UniProtKB - Q9P2F6 (RHG20_HUMAN)
Protein
Rho GTPase-activating protein 20
Gene
ARHGAP20
Organism
Homo sapiens (Human)
Status
Functioni
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.By similarity
Caution
The translocation involving this gene was originally published as t(X;11)(q13;23), but BRWD3 is localized to Xq21 and not to Xq13.1 Publication
GO - Molecular functioni
- GTPase activator activity Source: GO_Central
GO - Biological processi
- regulation of small GTPase mediated signal transduction Source: Reactome
- signal transduction Source: InterPro
Keywordsi
Molecular function | GTPase activation |
Enzyme and pathway databases
PathwayCommonsi | Q9P2F6 |
Reactomei | R-HSA-194840, Rho GTPase cycle |
SIGNORi | Q9P2F6 |
Names & Taxonomyi
Protein namesi | Recommended name: Rho GTPase-activating protein 20Alternative name(s): Rho-type GTPase-activating protein 20 |
Gene namesi | Name:ARHGAP20 Synonyms:KIAA1391 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000137727.12 |
HGNCi | HGNC:18357, ARHGAP20 |
MIMi | 609568, gene |
neXtProti | NX_Q9P2F6 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Pathology & Biotechi
Involvement in diseasei
A chromosomal aberration involving ARHGAP20 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL) (PubMed:15543602). Translocation t(X;11)(q21;q23) with BRWD3 does not result in fusion transcripts but disrupts both genes (PubMed:15543602).1 Publication
Keywords - Diseasei
Tumor suppressorOrganism-specific databases
DisGeNETi | 57569 |
OpenTargetsi | ENSG00000137727 |
PharmGKBi | PA134963885 |
Miscellaneous databases
Pharosi | Q9P2F6, Tbio |
Polymorphism and mutation databases
BioMutai | ARHGAP20 |
DMDMi | 143458429 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000283086 | 1 – 1191 | Rho GTPase-activating protein 20Add BLAST | 1191 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 46 | PhosphoserineBy similarity | 1 | |
Modified residuei | 704 | PhosphoserineBy similarity | 1 | |
Modified residuei | 730 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q9P2F6 |
PaxDbi | Q9P2F6 |
PeptideAtlasi | Q9P2F6 |
PRIDEi | Q9P2F6 |
ProteomicsDBi | 83803 [Q9P2F6-1] 83804 [Q9P2F6-2] 83805 [Q9P2F6-3] 83806 [Q9P2F6-4] |
PTM databases
iPTMneti | Q9P2F6 |
PhosphoSitePlusi | Q9P2F6 |
Expressioni
Tissue specificityi
Expressed predominantly in the brain. Lower expression is found in lymph nodes.1 Publication
Developmental stagei
Low expression is found in fetal liver.1 Publication
Gene expression databases
Bgeei | ENSG00000137727, Expressed in caudate nucleus and 193 other tissues |
ExpressionAtlasi | Q9P2F6, baseline and differential |
Genevisiblei | Q9P2F6, HS |
Organism-specific databases
HPAi | ENSG00000137727, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 121622, 5 interactors |
IntActi | Q9P2F6, 12 interactors |
STRINGi | 9606.ENSP00000260283 |
Miscellaneous databases
RNActi | Q9P2F6, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9P2F6 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9P2F6 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 78 – 180 | PHAdd BLAST | 103 | |
