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UniProtKB - Q9P275 (UBP36_HUMAN)

Entry version 178 (02 Jun 2021)
Sequence version 4 (28 Mar 2018)
Previous versions | rss
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Protein

Ubiquitin carboxyl-terminal hydrolase 36

Gene

USP36

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Deubiquitinase essential for the regulation of nucleolar structure and function. Required for cell and organism viability. Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability (PubMed:29273634, PubMed:19208757, PubMed:22902402).

Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (PubMed:29274341).

Specifically deubiquitinates MYC in the nucleolus, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 3 of FBXW7 (FBW7gamma) in the nucleolus and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm (PubMed:25775507).

Interacts to and regulates the actions of E3 ubiquitin-protein ligase NEDD4L over substrates such as NTRK1, KCNQ2 and KCNQ3, affecting their expression an functions (PubMed:27445338).

Deubiquitinates SOD2, regulates SOD2 protein stability (PubMed:21268071).

Deubiquitinase activity is required to control selective autophagy activation by ubiquitinated proteins (PubMed:22622177).

8 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei131NucleophilePROSITE-ProRule annotation5 Publications1
Active sitei382Proton acceptorPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9P275

Protein family/group databases

MEROPS protease database

More...MEROPSi		C19.042

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 36Curated (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 36
Ubiquitin thioesterase 36
Ubiquitin-specific-processing protease 36
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:USP36Imported
Synonyms:KIAA1453
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:20062, USP36

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		612543, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9P275

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000055483.19

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi131C → A or S: Abolishes deubiquitinase activity. No effect on NTRK1 ubiquitination levels. 5 Publications1

Organism-specific databases

DisGeNET

More...DisGeNETi		57602

Open Targets

More...OpenTargetsi		ENSG00000055483

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134949090

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9P275, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		USP36

Domain mapping of disease mutations (DMDM)

More...DMDMi		124056592

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000806661 – 1123Ubiquitin carboxyl-terminal hydrolase 36Add BLAST1123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei429PhosphoserineCombined sources1
Modified residuei464PhosphoserineCombined sources1
Modified residuei546PhosphoserineCombined sources1
Modified residuei582PhosphoserineCombined sources1
Modified residuei667PhosphoserineCombined sources1
Modified residuei682PhosphoserineCombined sources1
Modified residuei713PhosphoserineCombined sources1
Modified residuei742PhosphoserineCombined sources1
Modified residuei952PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Polyubiquitinated by NEDD4L, no effect on USP36 protein levels. Both proteins interact with and regulate each other's ubiquitination levels.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9P275

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9P275

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9P275

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9P275

PeptideAtlas

More...PeptideAtlasi		Q9P275

PRoteomics IDEntifications database

More...PRIDEi		Q9P275

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		Q9P275

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		Q9P275

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9P275

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9P275

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9P275

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Broadly expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000055483, Expressed in adenohypophysis and 226 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9P275, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9P275, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000055483, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with isoform 3 of FBXW7; the interaction inhibits MYC degradation induced by SCF(FBW7) complex (PubMed:25775507).

Interacts with NTRK1; USP36 does not deubiquitinate NTRK1 (PubMed:27445338).

Interacts with NEDD4L (via domains WW1, 3 and 4); the interaction inhibits ubiquitination of, at least, NTRK1, KCNQ2 and KCNQ3 by NEDD4L (PubMed:27445338).

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121651, 78 interactors

Protein interaction database and analysis system

More...IntActi		Q9P275, 35 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000441214

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9P275, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9P275

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini122 – 423USPAdd BLAST302

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 22DisorderedSequence analysisAdd BLAST22
Regioni67 – 95DisorderedSequence analysisAdd BLAST29
Regioni430 – 577DisorderedSequence analysisAdd BLAST148
Regioni589 – 999DisorderedSequence analysisAdd BLAST411

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi70 – 89Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi432 – 446Polar residuesSequence analysisAdd BLAST15
Compositional biasi457 – 471Polar residuesSequence analysisAdd BLAST15
Compositional biasi487 – 501Polar residuesSequence analysisAdd BLAST15
Compositional biasi549 – 577Polar residuesSequence analysisAdd BLAST29
Compositional biasi605 – 681Polar residuesSequence analysisAdd BLAST77
Compositional biasi742 – 758Polar residuesSequence analysisAdd BLAST17
Compositional biasi765 – 788Polar residuesSequence analysisAdd BLAST24
Compositional biasi858 – 872Polar residuesSequence analysisAdd BLAST15
Compositional biasi886 – 906Polar residuesSequence analysisAdd BLAST21
Compositional biasi917 – 932Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi964 – 979Basic and acidic residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1865, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157948

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9P275

Identification of Orthologs from Complete Genome Data

More...OMAi		KPPGMSE

Database of Orthologous Groups

More...OrthoDBi		929408at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9P275

