PTGFRN

Functionⁱ

Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity).By similarity

GO - Biological processⁱ

lipid droplet organization Source: Ensembl

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Prostaglandin F2 receptor negative regulator Alternative name(s): CD9 partner 1 Short name: CD9P-1 Glu-Trp-Ile EWI motif-containing protein F Short name: EWI-F Prostaglandin F2-alpha receptor regulatory protein Prostaglandin F2-alpha receptor-associated protein CD_antigen: CD315
Gene namesⁱ	Name:PTGFRN Synonyms:CD9P1, EWIF, FPRP, KIAA1436
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000134247.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9601 PTGFRN
MIMⁱ	601204 gene
neXtProtⁱ	NX_Q9P2B2

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	26 – 832	ExtracellularSequence analysisAdd BLAST	807
Transmembraneⁱ	833 – 853	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	854 – 879	CytoplasmicSequence analysisAdd BLAST	26

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5738
Open Targets More...OpenTargetsⁱ	ENSG00000134247
PharmGKBⁱ	PA33950

Polymorphism and mutation databases

BioMutaⁱ	PTGFRN
DMDMⁱ	28201801

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 25	Sequence analysisAdd BLAST		25
ChainⁱPRO_0000014762	26 – 879	Prostaglandin F2 receptor negative regulatorAdd BLAST		854

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	43 ↔ 119	PROSITE-ProRule annotation
Glycosylationⁱ	44	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	169 ↔ 247	PROSITE-ProRule annotation
Modified residueⁱ	271	PhosphothreonineBy similarity	1
Glycosylationⁱ	286	N-linked (GlcNAc...) asparagine2 Publications	1
Disulfide bondⁱ	299 ↔ 373	PROSITE-ProRule annotation
Glycosylationⁱ	300	N-linked (GlcNAc...) asparagine2 Publications	1
Glycosylationⁱ	383	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	413	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	429 ↔ 515	PROSITE-ProRule annotation
Glycosylationⁱ	525	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	571 ↔ 655	PROSITE-ProRule annotation
Glycosylationⁱ	600	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	618	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	691	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	711 ↔ 793	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	Q9P2B2
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9P2B2
PaxDbⁱ	Q9P2B2
PeptideAtlas More...PeptideAtlasⁱ	Q9P2B2
PRIDEⁱ	Q9P2B2
ProteomicsDBⁱ	83765

PTM databases

GlyConnectⁱ	1647
iPTMnetⁱ	Q9P2B2
PhosphoSitePlusⁱ	Q9P2B2
SwissPalmⁱ	Q9P2B2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000134247 Expressed in 187 organ(s), highest expression level in cardiac muscle of right atrium
CleanExⁱ	HS_PTGFRN
Genevisibleⁱ	Q9P2B2 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA017074

HPAⁱ

HPA017074

Interactionⁱ

Subunit structureⁱ

Interacts with CD9 and CD81. Also seems to interact with CD63, CD82 and CD151.1 Publication

Protein-protein interaction databases

BioGridⁱ	111710, 21 interactors
IntActⁱ	Q9P2B2, 2 interactors
Molecular INTeraction database More...MINTⁱ	Q9P2B2
STRINGⁱ	9606.ENSP00000376899

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9P2B2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	26 – 129	Ig-like C2-type 1Add BLAST	104
Domainⁱ	149 – 268	Ig-like C2-type 2Add BLAST	120
Domainⁱ	276 – 394	Ig-like C2-type 3Add BLAST	119
Domainⁱ	406 – 536	Ig-like C2-type 4Add BLAST	131
Domainⁱ	544 – 662	Ig-like C2-type 5Add BLAST	119
Domainⁱ	688 – 813	Ig-like C2-type 6Add BLAST	126

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	424 – 427	Endoplasmic reticulum retention signal		4
Motifⁱ	703 – 705	Cell attachment siteSequence analysis		3

Keywords - Domainⁱ

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IHZG Eukaryota ENOG4111FCJ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000010278
HOGENOMⁱ	HOG000112641
HOVERGENⁱ	HBG031554
InParanoidⁱ	Q9P2B2
KEGG Orthology (KO) More...KOⁱ	K06729
OMAⁱ	QTSGPIF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01C5
PhylomeDBⁱ	Q9P2B2
TreeFamⁱ	TF332702

