSRP AYTKKDTMEW 
      1010       1020       1030       1040       1050
HSQMHSVTLH PSTWLRNGVA SLKNWSLKKK AKAARPEEEK IASPKGPLEP 
      1060       1070       1080       1090       1100
PPHASGVPEA NSLQEEQKDL PLRAAEGLSP VQSAQRCSSS PFQDSERHCS 
      1110       1120       1130       1140       1150
SPFSLVESRL KLCMKSHEEI EPGSQSSSGS LPWERASASS WTLEDATSPD 
      1160 
SGPTVVCDIE DRYLTKDI

Show »

Length:1,168

Mass (Da):130,485

Checksum:ⁱ4A148F7B05DA3586

Isoform 4 (identifier: Q9P2F6-4) [UniParc]FASTA Add to basket

Also known as: 1e, 1d

The sequence of this isoform differs from the canonical sequence as follows:
1-36: Missing.

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        10         20         30         40         50
MKTLAERRRS APSLILDKAL QKRPTTRDSP SASVDTCTFL SSLVCSNRTL 
        60         70         80         90        100
LIDGRAELKR GLQRQERHLF LFNDLFVVAK IKYNNNFKIK NKIKLTDMWT 
       110        120        130        140        150
ASCVDEVGEG NTNAMKSFVL GWPTVNFVAT FSSPEQKDKW LSLLQRYINL 
       160        170        180        190        200
EKEKDYPKSI PLKIFAKDIG NCAYSKTITV MNSDTANEVI NMSLPMLGIT 
       210        220        230        240        250
GSERDYQLWV NSGKEEAPYP LIGHEYPYGI KMSHLRDSAL LTPGSKDSTT 
       260        270        280        290        300
PFNLQEPFLM EQLPREMQCQ FILKPSRLAA AQQLSDSGHK TFKRRRSIIN 
       310        320        330        340        350
WAFWRGSSTH LDNLPSSPTS PMPGQLFGIS LPNICENDNL PKPVLDMLFF 
       360        370        380        390        400
LNQKGPLTKG IFRQSANVKS CRELKEKLNS GVEVHLDCES IFVIASVLKD 
       410        420        430        440        450
FLRNIPGSIF SSDLYDHWVS VMDQGNDEEK INTVQRLLDQ LPRANVVLLR 
       460        470        480        490        500
YLFGVLHNIE QHSSSNQMTA FNLAVCVAPS ILWPPASSSP ELENEFTKKV 
       510        520        530        540        550
SLLIQFLIEN CLRIFGEEIT SLFREVSVRC DTRENASDIS CFQLNDSSYD 
       560        570        580        590        600
SLENELNEDV DAPCSDLVKK LGQGSRSMDS VLTLSDYDLD QPEVEGLLTL 
       610        620        630        640        650
SDFDLAHSKD EDVQMKRPLE SKPVNILVYT KIPLRDHARA PSAMCTPSYL 
       660        670        680        690        700
STAAANAAKS LRRHRRCSEP SIDYLDSKLS YLREFYQKKL RKSSCDAILS 
       710        720        730        740        750
QKDEDYLKQN QPLQEEGKTC FKQSLVTGTD VSKKNATTQN TKKKSLSGSE 
       760        770        780        790        800
GNHVKLFPKS KPVAISVASY SPMSSQDHSK NQPFDVNTSG YSPPHTADAL 
       810        820        830        840        850
KGPRTHRRCS EPNIEDQNRK LTYLRGIYSK KQHKTSCEAG LLHGEEDYLK 
       860        870        880        890        900
RHKSLQMEGQ KLINQSLVMG IEVGKSSATN QNTEKVLPPR LNLCPRTSYS 
       910        920        930        940        950
SLSSPGTSPS GSSVSSQDSA FSQISEHSVF TPTETSSPID CTFQAQRKRE 
       960        970        980        990       1000
DLSPDFSNAS HVSGMPGPSS GQACSRPAYT KKDTMEWHSQ MHSVTLHPST 
      1010       1020       1030       1040       1050
WLRNGVASLK NWSLKKKAKA ARPEEEKIAS PKGPLEPPPH ASGVPEANSL 
      1060       1070       1080       1090       1100
QEEQKDLPLR AAEGLSPVQS AQRCSSSPFQ DSERHCSSPF SLVESRLKLC 
      1110       1120       1130       1140       1150
MKSHEEIEPG SQSSSGSLPW ERASASSWTL EDATSPDSGP TVVCDIEDRY 

LTKDI

Show »

Length:1,155

Mass (Da):128,960

Checksum:ⁱEA4FF49422FE282E

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A0C4DGG5	A0A0C4DGG5_HUMAN		Rho GTPase-activating protein 20 Rho GTPase-activating protein 20	ARHGAP20	731	Annotation score:

