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Protein

Serine/threonine-protein kinase 26

Gene

STK26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediator of cell growth (PubMed:11641781, PubMed:17360971). Modulates apoptosis (PubMed:11641781, PubMed:17360971). In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Interaction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-178, possibly as a consequence of stabilization of dimer formation. May also be activated by C-terminal cleavage.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei53ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei144Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi30 – 38ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • identical protein binding Source: IntAct
  • magnesium ion binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • protein kinase activity Source: UniProtKB
  • protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processApoptosis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-111465 Apoptotic cleavage of cellular proteins

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9P289

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9P289

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase 26Curated (EC:2.7.11.11 Publication)
Alternative name(s):
MST3 and SOK1-related kinase1 Publication
Mammalian STE20-like protein kinase 41 Publication
Short name:
MST-4Curated
Short name:
STE20-like kinase MST4Curated
Serine/threonine-protein kinase MASKCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STK26Imported
Synonyms:MASK1 Publication, MST41 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000134602.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18174 STK26

Online Mendelian Inheritance in Man (OMIM)

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MIMi
300547 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9P289

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

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DisGeNETi
51765

Open Targets

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OpenTargetsi
ENSG00000134602

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL5941

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MST4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
73621232

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000864042 – 416Serine/threonine-protein kinase 26Add BLAST415

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei4PhosphoserineCombined sources1
Modified residuei178Phosphothreonine; by autocatalysisCombined sources1 Publication1
Modified residuei300PhosphoserineCombined sources1
Modified residuei304PhosphoserineCombined sources1
Modified residuei306PhosphoserineCombined sources1
Modified residuei309PhosphoserineBy similarity1
Modified residuei325PhosphoserineCombined sources1
Modified residuei327PhosphothreonineCombined sources1
Modified residuei328PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9P289

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9P289

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9P289

PeptideAtlas

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PeptideAtlasi
Q9P289

PRoteomics IDEntifications database

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PRIDEi
Q9P289

ProteomicsDB human proteome resource

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ProteomicsDBi
83756
83757 [Q9P289-2]
83758 [Q9P289-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9P289

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9P289

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9P289

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q9P289

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000134602 Expressed in 198 organ(s), highest expression level in cauda epididymis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9P289 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9P289 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA059921

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:20730082). Interacts with PDCD10 (PubMed:17360971, PubMed:19370760, PubMed:20332113). Interacts with GOLGA2 (PubMed:15037601, PubMed:20332113). Interacts with CTTNBP2NL (PubMed:18782753). Interacts with RIPOR1 (via C-terminus); this interaction occurs in a PDCD10-dependent and Rho-independent manner (PubMed:27807006). Interacts with PDCD10; this interaction is required for the association of STK26 with RIPOR1 (PubMed:27807006).7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119722, 81 interactors

Database of interacting proteins

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DIPi
DIP-34049N

Protein interaction database and analysis system

More...
IntActi
Q9P289, 36 interactors

Molecular INTeraction database

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MINTi
Q9P289

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000377867

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9P289

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1416
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9P289

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9P289

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9P289

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 274Protein kinasePROSITE-ProRule annotationAdd BLAST251

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0201 Eukaryota
ENOG410XP9G LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157904

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000234203

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108518

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9P289

KEGG Orthology (KO)

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KOi
K08838

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9P289

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06640 STKc_MST4, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR035056 STK_MST4

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9P289-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAHSPVAVQV PGMQNNIADP EELFTKLERI GKGSFGEVFK GIDNRTQQVV
60 70 80 90 100
AIKIIDLEEA EDEIEDIQQE ITVLSQCDSS YVTKYYGSYL KGSKLWIIME
110 120 130 140 150
YLGGGSALDL LRAGPFDEFQ IATMLKEILK GLDYLHSEKK IHRDIKAANV
160 170 180 190 200
LLSEQGDVKL ADFGVAGQLT DTQIKRNTFV GTPFWMAPEV IQQSAYDSKA
210 220 230 240 250
DIWSLGITAI ELAKGEPPNS DMHPMRVLFL IPKNNPPTLV GDFTKSFKEF
260 270 280 290 300
IDACLNKDPS FRPTAKELLK HKFIVKNSKK TSYLTELIDR FKRWKAEGHS
310 320 330 340 350
DDESDSEGSD SESTSRENNT HPEWSFTTVR KKPDPKKVQN GAEQDLVQTL
360 370 380 390 400
SCLSMIITPA FAELKQQDEN NASRNQAIEE LEKSIAVAEA ACPGITDKMV
410
KKLIEKFQKC SADESP
Length:416
Mass (Da):46,529
Last modified:October 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3E31B7E3CBDA5768
GO
Isoform 2 (identifier: Q9P289-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-91: Missing.

Show »
Length:339
Mass (Da):37,770
Checksum:iE80868882811C8DE
GO
Isoform 3 (identifier: Q9P289-3) [UniParc]FASTAAdd to basket
Also known as: MST4a

The sequence of this isoform differs from the canonical sequence as follows:
     200-261: Missing.

