CALCOCO1

Functionⁱ

Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity). In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).By similarity1 Publication

Seems to enhance inorganic pyrphosphatase thus activating phosphogluomutase (PMG). Probably functions as component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth.1 Publication

GO - Molecular functionⁱ

armadillo repeat domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16344550
beta-catenin binding
Source: AgBase
Inferred from physical interactionⁱ
- 16344550
chromatin binding Source: Ensembl
nuclear receptor transcription coactivator activity
Source: AgBase
Inferred from direct assayⁱ
- 16344550
protein C-terminus binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16344550
RNA polymerase II distal enhancer sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 24245781
sequence-specific DNA binding
Source: AgBase
Inferred from direct assayⁱ
- 16344550
transcription coactivator activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16344550
- 24245781
transcription coregulator activity
Source: UniProtKB
Inferred from direct assayⁱ
- 16344550
transcription regulatory region DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16344550

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

intracellular steroid hormone receptor signaling pathway Source: HGNC
positive regulation of gene expression
Source: AgBase
Inferred from direct assayⁱ
- 16344550
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16344550
positive regulation of transcription by RNA polymerase II Source: Ensembl
signal transduction Source: HGNC
transcription, DNA-templated Source: HGNC
Wnt signaling pathway Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator
Biological process	Transcription, Transcription regulation, Wnt signaling pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Calcium-binding and coiled-coil domain-containing protein 1 Alternative name(s): Calphoglin Coiled-coil coactivator protein Sarcoma antigen NY-SAR-3
Gene namesⁱ	Name:CALCOCO1 Synonyms:KIAA1536 ORF Names:PP13275, UNQ2436/PRO4996
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000012822.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29306 CALCOCO1
neXtProtⁱ	NX_Q9P1Z2

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	57658
Open Targets More...OpenTargetsⁱ	ENSG00000012822
PharmGKBⁱ	PA128394699

Polymorphism and mutation databases

BioMutaⁱ	CALCOCO1
DMDMⁱ	160017736

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000308899	1 – 691	Calcium-binding and coiled-coil domain-containing protein 1Add BLAST		691

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	4	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9P1Z2
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9P1Z2
PaxDbⁱ	Q9P1Z2
PeptideAtlas More...PeptideAtlasⁱ	Q9P1Z2
PRIDEⁱ	Q9P1Z2
ProteomicsDBⁱ	83683 83684 [Q9P1Z2-2] 83685 [Q9P1Z2-3] 83686 [Q9P1Z2-4]

PTM databases

iPTMnetⁱ	Q9P1Z2
PhosphoSitePlusⁱ	Q9P1Z2

Miscellaneous databases

PMAP-CutDBⁱ	Q9P1Z2

PMAP-CutDBⁱ

Q9P1Z2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000012822 Expressed in 230 organ(s), highest expression level in esophagus
CleanExⁱ	HS_CALCOCO1
ExpressionAtlasⁱ	Q9P1Z2 baseline and differential
Genevisibleⁱ	Q9P1Z2 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA038313 HPA038314

HPAⁱ

HPA038313
HPA038314

Interactionⁱ

Subunit structureⁱ

Part of a calphoglin complex consisting of CALCOCO1, PPA1 and PGM (Ref. 1). Interacts with the bHLH-PAS domains of GRIP1, AHR and ARNT. Interacts with CTNNB1 via both its N- and C-terminal regions. Interacts with EP300. Interacts with CCAR1 (via N-terminus) and GATA1 (By similarity).By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CEP19	Q96LK0	5	EBI-749920,EBI-741885
CWF19L2	Q2TBE0	5	EBI-749920,EBI-5453285
DUSP13	Q9UII6	5	EBI-749920,EBI-749800
FAM161A	Q3B820	3	EBI-749920,EBI-719941
GABARAPL2	P60520	3	EBI-749920,EBI-720116
ISOC1	Q96CN7	3	EBI-749920,EBI-2805787
NDC80	O14777	4	EBI-749920,EBI-715849
TBC1D15	Q8TC07	3	EBI-749920,EBI-1048247

GO - Molecular functionⁱ

armadillo repeat domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16344550
beta-catenin binding
Source: AgBase
Inferred from physical interactionⁱ
- 16344550
protein C-terminus binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16344550