Domaini | 194 – 295 | Ras-associatingPROSITE-ProRule annotationAdd BLAST | 102 | |
Domaini | 365 – 551 | Rho-GAPPROSITE-ProRule annotationAdd BLAST | 187 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 934 – 973 | Ser-richAdd BLAST | 40 |
Phylogenomic databases
eggNOGi | KOG4724, Eukaryota |
GeneTreei | ENSGT00940000154633 |
HOGENOMi | CLU_008526_0_0_1 |
InParanoidi | Q9P2F6 |
OMAi | MWTANCV |
OrthoDBi | 148399at2759 |
PhylomeDBi | Q9P2F6 |
TreeFami | TF331062 |
Family and domain databases
Gene3Di | 1.10.555.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR000159, RA_dom IPR008936, Rho_GTPase_activation_prot IPR000198, RhoGAP_dom IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF00788, RA, 1 hit PF00620, RhoGAP, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00324, RhoGAP, 1 hit |
SUPFAMi | SSF48350, SSF48350, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50200, RA, 1 hit PS50238, RHOGAP, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9P2F6-1) [UniParc]FASTAAdd to basket
Also known as: 1ad
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEAMSPQQET LGGQPGRSSS LTGVSRLAGG SCTKKKMKTL AERRRSAPSL
60 70 80 90 100
ILDKALQKRP TTRDSPSASV DTCTFLSSLV CSNRTLLIDG RAELKRGLQR
110 120 130 140 150
QERHLFLFND LFVVAKIKYN NNFKIKNKIK LTDMWTASCV DEVGEGNTNA
160 170 180 190 200
MKSFVLGWPT VNFVATFSSP EQKDKWLSLL QRYINLEKEK DYPKSIPLKI
210 220 230 240 250
FAKDIGNCAY SKTITVMNSD TANEVINMSL PMLGITGSER DYQLWVNSGK
260 270 280 290 300
EEAPYPLIGH EYPYGIKMSH LRDSALLTPG SKDSTTPFNL QEPFLMEQLP
310 320 330 340 350
REMQCQFILK PSRLAAAQQL SDSGHKTFKR RRSIINWAFW RGSSTHLDNL
360 370 380 390 400
PSSPTSPMPG QLFGISLPNI CENDNLPKPV LDMLFFLNQK GPLTKGIFRQ
410 420 430 440 450
SANVKSCREL KEKLNSGVEV HLDCESIFVI ASVLKDFLRN IPGSIFSSDL
460 470 480 490 500
YDHWVSVMDQ GNDEEKINTV QRLLDQLPRA NVVLLRYLFG VLHNIEQHSS
510 520 530 540 550
SNQMTAFNLA VCVAPSILWP PASSSPELEN EFTKKVSLLI QFLIENCLRI
560 570 580 590 600
FGEEITSLFR EVSVRCDTRE NASDISCFQL NDSSYDSLEN ELNEDVDAPC
610 620 630 640 650
SDLVKKLGQG SRSMDSVLTL SDYDLDQPEV EGLLTLSDFD LAHSKDEDVQ
660 670 680 690 700
MKRPLESKPV NILVYTKIPL RDHARAPSAM CTPSYLSTAA ANAAKSLRRH
710 720 730 740 750
RRCSEPSIDY LDSKLSYLRE FYQKKLRKSS CDAILSQKDE DYLKQNQPLQ
760 770 780 790 800
EEGKTCFKQS LVTGTDVSKK NATTQNTKKK SLSGSEGNHV KLFPKSKPVA
810 820 830 840 850
ISVASYSPMS SQDHSKNQPF DVNTSGYSPP HTADALKGPR THRRCSEPNI
860 870 880 890 900
EDQNRKLTYL RGIYSKKQHK TSCEAGLLHG EEDYLKRHKS LQMEGQKLIN
910 920 930 940 950
QSLVMGIEVG KSSATNQNTE KVLPPRLNLC PRTSYSSLSS PGTSPSGSSV
960 970 980 990 1000
SSQDSAFSQI SEHSVFTPTE TSSPIDCTFQ AQRKREDLSP DFSNASHVSG
1010 1020 1030 1040 1050
MPGPSSGQAC SRPAYTKKDT MEWHSQMHSV TLHPSTWLRN GVASLKNWSL
1060 1070 1080 1090 1100
KKKAKAARPE EEKIASPKGP LEPPPHASGV PEANSLQEEQ KDLPLRAAEG
1110 1120 1130 1140 1150
LSPVQSAQRC SSSPFQDSER HCSSPFSLVE SRLKLCMKSH EEIEPGSQSS
1160 1170 1180 1190
SGSLPWERAS ASSWTLEDAT SPDSGPTVVC DIEDRYLTKD I
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0C4DGG5 | A0A0C4DGG5_HUMAN | Rho GTPase-activating protein 20 | ARHGAP20 | 731 | Annotation score: |