Sequence cautionⁱ

The sequence AAH39340 differs from that shown. Probable cloning artifact.Curated

The sequence AAH39340 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

The sequence BAA92629 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

The sequence BAF84979 differs from that shown. Probable cloning artifact.Curated

The sequence BAF84979 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_031489	522	A → T. Corresponds to variant dbSNP:rs7936020Ensembl.		1
Natural variantⁱVAR_031490	632	G → D1 PublicationCorresponds to variant dbSNP:rs17853925Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_024296	1 – 36	Missing in isoform 4. 1 PublicationAdd BLAST	36
Alternative sequenceⁱVSP_024294	1 – 34	MEAMS…GSCTK → MTFWIIIN in isoform 2. 1 PublicationAdd BLAST	34
Alternative sequenceⁱVSP_024295	1 – 33	MEAMS…GGSCT → MSARERQPAL in isoform 3. 1 PublicationAdd BLAST	33

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY496263 mRNA Translation: AAS45466.1 AY496264 mRNA Translation: AAS45467.1 AY496265 mRNA Translation: AAS45468.1 AY496266 mRNA Translation: AAS45469.1 AY496267 mRNA Translation: AAS45470.1 AB037812 mRNA Translation: BAA92629.1 Different initiation. EF444953 Genomic DNA Translation: ACA05945.1 EF444953 Genomic DNA Translation: ACA05946.1 CH471065 Genomic DNA Translation: EAW67134.1 AK292290 mRNA Translation: BAF84979.1 Sequence problems. BC039340 mRNA Translation: AAH39340.1 Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31673.1 [Q9P2F6-1] CCDS58175.1 [Q9P2F6-4] CCDS58176.1 [Q9P2F6-2] CCDS58177.1 [Q9P2F6-3]
PIRⁱ	C59436
NCBI Reference Sequences More...RefSeqⁱ	NP_001245344.1, NM_001258415.1 [Q9P2F6-3] NP_001245345.1, NM_001258416.1 [Q9P2F6-2] NP_001245346.1, NM_001258417.1 [Q9P2F6-4] NP_001245347.1, NM_001258418.1 [Q9P2F6-4] NP_065860.2, NM_020809.3 [Q9P2F6-1] XP_006718956.1, XM_006718893.3

Genome annotation databases

Ensemblⁱ	ENST00000260283; ENSP00000260283; ENSG00000137727 [Q9P2F6-1] ENST00000524756; ENSP00000432076; ENSG00000137727 [Q9P2F6-3] ENST00000527598; ENSP00000431399; ENSG00000137727 [Q9P2F6-4] ENST00000528829; ENSP00000436319; ENSG00000137727 [Q9P2F6-4] ENST00000533353; ENSP00000436522; ENSG00000137727 [Q9P2F6-2]
GeneIDⁱ	57569
KEGGⁱ	hsa:57569
UCSC genome browser More...UCSCⁱ	uc001pky.3, human [Q9P2F6-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Chromosomal rearrangement, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q9P2F6	ARHGAP20 (Fragment)		HUMAN		1193	UniRef100_Q9P2F6
Isoform 4 of Rho GTPase-activating protein 20		HUMAN		1155
+2

Protein	Similar proteins		Species	Score	Length	Source
Q9P2F6	ARHGAP20 (Fragment)		HUMAN		1193	UniRef90_Q9P2F6
Rho GTPase activating protein 20		PANTR		1250
Uncharacterized protein		PANPA		1250
Uncharacterized protein		AOTNA		1233
Rho GTPase activating protein 20		CALJA		1193
+83

Protein	Similar proteins		Species	Score	Length	Source
Q9P2F6	Rho GTPase-activating protein 20		RAT		1182	UniRef50_Q9P2F6
Rho GTPase-activating protein 20		MOUSE		1182
ARHGAP20 (Fragment)		HUMAN		1193
Uncharacterized protein		PANPA		1250
Rho GTPase activating protein 20		PANTR		1250
+377

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY496263 mRNA Translation: AAS45466.1 AY496264 mRNA Translation: AAS45467.1 AY496265 mRNA Translation: AAS45468.1 AY496266 mRNA Translation: AAS45469.1 AY496267 mRNA Translation: AAS45470.1 AB037812 mRNA Translation: BAA92629.1 Different initiation. EF444953 Genomic DNA Translation: ACA05945.1 EF444953 Genomic DNA Translation: ACA05946.1 CH471065 Genomic DNA Translation: EAW67134.1 AK292290 mRNA Translation: BAF84979.1 Sequence problems. BC039340 mRNA Translation: AAH39340.1 Sequence problems.
CCDSⁱ	CCDS31673.1 [Q9P2F6-1] CCDS58175.1 [Q9P2F6-4] CCDS58176.1 [Q9P2F6-2] CCDS58177.1 [Q9P2F6-3]
PIRⁱ	C59436
RefSeqⁱ	NP_001245344.1, NM_001258415.1 [Q9P2F6-3] NP_001245345.1, NM_001258416.1 [Q9P2F6-2] NP_001245346.1, NM_001258417.1 [Q9P2F6-4] NP_001245347.1, NM_001258418.1 [Q9P2F6-4] NP_065860.2, NM_020809.3 [Q9P2F6-1] XP_006718956.1, XM_006718893.3

