UniProtKB - Q9P253 (VPS18_HUMAN)

BLAST

>sp|Q9P253|VPS18_HUMAN Vacuolar protein sorting-associated protein 18 homolog OS=Homo sapiens OX=9606 GN=VPS18 PE=1 SV=2
MASILDEYENSLSRSAVLQPGCPSVGIPHSGYVNAQLEKEVPIFTKQRIDFTPSERITSL
VVSSNQLCMSLGKDTLLRIDLGKANEPNHVELGRKDDAKVHKMFLDHTGSHLLIALSSTE
VLYVNRNGQKVRPLARWKGQLVESVGWNKALGTESSTGPILVGTAQGHIFEAELSASEGG
LFGPAPDLYFRPLYVLNEEGGPAPVCSLEAERGPDGRSFVIATTRQRLFQFIGRAAEGAE
AQGFSGLFAAYTDHPPPFREFPSNLGYSELAFYTPKLRSAPRAFAWMMGDGVLYGALDCG
RPDSLLSEERVWEYPEGVGPGASPPLAIVLTQFHFLLLLADRVEAVCTLTGQVVLRDHFL
EKFGPLKHMVKDSSTGQLWAYTERAVFRYHVQREARDVWRTYLDMNRFDLAKEYCRERPD
CLDTVLAREADFCFRQRRYLESARCYALTQSYFEEIALKFLEARQEEALAEFLQRKLASL
KPAERTQATLLTTWLTELYLSRLGALQGDPEALTLYRETKECFRTFLSSPRHKEWLFASR
ASIHELLASHGDTEHMVYFAVIMQDYERVVAYHCQHEAYEEALAVLARHRDPQLFYKFSP
ILIRHIPRQLVDAWIEMGSRLDARQLIPALVNYSQGGEVQQVSQAIRYMEFCVNVLGETE
QAIHNYLLSLYARGRPDSLLAYLEQAGASPHRVHYDLKYALRLCAEHGHHRACVHVYKVL
ELYEEAVDLALQVDVDLAKQCADLPEEDEELRKKLWLKIARHVVQEEEDVQTAMACLASC
PLLKIEDVLPFFPDFVTIDHFKEAICSSLKAYNHHIQELQREMEEATASAQRIRRDLQEL
RGRYGTVEPQDKCATCDFPLLNRPFYLFLCGHMFHADCLLQAVRPGLPAYKQARLEELQR
KLGAAPPPAKGSARAKEAEGGAATAGPSREQLKADLDELVAAECVYCGELMIRSIDRPFI
DPQRYEEEQLSWL

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History
Entry version 163 (07 Nov 2018)
Sequence version 2 (19 Sep 2002)
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Protein

Vacuolar protein sorting-associated protein 18 homolog

Gene

VPS18

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in dendrite development of Pukinje cells (By similarity).By similarity3 Publications1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	853 – 947	RING-typeAdd BLAST		95

GO - Molecular functionⁱ

actin binding Source: Ensembl
metal ion binding Source: UniProtKB-KW
protein binding, bridging
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
syntaxin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 11382755

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

autophagy Source: UniProtKB-KW
endosome organization
Source: UniProtKB
Inferred from direct assayⁱ
- 18799622
endosome to lysosome transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25783203
intracellular protein transport Source: InterPro
lysosome organization
Source: UniProtKB
Inferred from direct assayⁱ
- 18799622
regulation of SNARE complex assembly
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of synaptic vesicle exocytosis
Source: SynGO
Inferred from direct assayⁱ
- 17027648
vesicle docking involved in exocytosis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
viral entry into host cell Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Autophagy, Protein transport, Transport
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Vacuolar protein sorting-associated protein 18 homolog Short name: hVPS18
Gene namesⁱ	Name:VPS18 Synonyms:KIAA1475
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000104142.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15972 VPS18
MIMⁱ	608551 gene
neXtProtⁱ	NX_Q9P253

Keywords - Cellular componentⁱ

Cytoplasmic vesicle, Endosome, Lysosome, Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000104142
PharmGKBⁱ	PA38069

Polymorphism and mutation databases

BioMutaⁱ	VPS18
DMDMⁱ	23396938

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000055906	2 – 973	Vacuolar protein sorting-associated protein 18 homologAdd BLAST		972

