UniProtKB - Q9P253 (VPS18_HUMAN)
Vacuolar protein sorting-associated protein 18 homolog
VPS18
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 853 – 947 | RING-typeAdd BLAST | 95 |
GO - Molecular functioni
- actin binding Source: Ensembl
- metal ion binding Source: UniProtKB-KW
- protein-macromolecule adaptor activity Source: GO_Central
- syntaxin binding Source: UniProtKB
GO - Biological processi
- autophagy Source: UniProtKB-KW
- endosome organization Source: UniProtKB
- endosome to lysosome transport Source: UniProtKB
- intracellular protein transport Source: InterPro
- lysosome organization Source: UniProtKB
- regulation of SNARE complex assembly Source: GO_Central
- regulation of synaptic vesicle exocytosis Source: SynGO
- vacuole organization Source: GO_Central
- vesicle docking involved in exocytosis Source: GO_Central
- viral entry into host cell Source: Ensembl
Keywordsi
Biological process | Autophagy, Protein transport, Transport |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9P253 |
Names & Taxonomyi
Protein namesi | Recommended name: Vacuolar protein sorting-associated protein 18 homologShort name: hVPS18 |
Gene namesi | Name:VPS18 Synonyms:KIAA1475 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15972, VPS18 |
MIMi | 608551, gene |
neXtProti | NX_Q9P253 |
VEuPathDBi | HostDB:ENSG00000104142.10 |
Subcellular locationi
Lysosome
- Lysosome membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side Curated
Endosome
- Late endosome membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side Curated
- Early endosome 1 Publication
Other locations
- autophagosome Curated
- clathrin-coated vesicle Curated
Note: Cytoplasmic, peripheral membrane protein associated with early endosomes and late endosomes/lysosomes.
Cytoskeleton
- actin filament Source: Ensembl
Endosome
- CORVET complex Source: Ensembl
- early endosome Source: UniProtKB-SubCell
- endosome Source: GO_Central
- late endosome Source: UniProtKB
- late endosome membrane Source: UniProtKB-SubCell
Lysosome
- lysosomal membrane Source: UniProtKB
- lysosome Source: UniProtKB
Other locations
- AP-3 adaptor complex Source: Ensembl
- autophagosome Source: UniProtKB-SubCell
- clathrin-coated vesicle Source: UniProtKB-SubCell
- glutamatergic synapse Source: SynGO
- HOPS complex Source: UniProtKB
- presynapse Source: Ensembl
Keywords - Cellular componenti
Cytoplasmic vesicle, Endosome, Lysosome, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 57617 |
OpenTargetsi | ENSG00000104142 |
PharmGKBi | PA38069 |
Miscellaneous databases
Pharosi | Q9P253, Tbio |
Genetic variation databases
BioMutai | VPS18 |
DMDMi | 23396938 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000055906 | 2 – 973 | Vacuolar protein sorting-associated protein 18 homologAdd BLAST | 972 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 3 | PhosphoserineCombined sources | 1 | |
Modified residuei | 11 | PhosphoserineCombined sources | 1 | |
Modified residuei | 13 | PhosphoserineCombined sources | 1 | |
Modified residuei | 362 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 689 | PhosphoserineCombined sources | 1 | |
Modified residuei | 912 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9P253 |
jPOSTi | Q9P253 |
MassIVEi | Q9P253 |
MaxQBi | Q9P253 |
PaxDbi | Q9P253 |
PeptideAtlasi | Q9P253 |
PRIDEi | Q9P253 |
ProteomicsDBi | 83731 |
PTM databases
iPTMneti | Q9P253 |
PhosphoSitePlusi | Q9P253 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000104142, Expressed in stomach and 199 other tissues |
ExpressionAtlasi | Q9P253, baseline and differential |
Genevisiblei | Q9P253, HS |
Organism-specific databases
HPAi | ENSG00000104142, Low tissue specificity |
Interactioni
Subunit structurei
Core component of at least two putative endosomal tethering complexes, the homotypic fusion and vacuole protein sorting (HOPS) complex and the class C core vacuole/endosome tethering (CORVET) complex. Their common core is composed of the class C Vps proteins VPS11, VPS16, VPS18 and VPS33A, which in HOPS further associates with VPS39 and VPS41 and in CORVET with VPS8 and TGFBRAP1 (PubMed:23351085, PubMed:25783203, PubMed:23901104).
Interacts with RAB5C (By similarity).
