UniProtKB - Q9P2E9 (RRBP1_HUMAN)
Protein
Ribosome-binding protein 1
Gene
RRBP1
Organism
Homo sapiens (Human)
Status
Functioni
Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane.By similarity
GO - Molecular functioni
- RNA binding Source: UniProtKB
- signaling receptor activity Source: ProtInc
GO - Biological processi
- osteoblast differentiation Source: UniProtKB
- protein transport Source: UniProtKB-KW
- translation Source: ProtInc
Keywordsi
Biological process | Protein transport, Translocation, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q9P2E9 |
Names & Taxonomyi
Protein namesi | Recommended name: Ribosome-binding protein 1Alternative name(s): 180 kDa ribosome receptor homolog Short name: RRp ES/130-related protein Ribosome receptor protein |
Gene namesi | Name:RRBP1 Synonyms:KIAA1398 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10448, RRBP1 |
MIMi | 601418, gene |
neXtProti | NX_Q9P2E9 |
VEuPathDBi | HostDB:ENSG00000125844.15 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Single-pass type III membrane protein By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: HPA
- integral component of endoplasmic reticulum membrane Source: GO_Central
Other locations
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 7 | LumenalSequence analysis | 7 | |
Transmembranei | 8 – 28 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 29 – 1410 | CytoplasmicSequence analysisAdd BLAST | 1382 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 6238 |
OpenTargetsi | ENSG00000125844 |
PharmGKBi | PA34863 |
Miscellaneous databases
Pharosi | Q9P2E9, Tbio |
Chemistry databases
DrugBanki | DB12339, Radezolid |
Genetic variation databases
BioMutai | RRBP1 |
DMDMi | 23822112 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000097441 | 1 – 1410 | Ribosome-binding protein 1Add BLAST | 1410 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 148 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 159 | PhosphoserineBy similarity | 1 | |
Modified residuei | 165 | PhosphoserineBy similarity | 1 | |
Modified residuei | 225 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 235 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 245 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 255 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 533 | PhosphoserineCombined sources | 1 | |
Modified residuei | 573 | PhosphoserineCombined sources | 1 | |
Modified residuei | 583 | PhosphoserineCombined sources | 1 | |
Modified residuei | 615 | PhosphoserineCombined sources | 1 | |
Cross-linki | 620 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources | ||
Modified residuei | 900 | PhosphoserineCombined sources | 1 | |
Modified residuei | 932 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 959 | PhosphoserineCombined sources | 1 | |
Modified residuei | 978 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1276 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1277 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9P2E9 |
jPOSTi | Q9P2E9 |
MassIVEi | Q9P2E9 |
PaxDbi | Q9P2E9 |
PeptideAtlasi | Q9P2E9 |
PRIDEi | Q9P2E9 |
ProteomicsDBi | 83798 [Q9P2E9-1] 83800 [Q9P2E9-3] |
PTM databases
iPTMneti | Q9P2E9 |
MetOSitei | Q9P2E9 |
PhosphoSitePlusi | Q9P2E9 |
SwissPalmi | Q9P2E9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000125844, Expressed in pancreas and 244 other tissues |
ExpressionAtlasi | Q9P2E9, baseline and differential |
Genevisiblei | Q9P2E9, HS |
Organism-specific databases
HPAi | ENSG00000125844, Tissue enhanced (pancreas) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 112152, 139 interactors |