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Modified residueⁱ	3	PhosphoserineCombined sources	1
Modified residueⁱ	11	PhosphoserineCombined sources	1
Modified residueⁱ	13	PhosphoserineCombined sources	1
Modified residueⁱ	362	N6-acetyllysineCombined sources	1
Modified residueⁱ	689	PhosphoserineCombined sources	1
Modified residueⁱ	912	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9P253
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9P253
PaxDbⁱ	Q9P253
PeptideAtlas More...PeptideAtlasⁱ	Q9P253
PRIDEⁱ	Q9P253
ProteomicsDBⁱ	83731

PTM databases

iPTMnetⁱ	Q9P253
PhosphoSitePlusⁱ	Q9P253

Expressionⁱ

Tissue specificityⁱ

Ubiquitous. Expression was highest in heart and low in lung.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000104142 Expressed in 181 organ(s), highest expression level in tendon of biceps brachii
CleanExⁱ	HS_VPS18
ExpressionAtlasⁱ	Q9P253 baseline and differential
Genevisibleⁱ	Q9P253 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA040701

HPAⁱ

HPA040701

Interactionⁱ

Subunit structureⁱ

Core component of at least two putative endosomal tethering complexes, the homotypic fusion and vacuole protein sorting (HOPS) complex and the class C core vacuole/endosome tethering (CORVET) complex. Their common core is composed of the class C Vps proteins VPS11, VPS16, VPS18 and VPS33A, which in HOPS further associates with VPS39 and VPS41 and in CORVET with VPS8 and TGFBRAP1 (PubMed:23351085, PubMed:25783203, PubMed:23901104). Interacts with RAB5C (By similarity). Interacts with HOOK1 (By similarity). Interacts with STX7, MON1B (PubMed:20434987, PubMed:24554770). Associates with adaptor protein complex 3 (AP-3) and clathrin:AP-3 complexes (By similarity). Interacts with SYNPO2 (PubMed:23434281).By similarity1 Publication6 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
MON1B	Q7L1V2	2	EBI-1053363,EBI-2655311
STX7	O15400	2	EBI-1053363,EBI-3221827
VPS11	Q9H270	8	EBI-1053363,EBI-373380
VPS16	Q9H269	15	EBI-1053363,EBI-2655929
VPS33A	Q96AX1	6	EBI-1053363,EBI-2527283
Vps33a	Q63615	2	EBI-1053363,EBI-918669	From Rattus norvegicus.
VPS41	P49754	3	EBI-1053363,EBI-2130459

GO - Molecular functionⁱ

actin binding Source: Ensembl
protein binding, bridging
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
syntaxin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 11382755

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	121664, 58 interactors
CORUMⁱ	Q9P253
IntActⁱ	Q9P253, 38 interactors
STRINGⁱ	9606.ENSP00000220509

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9P253
SMRⁱ	Q9P253
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Repeatⁱ	618 – 772	CHCRAdd BLAST		155

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	454 – 481	Sequence analysisAdd BLAST		28
Coiled coilⁱ	802 – 848	Sequence analysisAdd BLAST		47

Sequence similaritiesⁱ

Belongs to the VPS18 family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	853 – 947	RING-typeAdd BLAST		95

Keywords - Domainⁱ

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG2034 Eukaryota ENOG410XRSD LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000015233
HOGENOMⁱ	HOG000172497
HOVERGENⁱ	HBG057876
InParanoidⁱ	Q9P253
KEGG Orthology (KO) More...KOⁱ	K20181
OMAⁱ	DAWIEMG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01XI
PhylomeDBⁱ	Q9P253
TreeFamⁱ	TF105704