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	121692, 40 interactors
Database of interacting proteins More...DIPⁱ	DIP-47322N
IntActⁱ	Q9P1Z2, 33 interactors
STRINGⁱ	9606.ENSP00000449960

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9P1Z2
SMRⁱ	Q9P1Z2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 190	N-terminal AD (CTNNB1 binding site)By similarityAdd BLAST	190
Regionⁱ	1 – 30	p300 KIX-bindingBy similarityAdd BLAST	30
Regionⁱ	45 – 125	Interaction with GATA1By similarityAdd BLAST	81
Regionⁱ	501 – 691	C-terminal AD (CTNNB1 binding site); interaction with CCAR1By similarityAdd BLAST	191

Coiled coil

Feature key	Position(s)	DescriptionActions	Length
Coiled coilⁱ	145 – 205	Sequence analysisAdd BLAST	61
Coiled coilⁱ	232 – 339	Sequence analysisAdd BLAST	108
Coiled coilⁱ	417 – 514	Sequence analysisAdd BLAST	98

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	367 – 372	Poly-Ala		6

Domainⁱ

The C-terminal activation region (AD) is used for downstream signaling. Seems to be essential for coactivator function with nuclear receptors and with the aryl hydrocarbon receptor (By similarity).By similarity

The N-terminal activation region (AD) is necessary and sufficient for synergistic activation of LEF1-mediated transcription by CTNNB1. Contains a EP3000 binding region which is important for synergistic cooperation (By similarity).By similarity

Recruitment by nuclear receptors is accomplished by the interaction of the coiled-coiled domain with p160 coactivators.By similarity

Sequence similaritiesⁱ

Belongs to the CALCOCO family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IHKH Eukaryota ENOG410ZVZ6 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063216
HOVERGENⁱ	HBG107573
InParanoidⁱ	Q9P1Z2
OMAⁱ	YDMASGF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01W2
PhylomeDBⁱ	Q9P1Z2
TreeFamⁱ	TF329501

Family and domain databases

InterProⁱ	View protein in InterPro IPR012852 CALCOCO1-like
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07888 CALCOCO1, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 9 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9P1Z2-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEESPLSRAP SRGGVNFLNV ARTYIPNTKV ECHYTLPPGT MPSASDWIGI 
        60         70         80         90        100
FKVEAACVRD YHTFVWSSVP ESTTDGSPIH TSVQFQASYL PKPGAQLYQF 
       110        120        130        140        150
RYVNRQGQVC GQSPPFQFRE PRPMDELVTL EEADGGSDIL LVVPKATVLQ 
       160        170        180        190        200
NQLDESQQER NDLMQLKLQL EGQVTELRSR VQELERALAT ARQEHTELME 
       210        220        230        240        250
QYKGISRSHG EITEERDILS RQQGDHVARI LELEDDIQTI SEKVLTKEVE 
       260        270        280        290        300
LDRLRDTVKA LTREQEKLLG QLKEVQADKE QSEAELQVAQ QENHHLNLDL 
       310        320        330        340        350
KEAKSWQEEQ SAQAQRLKDK VAQMKDTLGQ AQQRVAELEP LKEQLRGAQE 
       360        370        380        390        400
LAASSQQKAT LLGEELASAA AARDRTIAEL HRSRLEVAEV NGRLAELGLH 
       410        420        430        440        450
LKEEKCQWSK ERAGLLQSVE AEKDKILKLS AEILRLEKAV QEERTQNQVF 
       460        470        480        490        500
KTELAREKDS SLVQLSESKR ELTELRSALR VLQKEKEQLQ EEKQELLEYM 
       510        520        530        540        550
RKLEARLEKV ADEKWNEDAT TEDEEAAVGL SCPAALTDSE DESPEDMRLP 
       560        570        580        590        600
PYGLCERGDP GSSPAGPREA SPLVVISQPA PISPHLSGPA EDSSSDSEAE 
       610        620        630        640        650
DEKSVLMAAV QSGGEEANLL LPELGSAFYD MASGFTVGTL SETSTGGPAT 
       660        670        680        690 
PTWKECPICK ERFPAESDKD ALEDHMDGHF FFSTQDPFTF E

Length:691

Mass (Da):77,336

Last modified:October 23, 2007 - v2

Checksum:ⁱ06A4C6BAB896759F

GO

Isoform 2 (identifier: Q9P1Z2-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
633-691: SGFTVGTLSETSTGGPATPTWKECPICKERFPAESDKDALEDHMDGHFFFSTQDPFTFE → R

« Hide

        10         20         30         40         50
MEESPLSRAP SRGGVNFLNV ARTYIPNTKV ECHYTLPPGT MPSASDWIGI 
        60         70         80         90        100
FKVEAACVRD YHTFVWSSVP ESTTDGSPIH TSVQFQASYL PKPGAQLYQF 
       110        120        130        140        150
RYVNRQGQVC GQSPPFQFRE PRPMDELVTL EEADGGSDIL LVVPKATVLQ 
       160        170        180        190        200
NQLDESQQER NDLMQLKLQL EGQVTELRSR VQELERALAT ARQEHTELME 
       210        220        230        240        250
QYKGISRSHG EITEERDILS RQQGDHVARI LELEDDIQTI SEKVLTKEVE 
       260        270        280        290        300
LDRLRDTVKA LTREQEKLLG QLKEVQADKE QSEAELQVAQ QENHHLNLDL 
       310        320        330        340        350
KEAKSWQEEQ SAQAQRLKDK VAQMKDTLGQ AQQRVAELEP LKEQLRGAQE 
       360        370        380        390        400
LAASSQQKAT LLGEELASAA AARDRTIAEL HRSRLEVAEV NGRLAELGLH 
       410        420        430        440        450
LKEEKCQWSK ERAGLLQSVE AEKDKILKLS AEILRLEKAV QEERTQNQVF 
       460        470        480        490        500
KTELAREKDS SLVQLSESKR ELTELRSALR VLQKEKEQLQ EEKQELLEYM 
       510        520        530        540        550
RKLEARLEKV ADEKWNEDAT TEDEEAAVGL SCPAALTDSE DESPEDMRLP 
       560        570        580        590        600
PYGLCERGDP GSSPAGPREA SPLVVISQPA PISPHLSGPA EDSSSDSEAE 
       610        620        630 
DEKSVLMAAV QSGGEEANLL LPELGSAFYD MAR

Show »

Length:633

Mass (Da):70,978

Checksum:ⁱ44493B60B4E3BBF1

GO

Isoform 3 (identifier: Q9P1Z2-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
598-598: Missing.

« Hide

        10         20         30         40         50
MEESPLSRAP SRGGVNFLNV ARTYIPNTKV ECHYTLPPGT MPSASDWIGI 
        60         70         80         90        100
FKVEAACVRD YHTFVWSSVP ESTTDGSPIH TSVQFQASYL PKPGAQLYQF 
       110        120        130        140        150
RYVNRQGQVC GQSPPFQFRE PRPMDELVTL EEADGGSDIL LVVPKATVLQ 
       160        170        180        190        200
NQLDESQQER NDLMQLKLQL EGQVTELRSR VQELERALAT ARQEHTELME 
       210        220        230        240        250
QYKGISRSHG EITEERDILS RQQGDHVARI LELEDDIQTI SEKVLTKEVE 
       260        270        280        290        300
LDRLRDTVKA LTREQEKLLG QLKEVQADKE QSEAELQVAQ QENHHLNLDL 
       310        320        330        340        350
KEAKSWQEEQ SAQAQRLKDK VAQMKDTLGQ AQQRVAELEP LKEQLRGAQE 
       360        370        380        390        400
LAASSQQKAT LLGEELASAA AARDRTIAEL HRSRLEVAEV NGRLAELGLH 
       410        420        430        440        450
LKEEKCQWSK ERAGLLQSVE AEKDKILKLS AEILRLEKAV QEERTQNQVF 
       460        470        480        490        500
KTELAREKDS SLVQLSESKR ELTELRSALR VLQKEKEQLQ EEKQELLEYM 
       510        520        530        540        550
RKLEARLEKV ADEKWNEDAT TEDEEAAVGL SCPAALTDSE DESPEDMRLP 
       560        570        580        590        600
PYGLCERGDP GSSPAGPREA SPLVVISQPA PISPHLSGPA EDSSSDSAED 
       610        620        630        640        650
EKSVLMAAVQ SGGEEANLLL PELGSAFYDM ASGFTVGTLS ETSTGGPATP 
       660        670        680        690
TWKECPICKE RFPAESDKDA LEDHMDGHFF FSTQDPFTFE

Note: No experimental confirmation available.

