UniProtKB - Q9P1Z2 (CACO1_HUMAN)
Calcium-binding and coiled-coil domain-containing protein 1
CALCOCO1
Functioni
Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity).
In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).
By similarity1 PublicationSeems to enhance inorganic pyrophosphatase thus activating phosphogluomutase (PMG). Probably functions as component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth.
1 PublicationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 656 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 659 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 675 | ZincPROSITE-ProRule annotation | 1 | |
Metal bindingi | 679 | ZincPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 653 – 679 | UBZ1-typePROSITE-ProRule annotationAdd BLAST | 27 |
GO - Molecular functioni
- armadillo repeat domain binding Source: UniProtKB
- beta-catenin binding Source: AgBase
- chromatin binding Source: Ensembl
- metal ion binding Source: UniProtKB-KW
- nuclear receptor coactivator activity Source: AgBase
- protein C-terminus binding Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: UniProtKB
- sequence-specific DNA binding Source: AgBase
- transcription cis-regulatory region binding Source: UniProtKB
- transcription coactivator activity Source: UniProtKB
- transcription coregulator activity Source: UniProtKB
GO - Biological processi
- intracellular steroid hormone receptor signaling pathway Source: HGNC-UCL
- positive regulation of gene expression Source: AgBase
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: HGNC-UCL
- signal transduction Source: HGNC-UCL
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | Activator |
Biological process | Transcription, Transcription regulation, Wnt signaling pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9P1Z2 |
SignaLinki | Q9P1Z2 |
Names & Taxonomyi
Protein namesi | Recommended name: Calcium-binding and coiled-coil domain-containing protein 1Alternative name(s): Calphoglin Coiled-coil coactivator protein Sarcoma antigen NY-SAR-3 |
Gene namesi | Name:CALCOCO1 Synonyms:KIAA1536 ORF Names:PP13275, UNQ2436/PRO4996 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29306, CALCOCO1 |
neXtProti | NX_Q9P1Z2 |
VEuPathDBi | HostDB:ENSG00000012822 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nucleus Source: LIFEdb
Other locations
- chromatin Source: Ensembl
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 57658 |
OpenTargetsi | ENSG00000012822 |
PharmGKBi | PA128394699 |
Miscellaneous databases
Pharosi | Q9P1Z2, Tbio |
Genetic variation databases
BioMutai | CALCOCO1 |
DMDMi | 160017736 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000308899 | 1 – 691 | Calcium-binding and coiled-coil domain-containing protein 1Add BLAST | 691 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 4 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
CPTACi | CPTAC-1234 CPTAC-1235 |
jPOSTi | Q9P1Z2 |
MassIVEi | Q9P1Z2 |
MaxQBi | Q9P1Z2 |
PaxDbi | Q9P1Z2 |
PeptideAtlasi | Q9P1Z2 |
PRIDEi | Q9P1Z2 |
ProteomicsDBi | 83683 [Q9P1Z2-1] 83684 [Q9P1Z2-2] 83685 [Q9P1Z2-3] 83686 [Q9P1Z2-4] |
PTM databases
iPTMneti | Q9P1Z2 |
PhosphoSitePlusi | Q9P1Z2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000012822, Expressed in esophagus and 242 other tissues |
ExpressionAtlasi | Q9P1Z2, baseline and differential |
Genevisiblei | Q9P1Z2, HS |
Organism-specific databases
HPAi | ENSG00000012822, Low tissue specificity |
Interactioni
Subunit structurei
Part of a calphoglin complex consisting of CALCOCO1, PPA1 and PGM (Ref. 1).
Interacts with the bHLH-PAS domains of GRIP1, AHR and ARNT.
Interacts with CTNNB1 via both its N- and C-terminal regions.
Interacts with EP300.
Interacts with CCAR1 (via N-terminus) and GATA1 (By similarity).
