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Protein

Stromal interaction molecule 2

Gene

STIM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in mediating store-operated Ca2+ entry (SOCE), a Ca2+ influx following depletion of intracellular Ca2+ stores. Functions as a highly sensitive Ca2+ sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca2+-influx. Regulates basal cytosolic and endoplasmic reticulum Ca2+ concentrations. Upon mild variations of the endoplasmic reticulum Ca2+ concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca2+ release-activated Ca2+ (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca2+ influx.7 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi80 – 91Add BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium channel regulator activity Source: UniProtKB
  • calcium ion binding Source: UniProtKB
  • store-operated calcium channel activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCalcium transport, Ion transport, Transport
LigandCalcium, Metal-binding

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.52.1.1 the ca(2+) release-activated ca(2+) (crac) channel (crac-c) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Stromal interaction molecule 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STIM2
Synonyms:KIAA1482
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000109689.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19205 STIM2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610841 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9P246

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini15 – 218ExtracellularSequence analysisAdd BLAST204
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei219 – 235HelicalSequence analysisAdd BLAST17
Topological domaini236 – 746CytoplasmicSequence analysisAdd BLAST511

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi80D → A: No effect on inhibitory activity; when associated with A-91. 2 Publications1
Mutagenesisi91E → A: No effect on inhibitory activity; when associated with A-80. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
57620

Open Targets

More...
OpenTargetsi
ENSG00000109689

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134926985

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
STIM2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
17369338

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 141 PublicationAdd BLAST14
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003332815 – 746Stromal interaction molecule 2Add BLAST732

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei523PhosphoserineCombined sources1
Modified residuei609PhosphoserineCombined sources1
Modified residuei621PhosphoserineCombined sources1
Modified residuei640PhosphoserineBy similarity1
Modified residuei650PhosphoserineBy similarity1
Modified residuei661PhosphoserineCombined sources1
Modified residuei665PhosphoserineCombined sources1
Modified residuei680PhosphoserineCombined sources1
Modified residuei697PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.1 Publication
Phosphorylated predominantly on Ser residues.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9P246

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9P246

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9P246

PeptideAtlas

More...
PeptideAtlasi
Q9P246

PRoteomics IDEntifications database

More...
PRIDEi
Q9P246

ProteomicsDB human proteome resource

More...
ProteomicsDBi
83730

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9P246

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9P246

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all tissues and tumor cell lines examined.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000109689 Expressed in 192 organ(s), highest expression level in pituitary gland

CleanEx database of gene expression profiles

More...
CleanExi
HS_STIM2

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9P246 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9P246 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB037196
HPA036933
HPA057511

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Oligomer with STIM1. Interacts with ORAI1.3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
STIM1Q135864EBI-448891,EBI-448878

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
121666, 21 interactors

Protein interaction database and analysis system

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IntActi
Q9P246, 8 interactors

Molecular INTeraction database

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MINTi
Q9P246

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000417569

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1746
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9P246

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9P246

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini67 – 102EF-handAdd BLAST36
Domaini136 – 204SAMPROSITE-ProRule annotationAdd BLAST69

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili247 – 394Sequence analysisAdd BLAST148

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi533 – 559His/Pro-richAdd BLAST27
Compositional biasi730 – 746Lys-richAdd BLAST17

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4403 Eukaryota
ENOG410XRM6 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000000214

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000261647

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG079219

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9P246

KEGG Orthology (KO)

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KOi
K18196

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9P246

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09574 SAM_STIM2, 1 hit
cd11722 SOAR, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR032393 SOAR
IPR037608 STIM
IPR037610 STIM2_SAM

