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Protein

Probable phospholipid-transporting ATPase VD

Gene

ATP10D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable).Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei4384-aspartylphosphate intermediateBy similarity1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1056MagnesiumBy similarity1
Metal bindingi1060MagnesiumBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi996 – 1003ATPSequence analysis8
Nucleotide bindingi1364 – 1371ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • magnesium ion binding Source: UniProtKB
  • phospholipid-translocating ATPase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
Biological processLipid transport, Transport
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-936837 Ion transport by P-type ATPases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable phospholipid-transporting ATPase VD (EC:7.6.2.1)
Alternative name(s):
ATPase class V type 10D
P4-ATPase flippase complex alpha subunit ATP10D
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATP10D
Synonyms:ATPVD, KIAA1487
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000145246.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13549 ATP10D

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9P241

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 97CytoplasmicSequence analysisAdd BLAST97
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Topological domaini119 – 121Exoplasmic loopSequence analysis3
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Topological domaini143 – 321CytoplasmicSequence analysisAdd BLAST179
Transmembranei322 – 342HelicalSequence analysisAdd BLAST21
Topological domaini343 – 365Exoplasmic loopSequence analysisAdd BLAST23
Transmembranei366 – 386HelicalSequence analysisAdd BLAST21
Topological domaini387 – 1113CytoplasmicSequence analysisAdd BLAST727
Transmembranei1114 – 1134HelicalSequence analysisAdd BLAST21
Topological domaini1135 – 1145Exoplasmic loopSequence analysisAdd BLAST11
Transmembranei1146 – 1166HelicalSequence analysisAdd BLAST21
Topological domaini1167 – 1195CytoplasmicSequence analysisAdd BLAST29
Transmembranei1196 – 1216HelicalSequence analysisAdd BLAST21
Topological domaini1217 – 1224Exoplasmic loopSequence analysis8
Transmembranei1225 – 1245HelicalSequence analysisAdd BLAST21
Topological domaini1246 – 1252CytoplasmicSequence analysis7
Transmembranei1253 – 1273HelicalSequence analysisAdd BLAST21
Topological domaini1274 – 1292Exoplasmic loopSequence analysisAdd BLAST19
Transmembranei1293 – 1313HelicalSequence analysisAdd BLAST21
Topological domaini1314 – 1426CytoplasmicSequence analysisAdd BLAST113

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57205

Open Targets

More...
OpenTargetsi
ENSG00000145246

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25100

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ATP10D

Domain mapping of disease mutations (DMDM)

More...
DMDMi
300669610

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000463821 – 1426Probable phospholipid-transporting ATPase VDAdd BLAST1426

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9P241

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9P241

PeptideAtlas

More...
PeptideAtlasi
Q9P241

PRoteomics IDEntifications database

More...
PRIDEi
Q9P241

ProteomicsDB human proteome resource

More...
ProteomicsDBi
83721
83722 [Q9P241-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9P241

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9P241

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in placenta and, to a lesser extent, in kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000145246 Expressed in 203 organ(s), highest expression level in placenta

CleanEx database of gene expression profiles

More...
CleanExi
HS_ATP10D

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9P241 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9P241 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA050808

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit.Curated

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121446, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000273859

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9P241

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9P241

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0206 Eukaryota
ENOG410XSS0 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156728

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000202528

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG107129

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9P241

KEGG Orthology (KO)

More...
KOi
K01530

Identification of Orthologs from Complete Genome Data

More...
OMAi
CHEENAK

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0139

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9P241

TreeFam database of animal gene trees

More...
TreeFami
TF354252

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1110.10, 1 hit
3.40.50.1000, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030360 ATP10D
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c

The PANTHER Classification System

More...
PANTHERi
PTHR24092 PTHR24092, 1 hit
PTHR24092:SF84 PTHR24092:SF84, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01652 ATPase-Plipid, 2 hits
TIGR01494 ATPase_P-type, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9P241-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTEALQWARY HWRRLIRGAT RDDDSGPYNY SSLLACGRKS SQTPKLSGRH
60 70 80 90 100
RIVVPHIQPF KDEYEKFSGA YVNNRIRTTK YTLLNFVPRN LFEQFHRAAN
110 120 130 140 150
LYFLFLVVLN WVPLVEAFQK EITMLPLVVV LTIIAIKDGL EDYRKYKIDK
160 170 180 190 200
QINNLITKVY SRKEKKYIDR CWKDVTVGDF IRLSCNEVIP ADMVLLFSTD
210 220 230 240 250
PDGICHIETS GLDGESNLKQ RQVVRGYAEQ DSEVDPEKFS SRIECESPNN
260 270 280 290 300
DLSRFRGFLE HSNKERVGLS KENLLLRGCT IRNTEAVVGI VVYAGHETKA
310 320 330 340 350
MLNNSGPRYK RSKLERRANT DVLWCVMLLV IMCLTGAVGH GIWLSRYEKM
360 370 380 390 400
HFFNVPEPDG HIISPLLAGF YMFWTMIILL QVLIPISLYV SIEIVKLGQI
410 420 430 440 450
YFIQSDVDFY NEKMDSIVQC RALNIAEDLG QIQYLFSDKT GTLTENKMVF
460 470 480 490 500
RRCSVAGFDY CHEENARRLE SYQEAVSEDE DFIDTVSGSL SNMAKPRAPS
510 520 530 540 550
CRTVHNGPLG NKPSNHLAGS SFTLGSGEGA SEVPHSRQAA FSSPIETDVV
560 570 580 590 600
PDTRLLDKFS QITPRLFMPL DETIQNPPME TLYIIDFFIA LAICNTVVVS
610 620 630 640 650
APNQPRQKIR HPSLGGLPIK SLEEIKSLFQ RWSVRRSSSP SLNSGKEPSS
660 670 680 690 700
GVPNAFVSRL PLFSRMKPAS PVEEEVSQVC ESPQCSSSSA CCTETEKQHG
710 720 730 740 750
DAGLLNGKAE SLPGQPLACN LCYEAESPDE AALVYAARAY QCTLRSRTPE
760 770 780 790 800
QVMVDFAALG PLTFQLLHIL PFDSVRKRMS VVVRHPLSNQ VVVYTKGADS
810 820 830 840 850
VIMELLSVAS PDGASLEKQQ MIVREKTQKH LDDYAKQGLR TLCIAKKVMS
860 870 880 890 900
DTEYAEWLRN HFLAETSIDN REELLLESAM RLENKLTLLG ATGIEDRLQE
910 920 930 940 950
GVPESIEALH KAGIKIWMLT GDKQETAVNI AYACKLLEPD DKLFILNTQS
960 970 980 990 1000
KDACGMLMST ILKELQKKTQ ALPEQVSLSE DLLQPPVPRD SGLRAGLIIT
1010 1020 1030 1040 1050
GKTLEFALQE SLQKQFLELT SWCQAVVCCR ATPLQKSEVV KLVRSHLQVM
1060 1070 1080 1090 1100
TLAIGDGAND VSMIQVADIG IGVSGQEGMQ AVMASDFAVS QFKHLSKLLL
1110 1120 1130 1140 1150
VHGHWCYTRL SNMILYFFYK NVAYVNLLFW YQFFCGFSGT SMTDYWVLIF
1160 1170 1180 1190 1200
FNLLFTSAPP VIYGVLEKDV SAETLMQLPE LYRSGQKSEA YLPHTFWITL
1210 1220 1230 1240 1250
LDAFYQSLVC FFVPYFTYQG SDTDIFAFGN PLNTAALFIV LLHLVIESKS
1260 1270 1280 1290 1300
LTWIHLLVII GSILSYFLFA IVFGAMCVTC NPPSNPYWIM QEHMLDPVFY
1310 1320 1330 1340 1350
LVCILTTSIA LLPRFVYRVL QGSLFPSPIL RAKHFDRLTP EERTKALKKW
1360 1370 1380 1390 1400
RGAGKMNQVT SKYANQSAGK SGRRPMPGPS AVFAMKSASS CAIEQGNLSL
1410 1420
CETALDQGYS ETKAFEMAGP SKGKES
Length:1,426
Mass (Da):160,274
Last modified:July 13, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i97EE929F81AC59AE
GO
Isoform 2 (identifier: Q9P241-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     553-747: Missing.

Note: No experimental confirmation available.
Show »
Length:1,231
Mass (Da):138,890
Checksum:i67D834DFFCEA7A54
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6PEW3Q6PEW3_HUMAN
ATP10D protein
ATP10D
535Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8M7H0Y8M7_HUMAN
Probable phospholipid-transporting ...
ATP10D
224Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB55221 differs from that shown. Reason: Frameshift at position 748.Curated
The sequence BAC11299 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti142D → G in CAD29577 (PubMed:12532265).Curated1
Sequence conflicti1002K → R in CAD29577 (PubMed:12532265).Curated1
Sequence conflicti1090S → Y in CAD29577 (PubMed:12532265).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04838543T → I1 PublicationCorresponds to variant dbSNP:rs33995001Ensembl.1
Natural variantiVAR_048386171C → R. Corresponds to variant dbSNP:rs7683838Ensembl.1
Natural variantiVAR_048387320T → I. Corresponds to variant dbSNP:rs35596623Ensembl.1
Natural variantiVAR_048388337A → T. Corresponds to variant dbSNP:rs35012290Ensembl.1
Natural variantiVAR_048389511N → S. Corresponds to variant dbSNP:rs10003238Ensembl.1
Natural variantiVAR_048390522F → L. Corresponds to variant dbSNP:rs6843325Ensembl.1
Natural variantiVAR_048391716P → T. Corresponds to variant dbSNP:rs34208443Ensembl.1
Natural variantiVAR_048392720N → S. Corresponds to variant dbSNP:rs34169638Ensembl.1
Natural variantiVAR_048393959S → N. Corresponds to variant dbSNP:rs17462252Ensembl.1
Natural variantiVAR_0483941183R → K. Corresponds to variant dbSNP:rs16851681Ensembl.1
Natural variantiVAR_0201871240V → I1 PublicationCorresponds to variant dbSNP:rs1058793Ensembl.1
Natural variantiVAR_0243711389S → T1 PublicationCorresponds to variant dbSNP:rs4145944Ensembl.1
Natural variantiVAR_0483951392A → G. Corresponds to variant dbSNP:rs35375547Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_006954553 – 747Missing in isoform 2. 1 PublicationAdd BLAST195

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ441078 mRNA Translation: CAD29577.1
AC092597 Genomic DNA No translation available.
AC107398 Genomic DNA No translation available.
CH471069 Genomic DNA Translation: EAW93036.1
BC131535 mRNA Translation: AAI31536.1
AK027598 mRNA Translation: BAB55221.1 Frameshift.
AK074930 mRNA Translation: BAC11299.1 Different initiation.
AB040920 mRNA Translation: BAA96011.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS3476.1 [Q9P241-1]

NCBI Reference Sequences

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RefSeqi
NP_065186.3, NM_020453.3 [Q9P241-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.437241

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000273859; ENSP00000273859; ENSG00000145246 [Q9P241-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
57205

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:57205

UCSC genome browser

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UCSCi
uc003gxk.2 human [Q9P241-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ441078 mRNA Translation: CAD29577.1
AC092597 Genomic DNA No translation available.
AC107398 Genomic DNA No translation available.
CH471069 Genomic DNA Translation: EAW93036.1
BC131535 mRNA Translation: AAI31536.1
AK027598 mRNA Translation: BAB55221.1 Frameshift.
AK074930 mRNA Translation: BAC11299.1 Different initiation.
AB040920 mRNA Translation: BAA96011.1
CCDSiCCDS3476.1 [Q9P241-1]
RefSeqiNP_065186.3, NM_020453.3 [Q9P241-1]
UniGeneiHs.437241

3D structure databases

ProteinModelPortaliQ9P241
SMRiQ9P241
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121446, 1 interactor
STRINGi9606.ENSP00000273859

PTM databases

iPTMnetiQ9P241
PhosphoSitePlusiQ9P241

Polymorphism and mutation databases

BioMutaiATP10D
DMDMi300669610

Proteomic databases

EPDiQ9P241
PaxDbiQ9P241
PeptideAtlasiQ9P241
PRIDEiQ9P241
ProteomicsDBi83721
83722 [Q9P241-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273859; ENSP00000273859; ENSG00000145246 [Q9P241-1]
GeneIDi57205
KEGGihsa:57205
UCSCiuc003gxk.2 human [Q9P241-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57205
DisGeNETi57205
EuPathDBiHostDB:ENSG00000145246.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ATP10D
HGNCiHGNC:13549 ATP10D
HPAiHPA050808
neXtProtiNX_Q9P241
OpenTargetsiENSG00000145246
PharmGKBiPA25100

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0206 Eukaryota
ENOG410XSS0 LUCA
GeneTreeiENSGT00940000156728
HOGENOMiHOG000202528
HOVERGENiHBG107129
InParanoidiQ9P241
KOiK01530
OMAiCHEENAK
OrthoDBiEOG091G0139
PhylomeDBiQ9P241
TreeFamiTF354252

Enzyme and pathway databases

ReactomeiR-HSA-936837 Ion transport by P-type ATPases

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
57205

Protein Ontology

More...
PROi
PR:Q9P241

Gene expression databases

BgeeiENSG00000145246 Expressed in 203 organ(s), highest expression level in placenta
CleanExiHS_ATP10D
ExpressionAtlasiQ9P241 baseline and differential
GenevisibleiQ9P241 HS

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR030360 ATP10D
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c
PANTHERiPTHR24092 PTHR24092, 1 hit
PTHR24092:SF84 PTHR24092:SF84, 1 hit
PfamiView protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01652 ATPase-Plipid, 2 hits
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAT10D_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P241
Secondary accession number(s): A2RRC8
, D6REN2, Q8NC70, Q96SR3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: July 13, 2010
Last modified: December 5, 2018
This is version 165 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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