IntActi | Q9P2E9, 79 interactors |
MINTi | Q9P2E9 |
STRINGi | 9606.ENSP00000367038 |
Miscellaneous databases
RNActi | Q9P2E9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 197 – 206 | 1 | 10 | |
Repeati | 207 – 216 | 2 | 10 | |
Repeati | 217 – 226 | 3 | 10 | |
Repeati | 227 – 236 | 4 | 10 | |
Repeati | 237 – 246 | 5 | 10 | |
Repeati | 247 – 256 | 6 | 10 | |
Repeati | 257 – 266 | 7 | 10 | |
Repeati | 267 – 276 | 8 | 10 | |
Repeati | 277 – 286 | 9 | 10 | |
Repeati | 287 – 296 | 10 | 10 | |
Repeati | 297 – 306 | 11 | 10 | |
Repeati | 307 – 316 | 12 | 10 | |
Repeati | 317 – 326 | 13 | 10 | |
Repeati | 327 – 336 | 14 | 10 | |
Repeati | 337 – 346 | 15 | 10 | |
Repeati | 347 – 356 | 16 | 10 | |
Repeati | 357 – 366 | 17 | 10 | |
Repeati | 367 – 376 | 18 | 10 | |
Repeati | 377 – 386 | 19 | 10 | |
Repeati | 387 – 396 | 20 | 10 | |
Repeati | 397 – 406 | 21 | 10 | |
Repeati | 407 – 416 | 22 | 10 | |
Repeati | 417 – 426 | 23 | 10 | |
Repeati | 427 – 436 | 24 | 10 | |
Repeati | 437 – 446 | 25 | 10 | |
Repeati | 447 – 456 | 26 | 10 | |
Repeati | 457 – 466 | 27 | 10 | |
Repeati | 467 – 476 | 28 | 10 | |
Repeati | 477 – 486 | 29 | 10 | |
Repeati | 487 – 496 | 30 | 10 | |
Repeati | 497 – 506 | 31 | 10 | |
Repeati | 507 – 516 | 32 | 10 | |
Repeati | 517 – 526 | 33 | 10 | |
Repeati | 527 – 534 | 34; approximate | 8 | |
Repeati | 535 – 544 | 35 | 10 | |
Repeati | 545 – 554 | 36; approximate | 10 | |
Repeati | 555 – 564 | 37 | 10 | |
Repeati | 565 – 574 | 38 | 10 | |
Repeati | 575 – 584 | 39; approximate | 10 | |
Repeati | 585 – 594 | 40 | 10 | |
Repeati | 595 – 604 | 41 | 10 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 197 – 604 | 41 X 10 AA approximate tandem repeats of [TN]-Q-[GSA]-[KRQT]-K-[ATGSV]-[ED]-[GTAS]-[ATIS]-[PQTAS]Add BLAST | 408 |
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QV05, Eukaryota |
GeneTreei | ENSGT00940000158015 |
HOGENOMi | CLU_005662_1_0_1 |
InParanoidi | Q9P2E9 |
OMAi | LCRTQTS |
OrthoDBi | 327650at2759 |
PhylomeDBi | Q9P2E9 |
TreeFami | TF333579 |
Family and domain databases
InterProi | View protein in InterPro IPR007794, Rib_rcpt_KP IPR040248, RRBP1 |
PANTHERi | PTHR18939, PTHR18939, 2 hits |
Pfami | View protein in Pfam PF05104, Rib_recp_KP_reg, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketNote: Additional isoforms seem to exist. Additional isoforms may derive from alternative splicing in the repeat region.1 Publication
This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9P2E9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDIYDTQTLG VVVFGGFMVV SAIGIFLVST FSMKETSYEE ALANQRKEMA
60 70 80 90 100
KTHHQKVEKK KKEKTVEKKG KTKKKEEKPN GKIPDHDPAP NVTVLLREPV
110 120 130 140 150
RAPAVAVAPT PVQPPIIVAP VATVPAMPQE KLASSPKDKK KKEKKVAKVE
160 170 180 190 200
PAVSSVVNSI QVLTSKAAIL ETAPKEVPMV VVPPVGAKGN TPATGTTQGK
210 220 230 240 250
KAEGTQNQSK KAEGAPNQGR KAEGTPNQGK KTEGTPNQGK KAEGTPNQGK
260 270 280 290 300
KAEGTPNQGK KAEGAQNQGK KVDTTPNQGK KVEGAPTQGR KAEGAQNQAK
310 320 330 340 350
KVEGAQNQGK KAEGAQNQGK KGEGAQNQGK KAEGAQNQGK KAEGAQNQGK
360 370 380 390 400
KAEGAQNQGK KAEGAQNQGK KAEGAQNQGK KAEGAQNQGK KVEGAQNQGK
410 420 430 440 450
KAEGAQNQGK KAEGAQNQGK KAEGAQNQGK KAEGAQNQGK KAEGAQNQGK
460 470 480 490 500
KAEGAQNQGK KAEGAQNQGK KVEGAQNQGK KAEGAQNQGK KAEGAQNQGK
510 520 530 540 550
KAEGAQNQGQ KGEGAQNQGK KTEGAQGKKA ERSPNQGKKG EGAPIQGKKA
560 570 580 590 600
DSVANQGTKV EGITNQGKKA EGSPSEGKKA EGSPNQGKKA DAAANQGKKT
610 620 630 640 650
ESASVQGRNT DVAQSPEAPK QEAPAKKKSG SKKKGEPGPP DADGPLYLPY
660 670 680 690 700
KTLVSTVGSM VFNEGEAQRL IEILSEKAGI IQDTWHKATQ KGDPVAILKR
710 720 730 740 750
QLEEKEKLLA TEQEDAAVAK SKLRELNKEM AAEKAKAAAG EAKVKKQLVA
