NYAP2

Functionⁱ

Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis.By similarity

GO - Biological processⁱ

neuron projection morphogenesis Source: UniProtKB
phosphatidylinositol 3-kinase signaling Source: UniProtKB

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2
Gene namesⁱ	Name:NYAP2 Synonyms:KIAA1486
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000144460.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29291 NYAP2
MIMⁱ	615478 gene
neXtProtⁱ	NX_Q9P242

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	57624
Open Targets More...OpenTargetsⁱ	ENSG00000144460
PharmGKBⁱ	PA165696738

Polymorphism and mutation databases

BioMutaⁱ	NYAP2
DMDMⁱ	296439320

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000325830	1 – 653	Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2Add BLAST		653

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	81	Omega-N-methylarginineBy similarity	1
Modified residueⁱ	120	PhosphoserineBy similarity	1
Modified residueⁱ	206	PhosphoserineBy similarity	1
Modified residueⁱ	268	PhosphotyrosineBy similarity	1
Modified residueⁱ	434	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylated on tyrosine residues by FYN upon stimulation with CNTN5.By similarity

Keywords - PTMⁱ

Methylation, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9P242
PaxDbⁱ	Q9P242
PeptideAtlas More...PeptideAtlasⁱ	Q9P242
PRIDEⁱ	Q9P242
ProteomicsDBⁱ	83723 83724 [Q9P242-2] 83725 [Q9P242-3]

PTM databases

iPTMnetⁱ	Q9P242
PhosphoSitePlusⁱ	Q9P242

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000144460 Expressed in 37 organ(s), highest expression level in cerebellum
Genevisibleⁱ	Q9P242 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA045531

HPAⁱ

HPA045531

Interactionⁱ

Subunit structureⁱ

Interacts with ACOT9, ARHGAP26 and PIK3R2. Interacts with components of the WAVE1 complex, CYFIP1 and NCKAP1; this interaction mediates PI3K-WAVE1 association and actin cytoskeleton remodeling (By similarity).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
AGFG1	P52594	3	EBI-10269689,EBI-996560
MORN4	Q8NDC4	3	EBI-10269689,EBI-10269566

Protein-protein interaction databases

BioGridⁱ	121670, 13 interactors
IntActⁱ	Q9P242, 4 interactors

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9P242
SMRⁱ	Q9P242
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	150 – 161	Involved in CYFIP1- and NCKAP1-bindingBy similarityAdd BLAST		12

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	312 – 479	Pro-richAdd BLAST		168

Sequence similaritiesⁱ

Belongs to the NYAP family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IH9T Eukaryota ENOG410YEXE LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00890000139453
HOGENOMⁱ	HOG000111596
HOVERGENⁱ	HBG108036
InParanoidⁱ	Q9P242
OMAⁱ	ISSKMMS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G047B
PhylomeDBⁱ	Q9P242

Family and domain databases

InterProⁱ	View protein in InterPro IPR026722 NYAP1/NYAP2 IPR026723 NYAP2 IPR029353 NYAP_C IPR039482 NYAP_N
PANTHERⁱ	PTHR22633 PTHR22633, 1 hit PTHR22633:SF1 PTHR22633:SF1, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15452 NYAP_C, 1 hit PF15439 NYAP_N, 1 hit

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q9P242-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MISSKMMSSN PEEDPLDTFL QYIEDMGMKA YDGLVIQNAS DIARENDRLR 
        60         70         80         90        100
NETNLAYLKE KNEKRRRQEE AIKRIGGEVG RGHEGSYVGK HFRMGFMTMP 
       110        120        130        140        150
APQDRLPHPC SSGFSVRSQS LHSVGGTDDD SSCGSRRQPP PKPKRDPSTK 
       160        170        180        190        200
LSTSSETVSS TAASKSGKTP ERTEASAKPR PHSDEYSKKI PPPKPKRNPN 
       210        220        230        240        250
TQLSTSFDET YIKKHGPRRT SLPRDSSLSQ MGSPAGDPEE EEPVYIEMVG 
       260        270        280        290        300
NILRDFRKED DDQSEAVYEE MKYPIFDDLG QDAKCDFDHH SCSSQCATPT 
       310        320        330        340        350
VPDLDFAKAS VPCPPKGLLC DIPPPFPNLL SHRPPLLVFP PAPVHCSPNS 
       360        370        380        390        400
DESPLTPLEV TKLPVLENVS YMKQPAGASP STLPSHVPGH AKLEKEQAAA 
       410        420        430        440        450
LGPASATPAL SSSPPPPSTL YRTQSPHGYP KSHSTSPSPV SMGRSLTPLS 
       460        470        480        490        500
LKRPPPYDAV HSGSLSRSSP SVPHSTPRPV SQDGAKMVNA AVNTYGAAPG 
       510        520        530        540        550
GSRSRTPTSP LEELTSLFSS GRSLLRKSSS GRRSKEPAEK STEELKVRSH 
       560        570        580        590        600
STEPLPKLDN KERGHHGASS SREPVKAQEW DGTPGTPVVT SRLGRCSVSP 
       610        620        630        640        650
TLLAGNHSSE PKVSCKLGRS ASTSGVPPPS VTPLRQSSDL QQSQVPSSLA 

