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Entry version 158 (07 Oct 2020)
Sequence version 2 (10 Oct 2002)
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Protein

NFX1-type zinc finger-containing protein 1

Gene

ZNFX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1298 – 1320NF-X1-type 1Add BLAST23
Zinc fingeri1330 – 1346NF-X1-type 2Add BLAST17
Zinc fingeri1382 – 1400NF-X1-type 3Add BLAST19
Zinc fingeri1441 – 1463NF-X1-type 4Add BLAST23
Zinc fingeri1471 – 1488NF-X1-type 5Add BLAST18
Zinc fingeri1546 – 1564NF-X1-type 6Add BLAST19

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9P2E3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NFX1-type zinc finger-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNFX1
Synonyms:KIAA1404
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000124201.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29271, ZNFX1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
618931, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9P2E3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57169

Open Targets

More...
OpenTargetsi
ENSG00000124201

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485687

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9P2E3, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNFX1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
23821814

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000507951 – 1918NFX1-type zinc finger-containing protein 1Add BLAST1918

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9P2E3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9P2E3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9P2E3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9P2E3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9P2E3

PeptideAtlas

More...
PeptideAtlasi
Q9P2E3

PRoteomics IDEntifications database

More...
PRIDEi
Q9P2E3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
83792 [Q9P2E3-1]
83793 [Q9P2E3-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9P2E3

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q9P2E3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9P2E3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000124201, Expressed in cardiac muscle of right atrium and 219 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9P2E3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9P2E3, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000124201, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
121422, 30 interactors

Protein interaction database and analysis system

More...
IntActi
Q9P2E3, 31 interactors

Molecular INTeraction database

More...
MINTi
Q9P2E3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000379412

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9P2E3, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili286 – 313Sequence analysisAdd BLAST28
Coiled coili886 – 967Sequence analysisAdd BLAST82
Coiled coili1741 – 1820Sequence analysisAdd BLAST80

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi812 – 819Poly-Glu8
Compositional biasi839 – 842Poly-Glu4

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1298 – 1320NF-X1-type 1Add BLAST23
Zinc fingeri1330 – 1346NF-X1-type 2Add BLAST17
Zinc fingeri1382 – 1400NF-X1-type 3Add BLAST19
Zinc fingeri1441 – 1463NF-X1-type 4Add BLAST23
Zinc fingeri1471 – 1488NF-X1-type 5Add BLAST18
Zinc fingeri1546 – 1564NF-X1-type 6Add BLAST19

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1807, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155154

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001066_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9P2E3

Identification of Orthologs from Complete Genome Data

More...
OMAi
RFDDIRV

Database of Orthologous Groups

More...
OrthoDBi
271662at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9P2E3

