UniProtKB - Q9P2D8 (UNC79_HUMAN)
Protein
Protein unc-79 homolog
Gene
UNC79
Organism
Homo sapiens (Human)
Status
Functioni
Component of the NALCN sodium channel complex, a cation channel activated either by neuropeptides substance P or neurotensin that controls neuronal excitability.By similarity
GO - Biological processi
- ion transmembrane transport Source: Reactome
Enzyme and pathway databases
PathwayCommonsi | Q9P2D8 |
Reactomei | R-HSA-2672351, Stimuli-sensing channels |
Protein family/group databases
TCDBi | 1.A.1.11.15, the voltage-gated ion channel (vic) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Protein unc-79 homolog |
Gene namesi | Name:UNC79 Synonyms:KIAA1409 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19966, UNC79 |
neXtProti | NX_Q9P2D8 |
VEuPathDBi | HostDB:ENSG00000133958.13 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 2223 – 2243 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2466 – 2486 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 57578 |
OpenTargetsi | ENSG00000133958 |
PharmGKBi | PA134994003 |
Miscellaneous databases
Pharosi | Q9P2D8, Tdark |
Genetic variation databases
BioMutai | UNC79 |
DMDMi | 557952608 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000315618 | 1 – 2635 | Protein unc-79 homologAdd BLAST | 2635 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 754 | PhosphoserineBy similarity | 1 | |
Modified residuei | 758 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9P2D8 |
jPOSTi | Q9P2D8 |
MassIVEi | Q9P2D8 |
PaxDbi | Q9P2D8 |
PeptideAtlasi | Q9P2D8 |
PRIDEi | Q9P2D8 |
ProteomicsDBi | 6182 83787 [Q9P2D8-1] 83788 [Q9P2D8-2] 83789 [Q9P2D8-3] |
PTM databases
iPTMneti | Q9P2D8 |
PhosphoSitePlusi | Q9P2D8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000133958, Expressed in right hemisphere of cerebellum and 99 other tissues |
ExpressionAtlasi | Q9P2D8, baseline and differential |
Genevisiblei | Q9P2D8, HS |
Organism-specific databases
HPAi | ENSG00000133958, Tissue enhanced (brain, pituitary gland) |
Interactioni
Subunit structurei
Found in a complex with NALCN, UNC79 and UNC80; UNC80 bridges NALCN to UNC79.
By similarityProtein-protein interaction databases
BioGRIDi | 121631, 7 interactors |
IntActi | Q9P2D8, 3 interactors |
STRINGi | 9606.ENSP00000256339 |
Miscellaneous databases
RNActi | Q9P2D8, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the unc-79 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3685, Eukaryota KOG4820, Eukaryota |
GeneTreei | ENSGT00390000011802 |
InParanoidi | Q9P2D8 |
OMAi | KKFSYQQ |
OrthoDBi | 81334at2759 |
TreeFami | TF313437 |
Family and domain databases
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR024855, UNC79 |
