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UniProtKB - Q9P1Z3 (HCN3_HUMAN)

Entry version 174 (25 May 2022)
Sequence version 2 (28 Feb 2003)
Previous versions | rss
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Protein

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3

Gene

HCN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hyperpolarization-activated potassium channel. May also facilitate the permeation of sodium ions.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by Cs1+ and ZD7288. Is apparently not activated by cAMP.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi492 – 4953',5'-cAMPBy similarity4
Nucleotide bindingi502 – 5033',5'-cAMPBy similarity2
Nucleotide bindingi543 – 5463',5'-cAMPBy similarity4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Potassium channel, Sodium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Sodium transport, Transport
LigandcAMP, cAMP-binding, Nucleotide-binding, Potassium, Sodium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9P1Z3

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1296061, HCN channels

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9P1Z3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HCN3
Synonyms:KIAA1535
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:19183, HCN3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609973, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9P1Z3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000143630

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 97CytoplasmicSequence analysisAdd BLAST97
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei98 – 118Helical; Name=Segment S1Sequence analysisAdd BLAST21
Topological domaini119 – 124ExtracellularSequence analysis6
Transmembranei125 – 145Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini146 – 171CytoplasmicSequence analysisAdd BLAST26
Transmembranei172 – 192Helical; Name=Segment S3Sequence analysisAdd BLAST21
Topological domaini193 – 201ExtracellularSequence analysis9
Transmembranei202 – 222Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST21
Topological domaini223 – 253CytoplasmicSequence analysisAdd BLAST31
Transmembranei254 – 274Helical; Name=Segment S5Sequence analysisAdd BLAST21
Topological domaini275 – 297ExtracellularSequence analysisAdd BLAST23
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei298 – 319Pore-forming; Name=Segment H5Sequence analysisAdd BLAST22
Topological domaini320 – 329ExtracellularSequence analysis10
Transmembranei330 – 350Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini351 – 774CytoplasmicSequence analysisAdd BLAST424

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		57657

Open Targets

More...OpenTargetsi		ENSG00000143630

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38821

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9P1Z3, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1795173

DrugCentral

More...DrugCentrali		Q9P1Z3

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		402

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HCN3

Domain mapping of disease mutations (DMDM)

More...DMDMi		29840780

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000541141 – 774Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3Add BLAST774

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi291N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei634PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9P1Z3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9P1Z3

PeptideAtlas

More...PeptideAtlasi		Q9P1Z3

PRoteomics IDEntifications database

More...PRIDEi		Q9P1Z3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		83687

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9P1Z3, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9P1Z3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9P1Z3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000143630, Expressed in forebrain and 153 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9P1Z3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000143630, Tissue enhanced (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer. The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits.

Interacts with KCTD3 and PEX5L.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121691, 6 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-267, HCN3 channel complex

Database of interacting proteins

More...DIPi		DIP-62039N

Protein interaction database and analysis system

More...IntActi		Q9P1Z3, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000357342

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9P1Z3

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9P1Z3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9P1Z3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9P1Z3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 48DisorderedSequence analysisAdd BLAST48
Regioni46 – 91Involved in subunit assemblyBy similarityAdd BLAST46
Regioni354 – 774Interaction with KCTD3By similarityAdd BLAST421
Regioni682 – 774DisorderedSequence analysisAdd BLAST93

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi21 – 35Pro residuesSequence analysisAdd BLAST15
Compositional biasi747 – 764Pro residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the potassium channel HCN family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0498, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162023

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005746_15_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9P1Z3

Identification of Orthologs from Complete Genome Data

More...OMAi		SSIPMDC

Database of Orthologous Groups

More...OrthoDBi		281394at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9P1Z3

TreeFam database of animal gene trees

More...TreeFami		TF318250

Family and domain databases

Conserved Domains Database

More...CDDi		cd00038, CAP_ED, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR018490, cNMP-bd-like
IPR000595, cNMP-bd_dom
IPR005821, Ion_trans_dom
IPR013621, Ion_trans_N
IPR003938, K_chnl_volt-dep_EAG/ELK/ERG
IPR014710, RmlC-like_jellyroll