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3MSX	X-ray	1.65	B	351-551	[»]
SMRⁱ	Q9P2F6
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	121622, 5 interactors
IntActⁱ	Q9P2F6, 12 interactors
STRINGⁱ	9606.ENSP00000260283

PTM databases

iPTMnetⁱ	Q9P2F6
PhosphoSitePlusⁱ	Q9P2F6

Polymorphism and mutation databases

BioMutaⁱ	ARHGAP20
DMDMⁱ	143458429

Proteomic databases

jPOSTⁱ	Q9P2F6
PaxDbⁱ	Q9P2F6
PeptideAtlasⁱ	Q9P2F6
PRIDEⁱ	Q9P2F6
ProteomicsDBⁱ	83803 [Q9P2F6-1] 83804 [Q9P2F6-2] 83805 [Q9P2F6-3] 83806 [Q9P2F6-4]

Protocols and materials databases

Antibodypediaⁱ	32015, 120 antibodies
The DNASU plasmid repository More...DNASUⁱ	57569

Genome annotation databases

Ensemblⁱ	ENST00000260283; ENSP00000260283; ENSG00000137727 [Q9P2F6-1] ENST00000524756; ENSP00000432076; ENSG00000137727 [Q9P2F6-3] ENST00000527598; ENSP00000431399; ENSG00000137727 [Q9P2F6-4] ENST00000528829; ENSP00000436319; ENSG00000137727 [Q9P2F6-4] ENST00000533353; ENSP00000436522; ENSG00000137727 [Q9P2F6-2]
GeneIDⁱ	57569
KEGGⁱ	hsa:57569
UCSCⁱ	uc001pky.3, human [Q9P2F6-1]

Organism-specific databases

CTDⁱ	57569
DisGeNETⁱ	57569
EuPathDBⁱ	HostDB:ENSG00000137727.12
GeneCardsⁱ	ARHGAP20
HGNCⁱ	HGNC:18357, ARHGAP20
HPAⁱ	ENSG00000137727, Low tissue specificity
MIMⁱ	609568, gene
neXtProtⁱ	NX_Q9P2F6
OpenTargetsⁱ	ENSG00000137727
PharmGKBⁱ	PA134963885
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4724, Eukaryota
GeneTreeⁱ	ENSGT00940000154633
HOGENOMⁱ	CLU_008526_0_0_1
InParanoidⁱ	Q9P2F6
OMAⁱ	MWTANCV
OrthoDBⁱ	148399at2759
PhylomeDBⁱ	Q9P2F6
TreeFamⁱ	TF331062

Enzyme and pathway databases

PathwayCommonsⁱ	Q9P2F6
Reactomeⁱ	R-HSA-194840, Rho GTPase cycle
SIGNORⁱ	Q9P2F6

Miscellaneous databases

BioGRID-ORCSⁱ	57569, 1 hit in 842 CRISPR screens
EvolutionaryTraceⁱ	Q9P2F6
GenomeRNAiⁱ	57569
Pharosⁱ	Q9P2F6, Tbio
Protein Ontology More...PROⁱ	PR:Q9P2F6
RNActⁱ	Q9P2F6, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000137727, Expressed in caudate nucleus and 193 other tissues
ExpressionAtlasⁱ	Q9P2F6, baseline and differential
Genevisibleⁱ	Q9P2F6, HS

Family and domain databases

Gene3Dⁱ	1.10.555.10, 1 hit 2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR000159, RA_dom IPR008936, Rho_GTPase_activation_prot IPR000198, RhoGAP_dom IPR029071, Ubiquitin-like_domsf
Pfamⁱ	View protein in Pfam PF00788, RA, 1 hit PF00620, RhoGAP, 1 hit
SMARTⁱ	View protein in SMART SM00233, PH, 1 hit SM00324, RhoGAP, 1 hit
SUPFAMⁱ	SSF48350, SSF48350, 1 hit SSF54236, SSF54236, 1 hit
PROSITEⁱ	View protein in PROSITE PS50200, RA, 1 hit PS50238, RHOGAP, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RHG20_HUMAN
Accessionⁱ	Q9P2F6Primary (citable) accession number: Q9P2F6 Secondary accession number(s): A8K8C5 Q8IXS1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
	Last sequence update:	April 3, 2007
	Last modified:	December 2, 2020
	This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations

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UniProtKB - Q9P2F6 (RHG20_HUMAN)

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Rho GTPase-activating protein 20

ARHGAP20

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

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Amino acid modifications

Keywords - PTMi

Proteomic databases

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Gene expression databases

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<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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Family and domain databases

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

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PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

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Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