UniProtKB - Q9P2B2 (FPRP_HUMAN)
Protein
Prostaglandin F2 receptor negative regulator
Gene
PTGFRN
Organism
Homo sapiens (Human)
Status
Functioni
Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity). In myoblasts, associates with tetraspanins CD9 and CD81 to prevent myotube fusion during muscle regeneration (By similarity).By similarity
GO - Biological processi
- lipid droplet organization Source: Ensembl
- myoblast fusion involved in skeletal muscle regeneration Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q9P2B2 |
Names & Taxonomyi
Protein namesi | Recommended name: Prostaglandin F2 receptor negative regulatorAlternative name(s): CD9 partner 1 Short name: CD9P-1 Glu-Trp-Ile EWI motif-containing protein F Short name: EWI-F Prostaglandin F2-alpha receptor regulatory protein Prostaglandin F2-alpha receptor-associated protein CD_antigen: CD315 |
Gene namesi | Name:PTGFRN Synonyms:CD9P1, EWIF, FPRP, KIAA1436 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9601, PTGFRN |
MIMi | 601204, gene |
neXtProti | NX_Q9P2B2 |
VEuPathDBi | HostDB:ENSG00000134247.9 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein By similarity
Golgi apparatus
- trans-Golgi network membrane By similarity; Single-pass type I membrane protein By similarity
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Golgi apparatus
- Golgi apparatus Source: UniProtKB-SubCell
Other locations
- cell surface Source: UniProtKB
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 26 – 832 | ExtracellularSequence analysisAdd BLAST | 807 | |
Transmembranei | 833 – 853 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 854 – 879 | CytoplasmicSequence analysisAdd BLAST | 26 |
Keywords - Cellular componenti
Endoplasmic reticulum, Golgi apparatus, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 5738 |
OpenTargetsi | ENSG00000134247 |
PharmGKBi | PA33950 |
Miscellaneous databases
Pharosi | Q9P2B2, Tbio |
Genetic variation databases
BioMutai | PTGFRN |
DMDMi | 28201801 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_0000014762 | 26 – 879 | Prostaglandin F2 receptor negative regulatorAdd BLAST | 854 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 43 ↔ 119 | PROSITE-ProRule annotation | ||
Glycosylationi | 44 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 169 ↔ 247 | PROSITE-ProRule annotation | ||
Modified residuei | 271 | PhosphothreonineBy similarity | 1 | |
Glycosylationi | 286 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Disulfide bondi | 299 ↔ 373 | PROSITE-ProRule annotation | ||
Glycosylationi | 300 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Glycosylationi | 383 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 413 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 429 ↔ 515 | PROSITE-ProRule annotation | ||
Glycosylationi | 525 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 571 ↔ 655 | PROSITE-ProRule annotation | ||
Glycosylationi | 600 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 618 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 691 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 711 ↔ 793 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q9P2B2 |
jPOSTi | Q9P2B2 |
MassIVEi | Q9P2B2 |
MaxQBi | Q9P2B2 |
PaxDbi | Q9P2B2 |
PeptideAtlasi | Q9P2B2 |
PRIDEi | Q9P2B2 |
ProteomicsDBi | 83765 |
PTM databases
GlyConnecti | 1647, 35 N-Linked glycans (5 sites) |
GlyGeni | Q9P2B2, 9 sites, 1 N-linked glycan (1 site) |
