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Entry version 135 (26 Feb 2020)
Sequence version 3 (26 Feb 2008)
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Protein

Dynein heavy chain 2, axonemal

Gene

DNAH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1803 – 1810ATPSequence analysis8
Nucleotide bindingi2084 – 2091ATPSequence analysis8
Nucleotide bindingi2416 – 2423ATPSequence analysis8
Nucleotide bindingi2762 – 2769ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dynein heavy chain 2, axonemal
Alternative name(s):
Axonemal beta dynein heavy chain 2
Ciliary dynein heavy chain 2
Dynein heavy chain domain-containing protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DNAH2
Synonyms:DNAHC2, DNHD3, KIAA1503
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2948 DNAH2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603333 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9P225

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
146754

Open Targets

More...
OpenTargetsi
ENSG00000183914

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27401

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9P225 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DNAH2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
172044680

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003225421 – 4427Dynein heavy chain 2, axonemalAdd BLAST4427

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9P225

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9P225

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9P225

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9P225

PeptideAtlas

More...
PeptideAtlasi
Q9P225

PRoteomics IDEntifications database

More...
PRIDEi
Q9P225

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
83715 [Q9P225-1]
83716 [Q9P225-2]
83717 [Q9P225-3]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9P225-3 [Q9P225-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9P225

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9P225

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in lung.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000183914 Expressed in bronchial epithelial cell and 74 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9P225 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9P225 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA067103

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Consists of at least two heavy chains and a number of intermediate and light chains.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127007, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q9P225, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000458355

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9P225 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9P225

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1404 – 1439TPR 1Add BLAST36
Repeati2721 – 2754TPR 2Add BLAST34
Repeati3072 – 3105TPR 3Add BLAST34
Repeati4072 – 4104TPR 4Add BLAST33
Repeati4105 – 4140TPR 5Add BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 1764StemBy similarityAdd BLAST1764
Regioni1765 – 1986AAA 1By similarityAdd BLAST222
Regioni2046 – 2273AAA 2By similarityAdd BLAST228
Regioni2378 – 2625AAA 3By similarityAdd BLAST248
Regioni2722 – 2974AAA 4By similarityAdd BLAST253
Regioni2989 – 3272StalkBy similarityAdd BLAST284
Regioni3358 – 3588AAA 5By similarityAdd BLAST231
Regioni3804 – 4023AAA 6By similarityAdd BLAST220

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili3012 – 3049Sequence analysisAdd BLAST38
Coiled coili3216 – 3304Sequence analysisAdd BLAST89
Coiled coili3523 – 3567Sequence analysisAdd BLAST45

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dynein heavy chain family.Curated

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3595 Eukaryota
COG5245 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157623

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000038_0_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9P225

KEGG Orthology (KO)

More...
KOi
K10408

Identification of Orthologs from Complete Genome Data

More...
OMAi
KISRPPQ

Database of Orthologous Groups

More...
OrthoDBi
1492at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9P225

TreeFam database of animal gene trees

More...
TreeFami
TF316836

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.20.180.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR035699 AAA_6
IPR035706 AAA_9
IPR041658 AAA_lid_11
IPR042219 AAA_lid_11_sf
IPR026983 DHC_fam
IPR041589 DNAH3_AAA_lid_1
IPR042228 Dynein_2_C
IPR042222 Dynein_2_N
IPR041466 Dynein_AAA5_ext
IPR041228 Dynein_C
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_D6_P-loop
IPR013594 Dynein_heavy_dom-1
IPR013602 Dynein_heavy_dom-2
IPR027417 P-loop_NTPase

The PANTHER Classification System

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PANTHERi
PTHR10676 PTHR10676, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12774 AAA_6, 1 hit
PF12780 AAA_8, 1 hit
PF12781 AAA_9, 1 hit
PF17857 AAA_lid_1, 1 hit
PF18198 AAA_lid_11, 1 hit
PF08385 DHC_N1, 2 hits
PF08393 DHC_N2, 1 hit
PF17852 Dynein_AAA_lid, 1 hit
PF18199 Dynein_C, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9P225-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSKAEKKQR LSGRGSSQAS WSGRATRAAV ATQEQGNAPA VSEPELQAEL
60 70 80 90 100
PKEEPEPRLE GPQAQSEESV EPEADVKPLF LSRAALTGLA DAVWTQEHDA
110 120 130 140 150
ILEHFAQDPT ESILTIFIDP CFGLKLELGM PVQTQNQLVY FIRQAPVPIT
160 170 180 190 200
WENFEATVQF GTVRGPYIPA LLRLLGGVFA PQIFANTGWP ESIRNHFASH
210 220 230 240 250
LHKFLACLTD TRYKLEGHTV LYIPAEAMNM KPEMVIKDKE LVQRLETSMI
260 270 280 290 300
HWTRQIKEML SAQETVETGE NLGPLEEIEF WRNRCMDLSG ISKQLVKKGV
310 320 330 340 350
KHVESILHLA KSSYLAPFMK LAQQIQDGSR QAQSNLTFLS ILKEPYQELA
360 370 380 390 400
FMKPKDISSK LPKLISLIRI IWVNSPHYNT RERLTSLFRK VCDCQYHFAR
410 420 430 440 450
WEDGKQGPLP CFFGAQGPQI TRNLLEIEDI FHKNLHTLRA VRGGILDVKN
460 470 480 490 500
TCWHEDYNKF RAGIKDLEVM TQNLITSAFE LVRDVPHGVL LLDTFHRLAS
510 520 530 540 550
REAIKRTYDK KAVDLYMLFN SELALVNRER NKKWPDLEPY VAQYSGKARW
560 570 580 590 600
VHILRRRIDR VMTCLAGAHF LPRIGTGKES VHTYQQMVQA IDELVRKTFQ
610 620 630 640 650
EWTSSLDKDC IRRLDTPLLR ISQEKAGMLD VNFDKSLLIL FAEIDYWERL
660 670 680 690 700
LFETPHYVVN VAERAEDLRI LRENLLLVAR DYNRIIAMLS PDEQALFKER
710 720 730 740 750
IRLLDKKIHP GLKKLHWALK GASAFFITEC RIHASKVQMI VNEFKASTLT
760 770 780 790 800
IGWRAQEMSE KLLVRISGKR VYRDLEFEED QREHRAAVQQ KLMNLHQDVV
810 820 830 840 850
TIMTNSYEVF KNDGPEIQQQ WMLYMIRLDR MMEDALRLNV KWSLLELSKA
860 870 880 890 900
INGDGKTSPN PLFQVLVILK NDLQGSVAQV EFSPTLQTLA GVVNDIGNHL
910 920 930 940 950
FSTISVFCHL PDILTKRKLH REPIQTVVEQ DEDIKKIQTQ ISSGMTNNAS
960 970 980 990 1000
LLQNYLKTWD MYREIWEINK DSFIHRYQRL NPPVSSFVAD IARYTEVANN
1010 1020 1030 1040 1050
VQKEETVTNI QFVLLDCSHL KFSLVQHCNE WQNKFATLLR EMAAGRLLEL
1060 1070 1080 1090 1100
HTYLKENAEK ISRPPQTLEE LGVSLQLVDA LKHDLANVET QIPPIHEQFA
1110 1120 1130 1140 1150
ILEKYEVPVE DSVLEMLDSL NGEWVVFQQT LLDSKQMLKK HKEKFKTGLI
1160 1170 1180 1190 1200
HSADDFKKKA HTLLEDFEFK GHFTSNVGYM SALDQITQVR AMLMAMREEE
1210 1220 1230 1240 1250
NSLRANLGIF KIEQPPSKDL QNLEKELDAL QQIWEIARDW EENWNEWKTG
1260 1270 1280 1290 1300
RFLILQTETM ETTAHGLFRR LTKLAKEYKD RNWEIIETTR SKIEQFKRTM
1310 1320 1330 1340 1350
PLISDLRNPA LRERHWDQVR DEIQREFDQE SESFTLEQIV ELGMDQHVEK
1360 1370 1380 1390 1400
IGEISASATK ELAIEVALQN IAKTWDVTQL DIVPYKDKGH HRLRGTEEVF
1410 1420 1430 1440 1450
QALEDNQVAL STMKASRFVK AFEKDVDHWE RCLSLILEVI EMILTVQRQW
1460 1470 1480 1490 1500
MYLENIFLGE DIRKQLPNES TLFDQVNSNW KAIMDRMNKD NNALRSTHHP
1510 1520 1530 1540 1550
GLLDTLIEMN TILEDIQKSL DMYLETKRHI FPRFYFLSND DLLEILGQSR
1560 1570 1580 1590 1600
NPEAVQPHLK KCFDNIKLLR IQKVGGPSSK WEAVGMFSGD GEYIDFLHSV
1610 1620 1630 1640 1650
FLEGPVESWL GDVEQTMRVT LRDLLRNCHL ALRKFLNKRD KWVKEWAGQV
1660 1670 1680 1690 1700
VITASQIQWT ADVTKCLLTA KERADKKILK VMKKNQVSIL NKYSEAIRGN
1710 1720 1730 1740 1750
LTKIMRLKIV ALVTIEIHAR DVLEKLYKSG LMDVNSFDWL SQLRFYWEKD
1760 1770 1780 1790 1800
LDDCVIRQTN TQFQYNYEYL GNSGRLVITP LTDRCYMTLT TALHLHRGGS
1810 1820 1830 1840 1850
PKGPAGTGKT ETVKDLGKAL GIYVIVVNCS EGLDYKSMGR MYSGLAQTGA
1860 1870 1880 1890 1900
WGCFDEFNRI NIEVLSVVAH QILCILSALA AGLTHFHFDG FEINLVWSCG
1910 1920 1930 1940 1950
IFITMNPGYA GRTELPENLK SMFRPIAMVV PDSTLIAEII LFGEGFGNCK
1960 1970 1980 1990 2000
ILAKKVYTLY SLAVQQLSRQ DHYDFGLRAL TSLLRYAGKK RRLQPDLTDE
2010 2020 2030 2040 2050
EVLLLSMRDM NIAKLTSVDA PLFNAIVQDL FPNIELPVID YGKLRETVEQ
2060 2070 2080 2090 2100
EIRDMGLQST PFTLTKVFQL YETKNSRHST MIVGCTGSGK TASWRILQAS
2110 2120 2130 2140 2150
LSSLCRAGDP NFNIVREFPL NPKALSLGEL YGEYDLSTNE WTDGILSSVM
2160 2170 2180 2190 2200
RTACADEKPD EKWILFDGPV DTLWIENMNS VMDDNKVLTL INGERIAMPE
2210 2220 2230 2240 2250
QVSLLFEVED LAMASPATVS RCGMVYTDYA DLGWKPYVQS WLEKRPKAEV
2260 2270 2280 2290 2300
EPLQRMFEKL INKMLAFKKD NCKELVPLPE YSGITSLCKL YSALATPENG
2310 2320 2330 2340 2350
VNPADGENYV TMVEMTFVFS MIWSVCASVD EEGRKRIDSY LREIEGSFPN
2360 2370 2380 2390 2400
KDTVYEYFVD PKIRSWTSFE DKLPKSWRYP PNAPFYKIMV PTVDTVRYNY
2410 2420 2430 2440 2450
LVSSLVANQN PILLVGPVGT GKTSIAQSVL QSLPSSQWSV LVVNMSAQTT
2460 2470 2480 2490 2500
SNNVQSIIES RVEKRTKGVY VPFGGKSMIT FMDDLNMPAK DMFGSQPPLE
2510 2520 2530 2540 2550
LIRLWIDYGF WYDRTKQTIK YIREMFLMAA MGPPGGGRTV ISPRLRSRFN
2560 2570 2580 2590 2600
IINMTFPTKS QIIRIFGTMI NQKLQDFEEE VKPIGNVVTE ATLDMYNTVV
2610 2620 2630 2640 2650
QRFLPTPTKM HYLFNLRDIS KVFQGMLRAN KDFHDTKSSI TRLWIHECFR
2660 2670 2680 2690 2700
VFSDRLVDAA DTEAFMGIIS DKLGSFFDLT FHHLCPSKRP PIFGDFLKEP
2710 2720 2730 2740 2750
KVYEDLTDLT VLKTVMETAL NEYNLSPSVV PMQLVLFREA IEHITRIVRV
2760 2770 2780 2790 2800
IGQPRGNMLL VGIGGSGRQS LARLASSICD YTTFQIEVTK HYRKQEFRDD
2810 2820 2830 2840 2850
IKRLYRQAGV ELKTTSFIFV DTQIADESFL EDINNILSSG EVPNLYKPDE
2860 2870 2880 2890 2900
FEEIQSHIID QARVEQVPES SDSLFAYLIE RVQNNLHIVL CLSPMGDPFR
2910 2920 2930 2940 2950
NWIRQYPALV NCTTINWFSE WPQEALLEVA EKCLIGVDLG TQENIHRKVA
2960 2970 2980 2990 3000
QIFVTMHWSV AQYSQKMLLE LRRHNYVTPT KYLELLSGYK KLLGEKRQEL
3010 3020 3030 3040 3050
LAQANKLRTG LFKIDETREK VQVMSLELED AKKKVAEFQK QCEEYLVIIV
3060 3070 3080 3090 3100
QQKREADEQQ KAVTANSEKI AVEEIKCQAL ADNAQKDLEE ALPALEEAMR
3110 3120 3130 3140 3150
ALESLNKKDI GEIKSYGRPP AQVEIVMQAV MILRGNEPTW AEAKRQLGEQ
3160 3170 3180 3190 3200
NFIKSLINFD KDNISDKVLK KIGAYCAQPD FQPDIIGRVS LAAKSLCMWV
3210 3220 3230 3240 3250
RAMELYGRLY RVVEPKRIRM NAALAQLREK QAALAEAQEK LREVAEKLEM
3260 3270 3280 3290 3300
LKKQYDEKLA QKEELRKKSE EMELKLERAG MLVSGLAGEK ARWEETVQGL
3310 3320 3330 3340 3350
EEDLGYLVGD CLLAAAFLSY MGPFLTNYRD EIVNQIWIGK IWELQVPCSP
3360 3370 3380 3390 3400
SFAIDNFLCN PTKVRDWNIQ GLPSDAFSTE NGIIVTRGNR WALMIDPQAQ
3410 3420 3430 3440 3450
ALKWIKNMEG GQGLKIIDLQ MSDYLRILEH AIHFGYPVLL QNVQEYLDPT
3460 3470 3480 3490 3500
LNPMLNKSVA RIGGRLLMRI GDKEVEYNTN FRFYITTKLS NPHYSPETSA
3510 3520 3530 3540 3550
KTTIVNFAVK EQGLEAQLLG IVVRKERPEL EEQKDSLVIN IAAGKRKLKE
3560 3570 3580 3590 3600
LEDEILRLLN EATGSLLDDV QLVNTLHTSK ITATEVTEQL ETSETTEINT
3610 3620 3630 3640 3650
DLAREAYRPC AQRASILFFV LNDMGCIDPM YQFSLDAYIS LFILSIDKSH
3660 3670 3680 3690 3700
RSNKLEDRID YLNDYHTYAV YRYTCRTLFE RHKLLFSFHM CAKILETSGK
3710 3720 3730 3740 3750
LNMDEYNFFL RGGVVLDREG QMDNPCSSWL ADAYWDNITE LDKLTNFHGL
3760 3770 3780 3790 3800
MNSFEQYPRD WHLWYTNAAP EKAMLPGEWE NACNEMQRML IVRSLRQDRV
3810 3820 3830 3840 3850
AFCVTSFIIT NLGSRFIEPP VLNMKSVLED STPRSPLVFI LSPGVDPTSA
3860 3870 3880 3890 3900
LLQLAEHMGM AQRFHALSLG QGQAPIAARL LREGVTQGHW VFLANCHLSL
3910 3920 3930 3940 3950
SWMPNLDKLV EQLQVEDPHP SFRLWLSSIP HPDFPISILQ VSIKMTTEPP
3960 3970 3980 3990 4000
KGLKANMTRL YQLMSEPQFS RCSKPAKYKK LLFSLCFFHS VLLERKKFLQ
4010 4020 4030 4040 4050
LGWNIIYGFN DSDFEVSENL LSLYLDEYEE TPWDALKYLI AGINYGGHVT
4060 4070 4080 4090 4100
DDWDRRLLTT YINDYFCDQS LSTPFHRLSA LETYFIPKDG SLASYKEYIS
4110 4120 4130 4140 4150
LLPGMDPPEA FGQHPNADVA SQITEAQTLF DTLLSLQPQI TPTRAGGQTR
4160 4170 4180 4190 4200
EEKVLELAAD VKQKIPEMID YEGTQKLLAL DPSPLNVVLL QEIQRYNTLM
4210 4220 4230 4240 4250
QTILFSLTDL EKGIQGLIVM STSLEEIFNC IFDAHVPPLW GKAYPSQKPL
4260 4270 4280 4290 4300
AAWTRDLAMR VEQFELWASR ARPPVIFWLS GFTFPTGFLT AVLQSSARQN
4310 4320 4330 4340 4350
NVSVDSLSWE FIVSTVDDSN LVYPPKDGVW VRGLYLEGAG WDRKNSCLVE
4360 4370 4380 4390 4400
AEPMQLVCLM PTIHFRPAES RKKSAKGMYS CPCYYYPNRA GSSDRASFVI
4410 4420
GIDLRSGAMT PDHWIKRGTA LLMSLDS
Length:4,427
Mass (Da):507,698
Last modified:February 26, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA270F73DBDE2C3C4
GO
Isoform 2 (identifier: Q9P225-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3062-3100: Missing.
     4211-4235: EKGIQGLIVMSTSLEEIFNCIFDAH → EIPSCVSHKSERVVLELSAVKHPRQ
     4236-4427: Missing.

Show »
Length:4,196
Mass (Da):481,999
Checksum:i9E166534301BA935
GO
Isoform 3 (identifier: Q9P225-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     390-390: K → KMSNEIIRLC...FVQRCKDLIE
     636-790: SLLILFAEID...QREHRAAVQQ → YRSHLAPFPY...SPEPGRQRLQ
     791-4427: Missing.

Show »
Length:872
Mass (Da):99,915
Checksum:iC8AF185FABA6E9C5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L520I3L520_HUMAN
Dynein heavy chain 2, axonemal
DNAH2
1,158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4H9I3L4H9_HUMAN
Dynein heavy chain 2, axonemal
DNAH2
261Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AK128517 differs from that shown. Reason: Frameshift.Curated
The sequence BAA96027 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti593E → G in AAH34225 (PubMed:15489334).Curated1

<p>This subsection of the 'Sequence' section provides information relevant to all types of RNA editing events (conversion, insertion, deletion of nucleotides) that lead to one or more amino acid changes compared to the translation of the non-edited RNA version.<p><a href='/help/rna_editing' target='_top'>More...</a></p>RNA editingi

Modified position: not applicable.
Exon 13 is extensively edited in brain.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_039407100A → V. Corresponds to variant dbSNP:rs35664870Ensembl.1
Natural variantiVAR_039408312S → T. Corresponds to variant dbSNP:rs3744254Ensembl.1
Natural variantiVAR_0394091326E → G. Corresponds to variant dbSNP:rs11868946Ensembl.1
Natural variantiVAR_0394102548R → H. Corresponds to variant dbSNP:rs11656500Ensembl.1
Natural variantiVAR_0601342904R → H. Corresponds to variant dbSNP:rs2309808Ensembl.1
Natural variantiVAR_0394113600T → I. Corresponds to variant dbSNP:rs7213894EnsemblClinVar.1
Isoform 3 (identifier: Q9P225-3)
Natural variantiVAR_082806812E → G in RNA edited version. Curated1
Natural variantiVAR_082807814E → G in RNA edited version. Curated1
Natural variantiVAR_082808826T → A in RNA edited version. Curated1
Natural variantiVAR_082809833N → D in RNA edited version. Curated1
Natural variantiVAR_082810838K → E in RNA edited version. Curated1
Natural variantiVAR_082811839N → D in RNA edited version. Curated1
Natural variantiVAR_082812841K → E in RNA edited version. Curated1
Natural variantiVAR_082813843S → G in RNA edited version. Curated1
Natural variantiVAR_082814855T → A in RNA edited version. Curated1
Natural variantiVAR_082815865E → G in RNA edited version. Curated1
Natural variantiVAR_082816869Q → R in RNA edited version. Curated1
Natural variantiVAR_082817872Q → R in RNA edited version. Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_031913390K → KMSNEIIRLCCHAISLDRIF EGYVSSSKEDLQGCILCCHA WKDHYVQAVQMHIQFSSRGW VLDQTSIFAQVDAFVQRCKD LIE in isoform 3. 2 Publications1
Alternative sequenceiVSP_031914636 – 790SLLIL…AAVQQ → YRSHLAPFPYTPLLQLSQEF HSHLLTPLFIILSLSHTICL LSSFYFFFSSFIFVSPHLPP CYQHFNFTTYLKTQQNKTMI GQARWLTPVIPALWEAEVGA SLEPRSLRTAWATWQNPVSA KNTKISWAWWHKPVVSATWE GEVGGSPEPGRQRLQ in isoform 3. 2 PublicationsAdd BLAST155
Alternative sequenceiVSP_031915791 – 4427Missing in isoform 3. 2 PublicationsAdd BLAST3637
Alternative sequenceiVSP_0319163062 – 3100Missing in isoform 2. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_0319174211 – 4235EKGIQ…IFDAH → EIPSCVSHKSERVVLELSAV KHPRQ in isoform 2. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_0319184236 – 4427Missing in isoform 2. 1 PublicationAdd BLAST192

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB040936 mRNA Translation: BAA96027.2 Different initiation.
AK128517 mRNA No translation available.
AK292607 mRNA Translation: BAF85296.1
AC025335 Genomic DNA No translation available.
AC087388 Genomic DNA No translation available.
BC034225 mRNA Translation: AAH34225.1
U83570 Genomic DNA Translation: AAB82760.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32551.1 [Q9P225-1]
CCDS76937.1 [Q9P225-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001290199.1, NM_001303270.1 [Q9P225-3]
NP_065928.2, NM_020877.3 [Q9P225-1]
XP_011521969.1, XM_011523667.2 [Q9P225-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000389173; ENSP00000373825; ENSG00000183914 [Q9P225-1]
ENST00000570791; ENSP00000460245; ENSG00000183914 [Q9P225-3]
ENST00000572933; ENSP00000458355; ENSG00000183914 [Q9P225-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
146754

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:146754

UCSC genome browser

More...
UCSCi
uc002git.3 human [Q9P225-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism, RNA editing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040936 mRNA Translation: BAA96027.2 Different initiation.
AK128517 mRNA No translation available.
AK292607 mRNA Translation: BAF85296.1
AC025335 Genomic DNA No translation available.
AC087388 Genomic DNA No translation available.
BC034225 mRNA Translation: AAH34225.1
U83570 Genomic DNA Translation: AAB82760.1
CCDSiCCDS32551.1 [Q9P225-1]
CCDS76937.1 [Q9P225-3]
RefSeqiNP_001290199.1, NM_001303270.1 [Q9P225-3]
NP_065928.2, NM_020877.3 [Q9P225-1]
XP_011521969.1, XM_011523667.2 [Q9P225-1]

3D structure databases

SMRiQ9P225
ModBaseiSearch...

Protein-protein interaction databases

BioGridi127007, 3 interactors
IntActiQ9P225, 2 interactors
STRINGi9606.ENSP00000458355

PTM databases

iPTMnetiQ9P225
PhosphoSitePlusiQ9P225

Polymorphism and mutation databases

BioMutaiDNAH2
DMDMi172044680

Proteomic databases

EPDiQ9P225
jPOSTiQ9P225
MassIVEiQ9P225
PaxDbiQ9P225
PeptideAtlasiQ9P225
PRIDEiQ9P225
ProteomicsDBi83715 [Q9P225-1]
83716 [Q9P225-2]
83717 [Q9P225-3]
TopDownProteomicsiQ9P225-3 [Q9P225-3]

Genome annotation databases

EnsembliENST00000389173; ENSP00000373825; ENSG00000183914 [Q9P225-1]
ENST00000570791; ENSP00000460245; ENSG00000183914 [Q9P225-3]
ENST00000572933; ENSP00000458355; ENSG00000183914 [Q9P225-1]
GeneIDi146754
KEGGihsa:146754
UCSCiuc002git.3 human [Q9P225-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
146754
DisGeNETi146754

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DNAH2
HGNCiHGNC:2948 DNAH2
HPAiHPA067103
MIMi603333 gene
neXtProtiNX_Q9P225
OpenTargetsiENSG00000183914
PharmGKBiPA27401

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3595 Eukaryota
COG5245 LUCA
GeneTreeiENSGT00940000157623
HOGENOMiCLU_000038_0_3_1
InParanoidiQ9P225
KOiK10408
OMAiKISRPPQ
OrthoDBi1492at2759
PhylomeDBiQ9P225
TreeFamiTF316836

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DNAH2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
146754
PharosiQ9P225 Tdark

Protein Ontology

More...
PROi
PR:Q9P225
RNActiQ9P225 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000183914 Expressed in bronchial epithelial cell and 74 other tissues
ExpressionAtlasiQ9P225 baseline and differential
GenevisibleiQ9P225 HS

Family and domain databases

Gene3Di1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.20.180.20, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR035699 AAA_6
IPR035706 AAA_9
IPR041658 AAA_lid_11
IPR042219 AAA_lid_11_sf
IPR026983 DHC_fam
IPR041589 DNAH3_AAA_lid_1
IPR042228 Dynein_2_C
IPR042222 Dynein_2_N
IPR041466 Dynein_AAA5_ext
IPR041228 Dynein_C
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_D6_P-loop
IPR013594 Dynein_heavy_dom-1
IPR013602 Dynein_heavy_dom-2
IPR027417 P-loop_NTPase
PANTHERiPTHR10676 PTHR10676, 1 hit
PfamiView protein in Pfam
PF12774 AAA_6, 1 hit
PF12780 AAA_8, 1 hit
PF12781 AAA_9, 1 hit
PF17857 AAA_lid_1, 1 hit
PF18198 AAA_lid_11, 1 hit
PF08385 DHC_N1, 2 hits
PF08393 DHC_N2, 1 hit
PF17852 Dynein_AAA_lid, 1 hit
PF18199 Dynein_C, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDYH2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P225
Secondary accession number(s): A8K992
, B5MDX5, O15434, Q6PIH3, Q6ZR42
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: February 26, 2020
This is version 135 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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