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UniProtKB - Q9P2E9 (RRBP1_HUMAN)

Entry version 184 (02 Jun 2021)
Sequence version 5 (25 Apr 2018)
Previous versions | rss
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Protein

Ribosome-binding protein 1

Gene

RRBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Translocation, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9P2E9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ribosome-binding protein 1
Alternative name(s):
180 kDa ribosome receptor homolog
Short name:
RRp
ES/130-related protein
Ribosome receptor protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RRBP1
Synonyms:KIAA1398
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10448, RRBP1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601418, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9P2E9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000125844.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 7LumenalSequence analysis7
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 1410CytoplasmicSequence analysisAdd BLAST1382

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		6238

Open Targets

More...OpenTargetsi		ENSG00000125844

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34863

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9P2E9, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB12339, Radezolid

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RRBP1

Domain mapping of disease mutations (DMDM)

More...DMDMi		23822112

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000974411 – 1410Ribosome-binding protein 1Add BLAST1410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki148Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei159PhosphoserineBy similarity1
Modified residuei165PhosphoserineBy similarity1
Modified residuei225PhosphothreonineCombined sources1
Modified residuei235PhosphothreonineCombined sources1
Modified residuei245PhosphothreonineCombined sources1
Modified residuei255PhosphothreonineCombined sources1
Modified residuei533PhosphoserineCombined sources1
Modified residuei573PhosphoserineCombined sources1
Modified residuei583PhosphoserineCombined sources1
Modified residuei615PhosphoserineCombined sources1
Cross-linki620Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei900PhosphoserineCombined sources1
Modified residuei932N6-acetyllysineBy similarity1
Modified residuei959PhosphoserineCombined sources1
Modified residuei978PhosphoserineCombined sources1
Modified residuei1276PhosphoserineCombined sources1
Modified residuei1277PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9P2E9

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9P2E9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9P2E9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9P2E9

PeptideAtlas

More...PeptideAtlasi		Q9P2E9

PRoteomics IDEntifications database

More...PRIDEi		Q9P2E9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		83798 [Q9P2E9-1]
83800 [Q9P2E9-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9P2E9

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9P2E9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9P2E9

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9P2E9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000125844, Expressed in pancreas and 245 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9P2E9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9P2E9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000125844, Tissue enhanced (pancreas)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112152, 151 interactors

Protein interaction database and analysis system

More...IntActi		Q9P2E9, 80 interactors

Molecular INTeraction database

More...MINTi		Q9P2E9

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000367038

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9P2E9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9P2E9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati197 – 206110
Repeati207 – 216210
Repeati217 – 226310
Repeati227 – 236410
Repeati237 – 246510
Repeati247 – 256610
Repeati257 – 266710
Repeati267 – 276810
Repeati277 – 286910
Repeati287 – 2961010
Repeati297 – 3061110
Repeati307 – 3161210
Repeati317 – 3261310
Repeati327 – 3361410
Repeati337 – 3461510
Repeati347 – 3561610
Repeati357 – 3661710
Repeati367 – 3761810
Repeati377 – 3861910
Repeati387 – 3962010
Repeati397 – 4062110
Repeati407 – 4162210
Repeati417 – 4262310
Repeati427 – 4362410
Repeati437 – 4462510
Repeati447 – 4562610
Repeati457 – 4662710
Repeati467 – 4762810
Repeati477 – 4862910
Repeati487 – 4963010
Repeati497 – 5063110
Repeati507 – 5163210
Repeati517 – 5263310
Repeati527 – 53434; approximate8
Repeati535 – 5443510
Repeati545 – 55436; approximate10
Repeati555 – 5643710
Repeati565 – 5743810
Repeati575 – 58439; approximate10
Repeati585 – 5944010
Repeati595 – 6044110

