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Entry version 133 (12 Aug 2020)
Sequence version 2 (15 Jan 2008)
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Protein

Protein FAM135A

Gene

FAM135A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9P2D6

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

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ESTHERi
human-FAM135A, Duf_676

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM135A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM135A
Synonyms:KIAA1411
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000082269.16

Human Gene Nomenclature Database

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HGNCi
HGNC:21084, FAM135A

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9P2D6

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000082269

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA162386230

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q9P2D6, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
FAM135A

Domain mapping of disease mutations (DMDM)

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DMDMi
166233529

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003141681 – 1515Protein FAM135AAdd BLAST1515

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9P2D6

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9P2D6

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9P2D6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9P2D6

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9P2D6

PeptideAtlas

More...
PeptideAtlasi
Q9P2D6

PRoteomics IDEntifications database

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PRIDEi
Q9P2D6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
83778 [Q9P2D6-1]
83779 [Q9P2D6-2]
83780 [Q9P2D6-3]
83781 [Q9P2D6-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9P2D6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9P2D6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000082269, Expressed in esophagus squamous epithelium and 208 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9P2D6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9P2D6, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000082269, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
121632, 14 interactors

Protein interaction database and analysis system

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IntActi
Q9P2D6, 11 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000410768

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q9P2D6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9P2D6

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM135 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2205, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000157565

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9P2D6

Identification of Orthologs from Complete Genome Data

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OMAi
SITIHAC

Database of Orthologous Groups

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OrthoDBi
1132320at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9P2D6

TreeFam database of animal gene trees

More...
TreeFami
TF314837

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029058, AB_hydrolase
IPR022122, DUF3657
IPR007751, DUF676_lipase-like

Pfam protein domain database

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Pfami
View protein in Pfam
PF12394, DUF3657, 1 hit
PF05057, DUF676, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53474, SSF53474, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9P2D6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTEVQAMVEF SVELNKFYNV DLFQRGFYQI RASMKIPSRI PHRVEASLLH
60 70 80 90 100
ATGMTLAFPA SVHDSLICSK TFQILYKNEE VVLNDVMIFK VKMLLDERKI
110 120 130 140 150
EETLEEMNFL LSLDLHFTDG DYSADDLNAL QLISSRTLKL HFSPHRGLHH
160 170 180 190 200
HVNVMFDYFH LSVVSVTVHA SLVALHQPLI SFPRPVKTTW LNRNAPAQNK
210 220 230 240 250
DSVIPTLESV VFGINYTKQL SPDGCSFIIA DSFLHHAYRF HYTLCATLLL
260 270 280 290 300
AFKGLHSYFI TVTEEIPSCQ KLELEEMDVE ARLTELCEEV KKIENPDELA
310 320 330 340 350
ELINMNLAQL CSLLMALWGQ FLEVITLHEE LRILLAQEHH TLRVRRFSEA
360 370 380 390 400
FFCFEHPREA AIAYQELHAQ SHLQMCTAIK NTSFCSSLPP LPIECSELDG
410 420 430 440 450
DLNSLPIIFE DRYLDSVTED LDAPWMGIQN LQRSESSKMD KYETEESSVA
460 470 480 490 500
GLSSPELKVR PAGASSIWYT EGEKQLTKSL KGKNEESNKS KVKVTKLMKT
510 520 530 540 550
MKSENTKKLI KQNSKDSVVL VGYKCLKSTA SNDLIKCFEG NPSHSQKEGL
560 570 580 590 600
DPTICGYNFD PKTYMRQTSQ KEASCLPTNT ERTEQKSPDI ENVQPDQFDP
610 620 630 640 650
LNSGNLNLCA NLSISGKLDI SQDDSEITQM EHNLASRRSS DDCHDHQTTP
660 670 680 690 700
SLGVRTIEIK PSNKDPFSGE NITVKLGPWT ELRQEEILVD NLLPNFESLE
710 720 730 740 750
SNGKSKSIEI TFEKEALQEA KCLSIGESLT KLRSNLPAPS TKEYHVVVSG
760 770 780 790 800
DTIKLPDISA TYASSRFSDS GVESEPSSFA THPNTDLVFE TVQGQGPCNS
810 820 830 840 850
ERLFPQLLMK PDYNVKFSLG NHCTESTSAI SEIQSSLTSI NSLPSDDELS
860 870 880 890 900
PDENSKKSVV PECHLNDSKT VLNLGTTDLP KCDDTKKSSI TLQQQSVVFS
910 920 930 940 950
GNLDNETVAI HSLNSSIKDP LQFVFSDEET SSDVKSSCSS KPNLDTMCKG
960 970 980 990 1000
FQSPDKSNNS TGTAITLNSK LICLGTPCVI SGSISSNTDV SEDRTMKKNS
1010 1020 1030 1040 1050
DVLNLTQMYS EIPTVESETH LGTSDPFSAS TDIVKQGLVE NYFGSQSSTD
1060 1070 1080 1090 1100
ISDTCAVSYS NALSPQKETS EKEISNLQQE QDKEDEEEEQ DQQMVQNGYY
1110 1120 1130 1140 1150
EETDYSALDG TINAHYTSRD ELMEERLTKS EKINSDYLRD GINMPTVCTS
1160 1170 1180 1190 1200
GCLSFPSAPR ESPCNVKYSS KSKFDAITKQ PSSTSYNFTS SISWYESSPK
1210 1220 1230 1240 1250
PQIQAFLQAK EELKLLKLPG FMYSEVPLLA SSVPYFSVEE EDGSEDGVHL
1260 1270 1280 1290 1300
IVCVHGLDGN SADLRLVKTY IELGLPGGRI DFLMSERNQN DTFADFDSMT
1310 1320 1330 1340 1350
DRLLDEIIQY IQIYSLTVSK ISFIGHSLGN LIIRSVLTRP RFKYYLNKLH
1360 1370 1380 1390 1400
TFLSLSGPHL GTLYNSSALV NTGLWFMQKW KKSGSLLQLT CRDHSDPRQT
1410 1420 1430 1440 1450
FLYKLSNKAG LHYFKNVVLV GSLQDRYVPY HSARIEMCKT ALKDKQSGQI
1460 1470 1480 1490 1500
YSEMIHNLLR PVLQSKDCNL VRYNVINALP NTADSLIGRA AHIAVLDSEI
1510
FLEKFFLVAA LKYFQ
Length:1,515
Mass (Da):169,840
Last modified:January 15, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i43DB6301DE0F907F
GO
Isoform 2 (identifier: Q9P2D6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     420-615: Missing.