The PANTHER Classification System

More...
PANTHERi
PTHR15136 PTHR15136, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07647 SAM_2, 1 hit
PF16533 SOAR, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769 SSF47769, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50105 SAM_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9P246-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLVLGLLVAG AADGCELVPR HLRGRRATGS AATAASSPAA AAGDSPALMT
60 70 80 90 100
DPCMSLSPPC FTEEDRFSLE ALQTIHKQMD DDKDGGIEVE ESDEFIREDM
110 120 130 140 150
KYKDATNKHS HLHREDKHIT IEDLWKRWKT SEVHNWTLED TLQWLIEFVE
160 170 180 190 200
LPQYEKNFRD NNVKGTTLPR IAVHEPSFMI SQLKISDRSH RQKLQLKALD
210 220 230 240 250
VVLFGPLTRP PHNWMKDFIL TVSIVIGVGG CWFAYTQNKT SKEHVAKMMK
260 270 280 290 300
DLESLQTAEQ SLMDLQERLE KAQEENRNVA VEKQNLERKM MDEINYAKEE
310 320 330 340 350
ACRLRELREG AECELSRRQY AEQELEQVRM ALKKAEKEFE LRSSWSVPDA
360 370 380 390 400
LQKWLQLTHE VEVQYYNIKR QNAEMQLAIA KDEAEKIKKK RSTVFGTLHV
410 420 430 440 450
AHSSSLDEVD HKILEAKKAL SELTTCLRER LFRWQQIEKI CGFQIAHNSG
460 470 480 490 500
LPSLTSSLYS DHSWVVMPRV SIPPYPIAGG VDDLDEDTPP IVSQFPGTMA
510 520 530 540 550
KPPGSLARSS SLCRSRRSIV PSSPQPQRAQ LAPHAPHPSH PRHPHHPQHT
560 570 580 590 600
PHSLPSPDPD ILSVSSCPAL YRNEEEEEAI YFSAEKQWEV PDTASECDSL
610 620 630 640 650
NSSIGRKQSP PLSLEIYQTL SPRKISRDEV SLEDSSRGDS PVTVDVSWGS
660 670 680 690 700
PDCVGLTETK SMIFSPASKV YNGILEKSCS MNQLSSGIPV PKPRHTSCSS
710 720 730 740
AGNDSKPVQE APSVARISSI PHDLCHNGEK SKKPSKIKSL FKKKSK
Length:746
Mass (Da):83,971
Last modified:October 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB83855557F126254
GO
Isoform 2 (identifier: Q9P246-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MNAAGIRAPE...LLRRRRWAAL
     383-383: E → EVAASYLIQ

Note: No experimental confirmation available.
Show »
Length:841
Mass (Da):93,957
Checksum:iCD6ACEB84DE56442
GO
Isoform 3 (identifier: Q9P246-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     588-599: WEVPDTASECDS → CIHLGLGACKSE
     600-746: Missing.

Note: No experimental confirmation available.
Show »
Length:599
Mass (Da):68,026
Checksum:iCCD0B00D7B86E051
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y860H0Y860_HUMAN
Stromal interaction molecule 2
STIM2
754Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GMP0R4GMP0_HUMAN
Stromal interaction molecule 2
STIM2
214Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5A5H7C5A5_HUMAN
Stromal interaction molecule 2
STIM2
599Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PRA1A0A1W2PRA1_HUMAN
Stromal interaction molecule 2
STIM2
754Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1X7SBY3A0A1X7SBY3_HUMAN
Stromal interaction molecule 2
STIM2
746Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GN82R4GN82_HUMAN
Stromal interaction molecule 2
STIM2
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5K2H7C5K2_HUMAN
Stromal interaction molecule 2
STIM2
347Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5C6H7C5C6_HUMAN
Stromal interaction molecule 2
STIM2
221Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GNC5R4GNC5_HUMAN
Stromal interaction molecule 2
STIM2
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA96006 differs from that shown. Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.Curated
The sequence BAB14545 differs from that shown. Probable cloning artifact.Curated
The sequence BAB14545 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB66512 differs from that shown. Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti9A → P in CAB66512 (PubMed:11230166).Curated1
Sequence conflicti308R → G in AAH57231 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0571711M → MNAAGIRAPEAAGADGTRLA PGGSPCLRRRGRPEESPAAV VAPRGAGELQAAGAPLRFYP ASPRRLHRASTPGPAWGWLL RRRRWAAL in isoform 2. 1 Publication1
Alternative sequenceiVSP_057172383E → EVAASYLIQ in isoform 2. 1 Publication1
Alternative sequenceiVSP_057173588 – 599WEVPD…SECDS → CIHLGLGACKSE in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_057174600 – 746Missing in isoform 3. 1 PublicationAdd BLAST147