TreeFam database of animal gene trees

More...
TreeFami
TF323611

Family and domain databases

Conserved Domains Database

More...
CDDi
cd18808, SF1_C_Upf1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR041679, DNA2/NAM7-like_AAA
IPR041677, DNA2/NAM7_AAA_11
IPR027417, P-loop_NTPase
IPR000967, Znf_NFX1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13086, AAA_11, 1 hit
PF13087, AAA_12, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00438, ZnF_NFX, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit
SSF52540, SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9P2E3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEERRPHLDA RPRNSHTNHR GPVDGELPPR ARNQANNPPA NALRGGASHP
60 70 80 90 100
GRHPRANNHP AAYWQREERF RAMGRNPHQG RRNQEGHASD EARDQRHDQE
110 120 130 140 150
NDTRWRNGNQ DCRNRRPPWS NDNFQQWRTP HQKPTEQPQQ AKKLGYKFLE
160 170 180 190 200
SLLQKDPSEV VITLATSLGL KELLSHSSMK SNFLELICQV LRKACSSKMD
210 220 230 240 250
RQSVLHVLGI LKNSKFLKVC LPAYVVGMIT EPIPDIRNQY PEHISNIISL
260 270 280 290 300
LQDLVSVFPA SSVQETSMLV SLLPTSLNAL RASGVDIEEE TEKNLEKVQT
310 320 330 340 350
IIEHLQEKRR EGTLRVDTYT LVQPEAEDHV ESYRTMPIYP TYNEVHLDER
360 370 380 390 400
PFLRPNIISG KYDSTAIYLD THFRLLREDF VRPLREGILE LLQSFEDQGL
410 420 430 440 450
RKRKFDDIRI YFDTRIITPM CSSSGIVYKV QFDTKPLKFV RWQNSKRLLY
460 470 480 490 500
GSLVCMSKDN FETFLFATVS NREQEDLCRG IVQLCFNEQS QQLLAEVQPS
510 520 530 540 550
DSFLMVETTA YFEAYRHVLE GLQEVQEEDV PFQRNIVECN SHVKEPRYLL
560 570 580 590 600
MGGRYDFTPL IENPSATGEF LRNVEGLRHP RINVLDPGQW PSKEALKLDD
610 620 630 640 650
SQMEALQFAL TRELAIIQGP PGTGKTYVGL KIVQALLTNE SVWQISLQKF
660 670 680 690 700
PILVVCYTNH ALDQFLEGIY NCQKTSIVRV GGRSNSEILK QFTLRELRNK
710 720 730 740 750
REFRRNLPMH LRRAYMSIMT QMKESEQELH EGAKTLECTM RGVLREQYLQ
760 770 780 790 800
KYISPQHWES LMNGPVQDSE WICFQHWKHS MMLEWLGLGV GSFTQSVSPA
810 820 830 840 850
GPENTAQAEG DEEEEGEEES SLIEIAEEAD LIQADRVIEE EEVVRPQRRK
860 870 880 890 900
KEESGADQEL AKMLLAMRLD HCGTGTAAGQ EQATGEWQTQ RNQKKKMKKR
910 920 930 940 950
VKDELRKLNT MTAAEANEIE DVWQLDLSSR WQLYRLWLQL YQADTRRKIL
960 970 980 990 1000
SYERQYRTSA ERMAELRLQE DLHILKDAQV VGMTTTGAAK YRQILQKVEP
1010 1020 1030 1040 1050
RIVIVEEAAE VLEAHTIATL SKACQHLILI GDHQQLRPSA NVYDLAKNFN
1060 1070 1080 1090 1100
LEVSLFERLV KVNIPFVRLN YQHRMCPEIA RLLTPHIYQD LENHPSVLKY
1110 1120 1130 1140 1150
EKIKGVSSNL FFVEHNFPEQ EIQEGKSHQN QHEAHFVVEL CKYFLCQEYL
1160 1170 1180 1190 1200
PSQITILTTY TGQLFCLRKL MPAKTFAGVR VHVVDKYQGE ENDIILLSLV
1210 1220 1230 1240 1250
RSNQEGKVGF LQISNRICVA LSRAKKGMYC IGNMQMLAKV PLWSKIIHTL
1260 1270 1280 1290 1300
RENNQIGPML RLCCQNHPET HTLVSKASDF QKVPEGGCSL PCEFRLGCGH
1310 1320 1330 1340 1350
VCTRACHPYD SSHKEFQCMK PCQKVICQEG HRCPLVCFQE CQPCQVKVPK
1360 1370 1380 1390 1400
TIPRCGHEQM VPCSVPESDF CCQEPCSKSL RCGHRCSHPC GEDCVQLCSE
1410 1420 1430 1440 1450
MVTIKLKCGH SQPVKCGHVE GLLYGGLLVK CTTKCGTILD CGHPCPGSCH
1460 1470 1480 1490 1500
SCFEGRFHER CQQPCKRLLI CSHKCQEPCI GECPPCQRTC QNRCVHSQCK
1510 1520 1530 1540 1550
KKCGELCSPC VEPCVWRCQH YQCTKLCSEP CNRPPCYVPC TKLLVCGHPC
1560 1570 1580 1590 1600
IGLCGEPCPK KCRICHMDEV TQIFFGFEDE PDARFVQLED CSHIFEVQAL
1610 1620 1630 1640 1650
DRYMNEQKDD EVAIRLKVCP ICQVPIRKNL RYGTSIKQRL EEIEIIKEKI
1660 1670 1680 1690 1700
QGSAGEIATS QERLKALLER KSLLHQLLPE DFLMLKEKLA QKNLSVKDLG
1710 1720 1730 1740 1750
LVENYISFYD HLASLWDSLK KMHVLEEKRV RTRLEQVHEW LAKKRLSFTS
1760 1770 1780 1790 1800
QELSDLRSEI QRLTYLVNLL TRYKIAEKKV KDSIAVEVYS VQNILEKTCK
1810 1820 1830 1840 1850
FTQEDEQLVQ EKMEALKATL PCSGLGISEE ERVQIVSAIG YPRGHWFKCR
1860 1870 1880 1890 1900
NGHIYVIGDC GGAMERGTCP DCKEVIGGTN HTLERSNQLA SEMDGAQHAA
1910
WSDTANNLMN FEEIQGMM
Length:1,918
Mass (Da):220,227
Last modified:October 10, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4E6F2C193BC313CE
GO
Isoform 2 (identifier: Q9P2E3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     890-903: QRNQKKKMKKRVKD → VPCLVLMSADPAQP
     904-1918: Missing.

