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UniProtKB - Q9P1Z2 (CACO1_HUMAN)

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Protein

Calcium-binding and coiled-coil domain-containing protein 1

Gene

CALCOCO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity). In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).By similarity1 Publication
Seems to enhance inorganic pyrphosphatase thus activating phosphogluomutase (PMG). Probably functions as component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth.1 Publication

GO - Molecular functioni

  • armadillo repeat domain binding Source: UniProtKB
  • beta-catenin binding Source: AgBase
  • chromatin binding Source: Ensembl
  • ligand-dependent nuclear receptor transcription coactivator activity Source: AgBase
  • protein C-terminus binding Source: UniProtKB
  • RNA polymerase II distal enhancer sequence-specific DNA binding Source: UniProtKB
  • sequence-specific DNA binding Source: AgBase
  • transcription coactivator activity Source: UniProtKB
  • transcription coregulator activity Source: UniProtKB
  • transcription regulatory region DNA binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding and coiled-coil domain-containing protein 1
Alternative name(s):
Calphoglin
Coiled-coil coactivator protein
Sarcoma antigen NY-SAR-3
Gene namesi
Name:CALCOCO1
Synonyms:KIAA1536
ORF Names:PP13275, UNQ2436/PRO4996
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000012822.15
HGNCiHGNC:29306 CALCOCO1
neXtProtiNX_Q9P1Z2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi57658
OpenTargetsiENSG00000012822
PharmGKBiPA128394699

Polymorphism and mutation databases

BioMutaiCALCOCO1
DMDMi160017736

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003088991 – 691Calcium-binding and coiled-coil domain-containing protein 1Add BLAST691

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9P1Z2
MaxQBiQ9P1Z2
PaxDbiQ9P1Z2
PeptideAtlasiQ9P1Z2
PRIDEiQ9P1Z2
ProteomicsDBi83683
83684 [Q9P1Z2-2]
83685 [Q9P1Z2-3]
83686 [Q9P1Z2-4]

PTM databases

iPTMnetiQ9P1Z2
PhosphoSitePlusiQ9P1Z2

Miscellaneous databases

PMAP-CutDBiQ9P1Z2

Expressioni

Gene expression databases

BgeeiENSG00000012822
CleanExiHS_CALCOCO1
ExpressionAtlasiQ9P1Z2 baseline and differential
GenevisibleiQ9P1Z2 HS

Organism-specific databases

HPAiHPA038313
HPA038314

Interactioni

Subunit structurei

Part of a calphoglin complex consisting of CALCOCO1, PPA1 and PGM (Ref. 1). Interacts with the bHLH-PAS domains of GRIP1, AHR and ARNT. Interacts with CTNNB1 via both its N- and C-terminal regions. Interacts with EP300. Interacts with CCAR1 (via N-terminus) and GATA1 (By similarity).By similarity1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • armadillo repeat domain binding Source: UniProtKB
  • beta-catenin binding Source: AgBase
  • protein C-terminus binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi121692, 40 interactors
DIPiDIP-47322N
IntActiQ9P1Z2, 36 interactors
STRINGi9606.ENSP00000449960

Structurei

3D structure databases

ProteinModelPortaliQ9P1Z2
SMRiQ9P1Z2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 190N-terminal AD (CTNNB1 binding site)By similarityAdd BLAST190
Regioni1 – 30p300 KIX-bindingBy similarityAdd BLAST30
Regioni45 – 125Interaction with GATA1By similarityAdd BLAST81
Regioni501 – 691C-terminal AD (CTNNB1 binding site); interaction with CCAR1By similarityAdd BLAST191

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili145 – 205Sequence analysisAdd BLAST61
Coiled coili232 – 339Sequence analysisAdd BLAST108
Coiled coili417 – 514Sequence analysisAdd BLAST98

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi367 – 372Poly-Ala6

Domaini

The C-terminal activation region (AD) is used for downstream signaling. Seems to be essential for coactivator function with nuclear receptors and with the aryl hydrocarbon receptor (By similarity).By similarity
The N-terminal activation region (AD) is necessary and sufficient for synergistic activation of LEF1-mediated transcription by CTNNB1. Contains a EP3000 binding region which is important for synergistic cooperation (By similarity).By similarity
Recruitment by nuclear receptors is accomplished by the interaction of the coiled-coiled domain with p160 coactivators.By similarity

Sequence similaritiesi

Belongs to the CALCOCO family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IHKH Eukaryota
ENOG410ZVZ6 LUCA
GeneTreeiENSGT00530000063216
HOVERGENiHBG107573
InParanoidiQ9P1Z2
OMAiYDMASGF
OrthoDBiEOG091G01W2
PhylomeDBiQ9P1Z2
TreeFamiTF329501

Family and domain databases

InterProiView protein in InterPro
IPR012852 CALCOCO1-like
PfamiView protein in Pfam
PF07888 CALCOCO1, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P1Z2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEESPLSRAP SRGGVNFLNV ARTYIPNTKV ECHYTLPPGT MPSASDWIGI 
        60         70         80         90        100
FKVEAACVRD YHTFVWSSVP ESTTDGSPIH TSVQFQASYL PKPGAQLYQF 
       110        120        130        140        150
RYVNRQGQVC GQSPPFQFRE PRPMDELVTL EEADGGSDIL LVVPKATVLQ 
       160        170        180        190        200
NQLDESQQER NDLMQLKLQL EGQVTELRSR VQELERALAT ARQEHTELME 
       210        220        230        240        250
QYKGISRSHG EITEERDILS RQQGDHVARI LELEDDIQTI SEKVLTKEVE 
       260        270        280        290        300
LDRLRDTVKA LTREQEKLLG QLKEVQADKE QSEAELQVAQ QENHHLNLDL 
       310        320        330        340        350
KEAKSWQEEQ SAQAQRLKDK VAQMKDTLGQ AQQRVAELEP LKEQLRGAQE 
       360        370        380        390        400
LAASSQQKAT LLGEELASAA AARDRTIAEL HRSRLEVAEV NGRLAELGLH 
       410        420        430        440        450
LKEEKCQWSK ERAGLLQSVE AEKDKILKLS AEILRLEKAV QEERTQNQVF 
       460        470        480        490        500
KTELAREKDS SLVQLSESKR ELTELRSALR VLQKEKEQLQ EEKQELLEYM 
       510        520        530        540        550
RKLEARLEKV ADEKWNEDAT TEDEEAAVGL SCPAALTDSE DESPEDMRLP 
       560        570        580        590        600
PYGLCERGDP GSSPAGPREA SPLVVISQPA PISPHLSGPA EDSSSDSEAE 
       610        620        630        640        650
DEKSVLMAAV QSGGEEANLL LPELGSAFYD MASGFTVGTL SETSTGGPAT 
       660        670        680        690 
PTWKECPICK ERFPAESDKD ALEDHMDGHF FFSTQDPFTF E
Length:691
Mass (Da):77,336
Last modified:October 23, 2007 - v2
Checksum:i06A4C6BAB896759F
GO
Isoform 2 (identifier: Q9P1Z2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     633-691: SGFTVGTLSETSTGGPATPTWKECPICKERFPAESDKDALEDHMDGHFFFSTQDPFTFE → R

Show »
Length:633
Mass (Da):70,978
Checksum:i44493B60B4E3BBF1
GO
Isoform 3 (identifier: Q9P1Z2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     598-598: Missing.

Note: No experimental confirmation available.
Show »
Length:690
Mass (Da):77,207
Checksum:iB9369254792722D2
GO
Isoform 4 (identifier: Q9P1Z2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-119: Missing.
     287-338: Missing.

Note: No experimental confirmation available.
Show »
Length:606
Mass (Da):67,542
Checksum:i1166472275D9A569
GO

Sequence cautioni

The sequence BAA96060 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti381H → R in BAG53720 (PubMed:14702039).Curated1
Sequence conflicti486K → R in CAG38598 (Ref. 7) Curated1
Sequence conflicti660K → E in CAG38598 (Ref. 7) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036881393R → K1 PublicationCorresponds to variant dbSNP:rs3741659Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04147187 – 119Missing in isoform 4. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_041472287 – 338Missing in isoform 4. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_029052598Missing in isoform 3. 1 Publication1
Alternative sequenceiVSP_029053633 – 691SGFTV…PFTFE → R in isoform 2. 2 PublicationsAdd BLAST59

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY563137 mRNA Translation: AAT68474.1
AB040969 mRNA Translation: BAA96060.1 Different initiation.
AL136895 mRNA Translation: CAB66829.1
AY358397 mRNA Translation: AAQ88763.1
AK122773 mRNA Translation: BAG53720.1
AK027881 mRNA Translation: BAB55428.1
AF370415 mRNA Translation: AAQ15251.1
CR533567 mRNA Translation: CAG38598.1
CH471054 Genomic DNA Translation: EAW96728.1
BC003177 mRNA Translation: AAH03177.1
AY211909 mRNA Translation: AAO65163.1
CCDSiCCDS44908.1 [Q9P1Z2-4]
CCDS8864.1 [Q9P1Z2-1]
RefSeqiNP_001137154.1, NM_001143682.1 [Q9P1Z2-4]
NP_065949.1, NM_020898.2 [Q9P1Z2-1]
XP_016875196.1, XM_017019707.1 [Q9P1Z2-1]
UniGeneiHs.156667

Genome annotation databases

EnsembliENST00000262059; ENSP00000262059; ENSG00000012822 [Q9P1Z2-3]
ENST00000430117; ENSP00000397189; ENSG00000012822 [Q9P1Z2-4]
ENST00000548263; ENSP00000447647; ENSG00000012822 [Q9P1Z2-2]
ENST00000550804; ENSP00000449960; ENSG00000012822 [Q9P1Z2-1]
GeneIDi57658
KEGGihsa:57658
UCSCiuc001sef.4 human [Q9P1Z2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCACO1_HUMAN
AccessioniPrimary (citable) accession number: Q9P1Z2
Secondary accession number(s): B3KVA8
, Q6FI59, Q71RC3, Q86WF8, Q96JU3, Q9H090
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: July 18, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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