Family and domain databases

Gene3Dⁱ	2.60.40.10, 5 hits
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR013106 Ig_V-set
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07686 V-set, 2 hits
SMARTⁱ	View protein in SMART SM00409 IG, 6 hits SM00406 IGv, 3 hits
SUPFAMⁱ	SSF48726 SSF48726, 4 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 5 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9P2B2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGRLASRPLL LALLSLALCR GRVVRVPTAT LVRVVGTELV IPCNVSDYDG 
        60         70         80         90        100
PSEQNFDWSF SSLGSSFVEL ASTWEVGFPA QLYQERLQRG EILLRRTAND 
       110        120        130        140        150
AVELHIKNVQ PSDQGHYKCS TPSTDATVQG NYEDTVQVKV LADSLHVGPS 
       160        170        180        190        200
ARPPPSLSLR EGEPFELRCT AASASPLHTH LALLWEVHRG PARRSVLALT 
       210        220        230        240        250
HEGRFHPGLG YEQRYHSGDV RLDTVGSDAY RLSVSRALSA DQGSYRCIVS 
       260        270        280        290        300
EWIAEQGNWQ EIQEKAVEVA TVVIQPSVLR AAVPKNVSVA EGKELDLTCN 
       310        320        330        340        350
ITTDRADDVR PEVTWSFSRM PDSTLPGSRV LARLDRDSLV HSSPHVALSH 
       360        370        380        390        400
VDARSYHLLV RDVSKENSGY YYCHVSLWAP GHNRSWHKVA EAVSSPAGVG 
       410        420        430        440        450
VTWLEPDYQV YLNASKVPGF ADDPTELACR VVDTKSGEAN VRFTVSWYYR 
       460        470        480        490        500
MNRRSDNVVT SELLAVMDGD WTLKYGERSK QRAQDGDFIF SKEHTDTFNF 
       510        520        530        540        550
RIQRTTEEDR GNYYCVVSAW TKQRNNSWVK SKDVFSKPVN IFWALEDSVL 
       560        570        580        590        600
VVKARQPKPF FAAGNTFEMT CKVSSKNIKS PRYSVLIMAE KPVGDLSSPN 
       610        620        630        640        650
ETKYIISLDQ DSVVKLENWT DASRVDGVVL EKVQEDEFRY RMYQTQVSDA 
       660        670        680        690        700
GLYRCMVTAW SPVRGSLWRE AATSLSNPIE IDFQTSGPIF NASVHSDTPS 
       710        720        730        740        750
VIRGDLIKLF CIITVEGAAL DPDDMAFDVS WFAVHSFGLD KAPVLLSSLD 
       760        770        780        790        800
RKGIVTTSRR DWKSDLSLER VSVLEFLLQV HGSEDQDFGN YYCSVTPWVK 
       810        820        830        840        850
SPTGSWQKEA EIHSKPVFIT VKMDVLNAFK YPLLIGVGLS TVIGLLSCLI 
       860        870 
GYCSSHWCCK KEVQETRRER RRLMSMEMD

Length:879

Mass (Da):98,556

Last modified:February 1, 2003 - v2

Checksum:ⁱ9712C398A74DF570

GO

Sequence cautionⁱ

The sequence BAA92674 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAC11104 differs from that shown. Reason: Erroneous termination at position 864. Translated as Gln.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	109	V → A in BAC11104 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_059388	277	S → T1 PublicationCorresponds to variant dbSNP:rs4546904Ensembl.		1
Natural variantⁱVAR_024496	837	V → I. Corresponds to variant dbSNP:rs10801922Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB037857 mRNA Translation: BAA92674.1 Different initiation. AK074637 mRNA Translation: BAC11104.1 Sequence problems. AL445231 Genomic DNA No translation available. AL157904 Genomic DNA No translation available. BC152454 mRNA Translation: AAI52455.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS890.1
NCBI Reference Sequences More...RefSeqⁱ	NP_065173.2, NM_020440.3
UniGeneⁱ	Hs.418093

Genome annotation databases

Ensemblⁱ	ENST00000393203; ENSP00000376899; ENSG00000134247
GeneIDⁱ	5738
KEGGⁱ	hsa:5738
UCSC genome browser More...UCSCⁱ	uc001egv.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9P2B2	Prostaglandin F2 receptor inhibitor		SAIBB		962	UniRef90_Q9P2B2
Prostaglandin F2 receptor inhibitor		GORGO		902
SMAP-6 (Fragment)		HUMAN		186
Prostaglandin F2 receptor negative regulator (Fragment)		MACMU		78
Prostaglandin F2 receptor negative regulator (Fragment)		MACFA		78
+37

