Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Collagen alpha-1(XX) chain

Gene

COL20A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable collagen protein.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: GO_Central
  • mannose binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-8948216 Collagen chain trimerization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Collagen alpha-1(XX) chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COL20A1
Synonyms:KIAA1510
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000101203.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14670 COL20A1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9P218

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000101203

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672086

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
COL20A1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
292495087

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001398623 – 1284Collagen alpha-1(XX) chainAdd BLAST1262

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi607N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9P218

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9P218

PeptideAtlas

More...
PeptideAtlasi
Q9P218

PRoteomics IDEntifications database

More...
PRIDEi
Q9P218

ProteomicsDB human proteome resource

More...
ProteomicsDBi
83709
83710 [Q9P218-2]
83711 [Q9P218-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9P218

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9P218

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

High expression in heart, lung, liver, skeletal muscle, kidney, pancreas, spleen, testis, ovary, subthalamic nucleus and fetal liver. Weak expression in other tissues tested.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000101203 Expressed in 103 organ(s), highest expression level in pigmented layer of retina

CleanEx database of gene expression profiles

More...
CleanExi
HS_COL20A1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9P218 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9P218 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA051962

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121679, 11 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1761 Collagen type XX trimer

Protein interaction database and analysis system

More...
IntActi
Q9P218, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000351767

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11284
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9P218

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9P218

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9P218

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini28 – 119Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST92
Domaini179 – 354VWFAPROSITE-ProRule annotationAdd BLAST176
Domaini379 – 468Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST90
Domaini469 – 559Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST91
Domaini560 – 647Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST88
Domaini649 – 738Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST90
Domaini743 – 833Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST91
Domaini842 – 1037Laminin G-likeAdd BLAST196
Domaini1071 – 1127Collagen-like 1Add BLAST57
Domaini1133 – 1190Collagen-like 2Add BLAST58

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3544 Eukaryota
ENOG410XNMM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163709

