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Protein

Prostaglandin F2 receptor negative regulator

Gene

PTGFRN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity).By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin F2 receptor negative regulator
Alternative name(s):
CD9 partner 1
Short name:
CD9P-1
Glu-Trp-Ile EWI motif-containing protein F
Short name:
EWI-F
Prostaglandin F2-alpha receptor regulatory protein
Prostaglandin F2-alpha receptor-associated protein
CD_antigen: CD315
Gene namesi
Name:PTGFRN
Synonyms:CD9P1, EWIF, FPRP, KIAA1436
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000134247.9
HGNCiHGNC:9601 PTGFRN
MIMi601204 gene
neXtProtiNX_Q9P2B2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 832ExtracellularSequence analysisAdd BLAST807
Transmembranei833 – 853HelicalSequence analysisAdd BLAST21
Topological domaini854 – 879CytoplasmicSequence analysisAdd BLAST26

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5738
OpenTargetsiENSG00000134247
PharmGKBiPA33950

Polymorphism and mutation databases

BioMutaiPTGFRN
DMDMi28201801

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000001476226 – 879Prostaglandin F2 receptor negative regulatorAdd BLAST854

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 119PROSITE-ProRule annotation
Glycosylationi44N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi169 ↔ 247PROSITE-ProRule annotation
Modified residuei271PhosphothreonineBy similarity1
Glycosylationi286N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi299 ↔ 373PROSITE-ProRule annotation
Glycosylationi300N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi383N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi413N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi429 ↔ 515PROSITE-ProRule annotation
Glycosylationi525N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi571 ↔ 655PROSITE-ProRule annotation
Glycosylationi600N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi618N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi691N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi711 ↔ 793PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9P2B2
MaxQBiQ9P2B2
PaxDbiQ9P2B2
PeptideAtlasiQ9P2B2
PRIDEiQ9P2B2
ProteomicsDBi83765

PTM databases

GlyConnecti1647
iPTMnetiQ9P2B2
PhosphoSitePlusiQ9P2B2
SwissPalmiQ9P2B2

Expressioni

Gene expression databases

BgeeiENSG00000134247 Expressed in 187 organ(s), highest expression level in cardiac muscle of right atrium
CleanExiHS_PTGFRN
GenevisibleiQ9P2B2 HS

Organism-specific databases

HPAiHPA017074

Interactioni

Subunit structurei

Interacts with CD9 and CD81. Also seems to interact with CD63, CD82 and CD151.1 Publication

Protein-protein interaction databases

BioGridi111710, 21 interactors
IntActiQ9P2B2, 2 interactors
MINTiQ9P2B2
STRINGi9606.ENSP00000376899

Structurei

3D structure databases

ProteinModelPortaliQ9P2B2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 129Ig-like C2-type 1Add BLAST104
Domaini149 – 268Ig-like C2-type 2Add BLAST120
Domaini276 – 394Ig-like C2-type 3Add BLAST119
Domaini406 – 536Ig-like C2-type 4Add BLAST131
Domaini544 – 662Ig-like C2-type 5Add BLAST119
Domaini688 – 813Ig-like C2-type 6Add BLAST126

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi424 – 427Endoplasmic reticulum retention signal4
Motifi703 – 705Cell attachment siteSequence analysis3

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHZG Eukaryota
ENOG4111FCJ LUCA
GeneTreeiENSGT00390000010278
HOGENOMiHOG000112641
HOVERGENiHBG031554
InParanoidiQ9P2B2
KOiK06729
OMAiQTSGPIF
OrthoDBiEOG091G01C5
PhylomeDBiQ9P2B2
TreeFamiTF332702

Family and domain databases

Gene3Di2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 2 hits
SMARTiView protein in SMART
SM00409 IG, 6 hits
SM00406 IGv, 3 hits
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 5 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P2B2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRLASRPLL LALLSLALCR GRVVRVPTAT LVRVVGTELV IPCNVSDYDG
60 70 80 90 100
PSEQNFDWSF SSLGSSFVEL ASTWEVGFPA QLYQERLQRG EILLRRTAND
110 120 130 140 150
AVELHIKNVQ PSDQGHYKCS TPSTDATVQG NYEDTVQVKV LADSLHVGPS
160 170 180 190 200
ARPPPSLSLR EGEPFELRCT AASASPLHTH LALLWEVHRG PARRSVLALT
210 220 230 240 250
HEGRFHPGLG YEQRYHSGDV RLDTVGSDAY RLSVSRALSA DQGSYRCIVS
260 270 280 290 300
EWIAEQGNWQ EIQEKAVEVA TVVIQPSVLR AAVPKNVSVA EGKELDLTCN
310 320 330 340 350
ITTDRADDVR PEVTWSFSRM PDSTLPGSRV LARLDRDSLV HSSPHVALSH
360 370 380 390 400
VDARSYHLLV RDVSKENSGY YYCHVSLWAP GHNRSWHKVA EAVSSPAGVG
410 420 430 440 450
VTWLEPDYQV YLNASKVPGF ADDPTELACR VVDTKSGEAN VRFTVSWYYR
460 470 480 490 500
MNRRSDNVVT SELLAVMDGD WTLKYGERSK QRAQDGDFIF SKEHTDTFNF
510 520 530 540 550
RIQRTTEEDR GNYYCVVSAW TKQRNNSWVK SKDVFSKPVN IFWALEDSVL
560 570 580 590 600
VVKARQPKPF FAAGNTFEMT CKVSSKNIKS PRYSVLIMAE KPVGDLSSPN
610 620 630 640 650
ETKYIISLDQ DSVVKLENWT DASRVDGVVL EKVQEDEFRY RMYQTQVSDA
660 670 680 690 700
GLYRCMVTAW SPVRGSLWRE AATSLSNPIE IDFQTSGPIF NASVHSDTPS
710 720 730 740 750
VIRGDLIKLF CIITVEGAAL DPDDMAFDVS WFAVHSFGLD KAPVLLSSLD
760 770 780 790 800
RKGIVTTSRR DWKSDLSLER VSVLEFLLQV HGSEDQDFGN YYCSVTPWVK
810 820 830 840 850
SPTGSWQKEA EIHSKPVFIT VKMDVLNAFK YPLLIGVGLS TVIGLLSCLI
860 870
GYCSSHWCCK KEVQETRRER RRLMSMEMD
Length:879
Mass (Da):98,556
Last modified:February 1, 2003 - v2
Checksum:i9712C398A74DF570
GO