By similarity1 PublicationBinary interactionsi
Q9P1Z2
GO - Molecular functioni
- armadillo repeat domain binding Source: UniProtKB
- beta-catenin binding Source: AgBase
- protein C-terminus binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 121692, 67 interactors |
DIPi | DIP-47322N |
IntActi | Q9P1Z2, 47 interactors |
MINTi | Q9P1Z2 |
STRINGi | 9606.ENSP00000449960 |
Miscellaneous databases
RNActi | Q9P1Z2, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 190 | N-terminal AD (CTNNB1 binding site)By similarityAdd BLAST | 190 | |
Regioni | 1 – 30 | p300 KIX-bindingBy similarityAdd BLAST | 30 | |
Regioni | 45 – 125 | Interaction with GATA1By similarityAdd BLAST | 81 | |
Regioni | 501 – 691 | C-terminal AD (CTNNB1 binding site); interaction with CCAR1By similarityAdd BLAST | 191 | |
Regioni | 514 – 607 | DisorderedSequence analysisAdd BLAST | 94 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 145 – 205 | Sequence analysisAdd BLAST | 61 | |
Coiled coili | 232 – 339 | Sequence analysisAdd BLAST | 108 | |
Coiled coili | 417 – 514 | Sequence analysisAdd BLAST | 98 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 653 – 679 | UBZ1-typePROSITE-ProRule annotationAdd BLAST | 27 |
Keywords - Domaini
Coiled coil, Zinc-fingerPhylogenomic databases
eggNOGi | ENOG502QR9J, Eukaryota |
GeneTreei | ENSGT01040000241699 |
HOGENOMi | CLU_028857_0_0_1 |
InParanoidi | Q9P1Z2 |
OMAi | GLCEHGD |
OrthoDBi | 179838at2759 |
PhylomeDBi | Q9P1Z2 |
TreeFami | TF329501 |
Family and domain databases
InterProi | View protein in InterPro IPR012852, CALCOCO1-like IPR041641, CALCOCO1/2_Zn_UBZ1 IPR041611, SKICH |
Pfami | View protein in Pfam PF07888, CALCOCO1, 1 hit PF17751, SKICH, 1 hit PF18112, Zn-C2H2_12, 1 hit |
PROSITEi | View protein in PROSITE PS51905, ZF_UBZ1, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEESPLSRAP SRGGVNFLNV ARTYIPNTKV ECHYTLPPGT MPSASDWIGI
60 70 80 90 100
FKVEAACVRD YHTFVWSSVP ESTTDGSPIH TSVQFQASYL PKPGAQLYQF
110 120 130 140 150
RYVNRQGQVC GQSPPFQFRE PRPMDELVTL EEADGGSDIL LVVPKATVLQ
160 170 180 190 200
NQLDESQQER NDLMQLKLQL EGQVTELRSR VQELERALAT ARQEHTELME
210 220 230 240 250
QYKGISRSHG EITEERDILS RQQGDHVARI LELEDDIQTI SEKVLTKEVE
260 270 280 290 300
LDRLRDTVKA LTREQEKLLG QLKEVQADKE QSEAELQVAQ QENHHLNLDL
310 320 330 340 350
KEAKSWQEEQ SAQAQRLKDK VAQMKDTLGQ AQQRVAELEP LKEQLRGAQE
360 370 380 390 400
LAASSQQKAT LLGEELASAA AARDRTIAEL HRSRLEVAEV NGRLAELGLH
410 420 430 440 450
LKEEKCQWSK ERAGLLQSVE AEKDKILKLS AEILRLEKAV QEERTQNQVF
460 470 480 490 500
KTELAREKDS SLVQLSESKR ELTELRSALR VLQKEKEQLQ EEKQELLEYM
510 520 530 540 550
RKLEARLEKV ADEKWNEDAT TEDEEAAVGL SCPAALTDSE DESPEDMRLP
560 570 580 590 600
PYGLCERGDP GSSPAGPREA SPLVVISQPA PISPHLSGPA EDSSSDSEAE
610 620 630 640 650
DEKSVLMAAV QSGGEEANLL LPELGSAFYD MASGFTVGTL SETSTGGPAT
660 670 680 690
PTWKECPICK ERFPAESDKD ALEDHMDGHF FFSTQDPFTF E
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BRW8 | H3BRW8_HUMAN | Calcium-binding and coiled-coil dom... | CALCOCO1 | 232 | Annotation score: | ||
F8VXS2 | F8VXS2_HUMAN | Calcium-binding and coiled-coil dom... | CALCOCO1 | 160 | Annotation score: | ||