PANTHERi | PTHR21696, PTHR21696, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9P2D8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSTKAEQFAS KIRYLQEYHN RVLHNIYPVP SGTDIANTLK YFSQTLLSIL
60 70 80 90 100
SRTGKKENQD ASNLTVPMTM CLFPVPFPLT PSLRPQVSSI NPTVTRSLLY
110 120 130 140 150
SVLRDAPSER GPQSRDAQLS DYPSLDYQGL YVTLVTLLDL VPLLQHGQHD
160 170 180 190 200
LGQSIFYTTT CLLPFLNDDI LSTLPYTMIS TLATFPPFLH KDIIEYLSTS
210 220 230 240 250
FLPMAILGSS RREGVPAHVN LSASSMLMIA MQYTSNPVYH CQLLECLMKY
260 270 280 290 300
KQEVWKDLLY VIAYGPSQVK PPAVQMLFHY WPNLKPPGAI SEYRGLQYTA
310 320 330 340 350
WNPIHCQHIE CHNAINKPAV KMCIDPSLSV ALGDKPPPLY LCEECSERIA
360 370 380 390 400
GDHSEWLIDV LLPQAEISAI CQKKNCSSHV RRAVVTCFSA GCCGRHGNRP
410 420 430 440 450
VRYCKRCHSN HHSNEVGAAA ETHLYQTSPP PINTRECGAE ELVCAVEAVI
460 470 480 490 500
SLLKEAEFHA EQREHELNRR RQLGLSSSHH SLDNADFDNK DDDKHDQRLL
510 520 530 540 550
SQFGIWFLVS LCTPSENTPT ESLARLVAMV FQWFHSTAYM MDDEVGSLVE
560 570 580 590 600
KLKPQFVTKW LKTVCDVRFD VMVMCLLPKP MEFARVGGYW DKSCSTVTQL
610 620 630 640 650
KEGLNRILCL IPYNVINQSV WECIMPEWLE AIRTEVPDNQ LKEFREVLSK
660 670 680 690 700
MFDIELCPLP FSMEEMFGFI SCRFTGYPSS VQEQALLWLH VLSELDIMVP
710 720 730 740 750
LQLLISMFSD GVNSVKELAN QRKSRVSELA GNLASRRVSV ASDPGRRVQH
760 770 780 790 800
NMLSPFHSPF QSPFRSPLRS PFRSPFKNFG HPGGRTIDFD CEDDEMNLNC
810 820 830 840 850
FILMFDLLLK QMELQDDGIT MGLEHSLSKD IISIINNVFQ APWGGSHTCQ
860 870 880 890 900
KDEKAIECNL CQSSILCYQL ACELLERLAP KEESRLVEPT DSLEDSLLSS
910 920 930 940 950
RPEFIIGPEG EEEENPASKH GENPGNCTEP VEHAAVKNDT ERKFCYQQLP
960 970 980 990 1000
VTLRLIYTIF QEMAKFEEPD ILFNMLNCLK ILCLHGECLY IARKDHPQFL
1010 1020 1030 1040 1050
AYIQDHMLIA SLWRVVKSEF SQLSSLAVPL LLHALSLPHG ADIFWTIING
1060 1070 1080 1090 1100
NFNSKDWKMR FEAVEKVAVI CRFLDIHSVT KNHLLKYSLA HAFCCFLTAV
1110 1120 1130 1140 1150
EDVNPAVATR AGLLLDTIKR PALQGLCLCL DFQFDTVVKD RPTILSKLLL
1160 1170 1180 1190 1200
LHFLKQDIPA LSWEFFVNRF ETLSLEAQLH LDCNKEFPFP TTITAVRTNV
1210 1220 1230 1240 1250
ANLSDAALWK IKRARFARNR QKSVRSLRDS VKGPVESKRA LSLPETLTSK
1260 1270 1280 1290 1300
IRQQSPENDN TIKDLLPEDA GIDHQTVHQL ITVLMKFMAK DESSAESDIS
1310 1320 1330 1340 1350
SAKAFNTVKR HLYVLLGYDQ QEGCFMIAPQ KMRLSTCFNA FIAGIAQVMD
1360 1370 1380 1390 1400
YNINLGKHLL PLVVQVLKYC SCPQLRHYFQ QPPRCSLWSL KPHIRQMWLK
1410 1420 1430 1440 1450
ALLVILYKYP YRDCDISKIL LHLIHITVNT LNAQYHSCKP HATAGPLYSD
1460 1470 1480 1490 1500
NSNISRYSEK EKGEIELAEY RETGALQDSL LHCVREESIP KKKLRSFKQK
1510 1520 1530 1540 1550
SLDIGNADSL LFTLDEHRRK SCIDRCDIEK PPTQAAYIAQ RPNDPGRSRQ
1560 1570 1580 1590 1600
NSATRPDNSE IPENPAMEGF PDARRPVIPE VRLNCMETFE VKVDSPVKPA
1610 1620 1630 1640 1650
PKEDLDLIDL SSDSTSGPEK HSILSTSDSD SLVFEPLPPL RIVESDEEEE
