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UniProtKB - Q9P2F6 (RHG20_HUMAN)

Protein

Rho GTPase-activating protein 20

Gene

ARHGAP20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.By similarity

Caution

The translocation involving this gene was originally published as t(X;11)(q13;23), but BRWD3 is localized to Xq21 and not to Xq13.1 Publication

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 20
Alternative name(s):
Rho-type GTPase-activating protein 20
Gene namesi
Name:ARHGAP20
Synonyms:KIAA1391
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000137727.12
HGNCiHGNC:18357 ARHGAP20
MIMi609568 gene
neXtProtiNX_Q9P2F6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving ARHGAP20 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL) (PubMed:15543602). Translocation t(X;11)(q21;q23) with BRWD3 does not result in fusion transcripts but disrupts both genes (PubMed:15543602).1 Publication

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi57569
OpenTargetsiENSG00000137727
PharmGKBiPA134963885

Polymorphism and mutation databases

BioMutaiARHGAP20
DMDMi143458429

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002830861 – 1191Rho GTPase-activating protein 20Add BLAST1191

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei46PhosphoserineBy similarity1
Modified residuei704PhosphoserineBy similarity1
Modified residuei730PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9P2F6
PeptideAtlasiQ9P2F6
PRIDEiQ9P2F6
ProteomicsDBi83803
83804 [Q9P2F6-2]
83805 [Q9P2F6-3]
83806 [Q9P2F6-4]

PTM databases

iPTMnetiQ9P2F6
PhosphoSitePlusiQ9P2F6

Expressioni

Tissue specificityi

Expressed predominantly in the brain. Lower expression is found in lymph nodes.1 Publication

Developmental stagei

Low expression is found in fetal liver.1 Publication

Gene expression databases

BgeeiENSG00000137727 Expressed in 170 organ(s), highest expression level in caudate nucleus
CleanExiHS_ARHGAP20
ExpressionAtlasiQ9P2F6 baseline and differential
GenevisibleiQ9P2F6 HS

Organism-specific databases

HPAiHPA038458
HPA038459
HPA076303

Interactioni

Protein-protein interaction databases

BioGridi121622, 1 interactor
IntActiQ9P2F6, 1 interactor
STRINGi9606.ENSP00000260283

Structurei

Secondary structure

11191
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9P2F6
SMRiQ9P2F6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9P2F6

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 180PHAdd BLAST103
Domaini194 – 295Ras-associatingPROSITE-ProRule annotationAdd BLAST102
Domaini365 – 551Rho-GAPPROSITE-ProRule annotationAdd BLAST187

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi934 – 973Ser-richAdd BLAST40

Phylogenomic databases

eggNOGiKOG4724 Eukaryota
ENOG410YV4E LUCA
GeneTreeiENSGT00530000063299
HOVERGENiHBG061748
InParanoidiQ9P2F6
KOiK20641
OMAiNICENDN
OrthoDBiEOG091G02C4
PhylomeDBiQ9P2F6
TreeFamiTF331062

Family and domain databases

Gene3Di1.10.555.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000159 RA_dom
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF00788 RA, 1 hit
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00324 RhoGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50200 RA, 1 hit
PS50238 RHOGAP, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.iShow all

