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Entry version 164 (29 Sep 2021)
Sequence version 2 (15 Mar 2005)
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Protein

Calmodulin-regulated spectrin-associated protein 3

Gene

CAMSAP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647).

Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153).

Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153).

In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153).

Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755).

Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:27802168, PubMed:26715742).

Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity).

Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509).

Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021).

Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391).

Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391).

Plays an important role in motile cilia function by facilitatating proper orientation of basal bodies and formation of central microtubule pairs in motile cilia (By similarity).

By similarity8 Publications

Miscellaneous

'Nezha' is a deity in Chinese mythology.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9P1Y5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calmodulin-regulated spectrin-associated protein 3Curated
Alternative name(s):
Protein Nezha1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CAMSAP3Imported
Synonyms:KIAA15431 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29307, CAMSAP3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612685, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9P1Y5

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000076826

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57662

Open Targets

More...
OpenTargetsi
ENSG00000076826

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134885087

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9P1Y5, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CAMSAP3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
61213747

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000507991 – 1249Calmodulin-regulated spectrin-associated protein 3Add BLAST1249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei184PhosphothreonineCombined sources1
Modified residuei193PhosphoserineCombined sources1
Modified residuei334PhosphoserineCombined sources1
Modified residuei341PhosphoserineCombined sources1
Modified residuei347PhosphoserineCombined sources1
Modified residuei351PhosphoserineCombined sources1
Modified residuei368PhosphoserineCombined sources1
Modified residuei373PhosphoserineCombined sources1
Modified residuei382PhosphoserineCombined sources1
Modified residuei547PhosphoserineCombined sources1
Modified residuei554PhosphoserineCombined sources1
Modified residuei560PhosphoserineCombined sources1
Modified residuei685PhosphoserineCombined sources1
Modified residuei769PhosphoserineCombined sources1
Modified residuei799PhosphothreonineCombined sources1
Modified residuei814PhosphoserineCombined sources1
Modified residuei1074PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9P1Y5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9P1Y5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9P1Y5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9P1Y5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9P1Y5

PeptideAtlas

More...
PeptideAtlasi
Q9P1Y5

PRoteomics IDEntifications database

More...
PRIDEi
Q9P1Y5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
83677 [Q9P1Y5-1]
83678 [Q9P1Y5-2]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q9P1Y5

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9P1Y5, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9P1Y5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9P1Y5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000076826, Expressed in lower esophagus mucosa and 109 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9P1Y5, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000076826, Tissue enhanced (skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PLEKHA7 (PubMed:19041755).

Interacts with CAMSAP2 (By similarity).

Interacts with KATNA1 and KATNB1; leading to regulate the length of CAMSAP3-decorated microtubule stretches (PubMed:24486153, PubMed:28386021).

Interacts with AKAP9; regulating Golgi assembly in epithelial cells (PubMed:28089391).

Interacts with MACF1 (PubMed:27693509, PubMed:27802168).

Interacts with AKNA (By similarity).

By similarity6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
121695, 66 interactors

Database of interacting proteins

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DIPi
DIP-52405N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q9P1Y5

Protein interaction database and analysis system

More...
IntActi
Q9P1Y5, 47 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000416797

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9P1Y5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9P1Y5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini203 – 312Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST110
Domaini1109 – 1243CKKPROSITE-ProRule annotationAdd BLAST135

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni183 – 205DisorderedSequence analysisAdd BLAST23
Regioni328 – 385DisorderedSequence analysisAdd BLAST58
Regioni430 – 457DisorderedSequence analysisAdd BLAST28
Regioni473 – 609DisorderedSequence analysisAdd BLAST137
Regioni632 – 696DisorderedSequence analysisAdd BLAST65
Regioni714 – 1029DisorderedSequence analysisAdd BLAST316
Regioni1061 – 1111DisorderedSequence analysisAdd BLAST51

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili594 – 628Sequence analysisAdd BLAST35
Coiled coili696 – 729Sequence analysisAdd BLAST34
Coiled coili896 – 935Sequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi338 – 357Polar residuesSequence analysisAdd BLAST20
Compositional biasi366 – 383Polar residuesSequence analysisAdd BLAST18
Compositional biasi439 – 456Pro residuesSequence analysisAdd BLAST18
Compositional biasi732 – 746Pro residuesSequence analysisAdd BLAST15
Compositional biasi885 – 939Basic and acidic residuesSequence analysisAdd BLAST55
Compositional biasi967 – 999Basic and acidic residuesSequence analysisAdd BLAST33
Compositional biasi1061 – 1081Polar residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The CKK domain binds microtubules and specifically recognizes the minus-end of microtubules.PROSITE-ProRule annotation1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CAMSAP1 family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3654, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182975

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004833_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9P1Y5

Identification of Orthologs from Complete Genome Data

More...
OMAi
VVFAFEW

Database of Orthologous Groups

More...
OrthoDBi
741937at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9P1Y5

TreeFam database of animal gene trees

More...
TreeFami
TF315529

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.20.360, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032940, CAMSAP
IPR031372, CAMSAP_CC1
IPR022613, CAMSAP_CH
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR038209, CKK_dom_sf
IPR014797, CKK_domain
IPR011033, PRC_barrel-like_sf

The PANTHER Classification System

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PANTHERi
PTHR21595, PTHR21595, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17095, CAMSAP_CC1, 1 hit
PF11971, CAMSAP_CH, 1 hit
PF08683, CAMSAP_CKK, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01051, CAMSAP_CKK, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576, SSF47576, 1 hit
SSF50346, SSF50346, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50021, CH, 1 hit
PS51508, CKK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9P1Y5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVEAAPPGPG PLRRTFLVPE IKSLDQYDFS RAKAAASLAW VLRAAFGGAE
60 70 80 90 100
HVPPELWEPF YTDQYAQEHV KPPVTRLLLS AELYCRAWRQ ALPQLETPPN
110 120 130 140 150
PSALLALLAR RGTVPALPER PVREADLRHQ PILMGAHLAV IDALMAAFAF
160 170 180 190 200
EWTKTLPGPL ALTSLEHKLL FWVDTTVRRL QEKTEQEAAQ RASPAAPADG
210 220 230 240 250
AAPAQPSIRY RKDRVVARRA PCFPTVTSLQ DLASGAALAA TIHCYCPQLL
260 270 280 290 300
RLEEVCLKDP MSVADSLYNL QLVQDFCASR LPRGCPLSLE DLLYVPPPLK
310 320 330 340 350
VNLVVMLAEL FMCFEVLKPD FVQVKDLPDG HAASPRGTEA SPPQNNSGSS
360 370 380 390 400
SPVFTFRHPL LSSGGPQSPL RGSTGSLKSS PSMSHMEALG KAWNRQLSRP
410 420 430 440 450
LSQAVSFSTP FGLDSDVDVV MGDPVLLRSV SSDSLGPPRP APARTPTQPP
460 470 480 490 500
PEPGDLPTIE EALQIIHSAE PRLLPDGAAD GSFYLHSPEG PSKPSLASPY
510 520 530 540 550
LPEGTSKPLS DRPTKAPVYM PHPETPSKPS PCLVGEASKP PAPSEGSPKA
560 570 580 590 600
VASSPAATNS EVKMTSFAER KKQLVKAEAE AGAGSPTSTP APPEALSSEM
610 620 630 640 650
SELSARLEEK RRAIEAQKRR IEAIFAKHRQ RLGKSAFLQV QPREASGEAE
660 670 680 690 700
AEAEEADSGP VPGGERPAGE GQGEPTSRPK AVTFSPDLGP VPHEGLGEYN
710 720 730 740 750
RAVSKLSAAL SSLQRDMQRL TDQQQRLLAP PEAPGSAPPP AAWVIPGPTT
760 770 780 790 800
GPKAASPSPA RRVPATRRSP GPGPSQSPRS PKHTRPAELR LAPLTRVLTP
810 820 830 840 850
PHDVDSLPHL RKFSPSQVPV QTRSSILLAE ETPPEEPAAR PGLIEIPLGS
860 870 880 890 900
LADPAAEDEG DGSPAGAEDS LEEEASSEGE PRVGLGFFYK DEDKPEDEMA
910 920 930 940 950
QKRASLLERQ QRRAEEARRR KQWQEVEKEQ RREEAARLAQ EEAPGPAPLV
960 970 980 990 1000
SAVPMATPAP AARAPAEEEV GPRKGDFTRQ EYERRAQLKL MDDLDKVLRP
1010 1020 1030 1040 1050
RAAGSGGPGR GGRRATRPRS GCCDDSALAR SPARGLLGSR LSKIYSQSTL
1060 1070 1080 1090 1100
SLSTVANEAH NNLGVKRPTS RAPSPSGLMS PSRLPGSRER DWENGSNASS
1110 1120 1130 1140 1150
PASVPEYTGP RLYKEPSAKS NKFIIHNALS HCCLAGKVNE PQKNRILEEI
1160 1170 1180 1190 1200
EKSKANHFLI LFRDSSCQFR ALYTLSGETE ELSRLAGYGP RTVTPAMVEG
1210 1220 1230 1240
IYKYNSDRKR FTQIPAKTMS MSVDAFTIQG HLWQGKKPTT PKKGGGTPK
Length:1,249
Mass (Da):134,750
Last modified:March 15, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5A597E13531443CE
GO
Isoform 2 (identifier: Q9P1Y5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     207-207: S → SCPTRWYWKLVPHAIAFCLKESGSKPPM

Show »
Length:1,276
Mass (Da):137,878
Checksum:i4248F67ED7F3CEEE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti824S → P in BC035808 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053991335P → S. Corresponds to variant dbSNP:rs3745358Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_041473207S → SCPTRWYWKLVPHAIAFCLK ESGSKPPM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC008763 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW69025.1
BC020431 mRNA No translation available.
BC035808 mRNA No translation available.
AB040976 mRNA Translation: BAA96067.1
AL833927 mRNA Translation: CAD38783.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS42489.1 [Q9P1Y5-1]
CCDS45947.1 [Q9P1Y5-2]

NCBI Reference Sequences

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RefSeqi
NP_001073898.1, NM_001080429.2 [Q9P1Y5-2]
NP_065953.1, NM_020902.1 [Q9P1Y5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000160298; ENSP00000160298; ENSG00000076826 [Q9P1Y5-1]
ENST00000446248; ENSP00000416797; ENSG00000076826 [Q9P1Y5-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
57662

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:57662

UCSC genome browser

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UCSCi
uc002mgu.5, human [Q9P1Y5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008763 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW69025.1
BC020431 mRNA No translation available.
BC035808 mRNA No translation available.
AB040976 mRNA Translation: BAA96067.1
AL833927 mRNA Translation: CAD38783.1
CCDSiCCDS42489.1 [Q9P1Y5-1]
CCDS45947.1 [Q9P1Y5-2]
RefSeqiNP_001073898.1, NM_001080429.2 [Q9P1Y5-2]
NP_065953.1, NM_020902.1 [Q9P1Y5-1]

3D structure databases

SMRiQ9P1Y5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121695, 66 interactors
DIPiDIP-52405N
ELMiQ9P1Y5
IntActiQ9P1Y5, 47 interactors
STRINGi9606.ENSP00000416797

PTM databases

CarbonylDBiQ9P1Y5
GlyGeniQ9P1Y5, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ9P1Y5
PhosphoSitePlusiQ9P1Y5

Genetic variation databases

BioMutaiCAMSAP3
DMDMi61213747

Proteomic databases

EPDiQ9P1Y5
jPOSTiQ9P1Y5
MassIVEiQ9P1Y5
MaxQBiQ9P1Y5
PaxDbiQ9P1Y5
PeptideAtlasiQ9P1Y5
PRIDEiQ9P1Y5
ProteomicsDBi83677 [Q9P1Y5-1]
83678 [Q9P1Y5-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
Q9P1Y5, 8 sequenced antibodies

Antibodypedia a portal for validated antibodies

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Antibodypediai
50549, 80 antibodies

The DNASU plasmid repository

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DNASUi
57662

Genome annotation databases

EnsembliENST00000160298; ENSP00000160298; ENSG00000076826 [Q9P1Y5-1]
ENST00000446248; ENSP00000416797; ENSG00000076826 [Q9P1Y5-2]
GeneIDi57662
KEGGihsa:57662
UCSCiuc002mgu.5, human [Q9P1Y5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
57662
DisGeNETi57662

GeneCards: human genes, protein and diseases

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GeneCardsi
CAMSAP3
HGNCiHGNC:29307, CAMSAP3
HPAiENSG00000076826, Tissue enhanced (skin)
MIMi612685, gene
neXtProtiNX_Q9P1Y5
OpenTargetsiENSG00000076826
PharmGKBiPA134885087
VEuPathDBiHostDB:ENSG00000076826

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3654, Eukaryota
GeneTreeiENSGT00950000182975
HOGENOMiCLU_004833_1_0_1
InParanoidiQ9P1Y5
OMAiVVFAFEW
OrthoDBi741937at2759
PhylomeDBiQ9P1Y5
TreeFamiTF315529

Enzyme and pathway databases

PathwayCommonsiQ9P1Y5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
57662, 10 hits in 1010 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CAMSAP3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
57662
PharosiQ9P1Y5, Tbio

Protein Ontology

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PROi
PR:Q9P1Y5
RNActiQ9P1Y5, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000076826, Expressed in lower esophagus mucosa and 109 other tissues
GenevisibleiQ9P1Y5, HS

Family and domain databases

Gene3Di3.10.20.360, 1 hit
InterProiView protein in InterPro
IPR032940, CAMSAP
IPR031372, CAMSAP_CC1
IPR022613, CAMSAP_CH
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR038209, CKK_dom_sf
IPR014797, CKK_domain
IPR011033, PRC_barrel-like_sf
PANTHERiPTHR21595, PTHR21595, 1 hit
PfamiView protein in Pfam
PF17095, CAMSAP_CC1, 1 hit
PF11971, CAMSAP_CH, 1 hit
PF08683, CAMSAP_CKK, 1 hit
SMARTiView protein in SMART
SM01051, CAMSAP_CKK, 1 hit
SUPFAMiSSF47576, SSF47576, 1 hit
SSF50346, SSF50346, 1 hit
PROSITEiView protein in PROSITE
PS50021, CH, 1 hit
PS51508, CKK, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAMP3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P1Y5
Secondary accession number(s): Q8NDF1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: September 29, 2021
This is version 164 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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