760 770 780 790 800
REQEITAVQA RMQASYREHV KEVQQLQGKI RTLQEQLENG PNTQLARLQQ
810 820 830 840 850
ENSILRDALN QATSQVESKQ NAELAKLRQE LSKVSKELVE KSEAVRQDEQ
860 870 880 890 900
QRKALEAKAA AFEKQVLQLQ ASHRESEEAL QKRLDEVSRE LCHTQSSHAS
910 920 930 940 950
LRADAEKAQE QQQQMAELHS KLQSSEAEVR SKCEELSGLH GQLQEARAEN
960 970 980 990 1000
SQLTERIRSI EALLEAGQAR DAQDVQASQA EADQQQTRLK ELESQVSGLE
1010 1020 1030 1040 1050
KEAIELREAV EQQKVKNNDL REKNWKAMEA LATAEQACKE KLLSLTQAKE
1060 1070 1080 1090 1100
ESEKQLCLIE AQTMEALLAL LPELSVLAQQ NYTEWLQDLK EKGPTLLKHP
1110 1120 1130 1140 1150
PAPAEPSSDL ASKLREAEET QSTLQAECDQ YRSILAETEG MLRDLQKSVE
1160 1170 1180 1190 1200
EEEQVWRAKV GAAEEELQKS RVTVKHLEEI VEKLKGELES SDQVREHTSH
1210 1220 1230 1240 1250
LEAELEKHMA AASAECQNYA KEVAGLRQLL LESQSQLDAA KSEAQKQSDE
1260 1270 1280 1290 1300
LALVRQQLSE MKSHVEDGDI AGAPASSPEA PPAEQDPVQL KTQLEWTEAI
1310 1320 1330 1340 1350
LEDEQTQRQK LTAEFEEAQT SACRLQEELE KLRTAGPLES SETEEASQLK
1360 1370 1380 1390 1400
ERLEKEKKLT SDLGRAATRL QELLKTTQEQ LAREKDTVKK LQEQLEKAED
1410
GSSSKEGTSV
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8W7S5 | F8W7S5_HUMAN | Ribosome-binding protein 1 | RRBP1 | 751 | Annotation score: | ||
A0A087WU26 | A0A087WU26_HUMAN | Ribosome-binding protein 1 | RRBP1 | 346 | Annotation score: | ||
A0A087WVV2 | A0A087WVV2_HUMAN | Ribosome-binding protein 1 | RRBP1 | 934 | Annotation score: | ||
A2A2S5 | A2A2S5_HUMAN | Ribosome-binding protein 1 | RRBP1 | 300 | Annotation score: | ||
V9GY78 | V9GY78_HUMAN | Ribosome-binding protein 1 | RRBP1 | 229 | Annotation score: |
Sequence cautioni
The sequence BAA92636 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 350 | K → KKTEEAQKQGKKAEGAQIQG KKNEGAQTQGKKAEGAQNQG KKNEGAQTQGKKAEGAQTQG KKADGAQNQGKKAEGAQNQG KKAEGAQNQGKKAEGAQNQG KKADGAQNQGKKAEGAQNQG KKAEGAQNQGT in AAC25978 (PubMed:9628588).Curated | 1 | |
Sequence conflicti | 406 | Q → QNQGKKAEGAQNQGKKAEGA QNQGKKAEGAQNQGKKAEGA QNQDKKAEGAQNQGRKAEGA QNQGRKAEGAQNQGKKAEGA PNQGKKAEGAPNQGKKAEGT PNQGKKAEGTPNQGKKAEGT PNQGKKAEGAQNQGKKAEGA QNQGKKAEGTP in BAA92636 (PubMed:10718198).Curated | 1 | |
Sequence conflicti | 1043 | L → H in AAC25977 (PubMed:9628588).Curated | 1 | |
Sequence conflicti | 1043 | L → H in BAA92636 (PubMed:10718198).Curated | 1 | |
Sequence conflicti | 1043 | L → H in CAD38684 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 1043 | L → H in AAH00099 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1057 | C → R in CAD38684 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 1073 | E → K in CAD38684 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 1199 | S → L in BAA92636 (PubMed:10718198).Curated | 1 | |
Sequence conflicti | 1199 | S → L in CAD38684 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 1199 | S → L in AAH00099 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1312 | T → M in AAC25977 (PubMed:9628588).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_056982 | 1324 | R → L. Corresponds to variant dbSNP:rs1132274Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_003949 | 177 – 606 | Missing in isoform 2. 1 PublicationAdd BLAST | 430 | |
Alternative sequenceiVSP_003950 | 635 – 637 | Missing in isoform 2. 1 Publication | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF006751 mRNA Translation: AAC25977.1 AF007575 mRNA Translation: AAC25978.1 AB037819 mRNA Translation: BAA92636.2 Different initiation. AL132765 Genomic DNA No translation available. KF456852 Genomic DNA No translation available. AL833822 mRNA Translation: CAD38684.1 BC000099 mRNA Translation: AAH00099.4 |
CCDSi | CCDS13128.1 [Q9P2E9-3] |