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni44 – 90DisorderedSequence analysisAdd BLAST47
Regioni129 – 152DisorderedSequence analysisAdd BLAST24
Regioni173 – 648DisorderedSequence analysisAdd BLAST476
Regioni197 – 60441 X 10 AA approximate tandem repeats of [TN]-Q-[GSA]-[KRQT]-K-[ATGSV]-[ED]-[GTAS]-[ATIS]-[PQTAS]Add BLAST408
Regioni895 – 925DisorderedSequence analysisAdd BLAST31
Regioni1093 – 1122DisorderedSequence analysisAdd BLAST30
Regioni1260 – 1287DisorderedSequence analysisAdd BLAST28
Regioni1330 – 1362DisorderedSequence analysisAdd BLAST33
Regioni1377 – 1410DisorderedSequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi60 – 84Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi133 – 149Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi190 – 214Polar residuesSequence analysisAdd BLAST25
Compositional biasi221 – 275Polar residuesSequence analysisAdd BLAST55
Compositional biasi300 – 523Polar residuesSequence analysisAdd BLAST224
Compositional biasi551 – 571Polar residuesSequence analysisAdd BLAST21
Compositional biasi597 – 616Polar residuesSequence analysisAdd BLAST20
Compositional biasi621 – 639Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi895 – 921Polar residuesSequence analysisAdd BLAST27
Compositional biasi1378 – 1403Basic and acidic residuesSequence analysisAdd BLAST26

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QV05, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158015

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005662_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9P2E9

Identification of Orthologs from Complete Genome Data

More...OMAi		LCRTQTS

Database of Orthologous Groups

More...OrthoDBi		327650at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9P2E9

TreeFam database of animal gene trees

More...TreeFami		TF333579

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007794, Rib_rcpt_KP
IPR040248, RRBP1

The PANTHER Classification System

More...PANTHERi		PTHR18939, PTHR18939, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05104, Rib_recp_KP_reg, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist. Additional isoforms may derive from alternative splicing in the repeat region.1 Publication

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9P2E9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDIYDTQTLG VVVFGGFMVV SAIGIFLVST FSMKETSYEE ALANQRKEMA 
        60         70         80         90        100
KTHHQKVEKK KKEKTVEKKG KTKKKEEKPN GKIPDHDPAP NVTVLLREPV 
       110        120        130        140        150
RAPAVAVAPT PVQPPIIVAP VATVPAMPQE KLASSPKDKK KKEKKVAKVE 
       160        170        180        190        200
PAVSSVVNSI QVLTSKAAIL ETAPKEVPMV VVPPVGAKGN TPATGTTQGK 
       210        220        230        240        250
KAEGTQNQSK KAEGAPNQGR KAEGTPNQGK KTEGTPNQGK KAEGTPNQGK 
       260        270        280        290        300
KAEGTPNQGK KAEGAQNQGK KVDTTPNQGK KVEGAPTQGR KAEGAQNQAK 
       310        320        330        340        350
KVEGAQNQGK KAEGAQNQGK KGEGAQNQGK KAEGAQNQGK KAEGAQNQGK 
       360        370        380        390        400
KAEGAQNQGK KAEGAQNQGK KAEGAQNQGK KAEGAQNQGK KVEGAQNQGK 
       410        420        430        440        450
KAEGAQNQGK KAEGAQNQGK KAEGAQNQGK KAEGAQNQGK KAEGAQNQGK 
       460        470        480        490        500
KAEGAQNQGK KAEGAQNQGK KVEGAQNQGK KAEGAQNQGK KAEGAQNQGK 
       510        520        530        540        550
KAEGAQNQGQ KGEGAQNQGK KTEGAQGKKA ERSPNQGKKG EGAPIQGKKA 
       560        570        580        590        600
DSVANQGTKV EGITNQGKKA EGSPSEGKKA EGSPNQGKKA DAAANQGKKT 
       610        620        630        640        650
ESASVQGRNT DVAQSPEAPK QEAPAKKKSG SKKKGEPGPP DADGPLYLPY 
       660        670        680        690        700
KTLVSTVGSM VFNEGEAQRL IEILSEKAGI IQDTWHKATQ KGDPVAILKR 
       710        720        730        740        750
QLEEKEKLLA TEQEDAAVAK SKLRELNKEM AAEKAKAAAG EAKVKKQLVA 
       760        770        780        790        800
REQEITAVQA RMQASYREHV KEVQQLQGKI RTLQEQLENG PNTQLARLQQ 
       810        820        830        840        850
ENSILRDALN QATSQVESKQ NAELAKLRQE LSKVSKELVE KSEAVRQDEQ 
       860        870        880        890        900
QRKALEAKAA AFEKQVLQLQ ASHRESEEAL QKRLDEVSRE LCHTQSSHAS 
       910        920        930        940        950
LRADAEKAQE QQQQMAELHS KLQSSEAEVR SKCEELSGLH GQLQEARAEN 
       960        970        980        990       1000
SQLTERIRSI EALLEAGQAR DAQDVQASQA EADQQQTRLK ELESQVSGLE 
      1010       1020       1030       1040       1050
KEAIELREAV EQQKVKNNDL REKNWKAMEA LATAEQACKE KLLSLTQAKE 
      1060       1070       1080       1090       1100
ESEKQLCLIE AQTMEALLAL LPELSVLAQQ NYTEWLQDLK EKGPTLLKHP 
      1110       1120       1130       1140       1150
PAPAEPSSDL ASKLREAEET QSTLQAECDQ YRSILAETEG MLRDLQKSVE 
      1160       1170       1180       1190       1200
EEEQVWRAKV GAAEEELQKS RVTVKHLEEI VEKLKGELES SDQVREHTSH 
      1210       1220       1230       1240       1250
LEAELEKHMA AASAECQNYA KEVAGLRQLL LESQSQLDAA KSEAQKQSDE 
      1260       1270       1280       1290       1300
LALVRQQLSE MKSHVEDGDI AGAPASSPEA PPAEQDPVQL KTQLEWTEAI 
      1310       1320       1330       1340       1350
LEDEQTQRQK LTAEFEEAQT SACRLQEELE KLRTAGPLES SETEEASQLK 
      1360       1370       1380       1390       1400
ERLEKEKKLT SDLGRAATRL QELLKTTQEQ LAREKDTVKK LQEQLEKAED 
      1410
GSSSKEGTSV
Length:1,410
Mass (Da):152,456
Last modified:April 25, 2018 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i76E5D15D01D4B66B
GO
Isoform 2 (identifier: Q9P2E9-3) [UniParc]FASTAAdd to basket
Also known as: ES130

The sequence of this isoform differs from the canonical sequence as follows:
     177-606: Missing.
     635-637: Missing.

Show »
Length:977
Mass (Da):108,632
Checksum:i63B7644AAA334537
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W7S5F8W7S5_HUMAN
Ribosome-binding protein 1
RRBP1
751Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WU26A0A087WU26_HUMAN
Ribosome-binding protein 1
RRBP1
346Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WVV2A0A087WVV2_HUMAN
Ribosome-binding protein 1
RRBP1
934Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A2S5A2A2S5_HUMAN
Ribosome-binding protein 1
RRBP1
300Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GY78V9GY78_HUMAN
Ribosome-binding protein 1
RRBP1
229Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA92636 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti350K → KKTEEAQKQGKKAEGAQIQG KKNEGAQTQGKKAEGAQNQG KKNEGAQTQGKKAEGAQTQG KKADGAQNQGKKAEGAQNQG KKAEGAQNQGKKAEGAQNQG KKADGAQNQGKKAEGAQNQG KKAEGAQNQGT in AAC25978 (PubMed:9628588).Curated1
Sequence conflicti406Q → QNQGKKAEGAQNQGKKAEGA QNQGKKAEGAQNQGKKAEGA QNQDKKAEGAQNQGRKAEGA QNQGRKAEGAQNQGKKAEGA PNQGKKAEGAPNQGKKAEGT PNQGKKAEGTPNQGKKAEGT PNQGKKAEGAQNQGKKAEGA QNQGKKAEGTP in BAA92636 (PubMed:10718198).Curated1
Sequence conflicti1043L → H in AAC25977 (PubMed:9628588).Curated1
Sequence conflicti1043L → H in BAA92636 (PubMed:10718198).Curated1
Sequence conflicti1043L → H in CAD38684 (PubMed:17974005).Curated1
Sequence conflicti1043L → H in AAH00099 (PubMed:15489334).Curated1
Sequence conflicti1057C → R in CAD38684 (PubMed:17974005).Curated1
Sequence conflicti1073E → K in CAD38684 (PubMed:17974005).Curated1
Sequence conflicti1199S → L in BAA92636 (PubMed:10718198).Curated1
Sequence conflicti1199S → L in CAD38684 (PubMed:17974005).Curated1
Sequence conflicti1199S → L in AAH00099 (PubMed:15489334).Curated1
Sequence conflicti1312T → M in AAC25977 (PubMed:9628588).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0569821324R → L. Corresponds to variant dbSNP:rs1132274Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003949177 – 606Missing in isoform 2. 1 PublicationAdd BLAST430
Alternative sequenceiVSP_003950635 – 637Missing in isoform 2. 1 Publication3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF006751 mRNA Translation: AAC25977.1
AF007575 mRNA Translation: AAC25978.1
AB037819 mRNA Translation: BAA92636.2 Different initiation.
AL132765 Genomic DNA No translation available.
KF456852 Genomic DNA No translation available.
AL833822 mRNA Translation: CAD38684.1
BC000099 mRNA Translation: AAH00099.4