NRD

Length:653

Mass (Da):70,548

Last modified:May 18, 2010 - v3

Checksum:ⁱ78451871EC7822C6

GO

Isoform 2 (identifier: Q9P242-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
76-145: GGEVGRGHEG...RRQPPPKPKR → NRGTESPKPQ...LVSGKPQFRA
146-653: Missing.

« Hide

        10         20         30         40         50
MISSKMMSSN PEEDPLDTFL QYIEDMGMKA YDGLVIQNAS DIARENDRLR 
        60         70         80         90        100
NETNLAYLKE KNEKRRRQEE AIKRINRGTE SPKPQHGAIT KVGQQGKRPP 
       110        120        130        140 
WGVFLQRACQ SSGMGWNTRA TCGHQSTRKM LCEPHLVSGK PQFRA

Show »

Length:145

Mass (Da):16,536

Checksum:ⁱA9A52FFBEADF74F2

GO

Isoform 3 (identifier: Q9P242-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-486: Missing.
     645-645: V → I
     646-653: Missing.

« Hide

        10         20         30         40         50
MVNAAVNTYG AAPGGSRSRT PTSPLEELTS LFSSGRSLLR KSSSGRRSKE 
        60         70         80         90        100
PAEKSTEELK VRSHSTEPLP KLDNKERGHH GASSSREPVK AQEWDGTPGT 
       110        120        130        140        150
PVVTSRLGRC SVSPTLLAGN HSSEPKVSCK LGRSASTSGV PPPSVTPLRQ 

SSDLQQSQI

Show »

Length:159

Mass (Da):16,800

Checksum:ⁱEC892A314083B052

GO

Sequence cautionⁱ

The sequence BAA96010 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_039933	205	T → A. Corresponds to variant dbSNP:rs7422680Ensembl.		1
Natural variantⁱVAR_039934	586	T → P. Corresponds to variant dbSNP:rs3748993Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_032431	1 – 486	Missing in isoform 3. 1 PublicationAdd BLAST	486
Alternative sequenceⁱVSP_032432	76 – 145	GGEVG…PKPKR → NRGTESPKPQHGAITKVGQQ GKRPPWGVFLQRACQSSGMG WNTRATCGHQSTRKMLCEPH LVSGKPQFRA in isoform 2. 1 PublicationAdd BLAST	70
Alternative sequenceⁱVSP_032433	146 – 653	Missing in isoform 2. 1 PublicationAdd BLAST	508
Alternative sequenceⁱVSP_032434	645	V → I in isoform 3. 1 Publication	1
Alternative sequenceⁱVSP_032435	646 – 653	Missing in isoform 3. 1 Publication	8

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB040919 mRNA Translation: BAA96010.1 Different initiation. AK055226 mRNA Translation: BAB70880.1 AC016717 Genomic DNA No translation available. AC019231 Genomic DNA No translation available. AC067961 Genomic DNA No translation available. AC106890 Genomic DNA No translation available. BC131727 mRNA Translation: AAI31728.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS46529.1 [Q9P242-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_065915.1, NM_020864.1 [Q9P242-1] XP_005246765.1, XM_005246708.3 [Q9P242-1]
UniGeneⁱ	Hs.224409

