Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 161 (16 Oct 2019)
Sequence version 3 (26 Apr 2004)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Zinc finger and BTB domain-containing protein 4

Gene

ZBTB4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA (PubMed:16354688). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri234 – 256C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 388C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri726 – 748C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri765 – 787C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 4
Alternative name(s):
KAISO-like zinc finger protein 1
Short name:
KAISO-L1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZBTB4
Synonyms:KIAA1538
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23847 ZBTB4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612308 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9P1Z0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi795T → A: Impaired HIPK2-mediated phosphorylation; when associated with A-797 and A-983. 1 Publication1
Mutagenesisi797T → A: Impaired HIPK2-mediated phosphorylation; when associated with A-795 and A-983. 1 Publication1
Mutagenesisi983T → A: Impaired HIPK2-mediated phosphorylation; when associated with A-795 and A-797. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
57659

Open Targets

More...
OpenTargetsi
ENSG00000174282

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134959224

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9P1Z0

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZBTB4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
46577564

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000477121 – 1013Zinc finger and BTB domain-containing protein 4Add BLAST1013

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki40Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei391PhosphoserineCombined sources1
Cross-linki573Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki615Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei795Phosphothreonine; by HIPK21 Publication1
Modified residuei797Phosphothreonine; by HIPK21 Publication1
Modified residuei983Phosphothreonine; by HIPK21 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by HIPK2. This phosphorylation reduces stability and triggers ZBTB4 protein degradation in response to DNA damage.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9P1Z0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9P1Z0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9P1Z0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9P1Z0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9P1Z0

PeptideAtlas

More...
PeptideAtlasi
Q9P1Z0

PRoteomics IDEntifications database

More...
PRIDEi
Q9P1Z0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
83682

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q9P1Z0

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9P1Z0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9P1Z0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000174282 Expressed in 212 organ(s), highest expression level in amniotic fluid

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9P1Z0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB008980
HPA064763

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HIPK2.

Interacts with CBFA2T3.

Interacts with ZBTB38.

3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121693, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q9P1Z0, 17 interactors

Molecular INTeraction database

More...
MINTi
Q9P1Z0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000307858

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 152BTBPROSITE-ProRule annotationAdd BLAST123

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni186 – 348Interaction with CBFA2T31 PublicationAdd BLAST163

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili627 – 663Sequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi435 – 536Pro-richAdd BLAST102
Compositional biasi610 – 654Glu-richAdd BLAST45

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri234 – 256C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 388C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri726 – 748C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri765 – 787C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161268

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000065759

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9P1Z0

KEGG Orthology (KO)

More...
KOi
K10491

Identification of Orthologs from Complete Genome Data

More...
OMAi
KHQEAHS

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9P1Z0

TreeFam database of animal gene trees

More...
TreeFami
TF333100

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00651 BTB, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9P1Z0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPPAEVTDP SHAPAVLRQL NEQRLRGLFC DVTLIAGDTK FPAHRSVLAA
60 70 80 90 100
SSPFFREALL TSAPLPLPPA TGGAAPNPAT TTAASSSSSS SSSSSSSSSS
110 120 130 140 150
ASSSSSSSSS SPPPASPPAS SPPRVLELPG VPAAAFSDVL NFIYSARLAL
160 170 180 190 200
PGGGGDGAAV AEIGALGRRL GISRLQGLGE GGDAWVPPTP APMATSQPEE
210 220 230 240 250
DSFGPGPRPA GEWEGDRAEA QAPDLQCSLP RRPLPCPQCG KSFIHPKRLQ
260 270 280 290 300
THEAQCRRGA STRGSTGLGA GGAGPGGPAG VDASALPPPV GFRGGPEHVV
310 320 330 340 350
KVVGGHVLYV CAACERSYVT LSSLKRHSNV HSWRRKYPCR YCEKVFALAE
360 370 380 390 400
YRTKHEVWHT GERRYQCIFC WETFVTYYNL KTHQRAFHGI SPGLLASEKT
410 420 430 440 450
PNGGYKPKLN TLKLYRLLPM RAAKRPYKTY SQGAPEAPLS PTLNTPAPVA
460 470 480 490 500
MPASPPPGPP PAPEPGPPPS VITFAHPAPS VIVHGGSSSG GGGSGTASTG
510 520 530 540 550
GSQAASVITY TAPPRPPKKR EYPPPPPEPA ATPTSPATAV SPATAAGPAM
560 570 580 590 600
ATTTEEAKGR NPRAGRTLTY TAKPVGGIGG GGGPPTGAGR GPSQLQAPPP
610 620 630 640 650
LCQITVRIGE EAIVKRRISE TDLRPGELSG EEMEESEEDE EEEDEEEEEE
660 670 680 690 700
DEEESKAGGE DQLWRPYYSY KPKRKAGAAG GASVGGSGLP RGRRPPRWRQ
710 720 730 740 750
KLERRSWEET PAAESPAGRA RTERRHRCGD CAQTFTTLRK LRKHQEAHGG
760 770 780 790 800
GSHSSRAGRR PSTRFTCPHC AKVCKTAAAL SRHGQRHAAE RPGGTPTPVI
810 820 830 840 850
AYSKGSAGTR PGDVKEEAPQ EMQVSSSSGE AGGGSTAAEE ASETASLQDP
860 870 880 890 900
IISGGEEPPV VASGGSYVYP PVQEFPLALI GGGREPGGGR GKSGSEGPVG
910 920 930 940 950
AGEGDRMEGI GAAKVTFYPE PYPLVYGPQL LAAYPYNFSN LAALPVALNM
960 970 980 990 1000
VLPDEKGAGA LPFLPGVFGY AVNPQAAPPA PPTPPPPTLP PPIPPKGEGE
1010
RAGVERTQKG DVG
Length:1,013
Mass (Da):105,114
Last modified:April 26, 2004 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA4AB6A5230C2F52
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA96062 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti188P → S in AAH43352 (PubMed:15489334).Curated1
Sequence conflicti674R → C in AAH43352 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052913539A → V. Corresponds to variant dbSNP:rs35231078Ensembl.1
Natural variantiVAR_018383550M → I. Corresponds to variant dbSNP:rs871990Ensembl.1
Natural variantiVAR_052914561N → S. Corresponds to variant dbSNP:rs34914463Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY302699 mRNA Translation: AAP59447.1
AB040971 mRNA Translation: BAA96062.2 Different initiation.
AK122971 mRNA Translation: BAG53828.1
CH471108 Genomic DNA Translation: EAW90185.1
BC033259 mRNA Translation: AAH33259.1
BC043352 mRNA Translation: AAH43352.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11107.1

