Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 176 (12 Aug 2020)
Sequence version 3 (31 Oct 2006)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

Gene

PLCE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downtream of AVIL to allow ARP2/3 complex assembly (PubMed:29058690).8 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by the heterotrimeric G-protein subunits GNA12, GNA13 and GNB1-GNG2. Activated by HRAS, RAP1A, RHOA, RHOB, RHOC, RRAS and RRAS2. Activated by the G(s)-coupled GPCRs ADRB2, PTGER1 and CHRM3 through cyclic-AMP formation and RAP2B activation. Inhibited by G(i)-coupled GPCRs.6 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1407PROSITE-ProRule annotation1
Active sitei1452PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor, Hydrolase, Transducer
Biological processLipid degradation, Lipid metabolism
LigandCalcium, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS06473-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.4.11, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9P212

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1855204, Synthesis of IP3 and IP4 in the cytosol

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9P212

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000663

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (EC:3.1.4.11)
Alternative name(s):
Pancreas-enriched phospholipase C
Phosphoinositide phospholipase C-epsilon-1
Phospholipase C-epsilon-1
Short name:
PLC-epsilon-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLCE1
Synonyms:KIAA1516, PLCE, PPLC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000138193.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17175, PLCE1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608414, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9P212

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Nephrotic syndrome 3 (NPHS3)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of nephrotic syndrome, a renal disease clinically characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form and progress to end-stage renal failure. Most patients with NPHS3 show diffuse mesangial sclerosis on renal biopsy, which is a pathologic entity characterized by mesangial matrix expansion with no mesangial hypercellularity, hypertrophy of the podocytes, vacuolized podocytes, thickened basement membranes, and diminished patency of the capillary lumen.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0298831484S → L in NPHS3; gives rise to focal segmental glomerulosclerosis rather than diffuse mesangial sclerosis. 1 PublicationCorresponds to variant dbSNP:rs121912605EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1452H → L: Loss of the phospholipase C enzymatic activity. Still activates HRAS and the MAP kinase pathway. 1 Publication1
Mutagenesisi2140Q → E: Increases 2.8-fold the affinity for HRAS. 1 Publication1
Mutagenesisi2148Q → E: Decreases 17.5-fold the affinity for HRAS. 1 Publication1
Mutagenesisi2148Q → K: Increases 1.4-fold the affinity for HRAS. 1 Publication1
Mutagenesisi2150R → L: Abolishes interaction with HRAS. 1 Publication1
Mutagenesisi2171K → L: No effect on HRAS-binding. 1 Publication1
Mutagenesisi2174Y → L: Reduces HRAS-binding. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
51196

MalaCards human disease database

More...
MalaCardsi
PLCE1
MIMi610725, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000138193

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
656, Genetic steroid-resistant nephrotic syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33391

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9P212, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PLCE1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
118595723

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002562381 – 23021-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1Add BLAST2302

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1096PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9P212

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9P212

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9P212

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9P212

PeptideAtlas

More...
PeptideAtlasi
Q9P212

PRoteomics IDEntifications database

More...
PRIDEi
Q9P212

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
83705 [Q9P212-1]
83706 [Q9P212-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9P212

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9P212

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expressed in podocytes (PubMed:29058690).2 Publications
Broadly expressed and only absent in peripheral blood leukocytes.2 Publications
Specifically expressed in placenta, lung and spleen.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Overexpressed during heart failure.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000138193, Expressed in metanephric glomerulus and 227 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9P212, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000138193, Tissue enhanced (retina)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RHOA (By similarity).

Interacts with GTP-bound HRAS, RAP1A, RAP2A, RAP2B and RRAS (PubMed:11022048, PubMed:12444546, PubMed:16483931, PubMed:16537651).

Interacts with AVIL (PubMed:29058690).

Interacts with IQGAP1 (PubMed:17086182).

