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Protein

C5a anaphylatoxin chemotactic receptor 2

Gene

C5AR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways.3 Publications

GO - Molecular functioni

GO - Biological processi

  • chemotaxis Source: InterPro
  • inflammatory response Source: GO_Central
  • negative regulation of interleukin-6 secretion Source: UniProtKB
  • negative regulation of neutrophil chemotaxis Source: UniProtKB
  • negative regulation of tumor necrosis factor production Source: UniProtKB
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: GO_Central
  • positive regulation of cytosolic calcium ion concentration Source: GO_Central
  • positive regulation of epithelial cell proliferation Source: InterPro
  • positive regulation of ERK1 and ERK2 cascade Source: InterPro
  • regulation of complement activation Source: Reactome
  • regulation of interleukin-8 secretion Source: UniProtKB

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-977606 Regulation of Complement cascade
SIGNORiQ9P296

Names & Taxonomyi

Protein namesi
Recommended name:
C5a anaphylatoxin chemotactic receptor 2
Alternative name(s):
Complement component 5a receptor 2
G-protein coupled receptor 77
Gene namesi
Name:C5AR2
Synonyms:C5L2, GPR77
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000134830.5
HGNCiHGNC:4527 C5AR2
MIMi609949 gene
neXtProtiNX_Q9P296

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
Transmembranei39 – 61Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini62 – 72CytoplasmicSequence analysisAdd BLAST11
Transmembranei73 – 95Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini96 – 114ExtracellularSequence analysisAdd BLAST19
Transmembranei115 – 137Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini138 – 149CytoplasmicSequence analysisAdd BLAST12
Transmembranei150 – 172Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini173 – 202ExtracellularSequence analysisAdd BLAST30
Transmembranei203 – 225Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini226 – 237CytoplasmicSequence analysisAdd BLAST12
Transmembranei238 – 260Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini261 – 274ExtracellularSequence analysisAdd BLAST14
Transmembranei275 – 294Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini295 – 337CytoplasmicSequence analysisAdd BLAST43

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi27202
OpenTargetsiENSG00000134830
PharmGKBiPA28920

Chemistry databases

GuidetoPHARMACOLOGYi33

Polymorphism and mutation databases

DMDMi20137533

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692161 – 337C5a anaphylatoxin chemotactic receptor 2Add BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi107 ↔ 186PROSITE-ProRule annotation
Modified residuei320PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9P296
PeptideAtlasiQ9P296
PRIDEiQ9P296
ProteomicsDBi83760

PTM databases

iPTMnetiQ9P296
PhosphoSitePlusiQ9P296

Expressioni

Tissue specificityi

Frontal cortex, hippocampus, hypothalamus, pons and liver.2 Publications

Gene expression databases

BgeeiENSG00000134830
CleanExiHS_GPR77
GenevisibleiQ9P296 HS

Organism-specific databases

HPAiHPA016629

Interactioni

Subunit structurei

Interacts with C3 (the anaphylatoxin peptide C3a and the adipogenic hormone ASP); the interaction occurs with higher affinity for ASP, enhancing the phosphorylation and activation of GPR77, recruitment of ARRB2 to the cell surface and endocytosis of GRP77.1 Publication

Protein-protein interaction databases

BioGridi118077, 61 interactors
IntActiQ9P296, 1 interactor
STRINGi9606.ENSP00000257267

Structurei

3D structure databases

ProteinModelPortaliQ9P296
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHWH Eukaryota
ENOG4111DWV LUCA
GeneTreeiENSGT00760000118990
HOGENOMiHOG000234122
HOVERGENiHBG107547
InParanoidiQ9P296
KOiK04171
OMAiAACHWAL
OrthoDBiEOG091G0FUR
PhylomeDBiQ9P296
TreeFamiTF330976

Family and domain databases

InterProiView protein in InterPro
IPR001274 Anaphtx_C5AR1/C5AR2
IPR027809 Anaphtx_C5AR2
IPR000826 Formyl_rcpt-rel
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24225 PTHR24225, 1 hit
PTHR24225:SF1 PTHR24225:SF1, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 2 hits
PRINTSiPR00426 C5ANPHYLTXNR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9P296-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNDSVSYEY GDYSDLSDRP VDCLDGACLA IDPLRVAPLP LYAAIFLVGV
60 70 80 90 100
PGNAMVAWVA GKVARRRVGA TWLLHLAVAD LLCCLSLPIL AVPIARGGHW
110 120 130 140 150
PYGAVGCRAL PSIILLTMYA SVLLLAALSA DLCFLALGPA WWSTVQRACG
160 170 180 190 200
VQVACGAAWT LALLLTVPSA IYRRLHQEHF PARLQCVVDY GGSSSTENAV
210 220 230 240 250
TAIRFLFGFL GPLVAVASCH SALLCWAARR CRPLGTAIVV GFFVCWAPYH
260 270 280 290 300
LLGLVLTVAA PNSALLARAL RAEPLIVGLA LAHSCLNPML FLYFGRAQLR
310 320 330
RSLPAACHWA LRESQGQDES VDSKKSTSHD LVSEMEV
Length:337
Mass (Da):36,080
Last modified:October 1, 2000 - v1
Checksum:i53AF41B129FE8FE6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_068748233P → L1 PublicationCorresponds to variant dbSNP:rs149572881Ensembl.1
Natural variantiVAR_068749323S → I Rare polymorphism found in a family with familial combined hyperlipemia; associated with increased plasma triglyceride, plasma cholesterol, low-density lipoprotein cholesterol, apolipoprotein B and ASP. 2 PublicationsCorresponds to variant dbSNP:rs150599989Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038237 mRNA Translation: BAA95414.1
AF317655 Genomic DNA Translation: AAK12640.1
AY268430 Genomic DNA Translation: AAP23197.1
AK313994 mRNA Translation: BAG36706.1
AC008754 Genomic DNA No translation available.
CH471126 Genomic DNA Translation: EAW57472.1
BC067478 mRNA Translation: AAH67478.1
CCDSiCCDS12699.1
RefSeqiNP_001258678.1, NM_001271749.1
NP_001258679.1, NM_001271750.1
NP_060955.1, NM_018485.2
XP_011525038.1, XM_011526736.2
UniGeneiHs.534412

Genome annotation databases

EnsembliENST00000595464; ENSP00000472620; ENSG00000134830
ENST00000600626; ENSP00000471184; ENSG00000134830
GeneIDi27202
KEGGihsa:27202
UCSCiuc002pgk.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiC5AR2_HUMAN
AccessioniPrimary (citable) accession number: Q9P296
Secondary accession number(s): B2RA09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

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