Isoform 1 (identifier: Q9P2F6-1) [UniParc]FASTAAdd to basket
Also known as: 1ad

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEAMSPQQET LGGQPGRSSS LTGVSRLAGG SCTKKKMKTL AERRRSAPSL 
        60         70         80         90        100
ILDKALQKRP TTRDSPSASV DTCTFLSSLV CSNRTLLIDG RAELKRGLQR 
       110        120        130        140        150
QERHLFLFND LFVVAKIKYN NNFKIKNKIK LTDMWTASCV DEVGEGNTNA 
       160        170        180        190        200
MKSFVLGWPT VNFVATFSSP EQKDKWLSLL QRYINLEKEK DYPKSIPLKI 
       210        220        230        240        250
FAKDIGNCAY SKTITVMNSD TANEVINMSL PMLGITGSER DYQLWVNSGK 
       260        270        280        290        300
EEAPYPLIGH EYPYGIKMSH LRDSALLTPG SKDSTTPFNL QEPFLMEQLP 
       310        320        330        340        350
REMQCQFILK PSRLAAAQQL SDSGHKTFKR RRSIINWAFW RGSSTHLDNL 
       360        370        380        390        400
PSSPTSPMPG QLFGISLPNI CENDNLPKPV LDMLFFLNQK GPLTKGIFRQ 
       410        420        430        440        450
SANVKSCREL KEKLNSGVEV HLDCESIFVI ASVLKDFLRN IPGSIFSSDL 
       460        470        480        490        500
YDHWVSVMDQ GNDEEKINTV QRLLDQLPRA NVVLLRYLFG VLHNIEQHSS 
       510        520        530        540        550
SNQMTAFNLA VCVAPSILWP PASSSPELEN EFTKKVSLLI QFLIENCLRI 
       560        570        580        590        600
FGEEITSLFR EVSVRCDTRE NASDISCFQL NDSSYDSLEN ELNEDVDAPC 
       610        620        630        640        650
SDLVKKLGQG SRSMDSVLTL SDYDLDQPEV EGLLTLSDFD LAHSKDEDVQ 
       660        670        680        690        700
MKRPLESKPV NILVYTKIPL RDHARAPSAM CTPSYLSTAA ANAAKSLRRH 
       710        720        730        740        750
RRCSEPSIDY LDSKLSYLRE FYQKKLRKSS CDAILSQKDE DYLKQNQPLQ 
       760        770        780        790        800
EEGKTCFKQS LVTGTDVSKK NATTQNTKKK SLSGSEGNHV KLFPKSKPVA 
       810        820        830        840        850
ISVASYSPMS SQDHSKNQPF DVNTSGYSPP HTADALKGPR THRRCSEPNI 
       860        870        880        890        900
EDQNRKLTYL RGIYSKKQHK TSCEAGLLHG EEDYLKRHKS LQMEGQKLIN 
       910        920        930        940        950
QSLVMGIEVG KSSATNQNTE KVLPPRLNLC PRTSYSSLSS PGTSPSGSSV 
       960        970        980        990       1000
SSQDSAFSQI SEHSVFTPTE TSSPIDCTFQ AQRKREDLSP DFSNASHVSG 
      1010       1020       1030       1040       1050
MPGPSSGQAC SRPAYTKKDT MEWHSQMHSV TLHPSTWLRN GVASLKNWSL 
      1060       1070       1080       1090       1100
KKKAKAARPE EEKIASPKGP LEPPPHASGV PEANSLQEEQ KDLPLRAAEG 
      1110       1120       1130       1140       1150
LSPVQSAQRC SSSPFQDSER HCSSPFSLVE SRLKLCMKSH EEIEPGSQSS 
      1160       1170       1180       1190 
SGSLPWERAS ASSWTLEDAT SPDSGPTVVC DIEDRYLTKD I
Length:1,191
Mass (Da):132,608
Last modified:April 3, 2007 - v2
Checksum:i1837B9DF0655AF41
GO
Isoform 2 (identifier: Q9P2F6-2) [UniParc]FASTAAdd to basket
Also known as: 1be

The sequence of this isoform differs from the canonical sequence as follows:
     1-34: MEAMSPQQETLGGQPGRSSSLTGVSRLAGGSCTK → MTFWIIIN

Show »
Length:1,165
Mass (Da):130,235
Checksum:iDFAA6B800B24583C
GO
Isoform 3 (identifier: Q9P2F6-3) [UniParc]FASTAAdd to basket
Also known as: 1c

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: MEAMSPQQETLGGQPGRSSSLTGVSRLAGGSCT → MSARERQPAL

Show »
Length:1,168
Mass (Da):130,485
Checksum:i4A148F7B05DA3586
GO
Isoform 4 (identifier: Q9P2F6-4) [UniParc]FASTAAdd to basket
Also known as: 1e, 1d

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.

Show »
Length:1,155
Mass (Da):128,960
Checksum:iEA4FF49422FE282E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DGG5A0A0C4DGG5_HUMAN
Rho GTPase-activating protein 20
ARHGAP20
731Annotation score:

Sequence cautioni

The sequence AAH39340 differs from that shown. Probable cloning artifact.Curated
The sequence AAH39340 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA92629 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAF84979 differs from that shown. Probable cloning artifact.Curated
The sequence BAF84979 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031489522A → T. Corresponds to variant dbSNP:rs7936020Ensembl.1
Natural variantiVAR_031490632G → D1 PublicationCorresponds to variant dbSNP:rs17853925Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0242961 – 36Missing in isoform 4. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_0242941 – 34MEAMS…GSCTK → MTFWIIIN in isoform 2. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_0242951 – 33MEAMS…GGSCT → MSARERQPAL in isoform 3. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY496263 mRNA Translation: AAS45466.1
AY496264 mRNA Translation: AAS45467.1
AY496265 mRNA Translation: AAS45468.1
AY496266 mRNA Translation: AAS45469.1
AY496267 mRNA Translation: AAS45470.1
AB037812 mRNA Translation: BAA92629.1 Different initiation.
EF444953 Genomic DNA Translation: ACA05945.1
EF444953 Genomic DNA Translation: ACA05946.1
CH471065 Genomic DNA Translation: EAW67134.1
AK292290 mRNA Translation: BAF84979.1 Sequence problems.
BC039340 mRNA Translation: AAH39340.1 Sequence problems.
CCDSiCCDS31673.1 [Q9P2F6-1]
CCDS58175.1 [Q9P2F6-4]
CCDS58176.1 [Q9P2F6-2]
CCDS58177.1 [Q9P2F6-3]
PIRiC59436
RefSeqiNP_001245344.1, NM_001258415.1 [Q9P2F6-3]
NP_001245345.1, NM_001258416.1 [Q9P2F6-2]
NP_001245346.1, NM_001258417.1 [Q9P2F6-4]
NP_001245347.1, NM_001258418.1 [Q9P2F6-4]
NP_065860.2, NM_020809.3 [Q9P2F6-1]
XP_006718956.1, XM_006718893.3 [Q9P2F6-1]
UniGeneiHs.6136