By similarity6 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
119370, 8 interactors

Protein interaction database and analysis system

More...
IntActi
Q9P212, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000360431

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9P212, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12302
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9P212

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9P212

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini531 – 790Ras-GEFPROSITE-ProRule annotationAdd BLAST260
Domaini1392 – 1540PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST149
Domaini1730 – 1846PI-PLC Y-boxPROSITE-ProRule annotationAdd BLAST117
Domaini1851 – 1976C2PROSITE-ProRule annotationAdd BLAST126
Domaini2012 – 2114Ras-associating 1PROSITE-ProRule annotationAdd BLAST103
Domaini2135 – 2238Ras-associating 2PROSITE-ProRule annotationAdd BLAST104

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1686 – 1764Required for activation by RHOA, RHOB, GNA12, GNA13 and G-beta gammaBy similarityAdd BLAST79

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Ras-associating domain 1 is degenerated and may not bind HRAS. The Ras-associating domain 2 mediates interaction with GTP-bound HRAS, RAP1A, RAP2A and RAP2B and recruitment of HRAS to the cell membrane.
The Ras-GEF domain has a GEF activity towards HRAS and RAP1A. Mediates activation of the mitogen-activated protein kinase pathway.

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0169, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157356

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001158_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9P212

KEGG Orthology (KO)

More...
KOi
K05860

Identification of Orthologs from Complete Genome Data

More...
OMAi
NTTLTWG

Database of Orthologous Groups

More...
OrthoDBi
368239at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9P212

TreeFam database of animal gene trees

More...
TreeFami
TF314432

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 1 hit
3.20.20.190, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR011992, EF-hand-dom_pair
IPR001192, PI-PLC_fam
IPR028398, PLC-epsilon1
IPR017946, PLC-like_Pdiesterase_TIM-brl
IPR015359, PLC_EF-hand-like
IPR000909, PLipase_C_PInositol-sp_X_dom
IPR001711, PLipase_C_Pinositol-sp_Y
IPR000159, RA_dom
IPR023578, Ras_GEF_dom_sf
IPR001895, RASGEF_cat_dom
IPR029071, Ubiquitin-like_domsf

The PANTHER Classification System

More...
PANTHERi
PTHR10336, PTHR10336, 1 hit
PTHR10336:SF6, PTHR10336:SF6, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168, C2, 1 hit
PF09279, EF-hand_like, 1 hit
PF00388, PI-PLC-X, 1 hit
PF00387, PI-PLC-Y, 1 hit
PF00788, RA, 1 hit
PF00617, RasGEF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00390, PHPHLIPASEC

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239, C2, 1 hit
SM00148, PLCXc, 1 hit
SM00149, PLCYc, 1 hit
SM00314, RA, 1 hit
SM00147, RasGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473, SSF47473, 1 hit
SSF48366, SSF48366, 1 hit
SSF51695, SSF51695, 1 hit
SSF54236, SSF54236, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004, C2, 1 hit
PS50007, PIPLC_X_DOMAIN, 1 hit
PS50008, PIPLC_Y_DOMAIN, 1 hit
PS50200, RA, 1 hit
PS50009, RASGEF_CAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9P212-1) [UniParc]FASTAAdd to basket
Also known as: PLCepsilon1a