Family and domain databases

InterProⁱ	View protein in InterPro IPR000547 Clathrin_H-chain/VPS_repeat IPR007810 Pep3_Vps18
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00637 Clathrin, 1 hit PF05131 Pep3_Vps18, 1 hit
PROSITEⁱ	View protein in PROSITE PS50236 CHCR, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q9P253-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASILDEYEN SLSRSAVLQP GCPSVGIPHS GYVNAQLEKE VPIFTKQRID 
        60         70         80         90        100
FTPSERITSL VVSSNQLCMS LGKDTLLRID LGKANEPNHV ELGRKDDAKV 
       110        120        130        140        150
HKMFLDHTGS HLLIALSSTE VLYVNRNGQK VRPLARWKGQ LVESVGWNKA 
       160        170        180        190        200
LGTESSTGPI LVGTAQGHIF EAELSASEGG LFGPAPDLYF RPLYVLNEEG 
       210        220        230        240        250
GPAPVCSLEA ERGPDGRSFV IATTRQRLFQ FIGRAAEGAE AQGFSGLFAA 
       260        270        280        290        300
YTDHPPPFRE FPSNLGYSEL AFYTPKLRSA PRAFAWMMGD GVLYGALDCG 
       310        320        330        340        350
RPDSLLSEER VWEYPEGVGP GASPPLAIVL TQFHFLLLLA DRVEAVCTLT 
       360        370        380        390        400
GQVVLRDHFL EKFGPLKHMV KDSSTGQLWA YTERAVFRYH VQREARDVWR 
       410        420        430        440        450
TYLDMNRFDL AKEYCRERPD CLDTVLAREA DFCFRQRRYL ESARCYALTQ 
       460        470        480        490        500
SYFEEIALKF LEARQEEALA EFLQRKLASL KPAERTQATL LTTWLTELYL 
       510        520        530        540        550
SRLGALQGDP EALTLYRETK ECFRTFLSSP RHKEWLFASR ASIHELLASH 
       560        570        580        590        600
GDTEHMVYFA VIMQDYERVV AYHCQHEAYE EALAVLARHR DPQLFYKFSP 
       610        620        630        640        650
ILIRHIPRQL VDAWIEMGSR LDARQLIPAL VNYSQGGEVQ QVSQAIRYME 
       660        670        680        690        700
FCVNVLGETE QAIHNYLLSL YARGRPDSLL AYLEQAGASP HRVHYDLKYA 
       710        720        730        740        750
LRLCAEHGHH RACVHVYKVL ELYEEAVDLA LQVDVDLAKQ CADLPEEDEE 
       760        770        780        790        800
LRKKLWLKIA RHVVQEEEDV QTAMACLASC PLLKIEDVLP FFPDFVTIDH 
       810        820        830        840        850
FKEAICSSLK AYNHHIQELQ REMEEATASA QRIRRDLQEL RGRYGTVEPQ 
       860        870        880        890        900
DKCATCDFPL LNRPFYLFLC GHMFHADCLL QAVRPGLPAY KQARLEELQR 
       910        920        930        940        950
KLGAAPPPAK GSARAKEAEG GAATAGPSRE QLKADLDELV AAECVYCGEL 
       960        970 
MIRSIDRPFI DPQRYEEEQL SWL

Length:973

Mass (Da):110,186

Last modified:September 19, 2002 - v2

Checksum:ⁱ0008E21D66E8CFEC

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YLM6	H0YLM6_HUMAN	Vacuolar protein sorting-associated... Vacuolar protein sorting-associated protein 18 homolog	VPS18	130	Annotation score:
H0YMC9	H0YMC9_HUMAN	Vacuolar protein sorting-associated... Vacuolar protein sorting-associated protein 18 homolog	VPS18	121	Annotation score:

Sequence cautionⁱ

The sequence AAH01513 differs from that shown. Unlikely isoform. Aberrant splice sites.Curated

The sequence BAA95999 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_035950	913	A → S in a colorectal cancer sample; somatic mutation. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF308802 mRNA Translation: AAG34679.1 AB040908 mRNA Translation: BAA95999.1 Different initiation. AL713725 mRNA Translation: CAD28515.1 BC001513 mRNA Translation: AAH01513.1 Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10069.1
NCBI Reference Sequences More...RefSeqⁱ	NP_065908.1, NM_020857.2
UniGeneⁱ	Hs.23876

Genome annotation databases

Ensemblⁱ	ENST00000220509; ENSP00000220509; ENSG00000104142
GeneIDⁱ	57617
KEGGⁱ	hsa:57617
UCSC genome browser More...UCSCⁱ	uc001zne.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9P253	Vacuolar protein sorting protein 18, isoform CRA_d		HUMAN		973	UniRef100_Q9P253
UPI0005D02D32		HUMAN		871
UPI0007DC789A		HUMAN		605