Genome annotation databases

EnsembliENST00000260283; ENSP00000260283; ENSG00000137727 [Q9P2F6-1]
ENST00000524756; ENSP00000432076; ENSG00000137727 [Q9P2F6-3]
ENST00000527598; ENSP00000431399; ENSG00000137727 [Q9P2F6-4]
ENST00000528829; ENSP00000436319; ENSG00000137727 [Q9P2F6-4]
ENST00000533353; ENSP00000436522; ENSG00000137727 [Q9P2F6-2]
GeneIDi57569
KEGGihsa:57569
UCSCiuc001pky.3 human [Q9P2F6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY496263 mRNA Translation: AAS45466.1
AY496264 mRNA Translation: AAS45467.1
AY496265 mRNA Translation: AAS45468.1
AY496266 mRNA Translation: AAS45469.1
AY496267 mRNA Translation: AAS45470.1
AB037812 mRNA Translation: BAA92629.1 Different initiation.
EF444953 Genomic DNA Translation: ACA05945.1
EF444953 Genomic DNA Translation: ACA05946.1
CH471065 Genomic DNA Translation: EAW67134.1
AK292290 mRNA Translation: BAF84979.1 Sequence problems.
BC039340 mRNA Translation: AAH39340.1 Sequence problems.
CCDSiCCDS31673.1 [Q9P2F6-1]
CCDS58175.1 [Q9P2F6-4]
CCDS58176.1 [Q9P2F6-2]
CCDS58177.1 [Q9P2F6-3]
PIRiC59436
RefSeqiNP_001245344.1, NM_001258415.1 [Q9P2F6-3]
NP_001245345.1, NM_001258416.1 [Q9P2F6-2]
NP_001245346.1, NM_001258417.1 [Q9P2F6-4]
NP_001245347.1, NM_001258418.1 [Q9P2F6-4]
NP_065860.2, NM_020809.3 [Q9P2F6-1]
XP_006718956.1, XM_006718893.3 [Q9P2F6-1]
UniGeneiHs.6136

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MSXX-ray1.65B351-551[»]
ProteinModelPortaliQ9P2F6
SMRiQ9P2F6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121622, 1 interactor
IntActiQ9P2F6, 1 interactor
STRINGi9606.ENSP00000260283

PTM databases

iPTMnetiQ9P2F6
PhosphoSitePlusiQ9P2F6

Polymorphism and mutation databases

BioMutaiARHGAP20
DMDMi143458429

Proteomic databases

PaxDbiQ9P2F6
PeptideAtlasiQ9P2F6
PRIDEiQ9P2F6
ProteomicsDBi83803
83804 [Q9P2F6-2]
83805 [Q9P2F6-3]
83806 [Q9P2F6-4]

Protocols and materials databases

DNASUi57569
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260283; ENSP00000260283; ENSG00000137727 [Q9P2F6-1]
ENST00000524756; ENSP00000432076; ENSG00000137727 [Q9P2F6-3]
ENST00000527598; ENSP00000431399; ENSG00000137727 [Q9P2F6-4]
ENST00000528829; ENSP00000436319; ENSG00000137727 [Q9P2F6-4]
ENST00000533353; ENSP00000436522; ENSG00000137727 [Q9P2F6-2]
GeneIDi57569
KEGGihsa:57569
UCSCiuc001pky.3 human [Q9P2F6-1]

Organism-specific databases

CTDi57569
DisGeNETi57569
EuPathDBiHostDB:ENSG00000137727.12
GeneCardsiARHGAP20
H-InvDBiHIX0010100
HGNCiHGNC:18357 ARHGAP20
HPAiHPA038458
HPA038459
HPA076303
MIMi609568 gene
neXtProtiNX_Q9P2F6
OpenTargetsiENSG00000137727
PharmGKBiPA134963885
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4724 Eukaryota
ENOG410YV4E LUCA
GeneTreeiENSGT00530000063299
HOVERGENiHBG061748
InParanoidiQ9P2F6
KOiK20641
OMAiNICENDN
OrthoDBiEOG091G02C4
PhylomeDBiQ9P2F6
TreeFamiTF331062

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle

Miscellaneous databases

ChiTaRSiARHGAP20 human
EvolutionaryTraceiQ9P2F6
GenomeRNAii57569
PROiPR:Q9P2F6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137727 Expressed in 170 organ(s), highest expression level in caudate nucleus
CleanExiHS_ARHGAP20
ExpressionAtlasiQ9P2F6 baseline and differential
GenevisibleiQ9P2F6 HS

Family and domain databases

Gene3Di1.10.555.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000159 RA_dom
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF00788 RA, 1 hit
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00324 RhoGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50200 RA, 1 hit
PS50238 RHOGAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRHG20_HUMAN
AccessioniPrimary (citable) accession number: Q9P2F6
Secondary accession number(s): A8K8C5
, B0YIW7, B0YIW8, Q6RJU1, Q6RJU2, Q6RJU3, Q6RJU5, Q8IXS1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: September 12, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health

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