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Protein

Kinesin-like protein KIF17

Gene

KIF17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi91 – 98ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMotor protein
Biological processProtein transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-5620924 Intraflagellar transport

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF17
Alternative name(s):
KIF3-related motor protein
Gene namesi
Name:KIF17
Synonyms:KIAA1405, KIF3X
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000117245.12
HGNCiHGNC:19167 KIF17
MIMi605037 gene
neXtProtiNX_Q9P2E2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi57576
OpenTargetsiENSG00000117245
PharmGKBiPA38809

Polymorphism and mutation databases

BioMutaiKIF17
DMDMi317373436

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001254501 – 1029Kinesin-like protein KIF17Add BLAST1029

Proteomic databases

MaxQBiQ9P2E2
PaxDbiQ9P2E2
PeptideAtlasiQ9P2E2
PRIDEiQ9P2E2
ProteomicsDBi83790
83791 [Q9P2E2-3]

PTM databases

iPTMnetiQ9P2E2
PhosphoSitePlusiQ9P2E2

Expressioni

Gene expression databases

BgeeiENSG00000117245
CleanExiHS_KIF17
ExpressionAtlasiQ9P2E2 baseline and differential
GenevisibleiQ9P2E2 HS

Organism-specific databases

HPAiHPA032085

Interactioni

Subunit structurei

Interacts with LIN-10 PDZ domain. Interacts with PIWIL1 (By similarity). Interacts with TBATA (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121629, 6 interactors
IntActiQ9P2E2, 6 interactors
STRINGi9606.ENSP00000247986

Structurei

3D structure databases

ProteinModelPortaliQ9P2E2
SMRiQ9P2E2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 335Kinesin motorPROSITE-ProRule annotationAdd BLAST331

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili346 – 462Sequence analysisAdd BLAST117
Coiled coili739 – 846Sequence analysisAdd BLAST108

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4280 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00910000143992
HOVERGENiHBG052255
InParanoidiQ9P2E2
KOiK20198
OMAiILAQQMG
OrthoDBiEOG091G03RO
PhylomeDBiQ9P2E2
TreeFamiTF105223

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P2E2-1) [UniParc]FASTAAdd to basket
Also known as: KIF17b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASEAVKVVV RCRPMNQRER ELRCQPVVTV DCARAQCCIQ NPGAADEPPK
60 70 80 90 100
QFTFDGAYHV DHVTEQIYNE IAYPLVEGVT EGYNGTIFAY GQTGSGKSFT
110 120 130 140 150
MQGLPDPPSQ RGIIPRAFEH VFESVQCAEN TKFLVRASYL EIYNEDVRDL
160 170 180 190 200
LGADTKQKLE LKEHPEKGVY VKGLSMHTVH SVAQCEHIME TGWKNRSVGY
210 220 230 240 250
TLMNKDSSRS HSIFTISIEM SAVDERGKDH LRAGKLNLVD LAGSERQSKT
260 270 280 290 300
GATGERLKEA TKINLSLSAL GNVISALVDG RCKHVPYRDS KLTRLLQDSL
310 320 330 340 350
GGNTKTLMVA CLSPADNNYD ETLSTLRYAN RAKNIRNKPR INEDPKDALL
360 370 380 390 400
REYQEEIKKL KAILTQQMSP SSLSALLSRQ VPPDPVQVEE KLLPQPVIQH
410 420 430 440 450
DVEAEKQLIR EEYEERLARL KADYKAEQES RARLEEDITA MRNSYDVRLS
460 470 480 490 500
TLEENLRKET EAVLQVGVLY KAEVMSRAEF ASSAEYPPAF QYETVVKPKV
510 520 530 540 550
FSTTDTLPSD DVSKTQVSSR FAELPKVEPS KSEISLGSSE SSSLEETSVS
560 570 580 590 600
EAFPGPEEPS NVEVSMPTEE SRSRYFLDEC LGQEAAGHLL GEQNYLPQEE
610 620 630 640 650
PQEVPLQGLL GLQDPFAEVE AKLARLSSTV ARTDAPQADV PKVPVQVPAP
660 670 680 690 700
TDLLEPSDAR PEAEAADDFP PRPEVDLASE VALEVVRTAE PGVWLEAQAP
710 720 730 740 750
VALVAQPEPL PATAGVKRES VGMEVAVLTD DPLPVVDQQQ VLARLQLLEQ
760 770 780 790 800
QVVGGEQAKN KDLKEKHKRR KRYADERRKQ LVAALQNSDE DSGDWVLLNV
810 820 830 840 850
YDSIQEEVRA KSKLLEKMQR KLRAAEVEIK DLQSEFQLEK IDYLATIRRQ
860 870 880 890 900
ERDSMLLQQL LEQVQPLIRR DCNYSNLEKI LRESCWDEDN GFWKIPHPVI
910 920 930 940 950
TKTSLPVAVS TGPQNKPARK TSAADNGEPN MEDDRYRLML SRSNSENIAS
960 970 980 990 1000
NYFRSKRASQ ILSTDARKSL THHNSPPGLS CPLSNNSAIP PTQAPEMPQP
1010 1020
RPFRLESLDI PFTKAKRKKS KSNFGSEPL
Length:1,029
Mass (Da):115,068
Last modified:January 11, 2011 - v3
Checksum:iED1B7F9806CC9AF6
GO
Isoform 2 (identifier: Q9P2E2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     908-908: Missing.