Show »
Length:1,319
Mass (Da):148,065
Checksum:iDEA7ED3DC0993467
GO
Isoform 3 (identifier: Q9P2D6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     27-69: Missing.
     273-273: E → ELAKANMQLLYERLLRRKQLRTQKDNH
     420-615: Missing.

Show »
Length:1,302
Mass (Da):146,549
Checksum:iEAD715D6E55E0B48
GO
Isoform 4 (identifier: Q9P2D6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1449-1515: QIYSEMIHNL...FLVAALKYFQ → NGIKLFQRVIGINELFPKFFL

Show »
Length:1,469
Mass (Da):164,684
Checksum:i43057A50D33D6B94
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RCC7D6RCC7_HUMAN
Protein FAM135A
FAM135A
1,095Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RC17D6RC17_HUMAN
Protein FAM135A
FAM135A
505Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RFG9D6RFG9_HUMAN
Protein FAM135A
FAM135A
31Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6REA8D6REA8_HUMAN
Protein FAM135A
FAM135A
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BXC5H7BXC5_HUMAN
Protein FAM135A
FAM135A
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH65767 differs from that shown. Intron retention.Curated
The sequence BAA90995 differs from that shown. Intron retention.Curated
The sequence BAA92649 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB66754 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti738A → T in CAH18110 (PubMed:17974005).Curated1
Sequence conflicti1330N → D in CAH18110 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037854725I → V. Corresponds to variant dbSNP:rs9455142Ensembl.1
Natural variantiVAR_037855954P → S. Corresponds to variant dbSNP:rs16869301Ensembl.1
Natural variantiVAR_0378561242D → G3 PublicationsCorresponds to variant dbSNP:rs2747701Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03022527 – 69Missing in isoform 3. 2 PublicationsAdd BLAST43
Alternative sequenceiVSP_030226273E → ELAKANMQLLYERLLRRKQL RTQKDNH in isoform 3. 2 Publications1
Alternative sequenceiVSP_030227420 – 615Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST196
Alternative sequenceiVSP_0302301449 – 1515QIYSE…LKYFQ → NGIKLFQRVIGINELFPKFF L in isoform 4. 1 PublicationAdd BLAST67

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB037832 mRNA Translation: BAA92649.1 Different initiation.
CR749254 mRNA Translation: CAH18110.1
AL078591 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48820.1
BC065767 mRNA Translation: AAH65767.1 Sequence problems.
BC131782 mRNA Translation: AAI31783.1
AK000183 mRNA Translation: BAA90995.1 Sequence problems.
AK002067 mRNA Translation: BAA92066.1
AK023639 mRNA No translation available.
AL136820 mRNA Translation: CAB66754.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34481.1 [Q9P2D6-3]
CCDS47448.1 [Q9P2D6-2]
CCDS55028.1 [Q9P2D6-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001099001.1, NM_001105531.2 [Q9P2D6-2]
NP_001156001.1, NM_001162529.2 [Q9P2D6-1]
NP_001317926.1, NM_001330997.1 [Q9P2D6-2]
NP_001317930.1, NM_001331001.1 [Q9P2D6-2]
NP_001317931.1, NM_001331002.1 [Q9P2D6-2]
NP_065870.3, NM_020819.4 [Q9P2D6-3]
XP_016866614.1, XM_017011125.1
XP_016866615.1, XM_017011126.1
XP_016866616.1, XM_017011127.1 [Q9P2D6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000361499; ENSP00000354913; ENSG00000082269 [Q9P2D6-2]
ENST00000370479; ENSP00000359510; ENSG00000082269 [Q9P2D6-1]
ENST00000418814; ENSP00000410768; ENSG00000082269 [Q9P2D6-1]
ENST00000457062; ENSP00000409201; ENSG00000082269 [Q9P2D6-3]
ENST00000505868; ENSP00000423307; ENSG00000082269 [Q9P2D6-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57579

