UniProtKB - Q9P2A4 (ABI3_HUMAN)
Protein
ABI gene family member 3
Gene
ABI3
Organism
Homo sapiens (Human)
Status
Functioni
May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility.By similarity1 Publication
GO - Molecular functioni
- identical protein binding Source: IntAct
- SH3 domain binding Source: GO_Central
GO - Biological processi
- regulation of cell migration Source: MGI
Enzyme and pathway databases
PathwayCommonsi | Q9P2A4 |
Names & Taxonomyi
Protein namesi | Recommended name: ABI gene family member 3Alternative name(s): New molecule including SH3 Short name: Nesh |
Gene namesi | Name:ABI3 Synonyms:NESH |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000108798.8 |
HGNCi | HGNC:29859, ABI3 |
MIMi | 606363, gene |
neXtProti | NX_Q9P2A4 |
Subcellular locationi
Other locations
- Cytoplasm 1 Publication
Note: Colocalizes with PAK2 at leading edge of cells.
Other locations
- cytoplasm Source: LIFEdb
- lamellipodium Source: MGI
- membrane Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 51225 |
OpenTargetsi | ENSG00000108798 |
PharmGKBi | PA134951642 |
Miscellaneous databases
Pharosi | Q9P2A4, Tbio |
Polymorphism and mutation databases
BioMutai | ABI3 |
DMDMi | 296434384 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000191792 | 1 – 366 | ABI gene family member 3Add BLAST | 366 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 213 | PhosphoserineCombined sources | 1 | |
Modified residuei | 216 | PhosphoserineCombined sources | 1 | |
Modified residuei | 342 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9P2A4 |
jPOSTi | Q9P2A4 |
MassIVEi | Q9P2A4 |
MaxQBi | Q9P2A4 |
PaxDbi | Q9P2A4 |
PeptideAtlasi | Q9P2A4 |
PRIDEi | Q9P2A4 |
ProteomicsDBi | 83763 [Q9P2A4-1] 83764 [Q9P2A4-2] |
PTM databases
iPTMneti | Q9P2A4 |
PhosphoSitePlusi | Q9P2A4 |
Expressioni
Tissue specificityi
Expressed in heart, lung, liver, pancreas, kidney, placenta and at low levels in brain and skeletal muscle.1 Publication
Gene expression databases
Bgeei | ENSG00000108798, Expressed in granulocyte and 171 other tissues |
ExpressionAtlasi | Q9P2A4, baseline and differential |
Genevisiblei | Q9P2A4, HS |
Organism-specific databases
HPAi | ENSG00000108798, Tissue enhanced (blood, lymphoid tissue) |
Interactioni
Subunit structurei
May interact with PAK1 and PAK2. Probably interacts with TARSH.
1 PublicationBinary interactionsi
Q9P2A4
GO - Molecular functioni
- identical protein binding Source: IntAct
- SH3 domain binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 119389, 80 interactors |
CORUMi | Q9P2A4 |
IntActi | Q9P2A4, 75 interactors |
MINTi | Q9P2A4 |
STRINGi | 9606.ENSP00000225941 |
Miscellaneous databases
RNActi | Q9P2A4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 308 – 366 | SH3PROSITE-ProRule annotationAdd BLAST | 59 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 33 – 61 | Sequence analysisAdd BLAST | 29 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 224 – 306 | Pro-richAdd BLAST | 83 |
Sequence similaritiesi
Belongs to the ABI family.Curated
Keywords - Domaini
Coiled coil, SH3 domainPhylogenomic databases
eggNOGi | KOG2546, Eukaryota |
GeneTreei | ENSGT00940000161380 |
HOGENOMi | CLU_035421_0_0_1 |
InParanoidi | Q9P2A4 |
OMAi | CEGVCSE |
OrthoDBi | 1478981at2759 |
PhylomeDBi | Q9P2A4 |
TreeFami | TF314303 |
Family and domain databases
InterProi | View protein in InterPro IPR028457, ABI IPR028455, ABI3 IPR012849, Abl-interactor_HHR_dom IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR10460, PTHR10460, 1 hit PTHR10460:SF7, PTHR10460:SF7, 1 hit |
Pfami | View protein in Pfam PF07815, Abi_HHR, 1 hit PF14604, SH3_9, 1 hit |
PRINTSi | PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS50002, SH3, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9P2A4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAELQQLQEF EIPTGREALR GNHSALLRVA DYCEDNYVQA TDKRKALEET
60 70 80 90 100
MAFTTQALAS VAYQVGNLAG HTLRMLDLQG AALRQVEARV STLGQMVNMH
110 120 130 140 150
MEKVARREIG TLATVQRLPP GQKVIAPENL PPLTPYCRRP LNFGCLDDIG
160 170 180 190 200
HGIKDLSTQL SRTGTLSRKS IKAPATPASA TLGRPPRIPE PVHLPVVPDG
210 220 230 240 250
RLSAASSAFS LASAGSAEGV GGAPTPKGQA APPAPPLPSS LDPPPPPAAV
260 270 280 290 300
EVFQRPPTLE ELSPPPPDEE LPLPLDLPPP PPLDGDELGL PPPPPGFGPD
310 320 330 340 350
EPSWVPASYL EKVVTLYPYT SQKDNELSFS EGTVICVTRR YSDGWCEGVS
