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Entry version 121 (07 Apr 2021)
Sequence version 3 (18 May 2010)
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Protein

Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2

Gene

NYAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9P242

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NYAP2
Synonyms:KIAA1486
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29291, NYAP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615478, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9P242

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000144460.11

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57624

Open Targets

More...
OpenTargetsi
ENSG00000144460

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165696738

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9P242, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NYAP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439320

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003258301 – 653Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2Add BLAST653

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei81Omega-N-methylarginineBy similarity1
Modified residuei120PhosphoserineBy similarity1
Modified residuei206PhosphoserineBy similarity1
Modified residuei268PhosphotyrosineBy similarity1
Modified residuei434PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine residues by FYN upon stimulation with CNTN5.By similarity

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9P242

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9P242

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9P242

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9P242

PeptideAtlas

More...
PeptideAtlasi
Q9P242

PRoteomics IDEntifications database

More...
PRIDEi
Q9P242

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
83723 [Q9P242-1]
83724 [Q9P242-2]
83725 [Q9P242-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9P242

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9P242

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000144460, Expressed in cortical plate and 53 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9P242, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000144460, Group enriched (brain, pituitary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ACOT9, ARHGAP26 and PIK3R2.

Interacts with components of the WAVE1 complex, CYFIP1 and NCKAP1; this interaction mediates PI3K-WAVE1 association and actin cytoskeleton remodeling (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
121670, 14 interactors

Protein interaction database and analysis system

More...
IntActi
Q9P242, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000272907

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9P242, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9P242

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni150 – 161Involved in CYFIP1- and NCKAP1-bindingBy similarityAdd BLAST12

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi312 – 479Pro-richAdd BLAST168

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NYAP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QTY4, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00890000139453

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012558_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9P242

Identification of Orthologs from Complete Genome Data

More...
OMAi
DMIEKKR

Database of Orthologous Groups

More...
OrthoDBi
295010at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9P242

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026722, NYAP1/NYAP2
IPR026723, NYAP2
IPR029353, NYAP_C
IPR039482, NYAP_N

The PANTHER Classification System

More...
PANTHERi
PTHR22633, PTHR22633, 1 hit
PTHR22633:SF1, PTHR22633:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15452, NYAP_C, 1 hit
PF15439, NYAP_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9P242-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MISSKMMSSN PEEDPLDTFL QYIEDMGMKA YDGLVIQNAS DIARENDRLR
60 70 80 90 100
NETNLAYLKE KNEKRRRQEE AIKRIGGEVG RGHEGSYVGK HFRMGFMTMP
110 120 130 140 150
APQDRLPHPC SSGFSVRSQS LHSVGGTDDD SSCGSRRQPP PKPKRDPSTK
160 170 180 190 200
LSTSSETVSS TAASKSGKTP ERTEASAKPR PHSDEYSKKI PPPKPKRNPN
210 220 230 240 250
TQLSTSFDET YIKKHGPRRT SLPRDSSLSQ MGSPAGDPEE EEPVYIEMVG
260 270 280 290 300
NILRDFRKED DDQSEAVYEE MKYPIFDDLG QDAKCDFDHH SCSSQCATPT
310 320 330 340 350
VPDLDFAKAS VPCPPKGLLC DIPPPFPNLL SHRPPLLVFP PAPVHCSPNS
360 370 380 390 400
DESPLTPLEV TKLPVLENVS YMKQPAGASP STLPSHVPGH AKLEKEQAAA
410 420 430 440 450
LGPASATPAL SSSPPPPSTL YRTQSPHGYP KSHSTSPSPV SMGRSLTPLS
460 470 480 490 500
LKRPPPYDAV HSGSLSRSSP SVPHSTPRPV SQDGAKMVNA AVNTYGAAPG
510 520 530 540 550
GSRSRTPTSP LEELTSLFSS GRSLLRKSSS GRRSKEPAEK STEELKVRSH
560 570 580 590 600
STEPLPKLDN KERGHHGASS SREPVKAQEW DGTPGTPVVT SRLGRCSVSP
610 620 630 640 650
TLLAGNHSSE PKVSCKLGRS ASTSGVPPPS VTPLRQSSDL QQSQVPSSLA

NRD
Length:653
Mass (Da):70,548
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i78451871EC7822C6
GO
Isoform 2 (identifier: Q9P242-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-145: GGEVGRGHEG...RRQPPPKPKR → NRGTESPKPQ...LVSGKPQFRA
     146-653: Missing.

Show »
Length:145
Mass (Da):16,536
Checksum:iA9A52FFBEADF74F2
GO
Isoform 3 (identifier: Q9P242-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-486: Missing.
     645-645: V → I
     646-653: Missing.