TreeFam database of animal gene trees

More...TreeFami		TF315281

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR001394, Peptidase_C19_UCH
IPR018200, USP_CS
IPR028889, USP_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00443, UCH, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54001, SSF54001, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00972, USP_1, 1 hit
PS00973, USP_2, 1 hit
PS50235, USP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 16 potential isoforms that are computationally mapped.Show allAlign All

Q9P275-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPIVDKLKEA LKPGRKDSAD DGELGKLLAS SAKKVLLQKI EFEPASKSFS 
        60         70         80         90        100
YQLEALKSKY VLLNPKTEGA SRHKSGDDPP ARRQGSEHTY ESCGDGVPAP 
       110        120        130        140        150
QKVLFPTERL SLRWERVFRV GAGLHNLGNT CFLNATIQCL TYTPPLANYL 
       160        170        180        190        200
LSKEHARSCH QGSFCMLCVM QNHIVQAFAN SGNAIKPVSF IRDLKKIARH 
       210        220        230        240        250
FRFGNQEDAH EFLRYTIDAM QKACLNGCAK LDRQTQATTL VHQIFGGYLR 
       260        270        280        290        300
SRVKCSVCKS VSDTYDPYLD VALEIRQAAN IVRALELFVK ADVLSGENAY 
       310        320        330        340        350
MCAKCKKKVP ASKRFTIHRT SNVLTLSLKR FANFSGGKIT KDVGYPEFLN 
       360        370        380        390        400
IRPYMSQNNG DPVMYGLYAV LVHSGYSCHA GHYYCYVKAS NGQWYQMNDS 
       410        420        430        440        450
LVHSSNVKVV LNQQAYVLFY LRIPGSKKSP EGLISRTGSS SLPGRPSVIP 
       460        470        480        490        500
DHSKKNIGNG IISSPLTGKR QDSGTMKKPH TTEEIGVPIS RNGSTLGLKS 
       510        520        530        540        550
QNGCIPPKLP SGSPSPKLSQ TPTHMPTILD DPGKKVKKPA PPQHFSPRTA 
       560        570        580        590        600
QGLPGTSNSN SSRSGSQRQG SWDSRDVVLS TSPKLLATAT ANGHGLKGND 
       610        620        630        640        650
ESAGLDRRGS SSSSPEHSAS SDSTKAPQTP RSGAAHLCDS QETNCSTAGH 
       660        670        680        690        700
SKTPPSGADS KTVKLKSPVL SNTTTEPAST MSPPPAKKLA LSAKKASTLW 
       710        720        730        740        750
RATGNDLRPP PPSPSSDLTH PMKTSHPVVA STWPVHRARA VSPAPQSSSR 
       760        770        780        790        800
LQPPFSPHPT LLSSTPKPPG TSEPRSCSSI STALPQVNED LVSLPHQLPE 
       810        820        830        840        850
ASEPPQSPSE KRKKTFVGEP QRLGSETRLP QHIREATAAP HGKRKRKKKK 
       860        870        880        890        900
RPEDTAASAL QEGQTQRQPG SPMYRREGQA QLPAVRRQED GTQPQVNGQQ 
       910        920        930        940        950
VGCVTDGHHA SSRKRRRKGA EGLGEEGGLH QDPLRHSCSP MGDGDPEAME 
       960        970        980        990       1000
ESPRKKKKKK RKQETQRAVE EDGHLKCPRS AKPQDAVVPE SSSCAPSANG 
      1010       1020       1030       1040       1050
WCPGDRMGLS QAPPVSWNGE RESDVVQELL KYSSDKAYGR KVLTWDGKMS 
      1060       1070       1080       1090       1100
AVSQDAIEDS RQARTETVVD DWDEEFDRGK EKKIKKFKRE KRRNFNAFQK 
      1110       1120 
LQTRRNFWSV THPAKAASLS YRR
Length:1,123
Mass (Da):122,908
Last modified:March 28, 2018 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i65CD93C1B8655319
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PEW0E9PEW0_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP36
548Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A075B784A0A075B784_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP36
961Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EMM6K7EMM6_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP36
259Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ELR5K7ELR5_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP36
234Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQS0K7EQS0_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP36
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPT1K7EPT1_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP36
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8IXW9Q8IXW9_HUMAN
USP36 protein
USP36
285Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ELT3K7ELT3_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP36
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KQ92U3KQ92_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP36
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EIH0K7EIH0_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP36
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH16487 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA95977 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti82R → G in AAH71582 (PubMed:15489334).Curated1
Sequence conflicti573D → G in BAA91825 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037277271V → I1 PublicationCorresponds to variant dbSNP:rs3744793Ensembl.1
Natural variantiVAR_037278489I → M. Corresponds to variant dbSNP:rs3744795Ensembl.1
Natural variantiVAR_037279775R → Q. Corresponds to variant dbSNP:rs9889908Ensembl.1
Natural variantiVAR_037280806Q → R3 PublicationsCorresponds to variant dbSNP:rs3088040Ensembl.1
Natural variantiVAR_037281814K → N. Corresponds to variant dbSNP:rs3744797Ensembl.1
Natural variantiVAR_037282828R → C2 PublicationsCorresponds to variant dbSNP:rs1057040Ensembl.1
Natural variantiVAR_058034887R → P1 PublicationCorresponds to variant dbSNP:rs61760231EnsemblClinVar.1
Natural variantiVAR_080193959 – 960Missing 1 PublicationCorresponds to variant dbSNP:rs866027510Ensembl.2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB040886 mRNA Translation: BAA95977.1 Different initiation.
BC016487 mRNA Translation: AAH16487.1 Sequence problems.
BC027992 mRNA Translation: AAH27992.1
BC071582 mRNA Translation: AAH71582.1
AK001671 mRNA Translation: BAA91825.1
AL833835 mRNA Translation: CAD38695.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32755.1