Show »

Length:690

Mass (Da):77,207

Checksum:ⁱB9369254792722D2

GO

Isoform 4 (identifier: Q9P1Z2-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
87-119: Missing.
287-338: Missing.

« Hide

        10         20         30         40         50
MEESPLSRAP SRGGVNFLNV ARTYIPNTKV ECHYTLPPGT MPSASDWIGI 
        60         70         80         90        100
FKVEAACVRD YHTFVWSSVP ESTTDGSPIH TSVQFQEPRP MDELVTLEEA 
       110        120        130        140        150
DGGSDILLVV PKATVLQNQL DESQQERNDL MQLKLQLEGQ VTELRSRVQE 
       160        170        180        190        200
LERALATARQ EHTELMEQYK GISRSHGEIT EERDILSRQQ GDHVARILEL 
       210        220        230        240        250
EDDIQTISEK VLTKEVELDR LRDTVKALTR EQEKLLGQLK EVQADKEQSE 
       260        270        280        290        300
AELEPLKEQL RGAQELAASS QQKATLLGEE LASAAAARDR TIAELHRSRL 
       310        320        330        340        350
EVAEVNGRLA ELGLHLKEEK CQWSKERAGL LQSVEAEKDK ILKLSAEILR 
       360        370        380        390        400
LEKAVQEERT QNQVFKTELA REKDSSLVQL SESKRELTEL RSALRVLQKE 
       410        420        430        440        450
KEQLQEEKQE LLEYMRKLEA RLEKVADEKW NEDATTEDEE AAVGLSCPAA 
       460        470        480        490        500
LTDSEDESPE DMRLPPYGLC ERGDPGSSPA GPREASPLVV ISQPAPISPH 
       510        520        530        540        550
LSGPAEDSSS DSEAEDEKSV LMAAVQSGGE EANLLLPELG SAFYDMASGF 
       560        570        580        590        600
TVGTLSETST GGPATPTWKE CPICKERFPA ESDKDALEDH MDGHFFFSTQ 

DPFTFE

Note: No experimental confirmation available.

Show »

Length:606

Mass (Da):67,542

Checksum:ⁱ1166472275D9A569

GO

Computationally mapped potential isoform sequencesⁱ

There are 9 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H3BRW8	H3BRW8_HUMAN	Calcium-binding and coiled-coil dom... Calcium-binding and coiled-coil domain-containing protein 1	CALCOCO1	232	Annotation score:
F8VQE3	F8VQE3_HUMAN	Calcium-binding and coiled-coil dom... Calcium-binding and coiled-coil domain-containing protein 1	CALCOCO1	164	Annotation score:
F8VUB3	F8VUB3_HUMAN	Calcium-binding and coiled-coil dom... Calcium-binding and coiled-coil domain-containing protein 1	CALCOCO1	120	Annotation score:
F8W0X2	F8W0X2_HUMAN	Calcium-binding and coiled-coil dom... Calcium-binding and coiled-coil domain-containing protein 1	CALCOCO1	149	Annotation score:
F8VZI3	F8VZI3_HUMAN	Calcium-binding and coiled-coil dom... Calcium-binding and coiled-coil domain-containing protein 1	CALCOCO1	134	Annotation score:
F8VPN1	F8VPN1_HUMAN	Calcium-binding and coiled-coil dom... Calcium-binding and coiled-coil domain-containing protein 1	CALCOCO1	115	Annotation score:
F8VRQ9	F8VRQ9_HUMAN	Calcium-binding and coiled-coil dom... Calcium-binding and coiled-coil domain-containing protein 1	CALCOCO1	159	Annotation score:
F8VXS2	F8VXS2_HUMAN	Calcium-binding and coiled-coil dom... Calcium-binding and coiled-coil domain-containing protein 1	CALCOCO1	160	Annotation score:
F8VWP8	F8VWP8_HUMAN	Calcium-binding and coiled-coil dom... Calcium-binding and coiled-coil domain-containing protein 1	CALCOCO1	104	Annotation score:

Sequence cautionⁱ

The sequence BAA96060 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	381	H → R in BAG53720 (PubMed:14702039).Curated	1
Sequence conflictⁱ	486	K → R in CAG38598 (Ref. 7) Curated	1
Sequence conflictⁱ	660	K → E in CAG38598 (Ref. 7) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_036881	393	R → K1 PublicationCorresponds to variant dbSNP:rs3741659Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_041471	87 – 119	Missing in isoform 4. 1 PublicationAdd BLAST	33
Alternative sequenceⁱVSP_041472	287 – 338	Missing in isoform 4. 1 PublicationAdd BLAST	52
Alternative sequenceⁱVSP_029052	598	Missing in isoform 3. 1 Publication	1
Alternative sequenceⁱVSP_029053	633 – 691	SGFTV…PFTFE → R in isoform 2. 2 PublicationsAdd BLAST	59

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY563137 mRNA Translation: AAT68474.1 AB040969 mRNA Translation: BAA96060.1 Different initiation. AL136895 mRNA Translation: CAB66829.1 AY358397 mRNA Translation: AAQ88763.1 AK122773 mRNA Translation: BAG53720.1 AK027881 mRNA Translation: BAB55428.1 AF370415 mRNA Translation: AAQ15251.1 CR533567 mRNA Translation: CAG38598.1 CH471054 Genomic DNA Translation: EAW96728.1 BC003177 mRNA Translation: AAH03177.1 AY211909 mRNA Translation: AAO65163.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44908.1 [Q9P1Z2-4] CCDS8864.1 [Q9P1Z2-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001137154.1, NM_001143682.1 [Q9P1Z2-4] NP_065949.1, NM_020898.2 [Q9P1Z2-1] XP_016875196.1, XM_017019707.1 [Q9P1Z2-1]
UniGeneⁱ	Hs.156667

Genome annotation databases

Ensemblⁱ	ENST00000262059; ENSP00000262059; ENSG00000012822 [Q9P1Z2-3] ENST00000430117; ENSP00000397189; ENSG00000012822 [Q9P1Z2-4] ENST00000548263; ENSP00000447647; ENSG00000012822 [Q9P1Z2-2] ENST00000550804; ENSP00000449960; ENSG00000012822 [Q9P1Z2-1]
GeneIDⁱ	57658
KEGGⁱ	hsa:57658
UCSC genome browser More...UCSCⁱ	uc001sef.4 human [Q9P1Z2-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9P1Z2	Calcium binding and coiled-coil domain 1, isoform CRA_b		HUMAN		691	UniRef100_Q9P1Z2
UPI0007DC81EB		HUMAN		368

Protein	Similar proteins		Species	Score	Length	Source
Q9P1Z2	Calcium-binding and coiled-coil domain-containing protein 1		PONAB		691	UniRef90_Q9P1Z2
Calcium-binding and coiled-coil domain-containing protein 1		BOVIN		680
Calcium binding and coiled-coil domain 1, isoform CRA_b		HUMAN		691
Calphoglin		MACMU		771
CALCOCO1 isoform 17 (Fragment)		PANTR		120
+161
Q9P1Z2-4	CALCOCO1 isoform 15		PANTR		606	UniRef90_Q9P1Z2-4
Uncharacterized protein		PROCO		606
Calcium binding and coiled-coil domain 1		SAIBB		606
Uncharacterized protein		CALJA		606
Uncharacterized protein		COLAP		606
+27

Protein	Similar proteins		Species	Score	Length	Source
Q9P1Z2	Calcium-binding and coiled-coil domain-containing protein 1		PONAB		691	UniRef50_Q9P1Z2
Calcium-binding and coiled-coil domain-containing protein 1		BOVIN		680
Calcium-binding and coiled-coil domain-containing protein 1		RAT		691
Calcium-binding and coiled-coil domain-containing protein 1		MOUSE		691
Calcium binding and coiled-coil domain 1, isoform CRA_b		HUMAN		691
+291
Q9P1Z2-4	Calcium-binding and coiled-coil domain-containing protein 1-A		XENLA		560	UniRef50_Q9P1Z2-4
CALCOCO1 isoform 15		PANTR		606
Uncharacterized protein		AOTNA		606
Calcium binding and coiled-coil domain 1		GORGO		606
Uncharacterized protein		MACNE		606
+42