Interacts with HOOK1 (By similarity).
Interacts with STX7, MON1B (PubMed:20434987, PubMed:24554770). Associates with adaptor protein complex 3 (AP-3) and clathrin:AP-3 complexes (By similarity).
Interacts with SYNPO2 (PubMed:23434281).
By similarity1 Publication6 PublicationsBinary interactionsi
Hide detailsQ9P253
GO - Molecular functioni
- actin binding Source: Ensembl
- syntaxin binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 121664, 74 interactors |
CORUMi | Q9P253 |
IntActi | Q9P253, 47 interactors |
MINTi | Q9P253 |
STRINGi | 9606.ENSP00000220509 |
Miscellaneous databases
RNActi | Q9P253, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 618 – 772 | CHCRAdd BLAST | 155 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 454 – 481 | Sequence analysisAdd BLAST | 28 | |
Coiled coili | 802 – 848 | Sequence analysisAdd BLAST | 47 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 853 – 947 | RING-typeAdd BLAST | 95 |
Keywords - Domaini
Coiled coil, Zinc-fingerPhylogenomic databases
eggNOGi | KOG2034, Eukaryota |
GeneTreei | ENSGT00940000153635 |
HOGENOMi | CLU_003488_1_0_1 |
InParanoidi | Q9P253 |
OMAi | EHCFQNK |
OrthoDBi | 87842at2759 |
PhylomeDBi | Q9P253 |
TreeFami | TF105704 |
Family and domain databases
InterProi | View protein in InterPro IPR000547, Clathrin_H-chain/VPS_repeat IPR007810, Pep3_Vps18 |
Pfami | View protein in Pfam PF00637, Clathrin, 1 hit PF05131, Pep3_Vps18, 1 hit |
PROSITEi | View protein in PROSITE PS50236, CHCR, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MASILDEYEN SLSRSAVLQP GCPSVGIPHS GYVNAQLEKE VPIFTKQRID
60 70 80 90 100
FTPSERITSL VVSSNQLCMS LGKDTLLRID LGKANEPNHV ELGRKDDAKV
110 120 130 140 150
HKMFLDHTGS HLLIALSSTE VLYVNRNGQK VRPLARWKGQ LVESVGWNKA
160 170 180 190 200
LGTESSTGPI LVGTAQGHIF EAELSASEGG LFGPAPDLYF RPLYVLNEEG
210 220 230 240 250
GPAPVCSLEA ERGPDGRSFV IATTRQRLFQ FIGRAAEGAE AQGFSGLFAA
260 270 280 290 300
YTDHPPPFRE FPSNLGYSEL AFYTPKLRSA PRAFAWMMGD GVLYGALDCG
310 320 330 340 350
RPDSLLSEER VWEYPEGVGP GASPPLAIVL TQFHFLLLLA DRVEAVCTLT
360 370 380 390 400
GQVVLRDHFL EKFGPLKHMV KDSSTGQLWA YTERAVFRYH VQREARDVWR
410 420 430 440 450
TYLDMNRFDL AKEYCRERPD CLDTVLAREA DFCFRQRRYL ESARCYALTQ
460 470 480 490 500
SYFEEIALKF LEARQEEALA EFLQRKLASL KPAERTQATL LTTWLTELYL
510 520 530 540 550
SRLGALQGDP EALTLYRETK ECFRTFLSSP RHKEWLFASR ASIHELLASH
560 570 580 590 600
GDTEHMVYFA VIMQDYERVV AYHCQHEAYE EALAVLARHR DPQLFYKFSP
610 620 630 640 650
ILIRHIPRQL VDAWIEMGSR LDARQLIPAL VNYSQGGEVQ QVSQAIRYME
660 670 680 690 700
FCVNVLGETE QAIHNYLLSL YARGRPDSLL AYLEQAGASP HRVHYDLKYA
710 720 730 740 750
LRLCAEHGHH RACVHVYKVL ELYEEAVDLA LQVDVDLAKQ CADLPEEDEE
760 770 780 790 800
LRKKLWLKIA RHVVQEEEDV QTAMACLASC PLLKIEDVLP FFPDFVTIDH
810 820 830 840 850
FKEAICSSLK AYNHHIQELQ REMEEATASA QRIRRDLQEL RGRYGTVEPQ
860 870 880 890 900
DKCATCDFPL LNRPFYLFLC GHMFHADCLL QAVRPGLPAY KQARLEELQR
910 920 930 940 950
KLGAAPPPAK GSARAKEAEG GAATAGPSRE QLKADLDELV AAECVYCGEL
960 970
MIRSIDRPFI DPQRYEEEQL SWL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YMC9 | H0YMC9_HUMAN | Vacuolar protein sorting-associated... | VPS18 | 121 | Annotation score: | ||