Sequence cautioni
The sequence AAH39340 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAA92629 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAF84979 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_031489 | 522 | A → T. Corresponds to variant dbSNP:rs7936020Ensembl. | 1 | |
Natural variantiVAR_031490 | 632 | G → D1 PublicationCorresponds to variant dbSNP:rs17853925Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_024296 | 1 – 36 | Missing in isoform 4. 1 PublicationAdd BLAST | 36 | |
Alternative sequenceiVSP_024294 | 1 – 34 | MEAMS…GSCTK → MTFWIIIN in isoform 2. 1 PublicationAdd BLAST | 34 | |
Alternative sequenceiVSP_024295 | 1 – 33 | MEAMS…GGSCT → MSARERQPAL in isoform 3. 1 PublicationAdd BLAST | 33 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY496263 mRNA Translation: AAS45466.1 AY496264 mRNA Translation: AAS45467.1 AY496265 mRNA Translation: AAS45468.1 AY496266 mRNA Translation: AAS45469.1 AY496267 mRNA Translation: AAS45470.1 AB037812 mRNA Translation: BAA92629.1 Different initiation. EF444953 Genomic DNA Translation: ACA05945.1 EF444953 Genomic DNA Translation: ACA05946.1 CH471065 Genomic DNA Translation: EAW67134.1 AK292290 mRNA Translation: BAF84979.1 Sequence problems. BC039340 mRNA Translation: AAH39340.1 Sequence problems. |
CCDSi | CCDS31673.1 [Q9P2F6-1] CCDS58175.1 [Q9P2F6-4] CCDS58176.1 [Q9P2F6-2] CCDS58177.1 [Q9P2F6-3] |
PIRi | C59436 |
RefSeqi | NP_001245344.1, NM_001258415.1 [Q9P2F6-3] NP_001245345.1, NM_001258416.1 [Q9P2F6-2] NP_001245346.1, NM_001258417.1 [Q9P2F6-4] NP_001245347.1, NM_001258418.1 [Q9P2F6-4] NP_065860.2, NM_020809.3 [Q9P2F6-1] XP_006718956.1, XM_006718893.3 |
Genome annotation databases
Ensembli | ENST00000260283; ENSP00000260283; ENSG00000137727 [Q9P2F6-1] ENST00000524756; ENSP00000432076; ENSG00000137727 [Q9P2F6-3] ENST00000527598; ENSP00000431399; ENSG00000137727 [Q9P2F6-4] ENST00000528829; ENSP00000436319; ENSG00000137727 [Q9P2F6-4] ENST00000533353; ENSP00000436522; ENSG00000137727 [Q9P2F6-2] |
GeneIDi | 57569 |
KEGGi | hsa:57569 |
UCSCi | uc001pky.3, human [Q9P2F6-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangement, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY496263 mRNA Translation: AAS45466.1 AY496264 mRNA Translation: AAS45467.1 AY496265 mRNA Translation: AAS45468.1 AY496266 mRNA Translation: AAS45469.1 AY496267 mRNA Translation: AAS45470.1 AB037812 mRNA Translation: BAA92629.1 Different initiation. EF444953 Genomic DNA Translation: ACA05945.1 EF444953 Genomic DNA Translation: ACA05946.1 CH471065 Genomic DNA Translation: EAW67134.1 AK292290 mRNA Translation: BAF84979.1 Sequence problems. BC039340 mRNA Translation: AAH39340.1 Sequence problems. |
CCDSi | CCDS31673.1 [Q9P2F6-1] CCDS58175.1 [Q9P2F6-4] CCDS58176.1 [Q9P2F6-2] CCDS58177.1 [Q9P2F6-3] |
PIRi | C59436 |
RefSeqi | NP_001245344.1, NM_001258415.1 [Q9P2F6-3] NP_001245345.1, NM_001258416.1 [Q9P2F6-2] NP_001245346.1, NM_001258417.1 [Q9P2F6-4] NP_001245347.1, NM_001258418.1 [Q9P2F6-4] NP_065860.2, NM_020809.3 [Q9P2F6-1] XP_006718956.1, XM_006718893.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3MSX | X-ray | 1.65 | B | 351-551 | [»] | |