NCBI Reference Sequences

More...RefSeqi		NP_001308220.1, NM_001321291.1
XP_005257599.1, XM_005257542.2
XP_005257600.1, XM_005257543.2
XP_016880389.1, XM_017024900.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000312010; ENSP00000310590; ENSG00000055483
ENST00000542802; ENSP00000441214; ENSG00000055483
ENST00000589225; ENSP00000467280; ENSG00000055483

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57602

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:57602

UCSC genome browser

More...UCSCi		uc002jvz.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040886 mRNA Translation: BAA95977.1 Different initiation.
BC016487 mRNA Translation: AAH16487.1 Sequence problems.
BC027992 mRNA Translation: AAH27992.1
BC071582 mRNA Translation: AAH71582.1
AK001671 mRNA Translation: BAA91825.1
AL833835 mRNA Translation: CAD38695.1
CCDSiCCDS32755.1
RefSeqiNP_001308220.1, NM_001321291.1
XP_005257599.1, XM_005257542.2
XP_005257600.1, XM_005257543.2
XP_016880389.1, XM_017024900.1

3D structure databases

SMRiQ9P275
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121651, 78 interactors
IntActiQ9P275, 35 interactors
STRINGi9606.ENSP00000441214

Protein family/group databases

MEROPSiC19.042

PTM databases

CarbonylDBiQ9P275
iPTMnetiQ9P275
PhosphoSitePlusiQ9P275
SwissPalmiQ9P275

Genetic variation databases

BioMutaiUSP36
DMDMi124056592

2D gel databases

SWISS-2DPAGEiQ9P275

Proteomic databases

EPDiQ9P275
jPOSTiQ9P275
MassIVEiQ9P275
PaxDbiQ9P275
PeptideAtlasiQ9P275
PRIDEiQ9P275

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1709, 230 antibodies

The DNASU plasmid repository

More...DNASUi		57602

Genome annotation databases

EnsembliENST00000312010; ENSP00000310590; ENSG00000055483
ENST00000542802; ENSP00000441214; ENSG00000055483
ENST00000589225; ENSP00000467280; ENSG00000055483
GeneIDi57602
KEGGihsa:57602
UCSCiuc002jvz.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57602
DisGeNETi57602

GeneCards: human genes, protein and diseases

More...GeneCardsi		USP36
HGNCiHGNC:20062, USP36
HPAiENSG00000055483, Low tissue specificity
MIMi612543, gene
neXtProtiNX_Q9P275
OpenTargetsiENSG00000055483
PharmGKBiPA134949090
VEuPathDBiHostDB:ENSG00000055483.19

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1865, Eukaryota
GeneTreeiENSGT00940000157948
InParanoidiQ9P275
OMAiKPPGMSE
OrthoDBi929408at2759
PhylomeDBiQ9P275
TreeFamiTF315281

Enzyme and pathway databases

PathwayCommonsiQ9P275

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		57602, 557 hits in 1003 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		USP36, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		USP36

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		57602
PharosiQ9P275, Tbio

Protein Ontology

More...PROi		PR:Q9P275
RNActiQ9P275, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000055483, Expressed in adenohypophysis and 226 other tissues
ExpressionAtlasiQ9P275, baseline and differential
GenevisibleiQ9P275, HS

Family and domain databases

InterProiView protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR001394, Peptidase_C19_UCH
IPR018200, USP_CS
IPR028889, USP_dom
PfamiView protein in Pfam
PF00443, UCH, 1 hit
SUPFAMiSSF54001, SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00972, USP_1, 1 hit
PS00973, USP_2, 1 hit
PS50235, USP_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBP36_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P275
Secondary accession number(s): Q05C98
, Q05DD0, Q6IQ38, Q8NDM8, Q9NVC8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: March 28, 2018
Last modified: June 2, 2021
This is version 178 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families
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