1660 1670 1680 1690 1700
TMNQGDDGPS GKNAASSPSV PSHPSVLSLS TAPLVQVSVE DCSKDFSSKD
1710 1720 1730 1740 1750
SGNNQSAGNT DSALITLEDP MDAEGSSKPE ELPEFSCGSP LTLKQKRDLL
1760 1770 1780 1790 1800
QKSFALPEMS LDDHPDPGTE GEKPGELMPS SGAKTVLLKV PEDAENPTES
1810 1820 1830 1840 1850
EKPDTSAESD TEQNPERKVE EDGAEESEFK IQIVPRQRKQ RKIAVSAIQR
1860 1870 1880 1890 1900
EYLDISFNIL DKLGEQKDPD PSTKGLSTLE MPRESSSAPT LDAGVPETSS
1910 1920 1930 1940 1950
HSSISTQYRQ MKRGSLGVLT MSQLMKRQLE HQSSAPHNIS NWDTEQIQPG
1960 1970 1980 1990 2000
KRQCNVPTCL NPDLEGQPLR MRGATKSSLL SAPSIVSMFV PAPEEFTDEQ
2010 2020 2030 2040 2050
PTVMTDKCHD CGAILEEYDE ETLGLAIVVL STFIHLSPDL AAPLLLDIMQ
2060 2070 2080 2090 2100
SVGRLASSTT FSNQAESMMV PGNAAGVAKQ FLRCIFHQLA PNGIFPQLFQ
2110 2120 2130 2140 2150
STIKDGTFLR TLASSLMDFN ELSSIAALSQ LLEGLNNKKN LPAGGAMIRC
2160 2170 2180 2190 2200
LENIATFMEA LPMDSPSSLW TTISNQFQTF FAKLPCVLPL KCSLDSSLRI
2210 2220 2230 2240 2250
MICLLKIPST NATRSLLEPF SKLLSFVIQN AVFTLAYLVE LCGLCYRAFT
2260 2270 2280 2290 2300
KERDKFYLSR SVVLELLQAL KLKSPLPDTN LLLLVQFICA DAGTKLAEST
2310 2320 2330 2340 2350
ILSKQMIASV PGCGTAAMEC VRQYINEVLD FMADMHTLTK LKSHMKTCSQ
2360 2370 2380 2390 2400
PLHEDTFGGH LKVGLAQIAA MDISRGNHRD NKAVIRYLPW LYHPPSAMQQ
2410 2420 2430 2440 2450
GPKEFIECVS HIRLLSWLLL GSLTHNAVCP NASSPCLPIP LDAGSHVADH
2460 2470 2480 2490 2500
LIVILIGFPE QSKTSVLHMC SLFHAFIFAQ LWTVYCEQSA VATNLQNQNE
2510 2520 2530 2540 2550
FSFTAILTAL EFWSRVTPSI LQLMAHNKVM VEMVCLHVIS LMEALQECNS
2560 2570 2580 2590 2600
TIFVKLIPMW LPMIQSNIKH LSAGLQLRLQ AIQNHVNHHS LRTLPGSGQS
2610 2620 2630
SAGLAALRKW LQCTQFKMAQ VEIQSSEAAS QFYPL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V2U4 | G3V2U4_HUMAN | Protein unc-79 homolog | UNC79 | 2,596 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 494 | K → R in BAC86131 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1284 | L → P in BAC86131 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_038260 | 1597 | V → A. Corresponds to variant dbSNP:rs28670114Ensembl. | 1 | |
Natural variantiVAR_038261 | 1670 | V → I1 PublicationCorresponds to variant dbSNP:rs4905081Ensembl. | 1 | |
Natural variantiVAR_038262 | 2183 | K → R. Corresponds to variant dbSNP:rs2296687Ensembl. | 1 | |
Natural variantiVAR_038263 | 2444 | G → S. Corresponds to variant dbSNP:rs7359096Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_030583 | 1 – 177 | Missing in isoform 2. 1 PublicationAdd BLAST | 177 | |
Alternative sequenceiVSP_030584 | 1252 | R → PMRLTRHEQSAPALGGTPEQ TPG in isoform 3. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL122023 Genomic DNA No translation available. AL136338 Genomic DNA No translation available. AL157858 Genomic DNA No translation available. AK125327 mRNA Translation: BAC86131.1 AB037830 mRNA Translation: BAA92647.2 |