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTSEEMTASV LIPVTQRKVV SAQSAADESS EKVSDINISK AHTVRRSGET
60 70 80 90 100
SHTISQLNKL KEEPSGSNLP KILSIAREKI VSDENSNEKC WEKIMPDSAK
110 120 130 140 150
NLNINCNNIL RNHQHGLPQR QFYEMYNSVA EEDLCLETGI PSPLERKVFP
160 170 180 190 200
GIQLELDRPS MGISPLGNQS VIIETGRAHP DSRRAVFHFH YEVDRRMSDT
210 220 230 240 250
FCTLSENLIL DDCGNCVPLP GGEEKQKKNY VAYTCKLMEL AKNCDNKNEQ
260 270 280 290 300
LQCDHCDTLN DKYFCFEGSC EKVDMVYSGD SFCRKDFTDS QAAKTFLSHF
310 320 330 340 350
EDFPDNCDDV EEDAFKSKKE RSTLLVRRFC KNDREVKKSV YTGTRAIVRT
360 370 380 390 400
LPSGHIGLTA WSYIDQKRNG PLLPCGRVME PPSTVEIRQD GSQRLSEAQW
410 420 430 440 450
YPIYNAVRRE ETENTVGSLL HFLTKLPASE TAHGRISVGP CLKQCVRDTV
460 470 480 490 500
CEYRATLQRT SISQYITGSL LEATTSLGAR SGLLSTFGGS TGRMMLKERQ
510 520 530 540 550
PGPSVANSNA LPSSSAGISK ELIDLQPLIQ FPEEVASILM EQEQTIYRRV
560 570 580 590 600
LPVDYLCFLT RDLGTPECQS SLPCLKASIS ASILTTQNGE HNALEDLVMR
610 620 630 640 650
FNEVSSWVTW LILTAGSMEE KREVFSYLVH VAKCCWNMGN YNAVMEFLAG
660 670 680 690 700
LRSRKVLKMW QFMDQSDIET MRSLKDAMAQ HESSCEYRKV VTRALHIPGC
710 720 730 740 750
KVVPFCGVFL KELCEVLDGA SGLMKLCPRY NSQEETLEFV ADYSGQDNFL
760 770 780 790 800
QRVGQNGLKN SEKESTVNSI FQVIRSCNRS LETDEEDSPS EGNSSRKSSL
810 820 830 840 850
KDKSRWQFII GDLLDSDNDI FEQSKEYDSH GSEDSQKAFD HGTELIPWYV
860 870 880 890 900
LSIQADVHQF LLQGATVIHY DQDTHLSARC FLQLQPDNST LTWVKPTTAS
910 920 930 940 950
PASSKAKLGV LNNTAEPGKF PLLGNAGLSS LTEGVLDLFA VKAVYMGHPG
960 970 980 990 1000
IDIHTVCVQN KLGSMFLSET GVTLLYGLQT TDNRLLHFVA PKHTAKMLFS
1010 1020 1030 1040 1050
GLLELTRAVR KMRKFPDQRQ QWLRKQYVSL YQEDGRYEGP TLAHAVELFG
1060 1070 1080 1090 1100
GRRWSARNPS PGTSAKNAEK PNMQRNNTLG ISTTKKKKKI LMRGESGEVT
1110 1120 1130 1140 1150
DDEMATRKAK MHKECRSRSG SDPQDINEQE ESEVNAIANP PNPLPSRRAH
1160 1170 1180 1190 1200
SLTTAGSPNL AAGTSSPIRP VSSPVLSSSN KSPSSAWSSS SWHGRIKGGM
1210 1220 1230 1240 1250
KGFQSFMVSD SNMSFVEFVE LFKSFSVRSR KDLKDLFDVY AVPCNRSGSE
1260 1270 1280 1290 1300
SAPLYTNLTI DENTSDLQPD LDLLTRNVSD LGLFIKSKQQ LSDNQRQISD
1310 1320 1330 1340 1350
AIAAASIVTN GTGIESTSLG IFGVGILQLN DFLVNCQGEH CTYDEILSII
1360 1370 1380 1390 1400
QKFEPSISMC HQGLMSFEGF ARFLMDKENF ASKNDESQEN IKELQLPLSY
1410 1420 1430 1440 1450
YYIESSHNTY LTGHQLKGES SVELYSQVLL QGCRSVELDC WDGDDGMPII
1460 1470 1480 1490 1500
YHGHTLTTKI PFKEVVEAID RSAFINSDLP IIISIENHCS LPQQRKMAEI
1510 1520 1530 1540 1550
FKTVFGEKLV TKFLFETDFS DDPMLPSPDQ LRKKVLLKNK KLKAHQTPVD
1560 1570 1580 1590 1600
ILKQKAHQLA SMQVQAYNGG NANPRPANNE EEEDEEDEYD YDYESLSDDN
1610 1620 1630 1640 1650
ILEDRPENKS CNDKLQFEYN EEIPKRIKKA DNSACNKGKV YDMELGEEFY
1660 1670 1680 1690 1700
LDQNKKESRQ IAPELSDLVI YCQAVKFPGL STLNASGSSR GKERKSRKSI
1710 1720 1730 1740 1750
FGNNPGRMSP GETASFNKTS GKSSCEGIRQ TWEESSSPLN PTTSLSAIIR
1760 1770 1780 1790 1800
TPKCYHISSL NENAAKRLCR RYSQKLTQHT ACQLLRTYPA ATRIDSSNPN
1810 1820 1830 1840 1850
PLMFWLHGIQ LVALNYQTDD LPLHLNAAMF EANGGCGYVL KPPVLWDKNC
1860 1870 1880 1890 1900
PMYQKFSPLE RDLDSMDPAV YSLTIVSGQN VCPSNSMGSP CIEVDVLGMP
1910 1920 1930 1940 1950
LDSCHFRTKP IHRNTLNPMW NEQFLFHVHF EDLVFLRFAV VENNSSAVTA
1960 1970 1980 1990 2000
QRIIPLKALK RGYRHLQLRN LHNEVLEISS LFINSRRMEE NSSGNTMSAS
2010 2020 2030 2040 2050
SMFNTEERKC LQTHRVTVHG VPGPEPFTVF TINGGTKAKQ LLQQILTNEQ
2060 2070 2080 2090 2100
DIKPVTTDYF LMEEKYFISK EKNECRKQPF QRAIGPEEEI MQILSSWFPE
2110 2120 2130 2140 2150
EGYMGRIVLK TQQENLEEKN IVQDDKEVIL SSEEESFFVQ VHDVSPEQPR
2160 2170 2180 2190 2200
TVIKAPRVST AQDVIQQTLC KAKYSYSILS NPNPSDYVLL EEVVKDTTNK
2210 2220 2230 2240 2250
KTTTPKSSQR VLLDQECVFQ AQSKWKGAGK FILKLKEQVQ ASREDKKKGI
2260 2270 2280 2290 2300
SFASELKKLT KSTKQPRGLT SPSQLLTSES IQTKEEKPVG GLSSSDTMDY

RQ
Length:2,302
Mass (Da):258,715
Last modified:October 31, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i71DDE446277077A3
GO
Isoform 2 (identifier: Q9P212-2) [UniParc]FASTAAdd to basket
Also known as: PLCepsilon1b

The sequence of this isoform differs from the canonical sequence as follows:
     1-308: Missing.
     309-402: DVEEDAFKSK...QRLSEAQWYP → MVSEGSAAGR...CGCWRLKEDQ

Show »
Length:1,994
Mass (Da):223,872
Checksum:i069358CFA0D7A1CD
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF22005 differs from that shown. Reason: Frameshift.Curated
The sequence AAG17145 differs from that shown. Reason: Frameshift.Curated
The sequence BAA96040 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAB14090 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti502G → S in AAG28341 (PubMed:11022047).Curated1
Sequence conflicti703V → F in AAG28341 (PubMed:11022047).Curated1
Sequence conflicti1133E → K in AAG28341 (PubMed:11022047).Curated1
Sequence conflicti1229 – 1230SR → QA in AAF22005 (Ref. 8) Curated2
Sequence conflicti1456L → P in AAG17145 (PubMed:11022048).Curated1
Sequence conflicti1571N → D in BAB14090 (PubMed:14702039).Curated1
Sequence conflicti1575R → Q in AAG28341 (PubMed:11022047).Curated1
Sequence conflicti1672C → R in AAG17145 (PubMed:11022048).Curated1
Sequence conflicti1705P → L in BAB14090 (PubMed:14702039).Curated1
Sequence conflicti2125D → G in BAB14090 (PubMed:14702039).Curated1
Isoform 2 (identifier: Q9P212-2)
Sequence conflicti69L → P in AAG28341 (PubMed:11022047).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031843469S → T. Corresponds to variant dbSNP:rs17508082EnsemblClinVar.1
Natural variantiVAR_031844548R → L. Corresponds to variant dbSNP:rs17417407EnsemblClinVar.1
Natural variantiVAR_0298831484S → L in NPHS3; gives rise to focal segmental glomerulosclerosis rather than diffuse mesangial sclerosis. 1 PublicationCorresponds to variant dbSNP:rs121912605EnsemblClinVar.1
Natural variantiVAR_0318451575R → P. Corresponds to variant dbSNP:rs2274224EnsemblClinVar.1
Natural variantiVAR_0318461777T → I2 PublicationsCorresponds to variant dbSNP:rs3765524EnsemblClinVar.1
Natural variantiVAR_0318471927H → R4 PublicationsCorresponds to variant dbSNP:rs2274223EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0213351 – 308Missing in isoform 2. 2 PublicationsAdd BLAST308
Alternative sequenceiVSP_021336309 – 402DVEED…AQWYP → MVSEGSAAGRDFAGMEEVRQ LHVRFCKGIKIWHQAWFLCS LLGREPQEREAGCQLWLCTL SAVLKVGWLFPLSEVPNFTL LKDGCGCWRLKEDQ in isoform 2. 2 PublicationsAdd BLAST94