Protein	Similar proteins		Species	Score	Length	Source
Q9P253	Vacuolar protein sorting-associated protein 18 homolog		MOUSE		973	UniRef90_Q9P253
Vacuolar protein sorting protein 18, isoform CRA_d		HUMAN		973
Vacuolar protein sorting-associated protein 18 homolog		HETGA		974
Vacuolar protein sorting-associated protein 18 like protein		FUKDA		974
Uncharacterized protein		CAVPO		974
+149

Protein	Similar proteins		Species	Score	Length	Source
Q9P253	Vacuolar protein sorting-associated protein 18 homolog		MOUSE		973	UniRef50_Q9P253
Vacuolar protein sorting protein 18, isoform CRA_d		HUMAN		973
Uncharacterized protein		CAVPO		974
Vacuolar protein sorting-associated protein 18 homolog		HETGA		974
Vacuolar protein sorting-associated protein 18 like protein		FUKDA		974
+350

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF308802 mRNA Translation: AAG34679.1 AB040908 mRNA Translation: BAA95999.1 Different initiation. AL713725 mRNA Translation: CAD28515.1 BC001513 mRNA Translation: AAH01513.1 Sequence problems.
CCDSⁱ	CCDS10069.1
RefSeqⁱ	NP_065908.1, NM_020857.2
UniGeneⁱ	Hs.23876

3D structure databases

ProteinModelPortalⁱ	Q9P253
SMRⁱ	Q9P253
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121664, 58 interactors
CORUMⁱ	Q9P253
IntActⁱ	Q9P253, 38 interactors
STRINGⁱ	9606.ENSP00000220509

PTM databases

iPTMnetⁱ	Q9P253
PhosphoSitePlusⁱ	Q9P253

Polymorphism and mutation databases

BioMutaⁱ	VPS18
DMDMⁱ	23396938

Proteomic databases

EPDⁱ	Q9P253
MaxQBⁱ	Q9P253
PaxDbⁱ	Q9P253
PeptideAtlasⁱ	Q9P253
PRIDEⁱ	Q9P253
ProteomicsDBⁱ	83731

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	57617
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000220509; ENSP00000220509; ENSG00000104142
GeneIDⁱ	57617
KEGGⁱ	hsa:57617
UCSCⁱ	uc001zne.3 human

Organism-specific databases

CTDⁱ	57617
EuPathDBⁱ	HostDB:ENSG00000104142.10
GeneCardsⁱ	VPS18
HGNCⁱ	HGNC:15972 VPS18
HPAⁱ	HPA040701
MIMⁱ	608551 gene
neXtProtⁱ	NX_Q9P253
OpenTargetsⁱ	ENSG00000104142
PharmGKBⁱ	PA38069
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2034 Eukaryota ENOG410XRSD LUCA
GeneTreeⁱ	ENSGT00390000015233
HOGENOMⁱ	HOG000172497
HOVERGENⁱ	HBG057876
InParanoidⁱ	Q9P253
KOⁱ	K20181
OMAⁱ	DAWIEMG
OrthoDBⁱ	EOG091G01XI
PhylomeDBⁱ	Q9P253
TreeFamⁱ	TF105704

Miscellaneous databases

ChiTaRSⁱ	VPS18 human
GeneWikiⁱ	VPS18
GenomeRNAiⁱ	57617
Protein Ontology More...PROⁱ	PR:Q9P253
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000104142 Expressed in 181 organ(s), highest expression level in tendon of biceps brachii
CleanExⁱ	HS_VPS18
ExpressionAtlasⁱ	Q9P253 baseline and differential
Genevisibleⁱ	Q9P253 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000547 Clathrin_H-chain/VPS_repeat IPR007810 Pep3_Vps18
Pfamⁱ	View protein in Pfam PF00637 Clathrin, 1 hit PF05131 Pep3_Vps18, 1 hit
PROSITEⁱ	View protein in PROSITE PS50236 CHCR, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	VPS18_HUMAN
Accessionⁱ	Q9P253Primary (citable) accession number: Q9P253 Secondary accession number(s): Q8TCG0, Q96DI3, Q9H268
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
	Last sequence update:	September 19, 2002
	Last modified:	November 7, 2018
	This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM

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UniProtKB - Q9P253 (VPS18_HUMAN)

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Vacuolar protein sorting-associated protein 18 homolog

VPS18

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Lysosome

Other locations

Cytoskeleton

Endosome

Lysosome

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