Genome annotation databases

Ensemblⁱ	ENST00000272907; ENSP00000272907; ENSG00000144460 [Q9P242-1] ENST00000636099; ENSP00000490942; ENSG00000144460 [Q9P242-1]
GeneIDⁱ	57624
KEGGⁱ	hsa:57624
UCSC genome browser More...UCSCⁱ	uc002voe.3 human [Q9P242-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q9P242	Isoform 5 of Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2		MOUSE		716	UniRef90_Q8BM65-5
Uncharacterized protein		FELCA		722
Uncharacterized protein		MUSPF		721
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2		SAIBB		720
Uncharacterized protein		AOTNA		720
+120

Protein	Similar proteins		Species	Score	Length	Source
Q9P242	Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2		MOUSE		682	UniRef50_Q8BM65
Uncharacterized protein		LEPOC		711
Uncharacterized protein		TUPCH		702
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2		Asian bonytongue		698
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2		PELSI		616
+403
Q9P242-2	Uncharacterized protein		CAMFR		129	UniRef50_Q9P242-2

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB040919 mRNA Translation: BAA96010.1 Different initiation. AK055226 mRNA Translation: BAB70880.1 AC016717 Genomic DNA No translation available. AC019231 Genomic DNA No translation available. AC067961 Genomic DNA No translation available. AC106890 Genomic DNA No translation available. BC131727 mRNA Translation: AAI31728.1
CCDSⁱ	CCDS46529.1 [Q9P242-1]
RefSeqⁱ	NP_065915.1, NM_020864.1 [Q9P242-1] XP_005246765.1, XM_005246708.3 [Q9P242-1]
UniGeneⁱ	Hs.224409

3D structure databases

ProteinModelPortalⁱ	Q9P242
SMRⁱ	Q9P242
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121670, 13 interactors
IntActⁱ	Q9P242, 4 interactors

PTM databases

iPTMnetⁱ	Q9P242
PhosphoSitePlusⁱ	Q9P242

Polymorphism and mutation databases

BioMutaⁱ	NYAP2
DMDMⁱ	296439320

Proteomic databases

MaxQBⁱ	Q9P242
PaxDbⁱ	Q9P242
PeptideAtlasⁱ	Q9P242
PRIDEⁱ	Q9P242
ProteomicsDBⁱ	83723 83724 [Q9P242-2] 83725 [Q9P242-3]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000272907; ENSP00000272907; ENSG00000144460 [Q9P242-1] ENST00000636099; ENSP00000490942; ENSG00000144460 [Q9P242-1]
GeneIDⁱ	57624
KEGGⁱ	hsa:57624
UCSCⁱ	uc002voe.3 human [Q9P242-1]

Organism-specific databases

CTDⁱ	57624
DisGeNETⁱ	57624
EuPathDBⁱ	HostDB:ENSG00000144460.11
GeneCardsⁱ	NYAP2
HGNCⁱ	HGNC:29291 NYAP2
HPAⁱ	HPA045531
MIMⁱ	615478 gene
neXtProtⁱ	NX_Q9P242
OpenTargetsⁱ	ENSG00000144460
PharmGKBⁱ	PA165696738
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IH9T Eukaryota ENOG410YEXE LUCA
GeneTreeⁱ	ENSGT00890000139453
HOGENOMⁱ	HOG000111596
HOVERGENⁱ	HBG108036
InParanoidⁱ	Q9P242
OMAⁱ	ISSKMMS
OrthoDBⁱ	EOG091G047B
PhylomeDBⁱ	Q9P242

Miscellaneous databases

ChiTaRSⁱ	NYAP2 human
GenomeRNAiⁱ	57624
Protein Ontology More...PROⁱ	PR:Q9P242
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000144460 Expressed in 37 organ(s), highest expression level in cerebellum
Genevisibleⁱ	Q9P242 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR026722 NYAP1/NYAP2 IPR026723 NYAP2 IPR029353 NYAP_C IPR039482 NYAP_N
PANTHERⁱ	PTHR22633 PTHR22633, 1 hit PTHR22633:SF1 PTHR22633:SF1, 1 hit
Pfamⁱ	View protein in Pfam PF15452 NYAP_C, 1 hit PF15439 NYAP_N, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NYAP2_HUMAN
Accessionⁱ	Q9P242Primary (citable) accession number: Q9P242 Secondary accession number(s): A2RRN4, Q96NL2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
	Last sequence update:	May 18, 2010
	Last modified:	October 10, 2018
	This is version 104 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q9P242 (NYAP2_HUMAN)

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Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