Sequence cautioni

The sequence BAA92674 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC11104 differs from that shown. Reason: Erroneous termination at position 864. Translated as Gln.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti109V → A in BAC11104 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059388277S → T1 PublicationCorresponds to variant dbSNP:rs4546904Ensembl.1
Natural variantiVAR_024496837V → I. Corresponds to variant dbSNP:rs10801922Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037857 mRNA Translation: BAA92674.1 Different initiation.
AK074637 mRNA Translation: BAC11104.1 Sequence problems.
AL445231 Genomic DNA No translation available.
AL157904 Genomic DNA No translation available.
BC152454 mRNA Translation: AAI52455.1
CCDSiCCDS890.1
RefSeqiNP_065173.2, NM_020440.3
UniGeneiHs.418093

Genome annotation databases

EnsembliENST00000393203; ENSP00000376899; ENSG00000134247
GeneIDi5738
KEGGihsa:5738
UCSCiuc001egv.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037857 mRNA Translation: BAA92674.1 Different initiation.
AK074637 mRNA Translation: BAC11104.1 Sequence problems.
AL445231 Genomic DNA No translation available.
AL157904 Genomic DNA No translation available.
BC152454 mRNA Translation: AAI52455.1
CCDSiCCDS890.1
RefSeqiNP_065173.2, NM_020440.3
UniGeneiHs.418093

3D structure databases

ProteinModelPortaliQ9P2B2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111710, 21 interactors
IntActiQ9P2B2, 2 interactors
MINTiQ9P2B2
STRINGi9606.ENSP00000376899

PTM databases

GlyConnecti1647
iPTMnetiQ9P2B2
PhosphoSitePlusiQ9P2B2
SwissPalmiQ9P2B2

Polymorphism and mutation databases

BioMutaiPTGFRN
DMDMi28201801

Proteomic databases

EPDiQ9P2B2
MaxQBiQ9P2B2
PaxDbiQ9P2B2
PeptideAtlasiQ9P2B2
PRIDEiQ9P2B2
ProteomicsDBi83765

Protocols and materials databases

DNASUi5738
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393203; ENSP00000376899; ENSG00000134247
GeneIDi5738
KEGGihsa:5738
UCSCiuc001egv.2 human

Organism-specific databases

CTDi5738
DisGeNETi5738
EuPathDBiHostDB:ENSG00000134247.9
GeneCardsiPTGFRN
HGNCiHGNC:9601 PTGFRN
HPAiHPA017074
MIMi601204 gene
neXtProtiNX_Q9P2B2
OpenTargetsiENSG00000134247
PharmGKBiPA33950
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHZG Eukaryota
ENOG4111FCJ LUCA
GeneTreeiENSGT00390000010278
HOGENOMiHOG000112641
HOVERGENiHBG031554
InParanoidiQ9P2B2
KOiK06729
OMAiQTSGPIF
OrthoDBiEOG091G01C5
PhylomeDBiQ9P2B2
TreeFamiTF332702

Miscellaneous databases

ChiTaRSiPTGFRN human
GeneWikiiPTGFRN
GenomeRNAii5738
PROiPR:Q9P2B2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134247 Expressed in 187 organ(s), highest expression level in cardiac muscle of right atrium
CleanExiHS_PTGFRN
GenevisibleiQ9P2B2 HS

Family and domain databases

Gene3Di2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 2 hits
SMARTiView protein in SMART
SM00409 IG, 6 hits
SM00406 IGv, 3 hits
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFPRP_HUMAN
AccessioniPrimary (citable) accession number: Q9P2B2
Secondary accession number(s): Q5VVU9, Q8N2K6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: February 1, 2003
Last modified: October 10, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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