UniProtKB - Q9P242 (NYAP2_HUMAN)
Protein
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2
Gene
NYAP2
Organism
Homo sapiens (Human)
Status
Functioni
Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis.By similarity
GO - Biological processi
- neuron projection morphogenesis Source: UniProtKB
- phosphatidylinositol 3-kinase signaling Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q9P242 |
Names & Taxonomyi
Protein namesi | Recommended name: Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 |
Gene namesi | Name:NYAP2 Synonyms:KIAA1486 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29291, NYAP2 |
MIMi | 615478, gene |
neXtProti | NX_Q9P242 |
VEuPathDBi | HostDB:ENSG00000144460.11 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 57624 |
OpenTargetsi | ENSG00000144460 |
PharmGKBi | PA165696738 |
Miscellaneous databases
Pharosi | Q9P242, Tdark |
Genetic variation databases
BioMutai | NYAP2 |
DMDMi | 296439320 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000325830 | 1 – 653 | Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2Add BLAST | 653 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 81 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 120 | PhosphoserineBy similarity | 1 | |
Modified residuei | 206 | PhosphoserineBy similarity | 1 | |
Modified residuei | 268 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 434 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylated on tyrosine residues by FYN upon stimulation with CNTN5.By similarity
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
jPOSTi | Q9P242 |
MassIVEi | Q9P242 |
MaxQBi | Q9P242 |
PaxDbi | Q9P242 |
PeptideAtlasi | Q9P242 |
PRIDEi | Q9P242 |
ProteomicsDBi | 83723 [Q9P242-1] 83724 [Q9P242-2] 83725 [Q9P242-3] |
PTM databases
iPTMneti | Q9P242 |
PhosphoSitePlusi | Q9P242 |
Expressioni
Gene expression databases
Bgeei | ENSG00000144460, Expressed in cortical plate and 53 other tissues |
Genevisiblei | Q9P242, HS |
Organism-specific databases
HPAi | ENSG00000144460, Group enriched (brain, pituitary gland) |
Interactioni
Subunit structurei
Interacts with ACOT9, ARHGAP26 and PIK3R2.
Interacts with components of the WAVE1 complex, CYFIP1 and NCKAP1; this interaction mediates PI3K-WAVE1 association and actin cytoskeleton remodeling (By similarity).
By similarityBinary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 121670, 14 interactors |
IntActi | Q9P242, 5 interactors |
STRINGi | 9606.ENSP00000272907 |
Miscellaneous databases
RNActi | Q9P242, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 150 – 161 | Involved in CYFIP1- and NCKAP1-bindingBy similarityAdd BLAST | 12 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 312 – 479 | Pro-richAdd BLAST | 168 |
Sequence similaritiesi
Belongs to the NYAP family.Curated
Phylogenomic databases
eggNOGi | ENOG502QTY4, Eukaryota |
GeneTreei | ENSGT00890000139453 |
HOGENOMi | CLU_012558_1_0_1 |
InParanoidi | Q9P242 |
OMAi | DMIEKKR |
OrthoDBi | 295010at2759 |
PhylomeDBi | Q9P242 |
Family and domain databases
InterProi | View protein in InterPro IPR026722, NYAP1/NYAP2 IPR026723, NYAP2 IPR029353, NYAP_C IPR039482, NYAP_N |
PANTHERi | PTHR22633, PTHR22633, 1 hit PTHR22633:SF1, PTHR22633:SF1, 1 hit |
Pfami | View protein in Pfam PF15452, NYAP_C, 1 hit PF15439, NYAP_N, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9P242-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MISSKMMSSN PEEDPLDTFL QYIEDMGMKA YDGLVIQNAS DIARENDRLR
60 70 80 90 100
NETNLAYLKE KNEKRRRQEE AIKRIGGEVG RGHEGSYVGK HFRMGFMTMP
110 120 130 140 150
APQDRLPHPC SSGFSVRSQS LHSVGGTDDD SSCGSRRQPP PKPKRDPSTK
160 170 180 190 200
LSTSSETVSS TAASKSGKTP ERTEASAKPR PHSDEYSKKI PPPKPKRNPN
210 220 230 240 250
TQLSTSFDET YIKKHGPRRT SLPRDSSLSQ MGSPAGDPEE EEPVYIEMVG
260 270 280 290 300
NILRDFRKED DDQSEAVYEE MKYPIFDDLG QDAKCDFDHH SCSSQCATPT
310 320 330 340 350
VPDLDFAKAS VPCPPKGLLC DIPPPFPNLL SHRPPLLVFP PAPVHCSPNS
360 370 380 390 400
DESPLTPLEV TKLPVLENVS YMKQPAGASP STLPSHVPGH AKLEKEQAAA
410 420 430 440 450
LGPASATPAL SSSPPPPSTL YRTQSPHGYP KSHSTSPSPV SMGRSLTPLS
460 470 480 490 500
LKRPPPYDAV HSGSLSRSSP SVPHSTPRPV SQDGAKMVNA AVNTYGAAPG
510 520 530 540 550
GSRSRTPTSP LEELTSLFSS GRSLLRKSSS GRRSKEPAEK STEELKVRSH
560 570 580 590 600
STEPLPKLDN KERGHHGASS SREPVKAQEW DGTPGTPVVT SRLGRCSVSP
610 620 630 640 650
TLLAGNHSSE PKVSCKLGRS ASTSGVPPPS VTPLRQSSDL QQSQVPSSLA
NRD
Sequence cautioni