F8VUB3 | F8VUB3_HUMAN | Calcium-binding and coiled-coil dom... | CALCOCO1 | 120 | Annotation score: | ||
F8VZI3 | F8VZI3_HUMAN | Calcium-binding and coiled-coil dom... | CALCOCO1 | 134 | Annotation score: | ||
F8VPN1 | F8VPN1_HUMAN | Calcium-binding and coiled-coil dom... | CALCOCO1 | 115 | Annotation score: | ||
F8VQE3 | F8VQE3_HUMAN | Calcium-binding and coiled-coil dom... | CALCOCO1 | 164 | Annotation score: | ||
F8VWP8 | F8VWP8_HUMAN | Calcium-binding and coiled-coil dom... | CALCOCO1 | 104 | Annotation score: | ||
F8W0X2 | F8W0X2_HUMAN | Calcium-binding and coiled-coil dom... | CALCOCO1 | 149 | Annotation score: | ||
F8VRQ9 | F8VRQ9_HUMAN | Calcium-binding and coiled-coil dom... | CALCOCO1 | 159 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 381 | H → R in BAG53720 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 486 | K → R in CAG38598 (Ref. 7) Curated | 1 | |
Sequence conflicti | 660 | K → E in CAG38598 (Ref. 7) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036881 | 393 | R → K1 PublicationCorresponds to variant dbSNP:rs3741659Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_041471 | 87 – 119 | Missing in isoform 4. 1 PublicationAdd BLAST | 33 | |
Alternative sequenceiVSP_041472 | 287 – 338 | Missing in isoform 4. 1 PublicationAdd BLAST | 52 | |
Alternative sequenceiVSP_029052 | 598 | Missing in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_029053 | 633 – 691 | SGFTV…PFTFE → R in isoform 2. 2 PublicationsAdd BLAST | 59 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY563137 mRNA Translation: AAT68474.1 AB040969 mRNA Translation: BAA96060.1 Different initiation. AL136895 mRNA Translation: CAB66829.1 AY358397 mRNA Translation: AAQ88763.1 AK122773 mRNA Translation: BAG53720.1 AK027881 mRNA Translation: BAB55428.1 AF370415 mRNA Translation: AAQ15251.1 CR533567 mRNA Translation: CAG38598.1 CH471054 Genomic DNA Translation: EAW96728.1 BC003177 mRNA Translation: AAH03177.1 AY211909 mRNA Translation: AAO65163.1 |
CCDSi | CCDS44908.1 [Q9P1Z2-4] CCDS8864.1 [Q9P1Z2-1] |
RefSeqi | NP_001137154.1, NM_001143682.1 [Q9P1Z2-4] NP_065949.1, NM_020898.2 [Q9P1Z2-1] XP_016875196.1, XM_017019707.1 [Q9P1Z2-1] |
Genome annotation databases
Ensembli | ENST00000262059; ENSP00000262059; ENSG00000012822 [Q9P1Z2-3] ENST00000430117; ENSP00000397189; ENSG00000012822 [Q9P1Z2-4] ENST00000548263; ENSP00000447647; ENSG00000012822 [Q9P1Z2-2] ENST00000550804; ENSP00000449960; ENSG00000012822 |
GeneIDi | 57658 |
KEGGi | hsa:57658 |
MANE-Selecti | ENST00000550804.6; ENSP00000449960.1; NM_020898.3; NP_065949.1 |
UCSCi | uc001sef.4, human [Q9P1Z2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY563137 mRNA Translation: AAT68474.1 AB040969 mRNA Translation: BAA96060.1 Different initiation. AL136895 mRNA Translation: CAB66829.1 AY358397 mRNA Translation: AAQ88763.1 AK122773 mRNA Translation: BAG53720.1 AK027881 mRNA Translation: BAB55428.1 AF370415 mRNA Translation: AAQ15251.1 CR533567 mRNA Translation: CAG38598.1 CH471054 Genomic DNA Translation: EAW96728.1 BC003177 mRNA Translation: AAH03177.1 AY211909 mRNA Translation: AAO65163.1 |
CCDSi | CCDS44908.1 [Q9P1Z2-4] CCDS8864.1 [Q9P1Z2-1] |
RefSeqi | NP_001137154.1, NM_001143682.1 [Q9P1Z2-4] NP_065949.1, NM_020898.2 [Q9P1Z2-1] XP_016875196.1, XM_017019707.1 [Q9P1Z2-1] |
3D structure databases
SMRi | Q9P1Z2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121692, 67 interactors |
DIPi | DIP-47322N |
IntActi | Q9P1Z2, 47 interactors |
MINTi | Q9P1Z2 |
STRINGi | 9606.ENSP00000449960 |
PTM databases
iPTMneti | Q9P1Z2 |
PhosphoSitePlusi | Q9P1Z2 |
Genetic variation databases
BioMutai | CALCOCO1 |
DMDMi | 160017736 |
Proteomic databases
CPTACi | CPTAC-1234 CPTAC-1235 |
jPOSTi | Q9P1Z2 |
MassIVEi | Q9P1Z2 |
MaxQBi | Q9P1Z2 |
PaxDbi | Q9P1Z2 |
PeptideAtlasi | Q9P1Z2 |
PRIDEi | Q9P1Z2 |
ProteomicsDBi | 83683 [Q9P1Z2-1] 83684 [Q9P1Z2-2] 83685 [Q9P1Z2-3] 83686 [Q9P1Z2-4] |
Protocols and materials databases
Antibodypediai | 27237, 100 antibodies from 22 providers |
DNASUi | 57658 |
Genome annotation databases
Ensembli | ENST00000262059; ENSP00000262059; ENSG00000012822 [Q9P1Z2-3] ENST00000430117; ENSP00000397189; ENSG00000012822 [Q9P1Z2-4] ENST00000548263; ENSP00000447647; ENSG00000012822 [Q9P1Z2-2] ENST00000550804; ENSP00000449960; ENSG00000012822 |
GeneIDi | 57658 |
KEGGi | hsa:57658 |
MANE-Selecti | ENST00000550804.6; ENSP00000449960.1; NM_020898.3; NP_065949.1 |
UCSCi | uc001sef.4, human [Q9P1Z2-1] |
Organism-specific databases
CTDi | 57658 |
DisGeNETi | 57658 |
GeneCardsi | CALCOCO1 |
HGNCi | HGNC:29306, CALCOCO1 |
HPAi | ENSG00000012822, Low tissue specificity |
neXtProti | NX_Q9P1Z2 |
OpenTargetsi | ENSG00000012822 |
PharmGKBi | PA128394699 |
VEuPathDBi | HostDB:ENSG00000012822 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QR9J, Eukaryota |
GeneTreei | ENSGT01040000241699 |
HOGENOMi | CLU_028857_0_0_1 |
InParanoidi | Q9P1Z2 |
OMAi | GLCEHGD |
OrthoDBi | 179838at2759 |
PhylomeDBi | Q9P1Z2 |
TreeFami | TF329501 |
Enzyme and pathway databases
PathwayCommonsi | Q9P1Z2 |
SignaLinki | Q9P1Z2 |
Miscellaneous databases
BioGRID-ORCSi | 57658, 8 hits in 1050 CRISPR screens |
ChiTaRSi | CALCOCO1, human |
GeneWikii | CALCOCO1 |
GenomeRNAii | 57658 |
Pharosi | Q9P1Z2, Tbio |
PROi | PR:Q9P1Z2 |
RNActi | Q9P1Z2, protein |
Gene expression databases
Bgeei | ENSG00000012822, Expressed in esophagus and 242 other tissues |
ExpressionAtlasi | Q9P1Z2, baseline and differential |
Genevisiblei | Q9P1Z2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR012852, CALCOCO1-like IPR041641, CALCOCO1/2_Zn_UBZ1 IPR041611, SKICH |
Pfami | View protein in Pfam PF07888, CALCOCO1, 1 hit PF17751, SKICH, 1 hit PF18112, Zn-C2H2_12, 1 hit |
PROSITEi | View protein in PROSITE PS51905, ZF_UBZ1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CACO1_HUMAN | |
Accessioni | Q9P1Z2Primary (citable) accession number: Q9P1Z2 Secondary accession number(s): B3KVA8 Q9H090 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 23, 2007 |
Last sequence update: | October 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 148 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families