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG107744

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9P218

Identification of Orthologs from Complete Genome Data

More...
OMAi
VVYQIKW

Database of Orthologous Groups

More...
OrthoDBi
EOG091G002N

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9P218

TreeFam database of animal gene trees

More...
TreeFami
TF329914

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 6 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 6 hits
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR001791 Laminin_G
IPR002035 VWF_A
IPR036465 vWFA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01391 Collagen, 2 hits
PF00041 fn3, 5 hits
PF00092 VWA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 6 hits
SM00210 TSPN, 1 hit
SM00327 VWA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 4 hits
SSF49899 SSF49899, 1 hit
SSF53300 SSF53300, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 6 hits
PS50234 VWFA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9P218-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSGDPAHLG LCLWLWLGAT LGREQVQASG LLRLAVLPED RLQMKWRESE
60 70 80 90 100
GSGLGYLVQV KPMAGDSEQE VILTTKTPKA TVGGLSPSKG YTLQIFELTG
110 120 130 140 150
SGRFLLARRE FVIEDLKSSS LDRSSQRPLG SGAPEPTPSH TGSPDPEQAS
160 170 180 190 200
EPQVAFTPSQ DPRTPAGPQF RCLPPVPADM VFLVDGSWSI GHSHFQQVKD
210 220 230 240 250
FLASVIAPFE IGPDKVQVGL TQYSGDAQTE WDLNSLSTKE QVLAAVRRLR
260 270 280 290 300
YKGGNTFTGL ALTHVLGQNL QPAAGLRPEA AKVVILVTDG KSQDDVHTAA
310 320 330 340 350
RVLKDLGVNV FAVGVKNADE AELRLLASPP RDITVHSVLD FLQLGALAGL
360 370 380 390 400
LSRLICQRLQ GGSPRQGPAA APALDTLPAP TSLVLSQVTS SSIRLSWTPA
410 420 430 440 450
PRHPLKYLIV WRASRGGTPR EVVVEGPAAS TELHNLASRT EYLVSVFPIY
460 470 480 490 500
EGGVGEGLRG LVTTAPLPPP RALTLAAVTP RTVHLTWQPS AGATHYLVRC
510 520 530 540 550
SPASPKGEEE EREVQVGRPE VLLDGLEPGR DYEVSVQSLR GPEGSEARGI
560 570 580 590 600
RARTPTLAPP RHLGFSDVSH DAARVFWEGA PRPVRLVRVT YVSSEGGHSG
610 620 630 640 650
QTEAPGNATS ATLGPLSSST TYTVRVTCLY PGGGSSTLTG RVTTKKAPSP
660 670 680 690 700
SQLSMTELPG DAVQLAWVAA APSGVLVYQI TWTPLGEGKA HEISVPGNLG
710 720 730 740 750
TAVLPGLGRH TEYDVTILAY YRDGARSDPV SLRYTPSTVS RSPPSNLALA
760 770 780 790 800
SETPDSLQVS WTPPLGRVLH YWLTYAPASG LGPEKSVSVP GARSHVTLPD
810 820 830 840 850
LQAATKYRVL VSAIYAAGRS EAVSATGQTA CPALRPDGSL PGFDLMVAFS
860 870 880 890 900
LVEKAYASIR GVAMEPSAFG GTPTFTLFKD AQLTRRVSDV YPAPLPPEHT
910 920 930 940 950
IVFLVRLLPE TPREAFALWQ MTAEDFQPLL GVLLDAGKKS LTYFHRDPRA
960 970 980 990 1000
ALQEATFDPQ EVRKIFFGSF HKVHVAVGRS KVRLYVDCRK VAERPLGEMG
1010 1020 1030 1040 1050
SPPAAGFVTL GRLAKARGPR SSSAAFQLQM LQIVCSDTWA DEDRCCELPA
1060 1070 1080 1090 1100
SRDGETCPAF VSACSCSSET PGPPGPQGPP GLPGRNGTPG EQGFPGPRGP
1110 1120 1130 1140 1150
PGVKGEKGDH GLPGLQGHPG HQGIPGRVGL QGPKGMRGLE GTAGLPGPPG
1160 1170 1180 1190 1200
PRGFQGMAGA RGTSGERGPP GTVGPTGLPG PKGERGEKGE PQSLATLYQL
1210 1220 1230 1240 1250
VSQASHVSKF DSFHENTRPP MPILEQKLEP GTEPLGSPGT RSKALVPGEW
1260 1270 1280
GRGGRHLEGR GEPGAVGQMG SPGQQGASTQ GLWE
Length:1,284
Mass (Da):135,830
Last modified:March 23, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE84D522A932D89C6
GO
Isoform 2 (identifier: Q9P218-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     165-166: PA → PGGSEWRET
     1204-1205: AS → ACESAIQT

Show »
Length:1,297
Mass (Da):137,308
Checksum:i11FE854E7E368694
GO
Isoform 3 (identifier: Q9P218-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1098-1098: R → RGEPGPPGQMGPEGPGGQQGSPGTQGRAVQGPV

Note: No experimental confirmation available.
Show »
Length:1,316
Mass (Da):138,781
Checksum:i6D56DD83AE9EF73B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZBI4B7ZBI4_HUMAN
Collagen alpha-1(XX) chain
COL20A1
401Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7ZBI5B7ZBI5_HUMAN
Collagen alpha-1(XX) chain
COL20A1
250Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH19637 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti13L → V in AAH43183 (PubMed:15489334).Curated1
Sequence conflicti78P → H in AAH43183 (PubMed:15489334).Curated1
Sequence conflicti612T → M in BAA96034 (PubMed:10819331).Curated1
Sequence conflicti924E → K in AAH43183 (PubMed:15489334).Curated1
Sequence conflicti1230P → Q in AAH43183 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055671134P → L. Corresponds to variant dbSNP:rs753686Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_038876165 – 166PA → PGGSEWRET in isoform 2. 1 Publication2
Alternative sequenceiVSP_0388771098R → RGEPGPPGQMGPEGPGGQQG SPGTQGRAVQGPV in isoform 3. 1 Publication1
Alternative sequenceiVSP_0388781204 – 1205AS → ACESAIQT in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL121827 Genomic DNA No translation available.
BC013658 mRNA Translation: AAH13658.1
BC019637 mRNA Translation: AAH19637.1 Different initiation.
BC043183 mRNA Translation: AAH43183.1
AB040943 mRNA Translation: BAA96034.1
AI272270 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS46628.1 [Q9P218-1]