Show »
Length:159
Mass (Da):16,800
Checksum:iEC892A314083B052
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA96010 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_039933205T → A. Corresponds to variant dbSNP:rs7422680Ensembl.1
Natural variantiVAR_039934586T → P. Corresponds to variant dbSNP:rs3748993Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0324311 – 486Missing in isoform 3. 1 PublicationAdd BLAST486
Alternative sequenceiVSP_03243276 – 145GGEVG…PKPKR → NRGTESPKPQHGAITKVGQQ GKRPPWGVFLQRACQSSGMG WNTRATCGHQSTRKMLCEPH LVSGKPQFRA in isoform 2. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_032433146 – 653Missing in isoform 2. 1 PublicationAdd BLAST508
Alternative sequenceiVSP_032434645V → I in isoform 3. 1 Publication1
Alternative sequenceiVSP_032435646 – 653Missing in isoform 3. 1 Publication8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB040919 mRNA Translation: BAA96010.1 Different initiation.
AK055226 mRNA Translation: BAB70880.1
AC016717 Genomic DNA No translation available.
AC019231 Genomic DNA No translation available.
AC067961 Genomic DNA No translation available.
AC106890 Genomic DNA No translation available.
BC131727 mRNA Translation: AAI31728.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS46529.1 [Q9P242-1]

NCBI Reference Sequences

More...
RefSeqi
NP_065915.1, NM_020864.1 [Q9P242-1]
XP_005246765.1, XM_005246708.3 [Q9P242-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000272907; ENSP00000272907; ENSG00000144460 [Q9P242-1]
ENST00000636099; ENSP00000490942; ENSG00000144460 [Q9P242-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57624

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57624

UCSC genome browser

More...
UCSCi
uc002voe.3, human [Q9P242-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040919 mRNA Translation: BAA96010.1 Different initiation.
AK055226 mRNA Translation: BAB70880.1
AC016717 Genomic DNA No translation available.
AC019231 Genomic DNA No translation available.
AC067961 Genomic DNA No translation available.
AC106890 Genomic DNA No translation available.
BC131727 mRNA Translation: AAI31728.1
CCDSiCCDS46529.1 [Q9P242-1]
RefSeqiNP_065915.1, NM_020864.1 [Q9P242-1]
XP_005246765.1, XM_005246708.3 [Q9P242-1]

3D structure databases

SMRiQ9P242
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121670, 14 interactors
IntActiQ9P242, 5 interactors
STRINGi9606.ENSP00000272907

PTM databases

iPTMnetiQ9P242
PhosphoSitePlusiQ9P242

Genetic variation databases

BioMutaiNYAP2
DMDMi296439320

Proteomic databases

jPOSTiQ9P242
MassIVEiQ9P242
MaxQBiQ9P242
PaxDbiQ9P242
PeptideAtlasiQ9P242
PRIDEiQ9P242
ProteomicsDBi83723 [Q9P242-1]
83724 [Q9P242-2]
83725 [Q9P242-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
49421, 41 antibodies

Genome annotation databases

EnsembliENST00000272907; ENSP00000272907; ENSG00000144460 [Q9P242-1]
ENST00000636099; ENSP00000490942; ENSG00000144460 [Q9P242-1]
GeneIDi57624
KEGGihsa:57624
UCSCiuc002voe.3, human [Q9P242-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57624
DisGeNETi57624

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NYAP2
HGNCiHGNC:29291, NYAP2
HPAiENSG00000144460, Group enriched (brain, pituitary gland)
MIMi615478, gene
neXtProtiNX_Q9P242
OpenTargetsiENSG00000144460
PharmGKBiPA165696738
VEuPathDBiHostDB:ENSG00000144460.11

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QTY4, Eukaryota
GeneTreeiENSGT00890000139453
HOGENOMiCLU_012558_1_0_1
InParanoidiQ9P242
OMAiDMIEKKR
OrthoDBi295010at2759
PhylomeDBiQ9P242

Enzyme and pathway databases

PathwayCommonsiQ9P242

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
57624, 3 hits in 979 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NYAP2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57624
PharosiQ9P242, Tdark

Protein Ontology

More...
PROi
PR:Q9P242
RNActiQ9P242, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000144460, Expressed in cortical plate and 53 other tissues
GenevisibleiQ9P242, HS

Family and domain databases

InterProiView protein in InterPro
IPR026722, NYAP1/NYAP2
IPR026723, NYAP2
IPR029353, NYAP_C
IPR039482, NYAP_N
PANTHERiPTHR22633, PTHR22633, 1 hit
PTHR22633:SF1, PTHR22633:SF1, 1 hit
PfamiView protein in Pfam
PF15452, NYAP_C, 1 hit
PF15439, NYAP_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNYAP2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P242
Secondary accession number(s): A2RRN4, Q96NL2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 18, 2010
Last modified: April 7, 2021
This is version 121 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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