Show »
Length:1,028
Mass (Da):114,997
Checksum:i7827B2E000AD80C1
GO

Sequence cautioni

The sequence AAD01428 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence AAD01428 differs from that shown. Reason: Frameshift at positions 970 and 990.Curated
The sequence AAH36871 differs from that shown. Cloning artifact.Curated
The sequence BAA92643 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence CAH73471 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI23390 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti925D → Y in AAD01428 (Ref. 6) Curated1
Sequence conflicti957R → W in AAR33039 (PubMed:14673085).Curated1
Sequence conflicti957R → W in BAA92643 (PubMed:10718198).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055983341I → V. Corresponds to variant dbSNP:rs2296225Ensembl.1
Natural variantiVAR_061282369S → R. Corresponds to variant dbSNP:rs56750936Ensembl.1
Natural variantiVAR_023527402V → M3 PublicationsCorresponds to variant dbSNP:rs522496Ensembl.1
Natural variantiVAR_055984675V → I. Corresponds to variant dbSNP:rs558760Ensembl.1
Natural variantiVAR_055985735V → I. Corresponds to variant dbSNP:rs13375609Ensembl.1
Natural variantiVAR_023528933D → E4 PublicationsCorresponds to variant dbSNP:rs631357Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040346908Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY484427 mRNA Translation: AAR33039.1
AL391357, AL663074 Genomic DNA Translation: CAH73471.1 Sequence problems.
AL663074, AL391357 Genomic DNA Translation: CAI23390.1 Sequence problems.
AL391357, AL663074 Genomic DNA Translation: CAM12849.1
AL663074, AL391357 Genomic DNA Translation: CAM12853.1
AL391357, AL663074 Genomic DNA Translation: CAM12850.1
AL663074, AL391357 Genomic DNA Translation: CAM12852.1
BC036871 mRNA Translation: AAH36871.1 Sequence problems.
BC065927 mRNA Translation: AAH65927.1
AB037826 mRNA Translation: BAA92643.2 Sequence problems.
AF009624 mRNA Translation: AAD01428.1 Sequence problems.
CCDSiCCDS213.1 [Q9P2E2-1]
CCDS44079.1 [Q9P2E2-3]
RefSeqiNP_001116291.1, NM_001122819.2 [Q9P2E2-3]
NP_001274141.1, NM_001287212.1
NP_065867.2, NM_020816.3 [Q9P2E2-1]
UniGeneiHs.130411

Genome annotation databases

EnsembliENST00000247986; ENSP00000247986; ENSG00000117245 [Q9P2E2-1]
ENST00000400463; ENSP00000383311; ENSG00000117245 [Q9P2E2-3]
GeneIDi57576
KEGGihsa:57576
UCSCiuc001bdr.6 human [Q9P2E2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKIF17_HUMAN
AccessioniPrimary (citable) accession number: Q9P2E2
Secondary accession number(s): A2A3Q7
, A2A3Q8, O95077, Q53YS6, Q5VWA9, Q6GSA8, Q8N411
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: January 11, 2011
Last modified: June 20, 2018
This is version 150 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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