H0YLM6 | H0YLM6_HUMAN | Vacuolar protein sorting-associated... | VPS18 | 130 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035950 | 913 | A → S in a colorectal cancer sample; somatic mutation. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF308802 mRNA Translation: AAG34679.1 AB040908 mRNA Translation: BAA95999.1 Different initiation. AL713725 mRNA Translation: CAD28515.1 BC001513 mRNA Translation: AAH01513.1 Sequence problems. |
CCDSi | CCDS10069.1 |
RefSeqi | NP_065908.1, NM_020857.2 |
Genome annotation databases
Ensembli | ENST00000220509; ENSP00000220509; ENSG00000104142 |
GeneIDi | 57617 |
KEGGi | hsa:57617 |
UCSCi | uc001zne.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF308802 mRNA Translation: AAG34679.1 AB040908 mRNA Translation: BAA95999.1 Different initiation. AL713725 mRNA Translation: CAD28515.1 BC001513 mRNA Translation: AAH01513.1 Sequence problems. |
CCDSi | CCDS10069.1 |
RefSeqi | NP_065908.1, NM_020857.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 121664, 74 interactors |
CORUMi | Q9P253 |
IntActi | Q9P253, 47 interactors |
MINTi | Q9P253 |
STRINGi | 9606.ENSP00000220509 |
PTM databases
iPTMneti | Q9P253 |
PhosphoSitePlusi | Q9P253 |
Genetic variation databases
BioMutai | VPS18 |
DMDMi | 23396938 |
Proteomic databases
EPDi | Q9P253 |
jPOSTi | Q9P253 |
MassIVEi | Q9P253 |
MaxQBi | Q9P253 |
PaxDbi | Q9P253 |
PeptideAtlasi | Q9P253 |
PRIDEi | Q9P253 |
ProteomicsDBi | 83731 |
Protocols and materials databases
Antibodypediai | 23197, 142 antibodies |
DNASUi | 57617 |
Genome annotation databases
Ensembli | ENST00000220509; ENSP00000220509; ENSG00000104142 |
GeneIDi | 57617 |
KEGGi | hsa:57617 |
UCSCi | uc001zne.3, human |
Organism-specific databases
CTDi | 57617 |
DisGeNETi | 57617 |
GeneCardsi | VPS18 |
HGNCi | HGNC:15972, VPS18 |
HPAi | ENSG00000104142, Low tissue specificity |
MIMi | 608551, gene |
neXtProti | NX_Q9P253 |
OpenTargetsi | ENSG00000104142 |
PharmGKBi | PA38069 |
VEuPathDBi | HostDB:ENSG00000104142.10 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2034, Eukaryota |
GeneTreei | ENSGT00940000153635 |
HOGENOMi | CLU_003488_1_0_1 |
InParanoidi | Q9P253 |
OMAi | EHCFQNK |
OrthoDBi | 87842at2759 |
PhylomeDBi | Q9P253 |
TreeFami | TF105704 |
Enzyme and pathway databases
PathwayCommonsi | Q9P253 |
Miscellaneous databases
BioGRID-ORCSi | 57617, 553 hits in 886 CRISPR screens |
ChiTaRSi | VPS18, human |
GeneWikii | VPS18 |
GenomeRNAii | 57617 |
Pharosi | Q9P253, Tbio |
PROi | PR:Q9P253 |
RNActi | Q9P253, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000104142, Expressed in stomach and 199 other tissues |
ExpressionAtlasi | Q9P253, baseline and differential |
Genevisiblei | Q9P253, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000547, Clathrin_H-chain/VPS_repeat IPR007810, Pep3_Vps18 |
Pfami | View protein in Pfam PF00637, Clathrin, 1 hit PF05131, Pep3_Vps18, 1 hit |
PROSITEi | View protein in PROSITE PS50236, CHCR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VPS18_HUMAN | |
Accessioni | Q9P253Primary (citable) accession number: Q9P253 Secondary accession number(s): Q8TCG0, Q96DI3, Q9H268 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2002 |
Last sequence update: | September 19, 2002 | |
Last modified: | February 10, 2021 | |
This is version 177 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families