NCBI Reference Sequences

More...
RefSeqi
NP_065933.2, NM_020882.2 [Q9P218-1]
XP_011527242.1, XM_011528940.1 [Q9P218-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.271285

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000358894; ENSP00000351767; ENSG00000101203 [Q9P218-1]
ENST00000422202; ENSP00000414753; ENSG00000101203 [Q9P218-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57642

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57642

UCSC genome browser

More...
UCSCi
uc011aau.2 human [Q9P218-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121827 Genomic DNA No translation available.
BC013658 mRNA Translation: AAH13658.1
BC019637 mRNA Translation: AAH19637.1 Different initiation.
BC043183 mRNA Translation: AAH43183.1
AB040943 mRNA Translation: BAA96034.1
AI272270 mRNA No translation available.
CCDSiCCDS46628.1 [Q9P218-1]
RefSeqiNP_065933.2, NM_020882.2 [Q9P218-1]
XP_011527242.1, XM_011528940.1 [Q9P218-2]
UniGeneiHs.271285

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DKMNMR-A466-556[»]
2EE3NMR-A557-651[»]
2EKJNMR-A741-832[»]
5KF4X-ray2.50A/B/C/D368-466[»]
ProteinModelPortaliQ9P218
SMRiQ9P218
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121679, 11 interactors
ComplexPortaliCPX-1761 Collagen type XX trimer
IntActiQ9P218, 3 interactors
STRINGi9606.ENSP00000351767

PTM databases

iPTMnetiQ9P218
PhosphoSitePlusiQ9P218

Polymorphism and mutation databases

BioMutaiCOL20A1
DMDMi292495087

Proteomic databases

EPDiQ9P218
PaxDbiQ9P218
PeptideAtlasiQ9P218
PRIDEiQ9P218
ProteomicsDBi83709
83710 [Q9P218-2]
83711 [Q9P218-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358894; ENSP00000351767; ENSG00000101203 [Q9P218-1]
ENST00000422202; ENSP00000414753; ENSG00000101203 [Q9P218-2]
GeneIDi57642
KEGGihsa:57642
UCSCiuc011aau.2 human [Q9P218-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57642
EuPathDBiHostDB:ENSG00000101203.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
COL20A1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0015998
HGNCiHGNC:14670 COL20A1
HPAiHPA051962
neXtProtiNX_Q9P218
OpenTargetsiENSG00000101203
PharmGKBiPA142672086

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410XNMM LUCA
GeneTreeiENSGT00940000163709
HOVERGENiHBG107744
InParanoidiQ9P218
OMAiVVYQIKW
OrthoDBiEOG091G002N
PhylomeDBiQ9P218
TreeFamiTF329914

Enzyme and pathway databases

ReactomeiR-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-8948216 Collagen chain trimerization

Miscellaneous databases

EvolutionaryTraceiQ9P218

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57642

Protein Ontology

More...
PROi
PR:Q9P218

Gene expression databases

BgeeiENSG00000101203 Expressed in 103 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_COL20A1
ExpressionAtlasiQ9P218 baseline and differential
GenevisibleiQ9P218 HS

Family and domain databases

CDDicd00063 FN3, 6 hits
Gene3Di2.60.40.10, 6 hits
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR001791 Laminin_G
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01391 Collagen, 2 hits
PF00041 fn3, 5 hits
PF00092 VWA, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 6 hits
SM00210 TSPN, 1 hit
SM00327 VWA, 1 hit
SUPFAMiSSF49265 SSF49265, 4 hits
SSF49899 SSF49899, 1 hit
SSF53300 SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 6 hits
PS50234 VWFA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOKA1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P218
Secondary accession number(s): Q4VXQ4
, Q6PI59, Q8WUT2, Q96CY9, Q9BQU6, Q9BQU7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: March 23, 2010
Last modified: December 5, 2018
This is version 170 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again