SMRi | Q9P2F6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 121622, 5 interactors |
IntActi | Q9P2F6, 12 interactors |
STRINGi | 9606.ENSP00000260283 |
PTM databases
iPTMneti | Q9P2F6 |
PhosphoSitePlusi | Q9P2F6 |
Polymorphism and mutation databases
BioMutai | ARHGAP20 |
DMDMi | 143458429 |
Proteomic databases
jPOSTi | Q9P2F6 |
PaxDbi | Q9P2F6 |
PeptideAtlasi | Q9P2F6 |
PRIDEi | Q9P2F6 |
ProteomicsDBi | 83803 [Q9P2F6-1] 83804 [Q9P2F6-2] 83805 [Q9P2F6-3] 83806 [Q9P2F6-4] |
Protocols and materials databases
Antibodypediai | 32015, 120 antibodies |
DNASUi | 57569 |
Genome annotation databases
Ensembli | ENST00000260283; ENSP00000260283; ENSG00000137727 [Q9P2F6-1] ENST00000524756; ENSP00000432076; ENSG00000137727 [Q9P2F6-3] ENST00000527598; ENSP00000431399; ENSG00000137727 [Q9P2F6-4] ENST00000528829; ENSP00000436319; ENSG00000137727 [Q9P2F6-4] ENST00000533353; ENSP00000436522; ENSG00000137727 [Q9P2F6-2] |
GeneIDi | 57569 |
KEGGi | hsa:57569 |
UCSCi | uc001pky.3, human [Q9P2F6-1] |
Organism-specific databases
CTDi | 57569 |
DisGeNETi | 57569 |
EuPathDBi | HostDB:ENSG00000137727.12 |
GeneCardsi | ARHGAP20 |
HGNCi | HGNC:18357, ARHGAP20 |
HPAi | ENSG00000137727, Low tissue specificity |
MIMi | 609568, gene |
neXtProti | NX_Q9P2F6 |
OpenTargetsi | ENSG00000137727 |
PharmGKBi | PA134963885 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4724, Eukaryota |
GeneTreei | ENSGT00940000154633 |
HOGENOMi | CLU_008526_0_0_1 |
InParanoidi | Q9P2F6 |
OMAi | MWTANCV |
OrthoDBi | 148399at2759 |
PhylomeDBi | Q9P2F6 |
TreeFami | TF331062 |
Enzyme and pathway databases
PathwayCommonsi | Q9P2F6 |
Reactomei | R-HSA-194840, Rho GTPase cycle |
SIGNORi | Q9P2F6 |
Miscellaneous databases
BioGRID-ORCSi | 57569, 1 hit in 842 CRISPR screens |
EvolutionaryTracei | Q9P2F6 |
GenomeRNAii | 57569 |
Pharosi | Q9P2F6, Tbio |
PROi | PR:Q9P2F6 |
RNActi | Q9P2F6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000137727, Expressed in caudate nucleus and 193 other tissues |
ExpressionAtlasi | Q9P2F6, baseline and differential |
Genevisiblei | Q9P2F6, HS |
Family and domain databases
Gene3Di | 1.10.555.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR000159, RA_dom IPR008936, Rho_GTPase_activation_prot IPR000198, RhoGAP_dom IPR029071, Ubiquitin-like_domsf |
Pfami | View protein in Pfam PF00788, RA, 1 hit PF00620, RhoGAP, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00324, RhoGAP, 1 hit |
SUPFAMi | SSF48350, SSF48350, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50200, RA, 1 hit PS50238, RHOGAP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RHG20_HUMAN | |
Accessioni | Q9P2F6Primary (citable) accession number: Q9P2F6 Secondary accession number(s): A8K8C5 Q8IXS1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 3, 2007 |
Last sequence update: | April 3, 2007 | |
Last modified: | December 2, 2020 | |
This is version 143 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations