HCN3

Functionⁱ

Hyperpolarization-activated potassium channel. May also facilitate the permeation of sodium ions.1 Publication

Activity regulationⁱ

Inhibited by Cs¹⁺ and ZD7288. Is apparently not activated by cAMP.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	492 – 495	cAMPBy similarity	4
Nucleotide bindingⁱ	502 – 503	cAMPBy similarity	2
Nucleotide bindingⁱ	543 – 546	cAMPBy similarity	4

GO - Molecular functionⁱ

cAMP binding Source: UniProtKB-KW
voltage-gated potassium channel activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22748890
voltage-gated sodium channel activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22748890

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to dopamine Source: Ensembl
potassium ion transmembrane transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22748890
regulation of ion transmembrane transport Source: UniProtKB-KW
regulation of membrane potential
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22748890
response to cisplatin Source: Ensembl
sodium ion transmembrane transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22748890

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ion channel, Ligand-gated ion channel, Potassium channel, Sodium channel, Voltage-gated channel
Biological process	Ion transport, Potassium transport, Sodium transport, Transport
Ligand	cAMP, cAMP-binding, Nucleotide-binding, Potassium, Sodium

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1296061 HCN channels

Reactomeⁱ

R-HSA-1296061 HCN channels

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
Gene namesⁱ	Name:HCN3 Synonyms:KIAA1535
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000143630.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19183 HCN3
MIMⁱ	609973 gene
neXtProtⁱ	NX_Q9P1Z3

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 97	CytoplasmicSequence analysisAdd BLAST	97
Transmembraneⁱ	98 – 118	Helical; Name=Segment S1Sequence analysisAdd BLAST	21
Topological domainⁱ	119 – 124	ExtracellularSequence analysis	6
Transmembraneⁱ	125 – 145	Helical; Name=Segment S2Sequence analysisAdd BLAST	21
Topological domainⁱ	146 – 171	CytoplasmicSequence analysisAdd BLAST	26
Transmembraneⁱ	172 – 192	Helical; Name=Segment S3Sequence analysisAdd BLAST	21
Topological domainⁱ	193 – 201	ExtracellularSequence analysis	9
Transmembraneⁱ	202 – 222	Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST	21
Topological domainⁱ	223 – 253	CytoplasmicSequence analysisAdd BLAST	31
Transmembraneⁱ	254 – 274	Helical; Name=Segment S5Sequence analysisAdd BLAST	21
Topological domainⁱ	275 – 297	ExtracellularSequence analysisAdd BLAST	23
Intramembraneⁱ	298 – 319	Pore-forming; Name=Segment H5Sequence analysisAdd BLAST	22
Topological domainⁱ	320 – 329	ExtracellularSequence analysis	10
Transmembraneⁱ	330 – 350	Helical; Name=Segment S6Sequence analysisAdd BLAST	21
Topological domainⁱ	351 – 774	CytoplasmicSequence analysisAdd BLAST	424

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	57657
Open Targets More...OpenTargetsⁱ	ENSG00000143630
PharmGKBⁱ	PA38821

Chemistry databases

ChEMBLⁱ	CHEMBL1795173
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	402

Polymorphism and mutation databases

DMDMⁱ	29840780

DMDMⁱ

29840780

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000054114	1 – 774	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3Add BLAST		774

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	291	N-linked (GlcNAc...) asparagineSequence analysis		1
Modified residueⁱ	634	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	Q9P1Z3
PaxDbⁱ	Q9P1Z3
PeptideAtlas More...PeptideAtlasⁱ	Q9P1Z3
PRIDEⁱ	Q9P1Z3
ProteomicsDBⁱ	83687

PTM databases

iPTMnetⁱ	Q9P1Z3
PhosphoSitePlusⁱ	Q9P1Z3

Expressionⁱ

Tissue specificityⁱ

Detected in brain.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000143630 Expressed in 130 organ(s), highest expression level in forebrain
CleanExⁱ	HS_HCN3
Genevisibleⁱ	Q9P1Z3 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA026584

HPAⁱ

HPA026584

Interactionⁱ

Subunit structureⁱ

Homotetramer. The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits. Interacts with KCTD3 and PEX5L.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Shank3	Q4ACU6-1	3	EBI-11178054,EBI-16201983	From a different organism.

With

Entry

#Exp.

IntAct

Notes

Shank3

Q4ACU6-1

3

EBI-11178054,EBI-16201983

From a different organism.

Protein-protein interaction databases

BioGridⁱ	121691, 3 interactors
ComplexPortalⁱ	CPX-267 HCN3 channel complex
Database of interacting proteins More...DIPⁱ	DIP-62039N
IntActⁱ	Q9P1Z3, 2 interactors
STRINGⁱ	9606.ENSP00000357342

Chemistry databases

BindingDBⁱ

Q9P1Z3

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9P1Z3
SMRⁱ	Q9P1Z3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	46 – 91	Involved in subunit assemblyBy similarityAdd BLAST		46
Regionⁱ	354 – 774	Interaction with KCTD3By similarityAdd BLAST		421

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	696 – 765	Pro-richAdd BLAST		70

Domainⁱ

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesⁱ

Belongs to the potassium channel HCN family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0498 Eukaryota ENOG410XPSE LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140801
HOGENOMⁱ	HOG000230717
HOVERGENⁱ	HBG039489
InParanoidⁱ	Q9P1Z3
KEGG Orthology (KO) More...KOⁱ	K04956
OMAⁱ	VMEQHLV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0JQU
PhylomeDBⁱ	Q9P1Z3
TreeFamⁱ	TF318250

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00038 CAP_ED, 1 hit
Gene3Dⁱ	2.60.120.10, 1 hit
InterProⁱ	View protein in InterPro IPR018490 cNMP-bd-like IPR000595 cNMP-bd_dom IPR005821 Ion_trans_dom IPR013621 Ion_trans_N IPR003938 K_chnl_volt-dep_EAG/ELK/ERG IPR014710 RmlC-like_jellyroll
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00027 cNMP_binding, 1 hit PF00520 Ion_trans, 1 hit PF08412 Ion_trans_N, 1 hit
PRINTSⁱ	PR01463 EAGCHANLFMLY
SMARTⁱ	View protein in SMART SM00100 cNMP, 1 hit
SUPFAMⁱ	SSF51206 SSF51206, 1 hit
PROSITEⁱ	View protein in PROSITE PS50042 CNMP_BINDING_3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9P1Z3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEAEQRPAAG ASEGATPGLE AVPPVAPPPA TAASGPIPKS GPEPKRRHLG 
        60         70         80         90        100
TLLQPTVNKF SLRVFGSHKA VEIEQERVKS AGAWIIHPYS DFRFYWDLIM 
       110        120        130        140        150
LLLMVGNLIV LPVGITFFKE ENSPPWIVFN VLSDTFFLLD LVLNFRTGIV 
       160        170        180        190        200
VEEGAEILLA PRAIRTRYLR TWFLVDLISS IPVDYIFLVV ELEPRLDAEV 
       210        220        230        240        250
YKTARALRIV RFTKILSLLR LLRLSRLIRY IHQWEEIFHM TYDLASAVVR 
       260        270        280        290        300
IFNLIGMMLL LCHWDGCLQF LVPMLQDFPP DCWVSINHMV NHSWGRQYSH 
       310        320        330        340        350
ALFKAMSHML CIGYGQQAPV GMPDVWLTML SMIVGATCYA MFIGHATALI 
       360        370        380        390        400
QSLDSSRRQY QEKYKQVEQY MSFHKLPADT RQRIHEYYEH RYQGKMFDEE 
       410        420        430        440        450
SILGELSEPL REEIINFTCR GLVAHMPLFA HADPSFVTAV LTKLRFEVFQ 
       460        470        480        490        500
PGDLVVREGS VGRKMYFIQH GLLSVLARGA RDTRLTDGSY FGEICLLTRG 
       510        520        530        540        550
RRTASVRADT YCRLYSLSVD HFNAVLEEFP MMRRAFETVA MDRLLRIGKK 
       560        570        580        590        600
NSILQRKRSE PSPGSSGGIM EQHLVQHDRD MARGVRGRAP STGAQLSGKP 
       610        620        630        640        650
VLWEPLVHAP LQAAAVTSNV AIALTHQRGP LPLSPDSPAT LLARSAWRSA 
       660        670        680        690        700
GSPASPLVPV RAGPWASTSR LPAPPARTLH ASLSRAGRSQ VSLLGPPPGG 
       710        720        730        740        750
GGRRLGPRGR PLSASQPSLP QRATGDGSPG RKGSGSERLP PSGLLAKPPR 
       760        770 
TAQPPRPPVP EPATPRGLQL SANM

Length:774

Mass (Da):86,032

Last modified:February 28, 2003 - v2

Checksum:ⁱ37B9BC13E5E2C097

GO

Sequence cautionⁱ

The sequence AAH28024 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	206	A → G in AAH00066 (PubMed:15489334).Curated		1
Sequence conflictⁱ	734	S → T in BAA96059 (PubMed:10819331).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_048746	630	P → L. Corresponds to variant dbSNP:rs35001694Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL713999 Genomic DNA No translation available. AB040968 mRNA Translation: BAA96059.2 CH471121 Genomic DNA Translation: EAW53084.1 CH471121 Genomic DNA Translation: EAW53086.1 BC000066 mRNA Translation: AAH00066.1 BC028024 mRNA Translation: AAH28024.2 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1108.1
NCBI Reference Sequences More...RefSeqⁱ	NP_065948.1, NM_020897.2
UniGeneⁱ	Hs.706960

Genome annotation databases

Ensemblⁱ	ENST00000368358; ENSP00000357342; ENSG00000143630 ENST00000575670; ENSP00000458364; ENSG00000263324
GeneIDⁱ	57657
KEGGⁱ	hsa:57657
UCSC genome browser More...UCSCⁱ	uc001fjz.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9P1Z3	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3		RAT		780	UniRef90_Q9P1Z3
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3		MOUSE		779
Uncharacterized protein		MONDO		788
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3		Yangtze finless porpoise		786
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3		PHYCD		786
+130

Protein	Similar proteins		Species	Score	Length	Source
Q9P1Z3	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1	)	MOUSE		910	UniRef50_O88704
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1		RAT		910
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1		TARSY		839
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1		ALLSI		761
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1		FUNHE		874
+229

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL713999 Genomic DNA No translation available. AB040968 mRNA Translation: BAA96059.2 CH471121 Genomic DNA Translation: EAW53084.1 CH471121 Genomic DNA Translation: EAW53086.1 BC000066 mRNA Translation: AAH00066.1 BC028024 mRNA Translation: AAH28024.2 Different initiation.
CCDSⁱ	CCDS1108.1
RefSeqⁱ	NP_065948.1, NM_020897.2
UniGeneⁱ	Hs.706960

3D structure databases

ProteinModelPortalⁱ	Q9P1Z3
SMRⁱ	Q9P1Z3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121691, 3 interactors
ComplexPortalⁱ	CPX-267 HCN3 channel complex
DIPⁱ	DIP-62039N
IntActⁱ	Q9P1Z3, 2 interactors
STRINGⁱ	9606.ENSP00000357342

Chemistry databases

BindingDBⁱ	Q9P1Z3
ChEMBLⁱ	CHEMBL1795173
GuidetoPHARMACOLOGYⁱ	402

PTM databases

iPTMnetⁱ	Q9P1Z3
PhosphoSitePlusⁱ	Q9P1Z3

Polymorphism and mutation databases

DMDMⁱ	29840780

DMDMⁱ

29840780

Proteomic databases

EPDⁱ	Q9P1Z3
PaxDbⁱ	Q9P1Z3
PeptideAtlasⁱ	Q9P1Z3
PRIDEⁱ	Q9P1Z3
ProteomicsDBⁱ	83687

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	57657
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000368358; ENSP00000357342; ENSG00000143630 ENST00000575670; ENSP00000458364; ENSG00000263324
GeneIDⁱ	57657
KEGGⁱ	hsa:57657
UCSCⁱ	uc001fjz.3 human

Organism-specific databases

CTDⁱ	57657
DisGeNETⁱ	57657
EuPathDBⁱ	HostDB:ENSG00000143630.9
GeneCardsⁱ	HCN3
H-InvDBⁱ	HIX0001125
HGNCⁱ	HGNC:19183 HCN3
HPAⁱ	HPA026584
MIMⁱ	609973 gene
neXtProtⁱ	NX_Q9P1Z3
OpenTargetsⁱ	ENSG00000143630
PharmGKBⁱ	PA38821
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0498 Eukaryota ENOG410XPSE LUCA
GeneTreeⁱ	ENSGT00900000140801
HOGENOMⁱ	HOG000230717
HOVERGENⁱ	HBG039489
InParanoidⁱ	Q9P1Z3
KOⁱ	K04956
OMAⁱ	VMEQHLV
OrthoDBⁱ	EOG091G0JQU
PhylomeDBⁱ	Q9P1Z3
TreeFamⁱ	TF318250

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1296061 HCN channels

Reactomeⁱ

R-HSA-1296061 HCN channels

Miscellaneous databases

ChiTaRSⁱ	HCN3 human
GeneWikiⁱ	HCN3
GenomeRNAiⁱ	57657
Protein Ontology More...PROⁱ	PR:Q9P1Z3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000143630 Expressed in 130 organ(s), highest expression level in forebrain
CleanExⁱ	HS_HCN3
Genevisibleⁱ	Q9P1Z3 HS

Family and domain databases

CDDⁱ	cd00038 CAP_ED, 1 hit
Gene3Dⁱ	2.60.120.10, 1 hit
InterProⁱ	View protein in InterPro IPR018490 cNMP-bd-like IPR000595 cNMP-bd_dom IPR005821 Ion_trans_dom IPR013621 Ion_trans_N IPR003938 K_chnl_volt-dep_EAG/ELK/ERG IPR014710 RmlC-like_jellyroll
Pfamⁱ	View protein in Pfam PF00027 cNMP_binding, 1 hit PF00520 Ion_trans, 1 hit PF08412 Ion_trans_N, 1 hit
PRINTSⁱ	PR01463 EAGCHANLFMLY
SMARTⁱ	View protein in SMART SM00100 cNMP, 1 hit
SUPFAMⁱ	SSF51206 SSF51206, 1 hit
PROSITEⁱ	View protein in PROSITE PS50042 CNMP_BINDING_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HCN3_HUMAN
Accessionⁱ	Q9P1Z3Primary (citable) accession number: Q9P1Z3 Secondary accession number(s): D3DV90 , Q4VX12, Q8N6W6, Q9BWQ2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 28, 2003
	Last sequence update:	February 28, 2003
	Last modified:	September 12, 2018
	This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
SIMILARITY comments
Index of protein domains and families
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations

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UniProtKB - Q9P1Z3 (HCN3_HUMAN)

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Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