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00027, cNMP_binding, 1 hit
PF00520, Ion_trans, 1 hit
PF08412, Ion_trans_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01463, EAGCHANLFMLY

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00100, cNMP, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51206, SSF51206, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50042, CNMP_BINDING_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9P1Z3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAEQRPAAG ASEGATPGLE AVPPVAPPPA TAASGPIPKS GPEPKRRHLG 
        60         70         80         90        100
TLLQPTVNKF SLRVFGSHKA VEIEQERVKS AGAWIIHPYS DFRFYWDLIM 
       110        120        130        140        150
LLLMVGNLIV LPVGITFFKE ENSPPWIVFN VLSDTFFLLD LVLNFRTGIV 
       160        170        180        190        200
VEEGAEILLA PRAIRTRYLR TWFLVDLISS IPVDYIFLVV ELEPRLDAEV 
       210        220        230        240        250
YKTARALRIV RFTKILSLLR LLRLSRLIRY IHQWEEIFHM TYDLASAVVR 
       260        270        280        290        300
IFNLIGMMLL LCHWDGCLQF LVPMLQDFPP DCWVSINHMV NHSWGRQYSH 
       310        320        330        340        350
ALFKAMSHML CIGYGQQAPV GMPDVWLTML SMIVGATCYA MFIGHATALI 
       360        370        380        390        400
QSLDSSRRQY QEKYKQVEQY MSFHKLPADT RQRIHEYYEH RYQGKMFDEE 
       410        420        430        440        450
SILGELSEPL REEIINFTCR GLVAHMPLFA HADPSFVTAV LTKLRFEVFQ 
       460        470        480        490        500
PGDLVVREGS VGRKMYFIQH GLLSVLARGA RDTRLTDGSY FGEICLLTRG 
       510        520        530        540        550
RRTASVRADT YCRLYSLSVD HFNAVLEEFP MMRRAFETVA MDRLLRIGKK 
       560        570        580        590        600
NSILQRKRSE PSPGSSGGIM EQHLVQHDRD MARGVRGRAP STGAQLSGKP 
       610        620        630        640        650
VLWEPLVHAP LQAAAVTSNV AIALTHQRGP LPLSPDSPAT LLARSAWRSA 
       660        670        680        690        700
GSPASPLVPV RAGPWASTSR LPAPPARTLH ASLSRAGRSQ VSLLGPPPGG 
       710        720        730        740        750
GGRRLGPRGR PLSASQPSLP QRATGDGSPG RKGSGSERLP PSGLLAKPPR 
       760        770 
TAQPPRPPVP EPATPRGLQL SANM
Length:774
Mass (Da):86,032
Last modified:February 28, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i37B9BC13E5E2C097
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH28024 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti206A → G in AAH00066 (PubMed:15489334).Curated1
Sequence conflicti734S → T in BAA96059 (PubMed:10819331).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048746630P → L. Corresponds to variant dbSNP:rs35001694Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL713999 Genomic DNA No translation available.
AB040968 mRNA Translation: BAA96059.2
CH471121 Genomic DNA Translation: EAW53084.1
CH471121 Genomic DNA Translation: EAW53086.1
BC000066 mRNA Translation: AAH00066.1
BC028024 mRNA Translation: AAH28024.2 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1108.1

NCBI Reference Sequences

More...RefSeqi		NP_065948.1, NM_020897.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000368358.4; ENSP00000357342.3; ENSG00000143630.10
ENST00000575670.1; ENSP00000458364.1; ENSG00000263324.5

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57657

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:57657

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000368358.4; ENSP00000357342.3; NM_020897.3; NP_065948.1

UCSC genome browser

More...UCSCi		uc001fjz.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL713999 Genomic DNA No translation available.
AB040968 mRNA Translation: BAA96059.2
CH471121 Genomic DNA Translation: EAW53084.1
CH471121 Genomic DNA Translation: EAW53086.1
BC000066 mRNA Translation: AAH00066.1
BC028024 mRNA Translation: AAH28024.2 Different initiation.
CCDSiCCDS1108.1
RefSeqiNP_065948.1, NM_020897.2

3D structure databases

AlphaFoldDBiQ9P1Z3
SMRiQ9P1Z3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121691, 6 interactors
ComplexPortaliCPX-267, HCN3 channel complex
DIPiDIP-62039N
IntActiQ9P1Z3, 2 interactors
STRINGi9606.ENSP00000357342

Chemistry databases

BindingDBiQ9P1Z3
ChEMBLiCHEMBL1795173
DrugCentraliQ9P1Z3
GuidetoPHARMACOLOGYi402

PTM databases

GlyGeniQ9P1Z3, 1 site
iPTMnetiQ9P1Z3
PhosphoSitePlusiQ9P1Z3

Genetic variation databases

BioMutaiHCN3
DMDMi29840780

Proteomic databases

MassIVEiQ9P1Z3
PaxDbiQ9P1Z3
PeptideAtlasiQ9P1Z3
PRIDEiQ9P1Z3
ProteomicsDBi83687

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q9P1Z3, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		20417, 305 antibodies from 37 providers

The DNASU plasmid repository

More...DNASUi		57657

Genome annotation databases

EnsembliENST00000368358.4; ENSP00000357342.3; ENSG00000143630.10
ENST00000575670.1; ENSP00000458364.1; ENSG00000263324.5
GeneIDi57657
KEGGihsa:57657
MANE-SelectiENST00000368358.4; ENSP00000357342.3; NM_020897.3; NP_065948.1
UCSCiuc001fjz.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57657
DisGeNETi57657

GeneCards: human genes, protein and diseases

More...GeneCardsi		HCN3
HGNCiHGNC:19183, HCN3
HPAiENSG00000143630, Tissue enhanced (liver)
MIMi609973, gene
neXtProtiNX_Q9P1Z3
OpenTargetsiENSG00000143630
PharmGKBiPA38821
VEuPathDBiHostDB:ENSG00000143630

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0498, Eukaryota
GeneTreeiENSGT00940000162023
HOGENOMiCLU_005746_15_1_1
InParanoidiQ9P1Z3
OMAiSSIPMDC
OrthoDBi281394at2759
PhylomeDBiQ9P1Z3
TreeFamiTF318250

Enzyme and pathway databases

PathwayCommonsiQ9P1Z3
ReactomeiR-HSA-1296061, HCN channels
SignaLinkiQ9P1Z3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		57657, 10 hits in 1071 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		HCN3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		HCN3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		57657
PharosiQ9P1Z3, Tclin

Protein Ontology

More...PROi		PR:Q9P1Z3
RNActiQ9P1Z3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000143630, Expressed in forebrain and 153 other tissues
GenevisibleiQ9P1Z3, HS

Family and domain databases

CDDicd00038, CAP_ED, 1 hit
Gene3Di2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR018490, cNMP-bd-like
IPR000595, cNMP-bd_dom
IPR005821, Ion_trans_dom
IPR013621, Ion_trans_N
IPR003938, K_chnl_volt-dep_EAG/ELK/ERG
IPR014710, RmlC-like_jellyroll
PfamiView protein in Pfam
PF00027, cNMP_binding, 1 hit
PF00520, Ion_trans, 1 hit
PF08412, Ion_trans_N, 1 hit
PRINTSiPR01463, EAGCHANLFMLY
SMARTiView protein in SMART
SM00100, cNMP, 1 hit
SUPFAMiSSF51206, SSF51206, 1 hit
PROSITEiView protein in PROSITE
PS50042, CNMP_BINDING_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHCN3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P1Z3
Secondary accession number(s): D3DV90
, Q4VX12, Q8N6W6, Q9BWQ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: February 28, 2003
Last modified: May 25, 2022
This is version 174 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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