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Protein

Protocadherin-10

Gene

PCDH10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein.

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: GO_Central
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: Ensembl

Keywordsi

Biological processCell adhesion
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin-10
Gene namesi
Name:PCDH10
Synonyms:KIAA1400
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000138650.8
HGNCiHGNC:13404 PCDH10
MIMi608286 gene
neXtProtiNX_Q9P2E7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 715ExtracellularSequence analysisAdd BLAST697
Transmembranei716 – 736HelicalSequence analysisAdd BLAST21
Topological domaini737 – 1040CytoplasmicSequence analysisAdd BLAST304

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57575
OpenTargetsiENSG00000138650
PharmGKBiPA32995

Polymorphism and mutation databases

BioMutaiPCDH10
DMDMi41017507

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000000399519 – 1040Protocadherin-10Add BLAST1022

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi273N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi557N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9P2E7
PeptideAtlasiQ9P2E7
PRIDEiQ9P2E7
ProteomicsDBi83796

PTM databases

iPTMnetiQ9P2E7
PhosphoSitePlusiQ9P2E7
SwissPalmiQ9P2E7

Expressioni

Tissue specificityi

Moderately expressed in all regions of the brain examined, as well as in testis and ovary, and low expression in all other tissues tested.1 Publication

Gene expression databases

BgeeiENSG00000138650 Expressed in 126 organ(s), highest expression level in placenta
CleanExiHS_PCDH10
ExpressionAtlasiQ9P2E7 baseline and differential
GenevisibleiQ9P2E7 HS

Organism-specific databases

HPAiHPA011220
HPA073462

Interactioni

Protein-protein interaction databases

BioGridi121628, 13 interactors
IntActiQ9P2E7, 6 interactors
STRINGi9606.ENSP00000264360

Structurei

3D structure databases

ProteinModelPortaliQ9P2E7
SMRiQ9P2E7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 122Cadherin 1PROSITE-ProRule annotationAdd BLAST104
Domaini123 – 250Cadherin 2PROSITE-ProRule annotationAdd BLAST128
Domaini251 – 358Cadherin 3PROSITE-ProRule annotationAdd BLAST108
Domaini359 – 463Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini464 – 574Cadherin 5PROSITE-ProRule annotationAdd BLAST111
Domaini582 – 690Cadherin 6PROSITE-ProRule annotationAdd BLAST109

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi751 – 771Cys-richAdd BLAST21

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00900000140770
HOGENOMiHOG000220893
HOVERGENiHBG054878
InParanoidiQ9P2E7
KOiK16499
OMAiQNQNYCY
OrthoDBiEOG091G00QD
PhylomeDBiQ9P2E7
TreeFamiTF352008

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR032455 Cadherin_C
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
IPR030712 Protocadherin-10
PANTHERiPTHR24028:SF0 PTHR24028:SF0, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PF16492 Cadherin_C_2, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 6 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9P2E7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIVLLLFALL WMVEGVFSQL HYTVQEEQEH GTFVGNIAED LGLDITKLSA
60 70 80 90 100
RGFQTVPNSR TPYLDLNLET GVLYVNEKID REQICKQSPS CVLHLEVFLE
110 120 130 140 150
NPLELFQVEI EVLDINDNPP SFPEPDLTVE ISESATPGTR FPLESAFDPD
160 170 180 190 200
VGTNSLRDYE ITPNSYFSLD VQTQGDGNRF AELVLEKPLD REQQAVHRYV
210 220 230 240 250
LTAVDGGGGG GVGEGGGGGG GAGLPPQQQR TGTALLTIRV LDSNDNVPAF
260 270 280 290 300
DQPVYTVSLP ENSPPGTLVI QLNATDPDEG QNGEVVYSFS SHISPRAREL
310 320 330 340 350
FGLSPRTGRL EVSGELDYEE SPVYQVYVQA KDLGPNAVPA HCKVLVRVLD
360 370 380 390 400
ANDNAPEISF STVKEAVSEG AAPGTVVALF SVTDRDSEEN GQVQCELLGD
410 420 430 440 450
VPFRLKSSFK NYYTIVTEAP LDREAGDSYT LTVVARDRGE PALSTSKSIQ
460 470 480 490 500
VQVSDVNDNA PRFSQPVYDV YVTENNVPGA YIYAVSATDR DEGANAQLAY
510 520 530 540 550
SILECQIQGM SVFTYVSINS ENGYLYALRS FDYEQLKDFS FQVEARDAGS
560 570 580 590 600
PQALAGNATV NILIVDQNDN APAIVAPLPG RNGTPAREVL PRSAEPGYLL
610 620 630 640 650
TRVAAVDADD GENARLTYSI VRGNEMNLFR MDWRTGELRT ARRVPAKRDP
660 670 680 690 700
QRPYELVIEV RDHGQPPLSS TATLVVQLVD GAVEPQGGGG SGGGGSGEHQ
710 720 730 740 750
RPSRSGGGET SLDLTLILII ALGSVSFIFL LAMIVLAVRC QKEKKLNIYT
760 770 780 790 800
CLASDCCLCC CCCGGGGSTC CGRQARARKK KLSKSDIMLV QSSNVPSNPA
810 820 830 840 850
QVPIEESGGF GSHHHNQNYC YQVCLTPESA KTDLMFLKPC SPSRSTDTEH
860 870 880 890 900
NPCGAIVTGY TDQQPDIISN GSILSNETKH QRAELSYLVD RPRRVNSSAF
910 920 930 940 950
QEADIVSSKD SGHGDSEQGD SDHDATNRAQ SAGMDLFSNC TEECKALGHS
960 970 980 990 1000
DRCWMPSFVP SDGRQAADYR SNLHVPGMDS VPDTEVFETP EAQPGAERSF
1010 1020 1030 1040
STFGKEKALH STLERKELDG LLTNTRAPYK PPYLTRKRIC
Length:1,040
Mass (Da):112,936
Last modified:January 16, 2004 - v2
Checksum:iDE53F8B1A7198F85
GO
Isoform 2 (identifier: Q9P2E7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     878-896: TKHQRAELSYLVDRPRRVN → VRLKRKDHHLSSPPSESLL
     897-1040: Missing.