iPTMneti | Q9P2B2 |
PhosphoSitePlusi | Q9P2B2 |
SwissPalmi | Q9P2B2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000134247, Expressed in cardiac muscle of right atrium and 200 other tissues |
Genevisiblei | Q9P2B2, HS |
Organism-specific databases
HPAi | ENSG00000134247, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
Q9P2B2
With | #Exp. | IntAct |
---|---|---|
CD9 [P21926] | 10 | EBI-4290465,EBI-4280101 |
Protein-protein interaction databases
BioGRIDi | 111710, 24 interactors |
IntActi | Q9P2B2, 14 interactors |
MINTi | Q9P2B2 |
STRINGi | 9606.ENSP00000376899 |
Miscellaneous databases
RNActi | Q9P2B2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 129 | Ig-like C2-type 1Add BLAST | 104 | |
Domaini | 149 – 268 | Ig-like C2-type 2Add BLAST | 120 | |
Domaini | 276 – 394 | Ig-like C2-type 3Add BLAST | 119 | |
Domaini | 406 – 536 | Ig-like C2-type 4Add BLAST | 131 | |
Domaini | 544 – 662 | Ig-like C2-type 5Add BLAST | 119 | |
Domaini | 688 – 813 | Ig-like C2-type 6Add BLAST | 126 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 424 – 427 | Endoplasmic reticulum retention signal | 4 | |
Motifi | 703 – 705 | Cell attachment siteSequence analysis | 3 |
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QVD2, Eukaryota |
GeneTreei | ENSGT00940000158367 |
HOGENOMi | CLU_005187_1_0_1 |
InParanoidi | Q9P2B2 |
OMAi | FYWCDIT |
OrthoDBi | 151148at2759 |
PhylomeDBi | Q9P2B2 |
TreeFami | TF332702 |
Family and domain databases
Gene3Di | 2.60.40.10, 5 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF07686, V-set, 2 hits |
SMARTi | View protein in SMART SM00409, IG, 6 hits SM00406, IGv, 3 hits |
SUPFAMi | SSF48726, SSF48726, 4 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 5 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9P2B2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGRLASRPLL LALLSLALCR GRVVRVPTAT LVRVVGTELV IPCNVSDYDG
60 70 80 90 100
PSEQNFDWSF SSLGSSFVEL ASTWEVGFPA QLYQERLQRG EILLRRTAND
110 120 130 140 150
AVELHIKNVQ PSDQGHYKCS TPSTDATVQG NYEDTVQVKV LADSLHVGPS
160 170 180 190 200
ARPPPSLSLR EGEPFELRCT AASASPLHTH LALLWEVHRG PARRSVLALT
210 220 230 240 250
HEGRFHPGLG YEQRYHSGDV RLDTVGSDAY RLSVSRALSA DQGSYRCIVS
260 270 280 290 300
EWIAEQGNWQ EIQEKAVEVA TVVIQPSVLR AAVPKNVSVA EGKELDLTCN
310 320 330 340 350
ITTDRADDVR PEVTWSFSRM PDSTLPGSRV LARLDRDSLV HSSPHVALSH
360 370 380 390 400
VDARSYHLLV RDVSKENSGY YYCHVSLWAP GHNRSWHKVA EAVSSPAGVG
410 420 430 440 450
VTWLEPDYQV YLNASKVPGF ADDPTELACR VVDTKSGEAN VRFTVSWYYR
460 470 480 490 500
MNRRSDNVVT SELLAVMDGD WTLKYGERSK QRAQDGDFIF SKEHTDTFNF
510 520 530 540 550
RIQRTTEEDR GNYYCVVSAW TKQRNNSWVK SKDVFSKPVN IFWALEDSVL
560 570 580 590 600
VVKARQPKPF FAAGNTFEMT CKVSSKNIKS PRYSVLIMAE KPVGDLSSPN
610 620 630 640 650
ETKYIISLDQ DSVVKLENWT DASRVDGVVL EKVQEDEFRY RMYQTQVSDA
660 670 680 690 700
GLYRCMVTAW SPVRGSLWRE AATSLSNPIE IDFQTSGPIF NASVHSDTPS
710 720 730 740 750
VIRGDLIKLF CIITVEGAAL DPDDMAFDVS WFAVHSFGLD KAPVLLSSLD
760 770 780 790 800
RKGIVTTSRR DWKSDLSLER VSVLEFLLQV HGSEDQDFGN YYCSVTPWVK
810 820 830 840 850
SPTGSWQKEA EIHSKPVFIT VKMDVLNAFK YPLLIGVGLS TVIGLLSCLI
860 870
GYCSSHWCCK KEVQETRRER RRLMSMEMD
Sequence cautioni
The sequence BAA92674 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC11104 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 109 | V → A in BAC11104 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_059388 | 277 | S → T1 PublicationCorresponds to variant dbSNP:rs4546904Ensembl. | 1 | |