Show »
Length:354
Mass (Da):39,658
Checksum:i34BF60E79E9A42B4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8NBY1Q8NBY1_HUMAN
Serine/threonine-protein kinase 26
STK26
392Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4E0Y9B4E0Y9_HUMAN
Serine/threonine-protein kinase 26
STK26
438Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0408449Q → R1 PublicationCorresponds to variant dbSNP:rs56035648Ensembl.1
Natural variantiVAR_04084536G → W in a gastric adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_04084645R → C1 PublicationCorresponds to variant dbSNP:rs56044451Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04146915 – 91Missing in isoform 2. 1 PublicationAdd BLAST77
Alternative sequenceiVSP_041470200 – 261Missing in isoform 3. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF231012 mRNA Translation: AAK38484.1
AF344882 mRNA Translation: AAK29620.1
AF344883 mRNA Translation: AAK29621.1
AB040057 mRNA Translation: BAA92785.2
BT020099 mRNA Translation: AAV38902.1
AK075107 mRNA Translation: BAC11406.1
AK314356 mRNA Translation: BAG36989.1
AL109749 Genomic DNA No translation available.
CH471107 Genomic DNA Translation: EAX11786.1
CH471107 Genomic DNA Translation: EAX11787.1
BC098315 mRNA Translation: AAH98315.1
BC103503 mRNA Translation: AAI03504.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS14631.1 [Q9P289-1]
CCDS43995.1 [Q9P289-3]
CCDS48168.1 [Q9P289-2]

NCBI Reference Sequences

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RefSeqi
NP_001035917.1, NM_001042452.1 [Q9P289-3]
NP_001035918.1, NM_001042453.1 [Q9P289-2]
NP_057626.2, NM_016542.3 [Q9P289-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.444247

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000394334; ENSP00000377867; ENSG00000134602 [Q9P289-1]
ENST00000394335; ENSP00000377868; ENSG00000134602 [Q9P289-2]
ENST00000496850; ENSP00000419702; ENSG00000134602 [Q9P289-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
51765

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:51765

UCSC genome browser

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UCSCi
uc004ewk.2 human [Q9P289-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231012 mRNA Translation: AAK38484.1
AF344882 mRNA Translation: AAK29620.1
AF344883 mRNA Translation: AAK29621.1
AB040057 mRNA Translation: BAA92785.2
BT020099 mRNA Translation: AAV38902.1
AK075107 mRNA Translation: BAC11406.1
AK314356 mRNA Translation: BAG36989.1
AL109749 Genomic DNA No translation available.
CH471107 Genomic DNA Translation: EAX11786.1
CH471107 Genomic DNA Translation: EAX11787.1
BC098315 mRNA Translation: AAH98315.1
BC103503 mRNA Translation: AAI03504.1
CCDSiCCDS14631.1 [Q9P289-1]
CCDS43995.1 [Q9P289-3]
CCDS48168.1 [Q9P289-2]
RefSeqiNP_001035917.1, NM_001042452.1 [Q9P289-3]
NP_001035918.1, NM_001042453.1 [Q9P289-2]
NP_057626.2, NM_016542.3 [Q9P289-1]
UniGeneiHs.444247

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3GGFX-ray2.35A/B1-300[»]
3W8IX-ray2.40B346-416[»]
4FZAX-ray3.15B18-297[»]
4FZDX-ray3.25B18-297[»]
C323-327[»]
4FZFX-ray3.64B18-297[»]
4GEHX-ray1.95B/D325-413[»]
5XY9X-ray2.30C/D314-325[»]
5YF4X-ray1.90B320-335[»]
ProteinModelPortaliQ9P289
SMRiQ9P289
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119722, 81 interactors
DIPiDIP-34049N
IntActiQ9P289, 36 interactors
MINTiQ9P289
STRINGi9606.ENSP00000377867

Chemistry databases

BindingDBiQ9P289
ChEMBLiCHEMBL5941

PTM databases

iPTMnetiQ9P289
PhosphoSitePlusiQ9P289
SwissPalmiQ9P289

Polymorphism and mutation databases

BioMutaiMST4
DMDMi73621232

Proteomic databases

EPDiQ9P289
MaxQBiQ9P289
PaxDbiQ9P289
PeptideAtlasiQ9P289
PRIDEiQ9P289
ProteomicsDBi83756
83757 [Q9P289-2]
83758 [Q9P289-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
51765
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394334; ENSP00000377867; ENSG00000134602 [Q9P289-1]
ENST00000394335; ENSP00000377868; ENSG00000134602 [Q9P289-2]
ENST00000496850; ENSP00000419702; ENSG00000134602 [Q9P289-3]
GeneIDi51765
KEGGihsa:51765
UCSCiuc004ewk.2 human [Q9P289-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51765
DisGeNETi51765
EuPathDBiHostDB:ENSG00000134602.15

GeneCards: human genes, protein and diseases

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GeneCardsi
STK26
HGNCiHGNC:18174 STK26
HPAiHPA059921
MIMi300547 gene
neXtProtiNX_Q9P289
OpenTargetsiENSG00000134602

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0201 Eukaryota
ENOG410XP9G LUCA
GeneTreeiENSGT00940000157904
HOGENOMiHOG000234203
HOVERGENiHBG108518
InParanoidiQ9P289
KOiK08838
PhylomeDBiQ9P289

Enzyme and pathway databases

ReactomeiR-HSA-111465 Apoptotic cleavage of cellular proteins
SignaLinkiQ9P289
SIGNORiQ9P289

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
STK26 human
EvolutionaryTraceiQ9P289

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MST4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51765
PMAP-CutDBiQ9P289

Protein Ontology

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PROi
PR:Q9P289

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000134602 Expressed in 198 organ(s), highest expression level in cauda epididymis
ExpressionAtlasiQ9P289 baseline and differential
GenevisibleiQ9P289 HS

Family and domain databases

CDDicd06640 STKc_MST4, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR035056 STK_MST4
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTK26_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P289
Secondary accession number(s): B2RAU2
, Q3ZB77, Q8NC04, Q9BXC3, Q9BXC4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: October 1, 2001
Last modified: December 5, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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