Show »
Length:896
Mass (Da):97,002
Checksum:i2FB57D0B9C754C65
GO

Sequence cautioni

The sequence BAA92638 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054404878 – 896TKHQR…PRRVN → VRLKRKDHHLSSPPSESLL in isoform 2. 2 PublicationsAdd BLAST19
Alternative sequenceiVSP_054405897 – 1040Missing in isoform 2. 2 PublicationsAdd BLAST144

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY013874 mRNA Translation: AAK21987.1
AB037821 mRNA Translation: BAA92638.1 Different initiation.
AK314377 mRNA Translation: BAG37004.1
AC105383 Genomic DNA Translation: AAY41018.1
CH471056 Genomic DNA Translation: EAX05151.1
CH471056 Genomic DNA Translation: EAX05152.1
CCDSiCCDS34063.1 [Q9P2E7-1]
CCDS75192.1 [Q9P2E7-2]
RefSeqiNP_065866.1, NM_020815.2 [Q9P2E7-2]
NP_116586.1, NM_032961.2 [Q9P2E7-1]
UniGeneiHs.192859
Hs.654741
Hs.669234

Genome annotation databases

EnsembliENST00000264360; ENSP00000264360; ENSG00000138650 [Q9P2E7-1]
ENST00000618019; ENSP00000480512; ENSG00000138650 [Q9P2E7-2]
GeneIDi57575
KEGGihsa:57575
UCSCiuc003igz.4 human [Q9P2E7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY013874 mRNA Translation: AAK21987.1
AB037821 mRNA Translation: BAA92638.1 Different initiation.
AK314377 mRNA Translation: BAG37004.1
AC105383 Genomic DNA Translation: AAY41018.1
CH471056 Genomic DNA Translation: EAX05151.1
CH471056 Genomic DNA Translation: EAX05152.1
CCDSiCCDS34063.1 [Q9P2E7-1]
CCDS75192.1 [Q9P2E7-2]
RefSeqiNP_065866.1, NM_020815.2 [Q9P2E7-2]
NP_116586.1, NM_032961.2 [Q9P2E7-1]
UniGeneiHs.192859
Hs.654741
Hs.669234

3D structure databases

ProteinModelPortaliQ9P2E7
SMRiQ9P2E7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121628, 13 interactors
IntActiQ9P2E7, 6 interactors
STRINGi9606.ENSP00000264360

PTM databases

iPTMnetiQ9P2E7
PhosphoSitePlusiQ9P2E7
SwissPalmiQ9P2E7

Polymorphism and mutation databases

BioMutaiPCDH10
DMDMi41017507

Proteomic databases

PaxDbiQ9P2E7
PeptideAtlasiQ9P2E7
PRIDEiQ9P2E7
ProteomicsDBi83796

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264360; ENSP00000264360; ENSG00000138650 [Q9P2E7-1]
ENST00000618019; ENSP00000480512; ENSG00000138650 [Q9P2E7-2]
GeneIDi57575
KEGGihsa:57575
UCSCiuc003igz.4 human [Q9P2E7-1]

Organism-specific databases

CTDi57575
DisGeNETi57575
EuPathDBiHostDB:ENSG00000138650.8
GeneCardsiPCDH10
HGNCiHGNC:13404 PCDH10
HPAiHPA011220
HPA073462
MIMi608286 gene
neXtProtiNX_Q9P2E7
OpenTargetsiENSG00000138650
PharmGKBiPA32995
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
GeneTreeiENSGT00900000140770
HOGENOMiHOG000220893
HOVERGENiHBG054878
InParanoidiQ9P2E7
KOiK16499
OMAiQNQNYCY
OrthoDBiEOG091G00QD
PhylomeDBiQ9P2E7
TreeFamiTF352008

Miscellaneous databases

ChiTaRSiPCDH10 human
GeneWikiiPCDH10
GenomeRNAii57575
PROiPR:Q9P2E7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138650 Expressed in 126 organ(s), highest expression level in placenta
CleanExiHS_PCDH10
ExpressionAtlasiQ9P2E7 baseline and differential
GenevisibleiQ9P2E7 HS

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR032455 Cadherin_C
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
IPR030712 Protocadherin-10
PANTHERiPTHR24028:SF0 PTHR24028:SF0, 1 hit
PfamiView protein in Pfam
PF00028 Cadherin, 5 hits
PF08266 Cadherin_2, 1 hit
PF16492 Cadherin_C_2, 1 hit
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 6 hits
SUPFAMiSSF49313 SSF49313, 6 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 5 hits
PS50268 CADHERIN_2, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPCD10_HUMAN
AccessioniPrimary (citable) accession number: Q9P2E7
Secondary accession number(s): Q4W5F6, Q96SF0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: November 7, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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