Natural variantiVAR_024496 | 837 | V → I. Corresponds to variant dbSNP:rs10801922Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB037857 mRNA Translation: BAA92674.1 Different initiation. AK074637 mRNA Translation: BAC11104.1 Sequence problems. AL445231 Genomic DNA No translation available. AL157904 Genomic DNA No translation available. BC152454 mRNA Translation: AAI52455.1 |
CCDSi | CCDS890.1 |
RefSeqi | NP_065173.2, NM_020440.3 |
Genome annotation databases
Ensembli | ENST00000393203; ENSP00000376899; ENSG00000134247 |
GeneIDi | 5738 |
KEGGi | hsa:5738 |
UCSCi | uc001egv.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB037857 mRNA Translation: BAA92674.1 Different initiation. AK074637 mRNA Translation: BAC11104.1 Sequence problems. AL445231 Genomic DNA No translation available. AL157904 Genomic DNA No translation available. BC152454 mRNA Translation: AAI52455.1 |
CCDSi | CCDS890.1 |
RefSeqi | NP_065173.2, NM_020440.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 111710, 24 interactors |
IntActi | Q9P2B2, 14 interactors |
MINTi | Q9P2B2 |
STRINGi | 9606.ENSP00000376899 |
PTM databases
GlyConnecti | 1647, 35 N-Linked glycans (5 sites) |
GlyGeni | Q9P2B2, 9 sites, 1 N-linked glycan (1 site) |
iPTMneti | Q9P2B2 |
PhosphoSitePlusi | Q9P2B2 |
SwissPalmi | Q9P2B2 |
Genetic variation databases
BioMutai | PTGFRN |
DMDMi | 28201801 |
Proteomic databases
EPDi | Q9P2B2 |
jPOSTi | Q9P2B2 |
MassIVEi | Q9P2B2 |
MaxQBi | Q9P2B2 |
PaxDbi | Q9P2B2 |
PeptideAtlasi | Q9P2B2 |
PRIDEi | Q9P2B2 |
ProteomicsDBi | 83765 |
Protocols and materials databases
Antibodypediai | 2447, 134 antibodies |
DNASUi | 5738 |
Genome annotation databases
Ensembli | ENST00000393203; ENSP00000376899; ENSG00000134247 |
GeneIDi | 5738 |
KEGGi | hsa:5738 |
UCSCi | uc001egv.2, human |
Organism-specific databases
CTDi | 5738 |
DisGeNETi | 5738 |
GeneCardsi | PTGFRN |
HGNCi | HGNC:9601, PTGFRN |
HPAi | ENSG00000134247, Low tissue specificity |
MIMi | 601204, gene |
neXtProti | NX_Q9P2B2 |
OpenTargetsi | ENSG00000134247 |
PharmGKBi | PA33950 |
VEuPathDBi | HostDB:ENSG00000134247.9 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QVD2, Eukaryota |
GeneTreei | ENSGT00940000158367 |
HOGENOMi | CLU_005187_1_0_1 |
InParanoidi | Q9P2B2 |
OMAi | FYWCDIT |
OrthoDBi | 151148at2759 |
PhylomeDBi | Q9P2B2 |
TreeFami | TF332702 |
Enzyme and pathway databases
PathwayCommonsi | Q9P2B2 |
Miscellaneous databases
BioGRID-ORCSi | 5738, 5 hits in 877 CRISPR screens |
ChiTaRSi | PTGFRN, human |
GeneWikii | PTGFRN |
GenomeRNAii | 5738 |
Pharosi | Q9P2B2, Tbio |
PROi | PR:Q9P2B2 |
RNActi | Q9P2B2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000134247, Expressed in cardiac muscle of right atrium and 200 other tissues |
Genevisiblei | Q9P2B2, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 5 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF07686, V-set, 2 hits |
SMARTi | View protein in SMART SM00409, IG, 6 hits SM00406, IGv, 3 hits |
SUPFAMi | SSF48726, SSF48726, 4 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FPRP_HUMAN | |
Accessioni | Q9P2B2Primary (citable) accession number: Q9P2B2 Secondary accession number(s): Q5VVU9, Q8N2K6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 2003 |
Last sequence update: | February 1, 2003 | |
Last modified: | February 10, 2021 | |
This is version 166 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot