Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 133 (16 Oct 2019)
Sequence version 2 (20 Mar 2007)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Rho GTPase-activating protein 23

Gene

ARHGAP23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-194840 Rho GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho GTPase-activating protein 23
Alternative name(s):
Rho-type GTPase-activating protein 23
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARHGAP23
Synonyms:KIAA1501
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29293 ARHGAP23

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610590 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9P227

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57636

Open Targets

More...
OpenTargetsi
ENSG00000275832

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9P227

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARHGAP23

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002804711 – 1491Rho GTPase-activating protein 23Add BLAST1491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei361PhosphoserineCombined sources1
Modified residuei372PhosphoserineCombined sources1
Modified residuei423PhosphoserineCombined sources1
Modified residuei517PhosphoserineBy similarity1
Modified residuei583PhosphoserineBy similarity1
Modified residuei611PhosphoserineBy similarity1
Modified residuei623PhosphoserineBy similarity1
Modified residuei656PhosphothreonineBy similarity1
Modified residuei659PhosphoserineBy similarity1
Modified residuei662PhosphoserineBy similarity1
Modified residuei677PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki854Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9P227

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9P227

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9P227

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9P227

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9P227

PeptideAtlas

More...
PeptideAtlasi
Q9P227

PRoteomics IDEntifications database

More...
PRIDEi
Q9P227

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
83718 [Q9P227-1]
83719 [Q9P227-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9P227

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9P227

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9P227

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in placenta, prostate, hippocampus and brain medulla. Also expressed in brain tumor, salivary gland tumor, head and neck tumor.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000275832 Expressed in 204 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9P227 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9P227 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA019818
HPA047291

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121677, 8 interactors

Protein interaction database and analysis system

More...
IntActi
Q9P227, 4 interactors

Molecular INTeraction database

More...
MINTi
Q9P227

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000481862

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini71 – 155PDZPROSITE-ProRule annotationAdd BLAST85
Domaini688 – 808PHPROSITE-ProRule annotationAdd BLAST121
Domaini905 – 1097Rho-GAPPROSITE-ProRule annotationAdd BLAST193

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi183 – 279Pro-richAdd BLAST97
Compositional biasi1320 – 1405Arg-richAdd BLAST86

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4407 Eukaryota
ENOG410YY7B LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157982

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000049125

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9P227

KEGG Orthology (KO)

More...
KOi
K20315

Identification of Orthologs from Complete Genome Data

More...
OMAi
SAWATMV

Database of Orthologous Groups

More...
OrthoDBi
142586at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9P227