CCDSi | CCDS9911.2 [Q9P2D8-2] |
RefSeqi | NP_065869.3, NM_020818.4 [Q9P2D8-2] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL122023 Genomic DNA No translation available. AL136338 Genomic DNA No translation available. AL157858 Genomic DNA No translation available. AK125327 mRNA Translation: BAC86131.1 AB037830 mRNA Translation: BAA92647.2 |
CCDSi | CCDS9911.2 [Q9P2D8-2] |
RefSeqi | NP_065869.3, NM_020818.4 [Q9P2D8-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 121631, 7 interactors |
IntActi | Q9P2D8, 3 interactors |
STRINGi | 9606.ENSP00000256339 |
Protein family/group databases
TCDBi | 1.A.1.11.15, the voltage-gated ion channel (vic) superfamily |
PTM databases
iPTMneti | Q9P2D8 |
PhosphoSitePlusi | Q9P2D8 |
Genetic variation databases
BioMutai | UNC79 |
DMDMi | 557952608 |
Proteomic databases
EPDi | Q9P2D8 |
jPOSTi | Q9P2D8 |
MassIVEi | Q9P2D8 |
PaxDbi | Q9P2D8 |
PeptideAtlasi | Q9P2D8 |
PRIDEi | Q9P2D8 |
ProteomicsDBi | 6182 83787 [Q9P2D8-1] 83788 [Q9P2D8-2] 83789 [Q9P2D8-3] |
Protocols and materials databases
Antibodypediai | 77841, 28 antibodies |
Genome annotation databases
Organism-specific databases
CTDi | 57578 |
DisGeNETi | 57578 |
GeneCardsi | UNC79 |
HGNCi | HGNC:19966, UNC79 |
HPAi | ENSG00000133958, Tissue enhanced (brain, pituitary gland) |
neXtProti | NX_Q9P2D8 |
OpenTargetsi | ENSG00000133958 |
PharmGKBi | PA134994003 |
VEuPathDBi | HostDB:ENSG00000133958.13 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3685, Eukaryota KOG4820, Eukaryota |
GeneTreei | ENSGT00390000011802 |
InParanoidi | Q9P2D8 |
OMAi | KKFSYQQ |
OrthoDBi | 81334at2759 |
TreeFami | TF313437 |
Enzyme and pathway databases
PathwayCommonsi | Q9P2D8 |
Reactomei | R-HSA-2672351, Stimuli-sensing channels |
Miscellaneous databases
BioGRID-ORCSi | 57578, 17 hits in 988 CRISPR screens |
ChiTaRSi | UNC79, human |
GenomeRNAii | 57578 |
Pharosi | Q9P2D8, Tdark |
PROi | PR:Q9P2D8 |
RNActi | Q9P2D8, protein |
Gene expression databases
Bgeei | ENSG00000133958, Expressed in right hemisphere of cerebellum and 99 other tissues |
ExpressionAtlasi | Q9P2D8, baseline and differential |
Genevisiblei | Q9P2D8, HS |
Family and domain databases
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR024855, UNC79 |
PANTHERi | PTHR21696, PTHR21696, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UNC79_HUMAN | |
Accessioni | Q9P2D8Primary (citable) accession number: Q9P2D8 Secondary accession number(s): B5MDL6, Q6ZUT7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | November 13, 2013 | |
Last modified: | April 7, 2021 | |
This is version 118 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families