The sequence BAA96010 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_039933 | 205 | T → A. Corresponds to variant dbSNP:rs7422680Ensembl. | 1 | |
Natural variantiVAR_039934 | 586 | T → P. Corresponds to variant dbSNP:rs3748993Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_032431 | 1 – 486 | Missing in isoform 3. 1 PublicationAdd BLAST | 486 | |
Alternative sequenceiVSP_032432 | 76 – 145 | GGEVG…PKPKR → NRGTESPKPQHGAITKVGQQ GKRPPWGVFLQRACQSSGMG WNTRATCGHQSTRKMLCEPH LVSGKPQFRA in isoform 2. 1 PublicationAdd BLAST | 70 | |
Alternative sequenceiVSP_032433 | 146 – 653 | Missing in isoform 2. 1 PublicationAdd BLAST | 508 | |
Alternative sequenceiVSP_032434 | 645 | V → I in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_032435 | 646 – 653 | Missing in isoform 3. 1 Publication | 8 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB040919 mRNA Translation: BAA96010.1 Different initiation. AK055226 mRNA Translation: BAB70880.1 AC016717 Genomic DNA No translation available. AC019231 Genomic DNA No translation available. AC067961 Genomic DNA No translation available. AC106890 Genomic DNA No translation available. BC131727 mRNA Translation: AAI31728.1 |
CCDSi | CCDS46529.1 [Q9P242-1] |
RefSeqi | NP_065915.1, NM_020864.1 [Q9P242-1] XP_005246765.1, XM_005246708.3 [Q9P242-1] |
Genome annotation databases
Ensembli | ENST00000272907; ENSP00000272907; ENSG00000144460 [Q9P242-1] ENST00000636099; ENSP00000490942; ENSG00000144460 [Q9P242-1] |
GeneIDi | 57624 |
KEGGi | hsa:57624 |
UCSCi | uc002voe.3, human [Q9P242-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB040919 mRNA Translation: BAA96010.1 Different initiation. AK055226 mRNA Translation: BAB70880.1 AC016717 Genomic DNA No translation available. AC019231 Genomic DNA No translation available. AC067961 Genomic DNA No translation available. AC106890 Genomic DNA No translation available. BC131727 mRNA Translation: AAI31728.1 |
CCDSi | CCDS46529.1 [Q9P242-1] |
RefSeqi | NP_065915.1, NM_020864.1 [Q9P242-1] XP_005246765.1, XM_005246708.3 [Q9P242-1] |
3D structure databases
SMRi | Q9P242 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121670, 14 interactors |
IntActi | Q9P242, 5 interactors |
STRINGi | 9606.ENSP00000272907 |
PTM databases
iPTMneti | Q9P242 |
PhosphoSitePlusi | Q9P242 |
Genetic variation databases
BioMutai | NYAP2 |
DMDMi | 296439320 |
Proteomic databases
jPOSTi | Q9P242 |
MassIVEi | Q9P242 |
MaxQBi | Q9P242 |
PaxDbi | Q9P242 |
PeptideAtlasi | Q9P242 |
PRIDEi | Q9P242 |
ProteomicsDBi | 83723 [Q9P242-1] 83724 [Q9P242-2] 83725 [Q9P242-3] |
Protocols and materials databases
Antibodypediai | 49421, 41 antibodies |
Genome annotation databases
Ensembli | ENST00000272907; ENSP00000272907; ENSG00000144460 [Q9P242-1] ENST00000636099; ENSP00000490942; ENSG00000144460 [Q9P242-1] |
GeneIDi | 57624 |
KEGGi | hsa:57624 |
UCSCi | uc002voe.3, human [Q9P242-1] |
Organism-specific databases
CTDi | 57624 |
DisGeNETi | 57624 |
GeneCardsi | NYAP2 |
HGNCi | HGNC:29291, NYAP2 |
HPAi | ENSG00000144460, Group enriched (brain, pituitary gland) |
MIMi | 615478, gene |
neXtProti | NX_Q9P242 |
OpenTargetsi | ENSG00000144460 |
PharmGKBi | PA165696738 |
VEuPathDBi | HostDB:ENSG00000144460.11 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QTY4, Eukaryota |
GeneTreei | ENSGT00890000139453 |
HOGENOMi | CLU_012558_1_0_1 |
InParanoidi | Q9P242 |
OMAi | DMIEKKR |
OrthoDBi | 295010at2759 |
PhylomeDBi | Q9P242 |
Enzyme and pathway databases
PathwayCommonsi | Q9P242 |
Miscellaneous databases
BioGRID-ORCSi | 57624, 3 hits in 979 CRISPR screens |
ChiTaRSi | NYAP2, human |
GenomeRNAii | 57624 |
Pharosi | Q9P242, Tdark |
PROi | PR:Q9P242 |
RNActi | Q9P242, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000144460, Expressed in cortical plate and 53 other tissues |
Genevisiblei | Q9P242, HS |
Family and domain databases
InterProi | View protein in InterPro IPR026722, NYAP1/NYAP2 IPR026723, NYAP2 IPR029353, NYAP_C IPR039482, NYAP_N |
PANTHERi | PTHR22633, PTHR22633, 1 hit PTHR22633:SF1, PTHR22633:SF1, 1 hit |
Pfami | View protein in Pfam PF15452, NYAP_C, 1 hit PF15439, NYAP_N, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NYAP2_HUMAN | |
Accessioni | Q9P242Primary (citable) accession number: Q9P242 Secondary accession number(s): A2RRN4, Q96NL2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 18, 2008 |
Last sequence update: | May 18, 2010 | |
Last modified: | April 7, 2021 | |
This is version 121 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families