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF190642 mRNA Translation: AAG17145.2 Frameshift.
AF170071 mRNA Translation: AAG28341.1
AB040949 mRNA Translation: BAA96040.2 Different initiation.
AL139118 Genomic DNA No translation available.
AL139124 Genomic DNA No translation available.
AL365510 Genomic DNA No translation available.
AL389885 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW50042.1
CH471066 Genomic DNA Translation: EAW50043.1
BC140705 mRNA Translation: AAI40706.1
BC151854 mRNA Translation: AAI51855.1
AF117948 mRNA Translation: AAF22005.1 Frameshift.
AK022543 mRNA Translation: BAB14090.1 Different initiation.
AK289852 mRNA Translation: BAF82541.1
AY995135 mRNA Translation: AAY45890.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41552.1 [Q9P212-1]
CCDS53555.1 [Q9P212-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001159451.1, NM_001165979.2 [Q9P212-2]
NP_001275918.1, NM_001288989.1
NP_057425.3, NM_016341.3 [Q9P212-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000371375; ENSP00000360426; ENSG00000138193 [Q9P212-2]
ENST00000371380; ENSP00000360431; ENSG00000138193 [Q9P212-1]
ENST00000371385; ENSP00000360438; ENSG00000138193 [Q9P212-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
51196

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51196

UCSC genome browser

More...
UCSCi
uc001kjk.4, human [Q9P212-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190642 mRNA Translation: AAG17145.2 Frameshift.
AF170071 mRNA Translation: AAG28341.1
AB040949 mRNA Translation: BAA96040.2 Different initiation.
AL139118 Genomic DNA No translation available.
AL139124 Genomic DNA No translation available.
AL365510 Genomic DNA No translation available.
AL389885 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW50042.1
CH471066 Genomic DNA Translation: EAW50043.1
BC140705 mRNA Translation: AAI40706.1
BC151854 mRNA Translation: AAI51855.1
AF117948 mRNA Translation: AAF22005.1 Frameshift.
AK022543 mRNA Translation: BAB14090.1 Different initiation.
AK289852 mRNA Translation: BAF82541.1
AY995135 mRNA Translation: AAY45890.1
CCDSiCCDS41552.1 [Q9P212-1]
CCDS53555.1 [Q9P212-2]
RefSeqiNP_001159451.1, NM_001165979.2 [Q9P212-2]
NP_001275918.1, NM_001288989.1
NP_057425.3, NM_016341.3 [Q9P212-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BYENMR-A2006-2114[»]
2BYFNMR-A2131-2246[»]
2C5LX-ray1.90C/D2131-2246[»]
SMRiQ9P212
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi119370, 8 interactors
IntActiQ9P212, 4 interactors
STRINGi9606.ENSP00000360431

Chemistry databases

SwissLipidsiSLP:000000663

PTM databases

iPTMnetiQ9P212
PhosphoSitePlusiQ9P212

Polymorphism and mutation databases

BioMutaiPLCE1
DMDMi118595723

Proteomic databases

EPDiQ9P212
jPOSTiQ9P212
MassIVEiQ9P212
PaxDbiQ9P212
PeptideAtlasiQ9P212
PRIDEiQ9P212
ProteomicsDBi83705 [Q9P212-1]
83706 [Q9P212-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2889, 44 antibodies