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY563137 mRNA Translation: AAT68474.1 AB040969 mRNA Translation: BAA96060.1 Different initiation. AL136895 mRNA Translation: CAB66829.1 AY358397 mRNA Translation: AAQ88763.1 AK122773 mRNA Translation: BAG53720.1 AK027881 mRNA Translation: BAB55428.1 AF370415 mRNA Translation: AAQ15251.1 CR533567 mRNA Translation: CAG38598.1 CH471054 Genomic DNA Translation: EAW96728.1 BC003177 mRNA Translation: AAH03177.1 AY211909 mRNA Translation: AAO65163.1
CCDSⁱ	CCDS44908.1 [Q9P1Z2-4] CCDS8864.1 [Q9P1Z2-1]
RefSeqⁱ	NP_001137154.1, NM_001143682.1 [Q9P1Z2-4] NP_065949.1, NM_020898.2 [Q9P1Z2-1] XP_016875196.1, XM_017019707.1 [Q9P1Z2-1]
UniGeneⁱ	Hs.156667

3D structure databases

ProteinModelPortalⁱ	Q9P1Z2
SMRⁱ	Q9P1Z2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121692, 40 interactors
DIPⁱ	DIP-47322N
IntActⁱ	Q9P1Z2, 33 interactors
STRINGⁱ	9606.ENSP00000449960

PTM databases

iPTMnetⁱ	Q9P1Z2
PhosphoSitePlusⁱ	Q9P1Z2

Polymorphism and mutation databases

BioMutaⁱ	CALCOCO1
DMDMⁱ	160017736

Proteomic databases

EPDⁱ	Q9P1Z2
MaxQBⁱ	Q9P1Z2
PaxDbⁱ	Q9P1Z2
PeptideAtlasⁱ	Q9P1Z2
PRIDEⁱ	Q9P1Z2
ProteomicsDBⁱ	83683 83684 [Q9P1Z2-2] 83685 [Q9P1Z2-3] 83686 [Q9P1Z2-4]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	57658
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000262059; ENSP00000262059; ENSG00000012822 [Q9P1Z2-3] ENST00000430117; ENSP00000397189; ENSG00000012822 [Q9P1Z2-4] ENST00000548263; ENSP00000447647; ENSG00000012822 [Q9P1Z2-2] ENST00000550804; ENSP00000449960; ENSG00000012822 [Q9P1Z2-1]
GeneIDⁱ	57658
KEGGⁱ	hsa:57658
UCSCⁱ	uc001sef.4 human [Q9P1Z2-1]

Organism-specific databases

CTDⁱ	57658
DisGeNETⁱ	57658
EuPathDBⁱ	HostDB:ENSG00000012822.15
GeneCardsⁱ	CALCOCO1
H-InvDBⁱ	HIX0129676
HGNCⁱ	HGNC:29306 CALCOCO1
HPAⁱ	HPA038313 HPA038314
neXtProtⁱ	NX_Q9P1Z2
OpenTargetsⁱ	ENSG00000012822
PharmGKBⁱ	PA128394699
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IHKH Eukaryota ENOG410ZVZ6 LUCA
GeneTreeⁱ	ENSGT00530000063216
HOVERGENⁱ	HBG107573
InParanoidⁱ	Q9P1Z2
OMAⁱ	YDMASGF
OrthoDBⁱ	EOG091G01W2
PhylomeDBⁱ	Q9P1Z2
TreeFamⁱ	TF329501

Miscellaneous databases

ChiTaRSⁱ	CALCOCO1 human
GeneWikiⁱ	CALCOCO1
GenomeRNAiⁱ	57658
PMAP-CutDBⁱ	Q9P1Z2
Protein Ontology More...PROⁱ	PR:Q9P1Z2

Gene expression databases

Bgeeⁱ	ENSG00000012822 Expressed in 230 organ(s), highest expression level in esophagus
CleanExⁱ	HS_CALCOCO1
ExpressionAtlasⁱ	Q9P1Z2 baseline and differential
Genevisibleⁱ	Q9P1Z2 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR012852 CALCOCO1-like
Pfamⁱ	View protein in Pfam PF07888 CALCOCO1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CACO1_HUMAN
Accessionⁱ	Q9P1Z2Primary (citable) accession number: Q9P1Z2 Secondary accession number(s): B3KVA8 , Q6FI59, Q71RC3, Q86WF8, Q96JU3, Q9H090
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
	Last sequence update:	October 23, 2007
	Last modified:	September 12, 2018
	This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

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UniProtKB - Q9P1Z2 (CACO1_HUMAN)

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Calcium-binding and coiled-coil domain-containing protein 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Keywords - PTMi

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Gene expression databases

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<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

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3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