Show »
Length:903
Mass (Da):103,846
Checksum:i354E3DBA164492BB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JXR5Q5JXR5_HUMAN
NFX1-type zinc finger-containing pr...
ZNFX1
934Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JXR6Q5JXR6_HUMAN
NFX1-type zinc finger-containing pr...
ZNFX1
1,270Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JXR7Q5JXR7_HUMAN
NFX1-type zinc finger-containing pr...
ZNFX1
707Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91264 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA92642 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14149 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14696 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti738C → S in BAB14696 (PubMed:14702039).Curated1
Sequence conflicti755P → L in BAA92102 (PubMed:14702039).Curated1
Sequence conflicti891R → H in BAB14696 (PubMed:14702039).Curated1
Sequence conflicti1715L → P in BAB14696 (PubMed:14702039).Curated1
Sequence conflicti1743K → Q in BAA91264 (PubMed:14702039).Curated1
Sequence conflicti1773Y → N in BAB14696 (PubMed:14702039).Curated1
Sequence conflicti1856V → E in BAB14696 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_014078864L → V. Corresponds to variant dbSNP:rs2664578Ensembl.1
Natural variantiVAR_014079910T → A. Corresponds to variant dbSNP:rs2273148Ensembl.1
Natural variantiVAR_014080924Q → H2 PublicationsCorresponds to variant dbSNP:rs238221Ensembl.1
Natural variantiVAR_0244871259M → I. Corresponds to variant dbSNP:rs6512577Ensembl.1
Natural variantiVAR_0515041297G → S. Corresponds to variant dbSNP:rs36068952Ensembl.1
Natural variantiVAR_0140811351T → I1 PublicationCorresponds to variant dbSNP:rs238209Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_002434890 – 903QRNQK…KRVKD → VPCLVLMSADPAQP in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_002435904 – 1918Missing in isoform 2. 1 PublicationAdd BLAST1015

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB037825 mRNA Translation: BAA92642.1 Different initiation.
AK000573 mRNA Translation: BAA91264.1 Different initiation.
AK002139 mRNA Translation: BAA92102.1
AK022641 mRNA Translation: BAB14149.1 Different initiation.
AK023836 mRNA Translation: BAB14696.1 Sequence problems.
AL049766 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS13417.1 [Q9P2E3-1]