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57579

UCSC genome browser

More...
UCSCi
uc003pfh.4, human [Q9P2D6-1]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037832 mRNA Translation: BAA92649.1 Different initiation.
CR749254 mRNA Translation: CAH18110.1
AL078591 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48820.1
BC065767 mRNA Translation: AAH65767.1 Sequence problems.
BC131782 mRNA Translation: AAI31783.1
AK000183 mRNA Translation: BAA90995.1 Sequence problems.
AK002067 mRNA Translation: BAA92066.1
AK023639 mRNA No translation available.
AL136820 mRNA Translation: CAB66754.1 Different initiation.
CCDSiCCDS34481.1 [Q9P2D6-3]
CCDS47448.1 [Q9P2D6-2]
CCDS55028.1 [Q9P2D6-1]
RefSeqiNP_001099001.1, NM_001105531.2 [Q9P2D6-2]
NP_001156001.1, NM_001162529.2 [Q9P2D6-1]
NP_001317926.1, NM_001330997.1 [Q9P2D6-2]
NP_001317930.1, NM_001331001.1 [Q9P2D6-2]
NP_001317931.1, NM_001331002.1 [Q9P2D6-2]
NP_065870.3, NM_020819.4 [Q9P2D6-3]
XP_016866614.1, XM_017011125.1
XP_016866615.1, XM_017011126.1
XP_016866616.1, XM_017011127.1 [Q9P2D6-1]

3D structure databases

SMRiQ9P2D6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121632, 14 interactors
IntActiQ9P2D6, 11 interactors
STRINGi9606.ENSP00000410768

Protein family/group databases

ESTHERihuman-FAM135A, Duf_676

PTM databases

iPTMnetiQ9P2D6
PhosphoSitePlusiQ9P2D6

Polymorphism and mutation databases

BioMutaiFAM135A
DMDMi166233529

Proteomic databases

EPDiQ9P2D6
jPOSTiQ9P2D6
MassIVEiQ9P2D6
MaxQBiQ9P2D6
PaxDbiQ9P2D6
PeptideAtlasiQ9P2D6
PRIDEiQ9P2D6
ProteomicsDBi83778 [Q9P2D6-1]
83779 [Q9P2D6-2]
83780 [Q9P2D6-3]
83781 [Q9P2D6-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
31231, 23 antibodies

The DNASU plasmid repository

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DNASUi
57579

Genome annotation databases

EnsembliENST00000361499; ENSP00000354913; ENSG00000082269 [Q9P2D6-2]
ENST00000370479; ENSP00000359510; ENSG00000082269 [Q9P2D6-1]
ENST00000418814; ENSP00000410768; ENSG00000082269 [Q9P2D6-1]
ENST00000457062; ENSP00000409201; ENSG00000082269 [Q9P2D6-3]
ENST00000505868; ENSP00000423307; ENSG00000082269 [Q9P2D6-4]
GeneIDi57579
KEGGihsa:57579
UCSCiuc003pfh.4, human [Q9P2D6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57579
EuPathDBiHostDB:ENSG00000082269.16

GeneCards: human genes, protein and diseases

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GeneCardsi
FAM135A
HGNCiHGNC:21084, FAM135A
HPAiENSG00000082269, Low tissue specificity
neXtProtiNX_Q9P2D6
OpenTargetsiENSG00000082269
PharmGKBiPA162386230

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2205, Eukaryota
GeneTreeiENSGT00940000157565
InParanoidiQ9P2D6
OMAiSITIHAC
OrthoDBi1132320at2759
PhylomeDBiQ9P2D6
TreeFamiTF314837

Enzyme and pathway databases

PathwayCommonsiQ9P2D6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
57579, 4 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FAM135A, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
FAM135A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
57579
PharosiQ9P2D6, Tdark

Protein Ontology

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PROi
PR:Q9P2D6
RNActiQ9P2D6, protein

Gene expression databases

BgeeiENSG00000082269, Expressed in esophagus squamous epithelium and 208 other tissues
ExpressionAtlasiQ9P2D6, baseline and differential
GenevisibleiQ9P2D6, HS

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058, AB_hydrolase
IPR022122, DUF3657
IPR007751, DUF676_lipase-like
PfamiView protein in Pfam
PF12394, DUF3657, 1 hit
PF05057, DUF676, 1 hit
SUPFAMiSSF53474, SSF53474, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF135A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P2D6
Secondary accession number(s): A2RRQ5
, Q3C0H3, Q5JXK0, Q5JXK1, Q68DW0, Q6P081, Q9H0F2, Q9NU48, Q9NUQ5, Q9NXL5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: August 12, 2020
This is version 133 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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