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13128.1 [Q9P2E9-3]

NCBI Reference Sequences

More...RefSeqi		NP_001036041.1, NM_001042576.1 [Q9P2E9-3]
NP_004578.2, NM_004587.2 [Q9P2E9-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000246043; ENSP00000246043; ENSG00000125844 [Q9P2E9-1]
ENST00000360807; ENSP00000354045; ENSG00000125844 [Q9P2E9-3]
ENST00000377807; ENSP00000367038; ENSG00000125844 [Q9P2E9-3]
ENST00000377813; ENSP00000367044; ENSG00000125844 [Q9P2E9-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6238

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6238

UCSC genome browser

More...UCSCi		uc002wpu.4, human
uc002wpv.1, human [Q9P2E9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006751 mRNA Translation: AAC25977.1
AF007575 mRNA Translation: AAC25978.1
AB037819 mRNA Translation: BAA92636.2 Different initiation.
AL132765 Genomic DNA No translation available.
KF456852 Genomic DNA No translation available.
AL833822 mRNA Translation: CAD38684.1
BC000099 mRNA Translation: AAH00099.4
CCDSiCCDS13128.1 [Q9P2E9-3]
RefSeqiNP_001036041.1, NM_001042576.1 [Q9P2E9-3]
NP_004578.2, NM_004587.2 [Q9P2E9-3]

3D structure databases

SMRiQ9P2E9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi112152, 151 interactors
IntActiQ9P2E9, 80 interactors
MINTiQ9P2E9
STRINGi9606.ENSP00000367038

Chemistry databases

DrugBankiDB12339, Radezolid

PTM databases

iPTMnetiQ9P2E9
MetOSiteiQ9P2E9
PhosphoSitePlusiQ9P2E9
SwissPalmiQ9P2E9

Genetic variation databases

BioMutaiRRBP1
DMDMi23822112

Proteomic databases

EPDiQ9P2E9
jPOSTiQ9P2E9
MassIVEiQ9P2E9
PaxDbiQ9P2E9
PeptideAtlasiQ9P2E9
PRIDEiQ9P2E9
ProteomicsDBi83798 [Q9P2E9-1]
83800 [Q9P2E9-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2409, 235 antibodies

The DNASU plasmid repository

More...DNASUi		6238

Genome annotation databases

EnsembliENST00000246043; ENSP00000246043; ENSG00000125844 [Q9P2E9-1]
ENST00000360807; ENSP00000354045; ENSG00000125844 [Q9P2E9-3]
ENST00000377807; ENSP00000367038; ENSG00000125844 [Q9P2E9-3]
ENST00000377813; ENSP00000367044; ENSG00000125844 [Q9P2E9-1]
GeneIDi6238
KEGGihsa:6238
UCSCiuc002wpu.4, human
uc002wpv.1, human [Q9P2E9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6238
DisGeNETi6238

GeneCards: human genes, protein and diseases

More...GeneCardsi		RRBP1
HGNCiHGNC:10448, RRBP1
HPAiENSG00000125844, Tissue enhanced (pancreas)
MIMi601418, gene
neXtProtiNX_Q9P2E9
OpenTargetsiENSG00000125844
PharmGKBiPA34863
VEuPathDBiHostDB:ENSG00000125844.15

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QV05, Eukaryota
GeneTreeiENSGT00940000158015
HOGENOMiCLU_005662_1_0_1
InParanoidiQ9P2E9
OMAiLCRTQTS
OrthoDBi327650at2759
PhylomeDBiQ9P2E9
TreeFamiTF333579

Enzyme and pathway databases

PathwayCommonsiQ9P2E9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6238, 9 hits in 998 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RRBP1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RRBP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6238
PharosiQ9P2E9, Tbio

Protein Ontology

More...PROi		PR:Q9P2E9
RNActiQ9P2E9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000125844, Expressed in pancreas and 245 other tissues
ExpressionAtlasiQ9P2E9, baseline and differential
GenevisibleiQ9P2E9, HS

Family and domain databases

InterProiView protein in InterPro
IPR007794, Rib_rcpt_KP
IPR040248, RRBP1
PANTHERiPTHR18939, PTHR18939, 2 hits
PfamiView protein in Pfam
PF05104, Rib_recp_KP_reg, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRRBP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P2E9
Secondary accession number(s): A0A0A0MRV0
, A2A2S6, A6NCN6, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: April 25, 2018
Last modified: June 2, 2021
This is version 184 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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