TreeFam database of animal gene trees

More...
TreeFami
TF329345

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.555.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001478 PDZ
IPR041489 PDZ_6
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR041681 PH_9
IPR001849 PH_domain
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17820 PDZ_6, 1 hit
PF15410 PH_9, 1 hit
PF00620 RhoGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228 PDZ, 1 hit
SM00233 PH, 1 hit
SM00324 RhoGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350 SSF48350, 1 hit
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50238 RHOGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9P227-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNGVAFCLVG IPPRPEPRPP QLPLGPRDGC SPRRPFPWQG PRTLLLYKSP
60 70 80 90 100
QDGFGFTLRH FIVYPPESAV HCSLKEEENG GRGGGPSPRY RLEPMDTIFV
110 120 130 140 150
KNVKEDGPAH RAGLRTGDRL VKVNGESVIG KTYSQVIALI QNSDDTLELS
160 170 180 190 200
IMPKDEDILQ LAYSQDAYLK GNEPYSGEAR SIPEPPPICY PRKTYAPPAR
210 220 230 240 250
ASTRATMVPE PTSALPSDPR SPAAWSDPGL RVPPAARAHL DNSSLGMSQP
260 270 280 290 300
RPSPGAFPHL SSEPRTPRAF PEPGSRVPPS RLECQQALSH WLSNQVPRRA
310 320 330 340 350
GERRCPAMAP RARSASQDRL EEVAAPRPWP CSTSQDALSQ LGQEGWHRAR
360 370 380 390 400
SDDYLSRATR SAEALGPGAL VSPRFERCGW ASQRSSARTP ACPTRDLPGP
410 420 430 440 450
QAPPPSGLQG LDDLGYIGYR SYSPSFQRRT GLLHALSFRD SPFGGLPTFN
460 470 480 490 500
LAQSPASFPP EASEPPRVVR PEPSTRALEP PAEDRGDEVV LRQKPPTGRK
510 520 530 540 550
VQLTPARQMN LGFGDESPEP EASGRGERLG RKVAPLATTE DSLASIPFID
560 570 580 590 600
EPTSPSIDLQ AKHVPASAVV SSAMNSAPVL GTSPSSPTFT FTLGRHYSQD
610 620 630 640 650
CSSIKAGRRS SYLLAITTER SKSCDDGLNT FRDEGRVLRR LPNRIPSLRM
660 670 680 690 700
LRSFFTDGSL DSWGTSEDAD APSKRHSTSD LSDATFSDIR REGWLYYKQI
710 720 730 740 750
LTKKGKKAGS GLRQWKRVYA ALRARSLSLS KERREPGPAA AGAAAAGAGE
760 770 780 790 800
DEAAPVCIGS CLVDISYSET KRRHVFRLTT ADFCEYLFQA EDRDDMLGWI
810 820 830 840 850
RAIRENSRAE GEDPGCANQA LISKKLNDYR KVSHSSGPKA DSSPKGSRGL
860 870 880 890 900
GGLKSEFLKQ SAARGLRTQD LPAGSKDDSA AAPKTPWGIN IIKKNKKAAP
910 920 930 940 950
RAFGVRLEEC QPATENQRVP LIVAACCRIV EARGLESTGI YRVPGNNAVV
960 970 980 990 1000
SSLQEQLNRG PGDINLQDER WQDLNVISSL LKSFFRKLPE PLFTDDKYND
1010 1020 1030 1040 1050
FIEANRIEDA RERMRTLRKL IRDLPGHYYE TLKFLVGHLK TIADHSEKNK
1060 1070 1080 1090 1100
MEPRNLALVF GPTLVRTSED NMTDMVTHMP DRYKIVETLI QHSDWFFSDE
1110 1120 1130 1140 1150
EDKGERTPVG DKEPQAVPNI EYLLPNIGRT VPPGDPGSDS TTCSSAKSKG
1160 1170 1180 1190 1200
SWAPKKEPYA REMLAISFIS AVNRKRKKRR EARGLGSSTD DDSEQEAHKP
1210 1220 1230 1240 1250
GAGATAPGTQ ERPQGPLPGA VAPEAPGRLS PPAAPEERPA ADTRSIVSGY
1260 1270 1280 1290 1300
STLSTMDRSV CSGASGRRAG AGDEADDERS ELSHVETDTE GAAGAGPGGR
1310 1320 1330 1340 1350
LTRRPSFSSH HLMPCDTLAR RRLARGRPDG EGAGRGGPRA PEPPGSASSS
1360 1370 1380 1390 1400
SQESLRPPAA ALASRPSRME ALRLRLRGTA DDMLAVRLRR PLSPETRRRR
1410 1420 1430 1440 1450
SSWRRHTVVV QSPLTDLNFN EWKELGGGGP PEPAGARAHS DNKDSGLSSL
1460 1470 1480 1490
ESTKARAPSS AASQPPAPGD TGSLQSQPPR RSAASRLHQC L
Note: No experimental confirmation available. Gene prediction based on EST data.
Length:1,491
Mass (Da):162,192
Last modified:March 20, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1700D3F1AEF5C0B1
GO
Isoform 2 (identifier: Q9P227-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1139-1144: DSTTCS → ADLLEI
     1145-1491: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:1,144
Mass (Da):125,710
Checksum:i18AACA715BFDF853
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WTU4A0A087WTU4_HUMAN
Rho GTPase-activating protein 23
ARHGAP23
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X1W6A0A087X1W6_HUMAN
Rho GTPase-activating protein 23
ARHGAP23
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZ73A0A087WZ73_HUMAN
Rho GTPase-activating protein 23
ARHGAP23
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZZ2A0A087WZZ2_HUMAN
Rho GTPase-activating protein 23
ARHGAP23
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X0Z0A0A087X0Z0_HUMAN
Rho GTPase-activating protein 23
ARHGAP23
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WXU2A0A087WXU2_HUMAN
Rho GTPase-activating protein 23
ARHGAP23
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0237081139 – 1144DSTTCS → ADLLEI in isoform 2. 1 Publication6
Alternative sequenceiVSP_0237091145 – 1491Missing in isoform 2. 1 PublicationAdd BLAST347

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC115090 Genomic DNA No translation available.
AB040934 mRNA Translation: BAA96025.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS56027.1 [Q9P227-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A59434

NCBI Reference Sequences

More...
RefSeqi
NP_001186346.1, NM_001199417.1 [Q9P227-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000610551; ENSP00000479208; ENSG00000273780 [Q9P227-1]
ENST00000620417; ENSP00000482992; ENSG00000275832 [Q9P227-2]
ENST00000622683; ENSP00000481862; ENSG00000275832 [Q9P227-1]
ENST00000631799; ENSP00000488428; ENSG00000273780 [Q9P227-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57636

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57636

UCSC genome browser

More...
UCSCi
uc021twd.2 human [Q9P227-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC115090 Genomic DNA No translation available.
AB040934 mRNA Translation: BAA96025.1
CCDSiCCDS56027.1 [Q9P227-1]
PIRiA59434
RefSeqiNP_001186346.1, NM_001199417.1 [Q9P227-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi121677, 8 interactors
IntActiQ9P227, 4 interactors
MINTiQ9P227
STRINGi9606.ENSP00000481862

PTM databases

iPTMnetiQ9P227
PhosphoSitePlusiQ9P227
SwissPalmiQ9P227

Polymorphism and mutation databases

BioMutaiARHGAP23

Proteomic databases

EPDiQ9P227
jPOSTiQ9P227
MassIVEiQ9P227
MaxQBiQ9P227
PaxDbiQ9P227
PeptideAtlasiQ9P227
PRIDEiQ9P227
ProteomicsDBi83718 [Q9P227-1]
83719 [Q9P227-2]

Genome annotation databases

EnsembliENST00000610551; ENSP00000479208; ENSG00000273780 [Q9P227-1]
ENST00000620417; ENSP00000482992; ENSG00000275832 [Q9P227-2]
ENST00000622683; ENSP00000481862; ENSG00000275832 [Q9P227-1]
ENST00000631799; ENSP00000488428; ENSG00000273780 [Q9P227-2]
GeneIDi57636
KEGGihsa:57636
UCSCiuc021twd.2 human [Q9P227-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57636
DisGeNETi57636

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ARHGAP23
HGNCiHGNC:29293 ARHGAP23
HPAiHPA019818
HPA047291
MIMi610590 gene
neXtProtiNX_Q9P227
OpenTargetsiENSG00000275832

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4407 Eukaryota
ENOG410YY7B LUCA
GeneTreeiENSGT00940000157982
HOGENOMiHOG000049125
InParanoidiQ9P227
KOiK20315
OMAiSAWATMV
OrthoDBi142586at2759
PhylomeDBiQ9P227
TreeFamiTF329345

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ARHGAP23 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57636
PharosiQ9P227

Protein Ontology

More...
PROi
PR:Q9P227

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000275832 Expressed in 204 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ9P227 baseline and differential
GenevisibleiQ9P227 HS

Family and domain databases

Gene3Di1.10.555.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR001478 PDZ
IPR041489 PDZ_6
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR041681 PH_9
IPR001849 PH_domain
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
PfamiView protein in Pfam
PF17820 PDZ_6, 1 hit
PF15410 PH_9, 1 hit
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SM00233 PH, 1 hit
SM00324 RhoGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50238 RHOGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRHG23_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P227
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: October 16, 2019
This is version 133 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again