NCBI Reference Sequences

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RefSeqi
NP_066363.1, NM_021035.2 [Q9P2E3-1]
XP_006723899.1, XM_006723836.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000371752; ENSP00000360817; ENSG00000124201 [Q9P2E3-1]
ENST00000396105; ENSP00000379412; ENSG00000124201 [Q9P2E3-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
57169

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:57169

UCSC genome browser

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UCSCi
uc002xui.5, human [Q9P2E3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037825 mRNA Translation: BAA92642.1 Different initiation.
AK000573 mRNA Translation: BAA91264.1 Different initiation.
AK002139 mRNA Translation: BAA92102.1
AK022641 mRNA Translation: BAB14149.1 Different initiation.
AK023836 mRNA Translation: BAB14696.1 Sequence problems.
AL049766 Genomic DNA No translation available.
CCDSiCCDS13417.1 [Q9P2E3-1]
RefSeqiNP_066363.1, NM_021035.2 [Q9P2E3-1]
XP_006723899.1, XM_006723836.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi121422, 30 interactors
IntActiQ9P2E3, 31 interactors
MINTiQ9P2E3
STRINGi9606.ENSP00000379412

PTM databases

iPTMnetiQ9P2E3
MetOSiteiQ9P2E3
PhosphoSitePlusiQ9P2E3

Polymorphism and mutation databases

BioMutaiZNFX1
DMDMi23821814

Proteomic databases

EPDiQ9P2E3
jPOSTiQ9P2E3
MassIVEiQ9P2E3
MaxQBiQ9P2E3
PaxDbiQ9P2E3
PeptideAtlasiQ9P2E3
PRIDEiQ9P2E3
ProteomicsDBi83792 [Q9P2E3-1]
83793 [Q9P2E3-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
28464, 25 antibodies

Genome annotation databases

EnsembliENST00000371752; ENSP00000360817; ENSG00000124201 [Q9P2E3-1]
ENST00000396105; ENSP00000379412; ENSG00000124201 [Q9P2E3-1]
GeneIDi57169
KEGGihsa:57169
UCSCiuc002xui.5, human [Q9P2E3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
57169
DisGeNETi57169
EuPathDBiHostDB:ENSG00000124201.14

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNFX1
HGNCiHGNC:29271, ZNFX1
HPAiENSG00000124201, Low tissue specificity
MIMi618931, gene
neXtProtiNX_Q9P2E3
OpenTargetsiENSG00000124201
PharmGKBiPA143485687

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1807, Eukaryota
GeneTreeiENSGT00940000155154
HOGENOMiCLU_001066_0_1_1
InParanoidiQ9P2E3
OMAiRFDDIRV
OrthoDBi271662at2759
PhylomeDBiQ9P2E3
TreeFamiTF323611

Enzyme and pathway databases

PathwayCommonsiQ9P2E3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
57169, 12 hits in 875 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNFX1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
57169
PharosiQ9P2E3, Tdark

Protein Ontology

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PROi
PR:Q9P2E3
RNActiQ9P2E3, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000124201, Expressed in cardiac muscle of right atrium and 219 other tissues
ExpressionAtlasiQ9P2E3, baseline and differential
GenevisibleiQ9P2E3, HS

Family and domain databases

CDDicd18808, SF1_C_Upf1, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR041679, DNA2/NAM7-like_AAA
IPR041677, DNA2/NAM7_AAA_11
IPR027417, P-loop_NTPase
IPR000967, Znf_NFX1
PfamiView protein in Pfam
PF13086, AAA_11, 1 hit
PF13087, AAA_12, 1 hit
SMARTiView protein in SMART
SM00438, ZnF_NFX, 5 hits
SUPFAMiSSF48371, SSF48371, 1 hit
SSF52540, SSF52540, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZNFX1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P2E3
Secondary accession number(s): Q9BQM7
, Q9BQM8, Q9H8C1, Q9H9S2, Q9NUM1, Q9NWW1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 10, 2002
Last modified: October 7, 2020
This is version 158 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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