360
SEGTGFFPGN YVEPSC
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketI3L1X2 | I3L1X2_HUMAN | ABI gene family member 3 | ABI3 | 191 | Annotation score: | ||
I3L3W4 | I3L3W4_HUMAN | ABI gene family member 3 | ABI3 | 160 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_022030 | 44 | R → Q1 PublicationCorresponds to variant dbSNP:rs2233369Ensembl. | 1 | |
Natural variantiVAR_060243 | 203 | S → F. Corresponds to variant dbSNP:rs616338Ensembl. | 1 | |
Natural variantiVAR_060993 | 209 | F → SCombined sources3 PublicationsCorresponds to variant dbSNP:rs616338Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_041467 | 90 – 95 | Missing in isoform 2. Curated | 6 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB037886 mRNA Translation: BAA90667.1 AL136709 mRNA Translation: CAB66644.1 AC004797 Genomic DNA No translation available. AC069454 Genomic DNA No translation available. BC007780 mRNA Translation: AAH07780.1 |
CCDSi | CCDS11546.1 [Q9P2A4-1] |
RefSeqi | NP_001128658.1, NM_001135186.1 NP_057512.1, NM_016428.2 [Q9P2A4-1] |
Genome annotation databases
Ensembli | ENST00000225941; ENSP00000225941; ENSG00000108798 [Q9P2A4-1] ENST00000419580; ENSP00000406651; ENSG00000108798 [Q9P2A4-2] |
GeneIDi | 51225 |
KEGGi | hsa:51225 |
UCSCi | uc002iop.1, human [Q9P2A4-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB037886 mRNA Translation: BAA90667.1 AL136709 mRNA Translation: CAB66644.1 AC004797 Genomic DNA No translation available. AC069454 Genomic DNA No translation available. BC007780 mRNA Translation: AAH07780.1 |
CCDSi | CCDS11546.1 [Q9P2A4-1] |
RefSeqi | NP_001128658.1, NM_001135186.1 NP_057512.1, NM_016428.2 [Q9P2A4-1] |
3D structure databases
SMRi | Q9P2A4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119389, 80 interactors |
CORUMi | Q9P2A4 |
IntActi | Q9P2A4, 75 interactors |
MINTi | Q9P2A4 |
STRINGi | 9606.ENSP00000225941 |
PTM databases
iPTMneti | Q9P2A4 |
PhosphoSitePlusi | Q9P2A4 |
Polymorphism and mutation databases
BioMutai | ABI3 |
DMDMi | 296434384 |
Proteomic databases
EPDi | Q9P2A4 |
jPOSTi | Q9P2A4 |
MassIVEi | Q9P2A4 |
MaxQBi | Q9P2A4 |
PaxDbi | Q9P2A4 |
PeptideAtlasi | Q9P2A4 |
PRIDEi | Q9P2A4 |
ProteomicsDBi | 83763 [Q9P2A4-1] 83764 [Q9P2A4-2] |
Protocols and materials databases
Antibodypediai | 53503, 89 antibodies |
DNASUi | 51225 |
Genome annotation databases
Ensembli | ENST00000225941; ENSP00000225941; ENSG00000108798 [Q9P2A4-1] ENST00000419580; ENSP00000406651; ENSG00000108798 [Q9P2A4-2] |
GeneIDi | 51225 |
KEGGi | hsa:51225 |
UCSCi | uc002iop.1, human [Q9P2A4-1] |
Organism-specific databases
CTDi | 51225 |
DisGeNETi | 51225 |
EuPathDBi | HostDB:ENSG00000108798.8 |
GeneCardsi | ABI3 |
HGNCi | HGNC:29859, ABI3 |
HPAi | ENSG00000108798, Tissue enhanced (blood, lymphoid tissue) |
MIMi | 606363, gene |
neXtProti | NX_Q9P2A4 |
OpenTargetsi | ENSG00000108798 |
PharmGKBi | PA134951642 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2546, Eukaryota |
GeneTreei | ENSGT00940000161380 |
HOGENOMi | CLU_035421_0_0_1 |
InParanoidi | Q9P2A4 |
OMAi | CEGVCSE |
OrthoDBi | 1478981at2759 |
PhylomeDBi | Q9P2A4 |
TreeFami | TF314303 |
Enzyme and pathway databases
PathwayCommonsi | Q9P2A4 |
Miscellaneous databases
BioGRID-ORCSi | 51225, 4 hits in 836 CRISPR screens |
ChiTaRSi | ABI3, human |
GeneWikii | ABI3 |
GenomeRNAii | 51225 |
Pharosi | Q9P2A4, Tbio |
PROi | PR:Q9P2A4 |
RNActi | Q9P2A4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000108798, Expressed in granulocyte and 171 other tissues |
ExpressionAtlasi | Q9P2A4, baseline and differential |
Genevisiblei | Q9P2A4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR028457, ABI IPR028455, ABI3 IPR012849, Abl-interactor_HHR_dom IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR10460, PTHR10460, 1 hit PTHR10460:SF7, PTHR10460:SF7, 1 hit |
Pfami | View protein in Pfam PF07815, Abi_HHR, 1 hit PF14604, SH3_9, 1 hit |
PRINTSi | PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00326, SH3, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ABI3_HUMAN | |
Accessioni | Q9P2A4Primary (citable) accession number: Q9P2A4 Secondary accession number(s): C9IZN8, Q9H0P6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | May 18, 2010 | |
Last modified: | December 2, 2020 | |
This is version 163 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations