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Protein

Collagen alpha-1(XX) chain

Gene

COL20A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable collagen protein.

GO - Molecular functioni

  • calcium ion binding Source: GO_Central
  • mannose binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-8948216 Collagen chain trimerization

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(XX) chain
Gene namesi
Name:COL20A1
Synonyms:KIAA1510
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101203.16
HGNCiHGNC:14670 COL20A1
neXtProtiNX_Q9P218

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000101203
PharmGKBiPA142672086

Polymorphism and mutation databases

BioMutaiCOL20A1
DMDMi292495087

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001398623 – 1284Collagen alpha-1(XX) chainAdd BLAST1262

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi607N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9P218
PaxDbiQ9P218
PeptideAtlasiQ9P218
PRIDEiQ9P218
ProteomicsDBi83709
83710 [Q9P218-2]
83711 [Q9P218-3]

PTM databases

iPTMnetiQ9P218
PhosphoSitePlusiQ9P218

Expressioni

Tissue specificityi

High expression in heart, lung, liver, skeletal muscle, kidney, pancreas, spleen, testis, ovary, subthalamic nucleus and fetal liver. Weak expression in other tissues tested.

Gene expression databases

BgeeiENSG00000101203 Expressed in 103 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_COL20A1
ExpressionAtlasiQ9P218 baseline and differential
GenevisibleiQ9P218 HS

Organism-specific databases

HPAiHPA051962

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi121679, 11 interactors
ComplexPortaliCPX-1761 Collagen type XX trimer
IntActiQ9P218, 3 interactors
STRINGi9606.ENSP00000351767

Structurei

Secondary structure

11284
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9P218
SMRiQ9P218
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9P218

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 119Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST92
Domaini179 – 354VWFAPROSITE-ProRule annotationAdd BLAST176
Domaini379 – 468Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST90
Domaini469 – 559Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST91
Domaini560 – 647Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST88
Domaini649 – 738Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST90
Domaini743 – 833Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST91
Domaini842 – 1037Laminin G-likeAdd BLAST196
Domaini1071 – 1127Collagen-like 1Add BLAST57
Domaini1133 – 1190Collagen-like 2Add BLAST58

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410XNMM LUCA
GeneTreeiENSGT00760000119000
HOVERGENiHBG107744
InParanoidiQ9P218
OMAiVVYQIKW
OrthoDBiEOG091G002N
PhylomeDBiQ9P218
TreeFamiTF329914

Family and domain databases

CDDicd00063 FN3, 6 hits
Gene3Di2.60.40.10, 6 hits
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR001791 Laminin_G
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01391 Collagen, 2 hits
PF00041 fn3, 6 hits
PF00092 VWA, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 6 hits
SM00210 TSPN, 1 hit
SM00327 VWA, 1 hit
SUPFAMiSSF49265 SSF49265, 4 hits
SSF49899 SSF49899, 1 hit
SSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 6 hits
PS50234 VWFA, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9P218-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSGDPAHLG LCLWLWLGAT LGREQVQASG LLRLAVLPED RLQMKWRESE
60 70 80 90 100
GSGLGYLVQV KPMAGDSEQE VILTTKTPKA TVGGLSPSKG YTLQIFELTG
110 120 130 140 150
SGRFLLARRE FVIEDLKSSS LDRSSQRPLG SGAPEPTPSH TGSPDPEQAS
160 170 180 190 200
EPQVAFTPSQ DPRTPAGPQF RCLPPVPADM VFLVDGSWSI GHSHFQQVKD
210 220 230 240 250
FLASVIAPFE IGPDKVQVGL TQYSGDAQTE WDLNSLSTKE QVLAAVRRLR
260 270 280 290 300
YKGGNTFTGL ALTHVLGQNL QPAAGLRPEA AKVVILVTDG KSQDDVHTAA
310 320 330 340 350
RVLKDLGVNV FAVGVKNADE AELRLLASPP RDITVHSVLD FLQLGALAGL
360 370 380 390 400
LSRLICQRLQ GGSPRQGPAA APALDTLPAP TSLVLSQVTS SSIRLSWTPA
410 420 430 440 450
PRHPLKYLIV WRASRGGTPR EVVVEGPAAS TELHNLASRT EYLVSVFPIY
460 470 480 490 500
EGGVGEGLRG LVTTAPLPPP RALTLAAVTP RTVHLTWQPS AGATHYLVRC
510 520 530 540 550
SPASPKGEEE EREVQVGRPE VLLDGLEPGR DYEVSVQSLR GPEGSEARGI
560 570 580 590 600
RARTPTLAPP RHLGFSDVSH DAARVFWEGA PRPVRLVRVT YVSSEGGHSG
610 620 630 640 650
QTEAPGNATS ATLGPLSSST TYTVRVTCLY PGGGSSTLTG RVTTKKAPSP
660 670 680 690 700
SQLSMTELPG DAVQLAWVAA APSGVLVYQI TWTPLGEGKA HEISVPGNLG
710 720 730 740 750
TAVLPGLGRH TEYDVTILAY YRDGARSDPV SLRYTPSTVS RSPPSNLALA
760 770 780 790 800
SETPDSLQVS WTPPLGRVLH YWLTYAPASG LGPEKSVSVP GARSHVTLPD
810 820 830 840 850
LQAATKYRVL VSAIYAAGRS EAVSATGQTA CPALRPDGSL PGFDLMVAFS
860 870 880 890 900
LVEKAYASIR GVAMEPSAFG GTPTFTLFKD AQLTRRVSDV YPAPLPPEHT
910 920 930 940 950
IVFLVRLLPE TPREAFALWQ MTAEDFQPLL GVLLDAGKKS LTYFHRDPRA
960 970 980 990 1000
ALQEATFDPQ EVRKIFFGSF HKVHVAVGRS KVRLYVDCRK VAERPLGEMG
1010 1020 1030 1040 1050
SPPAAGFVTL GRLAKARGPR SSSAAFQLQM LQIVCSDTWA DEDRCCELPA
1060 1070 1080 1090 1100
SRDGETCPAF VSACSCSSET PGPPGPQGPP GLPGRNGTPG EQGFPGPRGP
1110 1120 1130 1140 1150
PGVKGEKGDH GLPGLQGHPG HQGIPGRVGL QGPKGMRGLE GTAGLPGPPG
1160 1170 1180 1190 1200
PRGFQGMAGA RGTSGERGPP GTVGPTGLPG PKGERGEKGE PQSLATLYQL
1210 1220 1230 1240 1250
VSQASHVSKF DSFHENTRPP MPILEQKLEP GTEPLGSPGT RSKALVPGEW
1260 1270 1280
GRGGRHLEGR GEPGAVGQMG SPGQQGASTQ GLWE
Length:1,284
Mass (Da):135,830
Last modified:March 23, 2010 - v4
Checksum:iE84D522A932D89C6
GO
Isoform 2 (identifier: Q9P218-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     165-166: PA → PGGSEWRET
     1204-1205: AS → ACESAIQT

Show »
Length:1,297
Mass (Da):137,308
Checksum:i11FE854E7E368694
GO
Isoform 3 (identifier: Q9P218-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1098-1098: R → RGEPGPPGQMGPEGPGGQQGSPGTQGRAVQGPV

Note: No experimental confirmation available.
Show »
Length:1,316
Mass (Da):138,781
Checksum:i6D56DD83AE9EF73B
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZBI4B7ZBI4_HUMAN
Collagen alpha-1(XX) chain
COL20A1
401Annotation score:
B7ZBI5B7ZBI5_HUMAN
Collagen alpha-1(XX) chain
COL20A1
250Annotation score:

Sequence cautioni

The sequence AAH19637 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13L → V in AAH43183 (PubMed:15489334).Curated1
Sequence conflicti78P → H in AAH43183 (PubMed:15489334).Curated1
Sequence conflicti612T → M in BAA96034 (PubMed:10819331).Curated1
Sequence conflicti924E → K in AAH43183 (PubMed:15489334).Curated1
Sequence conflicti1230P → Q in AAH43183 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055671134P → L. Corresponds to variant dbSNP:rs753686Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_038876165 – 166PA → PGGSEWRET in isoform 2. 1 Publication2
Alternative sequenceiVSP_0388771098R → RGEPGPPGQMGPEGPGGQQG SPGTQGRAVQGPV in isoform 3. 1 Publication1
Alternative sequenceiVSP_0388781204 – 1205AS → ACESAIQT in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121827 Genomic DNA No translation available.
BC013658 mRNA Translation: AAH13658.1
BC019637 mRNA Translation: AAH19637.1 Different initiation.
BC043183 mRNA Translation: AAH43183.1
AB040943 mRNA Translation: BAA96034.1
AI272270 mRNA No translation available.
CCDSiCCDS46628.1 [Q9P218-1]
RefSeqiNP_065933.2, NM_020882.2 [Q9P218-1]
XP_011527242.1, XM_011528940.1 [Q9P218-2]
UniGeneiHs.271285

Genome annotation databases

EnsembliENST00000358894; ENSP00000351767; ENSG00000101203 [Q9P218-1]
ENST00000422202; ENSP00000414753; ENSG00000101203 [Q9P218-2]
GeneIDi57642
KEGGihsa:57642
UCSCiuc011aau.2 human [Q9P218-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121827 Genomic DNA No translation available.
BC013658 mRNA Translation: AAH13658.1
BC019637 mRNA Translation: AAH19637.1 Different initiation.
BC043183 mRNA Translation: AAH43183.1
AB040943 mRNA Translation: BAA96034.1
AI272270 mRNA No translation available.
CCDSiCCDS46628.1 [Q9P218-1]
RefSeqiNP_065933.2, NM_020882.2 [Q9P218-1]
XP_011527242.1, XM_011528940.1 [Q9P218-2]
UniGeneiHs.271285

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DKMNMR-A466-556[»]
2EE3NMR-A557-651[»]
2EKJNMR-A741-832[»]
5KF4X-ray2.50A/B/C/D368-466[»]
ProteinModelPortaliQ9P218
SMRiQ9P218
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121679, 11 interactors
ComplexPortaliCPX-1761 Collagen type XX trimer
IntActiQ9P218, 3 interactors
STRINGi9606.ENSP00000351767

PTM databases

iPTMnetiQ9P218
PhosphoSitePlusiQ9P218

Polymorphism and mutation databases

BioMutaiCOL20A1
DMDMi292495087

Proteomic databases

EPDiQ9P218
PaxDbiQ9P218
PeptideAtlasiQ9P218
PRIDEiQ9P218
ProteomicsDBi83709
83710 [Q9P218-2]
83711 [Q9P218-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358894; ENSP00000351767; ENSG00000101203 [Q9P218-1]
ENST00000422202; ENSP00000414753; ENSG00000101203 [Q9P218-2]
GeneIDi57642
KEGGihsa:57642
UCSCiuc011aau.2 human [Q9P218-1]

Organism-specific databases

CTDi57642
EuPathDBiHostDB:ENSG00000101203.16
GeneCardsiCOL20A1
H-InvDBiHIX0015998
HGNCiHGNC:14670 COL20A1
HPAiHPA051962
neXtProtiNX_Q9P218
OpenTargetsiENSG00000101203
PharmGKBiPA142672086
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410XNMM LUCA
GeneTreeiENSGT00760000119000
HOVERGENiHBG107744
InParanoidiQ9P218
OMAiVVYQIKW
OrthoDBiEOG091G002N
PhylomeDBiQ9P218
TreeFamiTF329914

Enzyme and pathway databases

ReactomeiR-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-8948216 Collagen chain trimerization

Miscellaneous databases

EvolutionaryTraceiQ9P218
GenomeRNAii57642
PROiPR:Q9P218

Gene expression databases

BgeeiENSG00000101203 Expressed in 103 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_COL20A1
ExpressionAtlasiQ9P218 baseline and differential
GenevisibleiQ9P218 HS

Family and domain databases

CDDicd00063 FN3, 6 hits
Gene3Di2.60.40.10, 6 hits
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR001791 Laminin_G
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01391 Collagen, 2 hits
PF00041 fn3, 6 hits
PF00092 VWA, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 6 hits
SM00210 TSPN, 1 hit
SM00327 VWA, 1 hit
SUPFAMiSSF49265 SSF49265, 4 hits
SSF49899 SSF49899, 1 hit
SSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 6 hits
PS50234 VWFA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOKA1_HUMAN
AccessioniPrimary (citable) accession number: Q9P218
Secondary accession number(s): Q4VXQ4
, Q6PI59, Q8WUT2, Q96CY9, Q9BQU6, Q9BQU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: March 23, 2010
Last modified: November 7, 2018
This is version 169 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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