NCBI Reference Sequences

More...
RefSeqi
NP_001122305.1, NM_001128833.1
NP_065950.2, NM_020899.3
XP_006721626.1, XM_006721563.3
XP_006721627.1, XM_006721564.2
XP_011522274.1, XM_011523972.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000311403; ENSP00000307858; ENSG00000174282
ENST00000380599; ENSP00000369973; ENSG00000174282
ENST00000639670; ENSP00000492232; ENSG00000283868
ENST00000639962; ENSP00000492616; ENSG00000283868

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57659

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57659

UCSC genome browser

More...
UCSCi
uc002ghc.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY302699 mRNA Translation: AAP59447.1
AB040971 mRNA Translation: BAA96062.2 Different initiation.
AK122971 mRNA Translation: BAG53828.1
CH471108 Genomic DNA Translation: EAW90185.1
BC033259 mRNA Translation: AAH33259.1
BC043352 mRNA Translation: AAH43352.1
CCDSiCCDS11107.1
RefSeqiNP_001122305.1, NM_001128833.1
NP_065950.2, NM_020899.3
XP_006721626.1, XM_006721563.3
XP_006721627.1, XM_006721564.2
XP_011522274.1, XM_011523972.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi121693, 9 interactors
IntActiQ9P1Z0, 17 interactors
MINTiQ9P1Z0
STRINGi9606.ENSP00000307858

PTM databases

CarbonylDBiQ9P1Z0
iPTMnetiQ9P1Z0
PhosphoSitePlusiQ9P1Z0

Polymorphism and mutation databases

BioMutaiZBTB4
DMDMi46577564

Proteomic databases

EPDiQ9P1Z0
jPOSTiQ9P1Z0
MassIVEiQ9P1Z0
MaxQBiQ9P1Z0
PaxDbiQ9P1Z0
PeptideAtlasiQ9P1Z0
PRIDEiQ9P1Z0
ProteomicsDBi83682

Genome annotation databases

EnsembliENST00000311403; ENSP00000307858; ENSG00000174282
ENST00000380599; ENSP00000369973; ENSG00000174282
ENST00000639670; ENSP00000492232; ENSG00000283868
ENST00000639962; ENSP00000492616; ENSG00000283868
GeneIDi57659
KEGGihsa:57659
UCSCiuc002ghc.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57659
DisGeNETi57659

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZBTB4
HGNCiHGNC:23847 ZBTB4
HPAiCAB008980
HPA064763
MIMi612308 gene
neXtProtiNX_Q9P1Z0
OpenTargetsiENSG00000174282
PharmGKBiPA134959224

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000161268
HOGENOMiHOG000065759
InParanoidiQ9P1Z0
KOiK10491
OMAiKHQEAHS
OrthoDBi1318335at2759
PhylomeDBiQ9P1Z0
TreeFamiTF333100

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZBTB4 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57659
PharosiQ9P1Z0

Protein Ontology

More...
PROi
PR:Q9P1Z0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000174282 Expressed in 212 organ(s), highest expression level in amniotic fluid
GenevisibleiQ9P1Z0 HS

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZBTB4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P1Z0
Secondary accession number(s): B3KVL6
, Q7Z697, Q86XJ4, Q8N4V8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: October 16, 2019
This is version 161 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again