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF328905 mRNA Translation: AAK82337.1
AB040915 mRNA Translation: BAA96006.1 Sequence problems.
AL136577 mRNA Translation: CAB66512.2 Sequence problems.
BC015659 mRNA Translation: AAH15659.2
BC057231 mRNA Translation: AAH57231.1
BC136449 mRNA Translation: AAI36450.1
BC146661 mRNA Translation: AAI46662.1
BC152554 mRNA Translation: AAI52555.1
BC171766 mRNA Translation: AAI71766.1
AK023369 mRNA Translation: BAB14545.1 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS3440.2 [Q9P246-1]
CCDS54752.1 [Q9P246-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001162588.1, NM_001169117.1 [Q9P246-3]
NP_001162589.1, NM_001169118.1
NP_065911.3, NM_020860.3 [Q9P246-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.744950

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000639640; ENSP00000492400; ENSG00000109689 [Q9P246-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
57620

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:57620

UCSC genome browser

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UCSCi
uc003gsg.6 human [Q9P246-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF328905 mRNA Translation: AAK82337.1
AB040915 mRNA Translation: BAA96006.1 Sequence problems.
AL136577 mRNA Translation: CAB66512.2 Sequence problems.
BC015659 mRNA Translation: AAH15659.2
BC057231 mRNA Translation: AAH57231.1
BC136449 mRNA Translation: AAI36450.1
BC146661 mRNA Translation: AAI46662.1
BC152554 mRNA Translation: AAI52555.1
BC171766 mRNA Translation: AAI71766.1
AK023369 mRNA Translation: BAB14545.1 Sequence problems.
CCDSiCCDS3440.2 [Q9P246-1]
CCDS54752.1 [Q9P246-3]
RefSeqiNP_001162588.1, NM_001169117.1 [Q9P246-3]
NP_001162589.1, NM_001169118.1
NP_065911.3, NM_020860.3 [Q9P246-1]
UniGeneiHs.744950

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L5YNMR-A62-205[»]
ProteinModelPortaliQ9P246
SMRiQ9P246
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121666, 21 interactors
IntActiQ9P246, 8 interactors
MINTiQ9P246
STRINGi9606.ENSP00000417569

Protein family/group databases

TCDBi1.A.52.1.1 the ca(2+) release-activated ca(2+) (crac) channel (crac-c) family

PTM databases

iPTMnetiQ9P246
PhosphoSitePlusiQ9P246

Polymorphism and mutation databases

BioMutaiSTIM2
DMDMi17369338

Proteomic databases

EPDiQ9P246
MaxQBiQ9P246
PaxDbiQ9P246
PeptideAtlasiQ9P246
PRIDEiQ9P246
ProteomicsDBi83730

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000639640; ENSP00000492400; ENSG00000109689 [Q9P246-1]
GeneIDi57620
KEGGihsa:57620
UCSCiuc003gsg.6 human [Q9P246-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57620
DisGeNETi57620
EuPathDBiHostDB:ENSG00000109689.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
STIM2
HGNCiHGNC:19205 STIM2
HPAiCAB037196
HPA036933
HPA057511
MIMi610841 gene
neXtProtiNX_Q9P246
OpenTargetsiENSG00000109689
PharmGKBiPA134926985

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4403 Eukaryota
ENOG410XRM6 LUCA
GeneTreeiENSGT00390000000214
HOGENOMiHOG000261647
HOVERGENiHBG079219
InParanoidiQ9P246
KOiK18196
PhylomeDBiQ9P246

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
STIM2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
STIM2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57620

Protein Ontology

More...
PROi
PR:Q9P246

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000109689 Expressed in 192 organ(s), highest expression level in pituitary gland
CleanExiHS_STIM2
ExpressionAtlasiQ9P246 baseline and differential
GenevisibleiQ9P246 HS

Family and domain databases

CDDicd09574 SAM_STIM2, 1 hit
cd11722 SOAR, 1 hit
InterProiView protein in InterPro
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR032393 SOAR
IPR037608 STIM
IPR037610 STIM2_SAM
PANTHERiPTHR15136 PTHR15136, 1 hit
PfamiView protein in Pfam
PF07647 SAM_2, 1 hit
PF16533 SOAR, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS50105 SAM_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTIM2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P246
Secondary accession number(s): A6H8L7
, B7ZVY0, Q96BF1, Q9BQH2, Q9H8R1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: October 1, 2001
Last modified: December 5, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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