Protein	Similar proteins		Species	Score	Length	Source
Q9P2B2	Prostaglandin F2 receptor negative regulator		MOUSE		879	UniRef50_Q9P2B2
Prostaglandin F2 receptor negative regulator		RAT		879
Prostaglandin F2 receptor inhibitor		SAIBB		962
Prostaglandin F2 receptor inhibitor		GORGO		902
SMAP-6 (Fragment)		HUMAN		186
+196

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB037857 mRNA Translation: BAA92674.1 Different initiation. AK074637 mRNA Translation: BAC11104.1 Sequence problems. AL445231 Genomic DNA No translation available. AL157904 Genomic DNA No translation available. BC152454 mRNA Translation: AAI52455.1
CCDSⁱ	CCDS890.1
RefSeqⁱ	NP_065173.2, NM_020440.3
UniGeneⁱ	Hs.418093

3D structure databases

ProteinModelPortalⁱ	Q9P2B2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111710, 21 interactors
IntActⁱ	Q9P2B2, 2 interactors
MINTⁱ	Q9P2B2
STRINGⁱ	9606.ENSP00000376899

PTM databases

GlyConnectⁱ	1647
iPTMnetⁱ	Q9P2B2
PhosphoSitePlusⁱ	Q9P2B2
SwissPalmⁱ	Q9P2B2

Polymorphism and mutation databases

BioMutaⁱ	PTGFRN
DMDMⁱ	28201801

Proteomic databases

EPDⁱ	Q9P2B2
MaxQBⁱ	Q9P2B2
PaxDbⁱ	Q9P2B2
PeptideAtlasⁱ	Q9P2B2
PRIDEⁱ	Q9P2B2
ProteomicsDBⁱ	83765

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5738
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000393203; ENSP00000376899; ENSG00000134247
GeneIDⁱ	5738
KEGGⁱ	hsa:5738
UCSCⁱ	uc001egv.2 human

Organism-specific databases

CTDⁱ	5738
DisGeNETⁱ	5738
EuPathDBⁱ	HostDB:ENSG00000134247.9
GeneCardsⁱ	PTGFRN
HGNCⁱ	HGNC:9601 PTGFRN
HPAⁱ	HPA017074
MIMⁱ	601204 gene
neXtProtⁱ	NX_Q9P2B2
OpenTargetsⁱ	ENSG00000134247
PharmGKBⁱ	PA33950
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IHZG Eukaryota ENOG4111FCJ LUCA
GeneTreeⁱ	ENSGT00390000010278
HOGENOMⁱ	HOG000112641
HOVERGENⁱ	HBG031554
InParanoidⁱ	Q9P2B2
KOⁱ	K06729
OMAⁱ	QTSGPIF
OrthoDBⁱ	EOG091G01C5
PhylomeDBⁱ	Q9P2B2
TreeFamⁱ	TF332702

Miscellaneous databases

ChiTaRSⁱ	PTGFRN human
GeneWikiⁱ	PTGFRN
GenomeRNAiⁱ	5738
Protein Ontology More...PROⁱ	PR:Q9P2B2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000134247 Expressed in 187 organ(s), highest expression level in cardiac muscle of right atrium
CleanExⁱ	HS_PTGFRN
Genevisibleⁱ	Q9P2B2 HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 5 hits
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR013106 Ig_V-set
Pfamⁱ	View protein in Pfam PF07686 V-set, 2 hits
SMARTⁱ	View protein in SMART SM00409 IG, 6 hits SM00406 IGv, 3 hits
SUPFAMⁱ	SSF48726 SSF48726, 4 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 5 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FPRP_HUMAN
Accessionⁱ	Q9P2B2Primary (citable) accession number: Q9P2B2 Secondary accession number(s): Q5VVU9, Q8N2K6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 2003
	Last sequence update:	February 1, 2003
	Last modified:	October 10, 2018
	This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q9P2B2 (FPRP_HUMAN)

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Prostaglandin F2 receptor negative regulator

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Endoplasmic reticulum

Endoplasmic reticulum

Golgi apparatus

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