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Protein

SLAIN motif-containing protein 2

Gene

SLAIN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei581Important for interaction with CLIP11

GO - Biological processi

  • cytoplasmic microtubule organization Source: UniProtKB
  • microtubule nucleation Source: UniProtKB
  • positive regulation of microtubule polymerization Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
SLAIN motif-containing protein 2
Gene namesi
Name:SLAIN2
Synonyms:KIAA1458
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000109171.14
HGNCiHGNC:29282 SLAIN2
MIMi610492 gene
neXtProtiNX_Q9P270

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi581Missing : Abolishes interaction with CLIP1. 1 Publication1

Organism-specific databases

DisGeNETi57606
OpenTargetsiENSG00000109171
PharmGKBiPA162403457

Polymorphism and mutation databases

BioMutaiSLAIN2
DMDMi166977679

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003169651 – 581SLAIN motif-containing protein 2Add BLAST581

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei43PhosphoserineCombined sources1
Modified residuei48PhosphoserineCombined sources1
Modified residuei63PhosphoserineCombined sources1
Modified residuei88PhosphoserineBy similarity1
Modified residuei134PhosphoserineCombined sources1
Modified residuei147PhosphoserineCombined sources1
Modified residuei160PhosphoserineCombined sources1
Modified residuei179PhosphoserineCombined sources1
Modified residuei247PhosphoserineCombined sources1
Modified residuei250PhosphoserineCombined sources1
Modified residuei251PhosphoserineCombined sources1
Modified residuei254PhosphoserineCombined sources1
Modified residuei315PhosphoserineCombined sources1
Modified residuei323PhosphoserineCombined sources1
Modified residuei377PhosphoserineCombined sources1
Modified residuei391PhosphoserineCombined sources1
Modified residuei413PhosphoserineCombined sources1
Modified residuei433PhosphoserineCombined sources1
Modified residuei456PhosphoserineCombined sources1
Modified residuei462PhosphoserineCombined sources1
Modified residuei467PhosphoserineCombined sources1
Modified residuei538Omega-N-methylarginineBy similarity1
Modified residuei551Omega-N-methylarginineCombined sources1

Post-translational modificationi

Is highly phosphorylated during mitosis, but not during interphase. The highly phosphorylated form does not localize at microtubule plus ends and does not interact with MAPRE1 or CKAP5.1 Publication

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ9P270
MaxQBiQ9P270
PaxDbiQ9P270
PeptideAtlasiQ9P270
PRIDEiQ9P270
ProteomicsDBi83740

PTM databases

iPTMnetiQ9P270
PhosphoSitePlusiQ9P270

Expressioni

Tissue specificityi

Widely expressed with highest levels in adult liver, testis and ovary, and lowest levels in adult pancreas and spleen and in fetal brain.1 Publication

Gene expression databases

BgeeiENSG00000109171
CleanExiHS_SLAIN2
ExpressionAtlasiQ9P270 baseline and differential
GenevisibleiQ9P270 HS

Organism-specific databases

HPAiHPA035824
HPA063599

Interactioni

Subunit structurei

Interacts with CLIP1, CLIP2, CKAP5, CLASP1, MAPRE1 and MAPRE3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CKAP5Q140084EBI-3959887,EBI-310585

Protein-protein interaction databases

BioGridi121654, 52 interactors
ELMiQ9P270
IntActiQ9P270, 47 interactors
MINTiQ9P270
STRINGi9606.ENSP00000264313

Structurei

Secondary structure

1581
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi575 – 577Combined sources3

3D structure databases

ProteinModelPortaliQ9P270
SMRiQ9P270
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili4 – 391 PublicationAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi124 – 128Poly-Glu5

Domaini

The N-terminus forms a two-stranded coiled coil.

Sequence similaritiesi

Belongs to the SLAIN motif-containing family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IF0R Eukaryota
ENOG410XPVV LUCA
GeneTreeiENSGT00390000017860
HOGENOMiHOG000057277
HOVERGENiHBG072961
InParanoidiQ9P270
KOiK16580
OMAiMQKSVSP
OrthoDBiEOG091G057F
PhylomeDBiQ9P270
TreeFamiTF331616

Family and domain databases

InterProiView protein in InterPro
IPR026179 Slain
PANTHERiPTHR22406 PTHR22406, 1 hit
PfamiView protein in Pfam
PF15301 SLAIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q9P270-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDVNSNVNA DQEVRKLQEL VKKLEKQNEQ LRSRSGAVQG AGSLGPGSPV
60 70 80 90 100
RAGASIPSSG AASPRGFPLG LSAKSGGGPG SGPRRTSSEE LRDATSLLAA
110 120 130 140 150
GEGGLLDEVE PLRPDELERL SGWEEEEESW LYSSPKKKLT PMQKSVSPLV
160 170 180 190 200
WCRQVLDYPS PDVECAKKSL IHKLDQTMSA LKRQNLYNNP FNSMSYTSPY
210 220 230 240 250
SPNASSPYSS GFNSPSSTPV RPPIVKQLIL PGNSGNLKSS DRNPPLSPQS
260 270 280 290 300
SIDSELSASE LDEDSIGSNY KLNDVTDVQI LARMQEESLR QEYAATTSRR
310 320 330 340 350
SSGSSCNSTR RGTFSDQELD AQSLDDEDDN MHHAVYPAVN RFSPSPRNSP
360 370 380 390 400
RPSPKQSPRN SPRSRSPARG IEYSRVSPQP MISRLQQPRL SLQGHPTDLQ
410 420 430 440 450
TSNVKNEEKL RRSLPNLSRT SNTQVDSVKS SRSDSNFQVP NGGIPRMQPQ
460 470 480 490 500
ASAIPSPGKF RSPAAPSPLA LRQPVKAFSN HGSGSPGSQE ITQLTQTTSS
510 520 530 540 550
PGPPMVQSTV SANPPSNINS ATLTRPAGTT AMRSGLPRPS APSAGGIPVP
560 570 580
RSKLAQPVRR SLPAPKTYGS MKDDSWKDGC Y
Length:581
Mass (Da):62,543
Last modified:February 5, 2008 - v2
Checksum:i44B10B1BBD555B26
GO

Sequence cautioni

The sequence AAH31691 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA95982 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti233N → D in BAF83695 (PubMed:14702039).Curated1
Sequence conflicti558V → A in BAF83695 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040891 mRNA Translation: BAA95982.1 Different initiation.
AK291006 mRNA Translation: BAF83695.1
BC031691 mRNA Translation: AAH31691.2 Different initiation.
CCDSiCCDS47051.1
RefSeqiNP_065897.1, NM_020846.1
UniGeneiHs.479677

Genome annotation databases

EnsembliENST00000264313; ENSP00000264313; ENSG00000109171
GeneIDi57606
KEGGihsa:57606
UCSCiuc003gya.5 human

Similar proteinsi

Entry informationi

Entry nameiSLAI2_HUMAN
AccessioniPrimary (citable) accession number: Q9P270
Secondary accession number(s): A8K4P1, Q8N5R3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: June 20, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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