Genome annotation databases

EnsembliENST00000371375; ENSP00000360426; ENSG00000138193 [Q9P212-2]
ENST00000371380; ENSP00000360431; ENSG00000138193 [Q9P212-1]
ENST00000371385; ENSP00000360438; ENSG00000138193 [Q9P212-2]
GeneIDi51196
KEGGihsa:51196
UCSCiuc001kjk.4, human [Q9P212-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51196
DisGeNETi51196
EuPathDBiHostDB:ENSG00000138193.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PLCE1
HGNCiHGNC:17175, PLCE1
HPAiENSG00000138193, Tissue enhanced (retina)
MalaCardsiPLCE1
MIMi608414, gene
610725, phenotype
neXtProtiNX_Q9P212
OpenTargetsiENSG00000138193
Orphaneti656, Genetic steroid-resistant nephrotic syndrome
PharmGKBiPA33391

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0169, Eukaryota
GeneTreeiENSGT00940000157356
HOGENOMiCLU_001158_0_0_1
InParanoidiQ9P212
KOiK05860
OMAiNTTLTWG
OrthoDBi368239at2759
PhylomeDBiQ9P212
TreeFamiTF314432

Enzyme and pathway databases

BioCyciMetaCyc:HS06473-MONOMER
BRENDAi3.1.4.11, 2681
PathwayCommonsiQ9P212
ReactomeiR-HSA-1855204, Synthesis of IP3 and IP4 in the cytosol
SIGNORiQ9P212

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
51196, 8 hits in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PLCE1, human
EvolutionaryTraceiQ9P212

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PLCE1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51196
PharosiQ9P212, Tbio

Protein Ontology

More...
PROi
PR:Q9P212
RNActiQ9P212, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000138193, Expressed in metanephric glomerulus and 227 other tissues
GenevisibleiQ9P212, HS

Family and domain databases

Gene3Di2.60.40.150, 1 hit
3.20.20.190, 2 hits
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR011992, EF-hand-dom_pair
IPR001192, PI-PLC_fam
IPR028398, PLC-epsilon1
IPR017946, PLC-like_Pdiesterase_TIM-brl
IPR015359, PLC_EF-hand-like
IPR000909, PLipase_C_PInositol-sp_X_dom
IPR001711, PLipase_C_Pinositol-sp_Y
IPR000159, RA_dom
IPR023578, Ras_GEF_dom_sf
IPR001895, RASGEF_cat_dom
IPR029071, Ubiquitin-like_domsf
PANTHERiPTHR10336, PTHR10336, 1 hit
PTHR10336:SF6, PTHR10336:SF6, 1 hit
PfamiView protein in Pfam
PF00168, C2, 1 hit
PF09279, EF-hand_like, 1 hit
PF00388, PI-PLC-X, 1 hit
PF00387, PI-PLC-Y, 1 hit
PF00788, RA, 1 hit
PF00617, RasGEF, 1 hit
PRINTSiPR00390, PHPHLIPASEC
SMARTiView protein in SMART
SM00239, C2, 1 hit
SM00148, PLCXc, 1 hit
SM00149, PLCYc, 1 hit
SM00314, RA, 1 hit
SM00147, RasGEF, 1 hit
SUPFAMiSSF47473, SSF47473, 1 hit
SSF48366, SSF48366, 1 hit
SSF51695, SSF51695, 1 hit
SSF54236, SSF54236, 2 hits
PROSITEiView protein in PROSITE
PS50004, C2, 1 hit
PS50007, PIPLC_X_DOMAIN, 1 hit
PS50008, PIPLC_Y_DOMAIN, 1 hit
PS50200, RA, 1 hit
PS50009, RASGEF_CAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLCE1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P212
Secondary accession number(s): A6NGW0
, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9UHV3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: August 12, 2020
This is version 176 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again