RefSeqi | NP_001036041.1, NM_001042576.1 [Q9P2E9-3] NP_004578.2, NM_004587.2 [Q9P2E9-3] |
Genome annotation databases
Ensembli | ENST00000246043; ENSP00000246043; ENSG00000125844 [Q9P2E9-1] ENST00000360807; ENSP00000354045; ENSG00000125844 [Q9P2E9-3] ENST00000377807; ENSP00000367038; ENSG00000125844 [Q9P2E9-3] ENST00000377813; ENSP00000367044; ENSG00000125844 [Q9P2E9-1] |
GeneIDi | 6238 |
KEGGi | hsa:6238 |
UCSCi | uc002wpu.4, human uc002wpv.1, human [Q9P2E9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF006751 mRNA Translation: AAC25977.1 AF007575 mRNA Translation: AAC25978.1 AB037819 mRNA Translation: BAA92636.2 Different initiation. AL132765 Genomic DNA No translation available. KF456852 Genomic DNA No translation available. AL833822 mRNA Translation: CAD38684.1 BC000099 mRNA Translation: AAH00099.4 |
CCDSi | CCDS13128.1 [Q9P2E9-3] |
RefSeqi | NP_001036041.1, NM_001042576.1 [Q9P2E9-3] NP_004578.2, NM_004587.2 [Q9P2E9-3] |
3D structure databases
SMRi | Q9P2E9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 112152, 139 interactors |
IntActi | Q9P2E9, 79 interactors |
MINTi | Q9P2E9 |
STRINGi | 9606.ENSP00000367038 |
Chemistry databases
DrugBanki | DB12339, Radezolid |
PTM databases
iPTMneti | Q9P2E9 |
MetOSitei | Q9P2E9 |
PhosphoSitePlusi | Q9P2E9 |
SwissPalmi | Q9P2E9 |
Genetic variation databases
BioMutai | RRBP1 |
DMDMi | 23822112 |
Proteomic databases
EPDi | Q9P2E9 |
jPOSTi | Q9P2E9 |
MassIVEi | Q9P2E9 |
PaxDbi | Q9P2E9 |
PeptideAtlasi | Q9P2E9 |
PRIDEi | Q9P2E9 |
ProteomicsDBi | 83798 [Q9P2E9-1] 83800 [Q9P2E9-3] |
Protocols and materials databases
Antibodypediai | 2409, 231 antibodies |
Genome annotation databases
Ensembli | ENST00000246043; ENSP00000246043; ENSG00000125844 [Q9P2E9-1] ENST00000360807; ENSP00000354045; ENSG00000125844 [Q9P2E9-3] ENST00000377807; ENSP00000367038; ENSG00000125844 [Q9P2E9-3] ENST00000377813; ENSP00000367044; ENSG00000125844 [Q9P2E9-1] |
GeneIDi | 6238 |
KEGGi | hsa:6238 |
UCSCi | uc002wpu.4, human uc002wpv.1, human [Q9P2E9-1] |
Organism-specific databases
CTDi | 6238 |
DisGeNETi | 6238 |
GeneCardsi | RRBP1 |
HGNCi | HGNC:10448, RRBP1 |
HPAi | ENSG00000125844, Tissue enhanced (pancreas) |
MIMi | 601418, gene |
neXtProti | NX_Q9P2E9 |
OpenTargetsi | ENSG00000125844 |
PharmGKBi | PA34863 |
VEuPathDBi | HostDB:ENSG00000125844.15 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QV05, Eukaryota |
GeneTreei | ENSGT00940000158015 |
HOGENOMi | CLU_005662_1_0_1 |
InParanoidi | Q9P2E9 |
OMAi | LCRTQTS |
OrthoDBi | 327650at2759 |
PhylomeDBi | Q9P2E9 |
TreeFami | TF333579 |
Enzyme and pathway databases
PathwayCommonsi | Q9P2E9 |
Miscellaneous databases
BioGRID-ORCSi | 6238, 8 hits in 876 CRISPR screens |
ChiTaRSi | RRBP1, human |
GeneWikii | RRBP1 |
GenomeRNAii | 6238 |
Pharosi | Q9P2E9, Tbio |
PROi | PR:Q9P2E9 |
RNActi | Q9P2E9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000125844, Expressed in pancreas and 244 other tissues |
ExpressionAtlasi | Q9P2E9, baseline and differential |
Genevisiblei | Q9P2E9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007794, Rib_rcpt_KP IPR040248, RRBP1 |
PANTHERi | PTHR18939, PTHR18939, 2 hits |
Pfami | View protein in Pfam PF05104, Rib_recp_KP_reg, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RRBP1_HUMAN | |
Accessioni | Q9P2E9Primary (citable) accession number: Q9P2E9 Secondary accession number(s): A0A0A0MRV0 Q9H476 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2002 |
Last sequence update: | April 25, 2018 | |
Last modified: | February 10, 2021 | |
This is version 182 of the entry and version 5 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants