Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Signal-regulatory protein gamma

Gene

SIRPG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.1 Publication

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-391160 Signal regulatory protein family interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Signal-regulatory protein gamma
Short name:
SIRP-gamma
Alternative name(s):
CD172 antigen-like family member B
Signal-regulatory protein beta-2
Short name:
SIRP-b2
Short name:
SIRP-beta-2
CD_antigen: CD172g
Gene namesi
Name:SIRPG
Synonyms:SIRPB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000089012.14
HGNCiHGNC:15757 SIRPG
MIMi605466 gene
neXtProtiNX_Q9P1W8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 360ExtracellularSequence analysisAdd BLAST332
Transmembranei361 – 383HelicalSequence analysisAdd BLAST23
Topological domaini384 – 387CytoplasmicSequence analysis4

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55423
OpenTargetsiENSG00000089012
PharmGKBiPA38034

Polymorphism and mutation databases

BioMutaiSIRPG
DMDMi124053651

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000001495729 – 387Signal-regulatory protein gammaAdd BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 119PROSITE-ProRule annotation1 Publication
Disulfide bondi168 ↔ 226PROSITE-ProRule annotation
Glycosylationi243N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi268N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi271 ↔ 329PROSITE-ProRule annotation
Glycosylationi309N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi317N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9P1W8
MaxQBiQ9P1W8
PaxDbiQ9P1W8
PeptideAtlasiQ9P1W8
PRIDEiQ9P1W8
ProteomicsDBi83672
83673 [Q9P1W8-2]
83674 [Q9P1W8-3]
83675 [Q9P1W8-4]

PTM databases

iPTMnetiQ9P1W8
PhosphoSitePlusiQ9P1W8

Expressioni

Tissue specificityi

Detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. Mainly present in the paracortical T-cell area of lymph nodes, with only sparse positive cells in the mantle and in the germinal center of B-cell follicles. In the thymus, primarily expressed in the medulla on mature T-lymphocytes that have undergone thymic selection.2 Publications

Gene expression databases

BgeeiENSG00000089012 Expressed in 97 organ(s), highest expression level in amniotic fluid
CleanExiHS_SIRPG
GenevisibleiQ9P1W8 HS

Interactioni

Subunit structurei

Interacts with CD47.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CD47Q087222EBI-1268284,EBI-1268321

Protein-protein interaction databases

BioGridi120664, 3 interactors
IntActiQ9P1W8, 1 interactor
STRINGi9606.ENSP00000305529

Structurei

Secondary structure

1387
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9P1W8
SMRiQ9P1W8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9P1W8

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 137Ig-like V-typeAdd BLAST109
Domaini146 – 245Ig-like C1-type 1Add BLAST100
Domaini252 – 340Ig-like C1-type 2Add BLAST89

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKYM Eukaryota
ENOG410YKK2 LUCA
GeneTreeiENSGT00440000033339
HOVERGENiHBG056632
InParanoidiQ9P1W8
KOiK06551
OMAiSWFLVNV
OrthoDBiEOG091G05RP
PhylomeDBiQ9P1W8
TreeFamiTF341862

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003597 Ig_C1-set
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07654 C1-set, 2 hits
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00407 IGc1, 2 hits
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9P1W8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPVPASWPHP PGPFLLLTLL LGLTEVAGEE ELQMIQPEKL LLVTVGKTAT
60 70 80 90 100
LHCTVTSLLP VGPVLWFRGV GPGRELIYNQ KEGHFPRVTT VSDLTKRNNM
110 120 130 140 150
DFSIRISSIT PADVGTYYCV KFRKGSPENV EFKSGPGTEM ALGAKPSAPV
160 170 180 190 200
VLGPAARTTP EHTVSFTCES HGFSPRDITL KWFKNGNELS DFQTNVDPTG
210 220 230 240 250
QSVAYSIRST ARVVLDPWDV RSQVICEVAH VTLQGDPLRG TANLSEAIRV
260 270 280 290 300
PPTLEVTQQP MRVGNQVNVT CQVRKFYPQS LQLTWSENGN VCQRETASTL
310 320 330 340 350
TENKDGTYNW TSWFLVNISD QRDDVVLTCQ VKHDGQLAVS KRLALEVTVH
360 370 380
QKDQSSDATP GPASSLTALL LIAVLLGPIY VPWKQKT
Length:387
Mass (Da):42,498
Last modified:January 23, 2007 - v3
Checksum:i0F5099BE1DE35AC8
GO
Isoform 2 (identifier: Q9P1W8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.

Note: No experimental confirmation available.
Show »
Length:354
Mass (Da):38,962
Checksum:i41D5122588FE7C42
GO
Isoform 3 (identifier: Q9P1W8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     144-360: Missing.

Note: No experimental confirmation available.
Show »
Length:170
Mass (Da):18,466
Checksum:i0439DB85CAAB167A
GO
Isoform 4 (identifier: Q9P1W8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     250-360: Missing.

Show »
Length:276
Mass (Da):29,967
Checksum:iAF76A8692051D6C1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049936263V → A1 PublicationCorresponds to variant dbSNP:rs6043409Ensembl.1
Natural variantiVAR_049937286S → L1 PublicationCorresponds to variant dbSNP:rs6034239Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0070271 – 33Missing in isoform 2. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_007028144 – 360Missing in isoform 3. 1 PublicationAdd BLAST217
Alternative sequenceiVSP_026960250 – 360Missing in isoform 4. 1 PublicationAdd BLAST111

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042624 mRNA Translation: BAA95692.1
AY748247 mRNA Translation: AAV88530.1
AY748248 mRNA Translation: AAV88531.1
AL109809 Genomic DNA No translation available.
AL138804 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10616.1
BC020629 mRNA Translation: AAH20629.2
BC064532 mRNA Translation: AAH64532.1
CCDSiCCDS13020.2 [Q9P1W8-1]
CCDS13021.2 [Q9P1W8-3]
CCDS33434.1 [Q9P1W8-4]
RefSeqiNP_001034597.1, NM_001039508.1 [Q9P1W8-4]
NP_061026.2, NM_018556.3 [Q9P1W8-1]
NP_543006.2, NM_080816.2 [Q9P1W8-3]
XP_011527588.1, XM_011529286.2 [Q9P1W8-2]
UniGeneiHs.590883

Genome annotation databases

EnsembliENST00000216927; ENSP00000216927; ENSG00000089012 [Q9P1W8-4]
ENST00000303415; ENSP00000305529; ENSG00000089012 [Q9P1W8-1]
ENST00000344103; ENSP00000342759; ENSG00000089012 [Q9P1W8-3]
ENST00000381580; ENSP00000370992; ENSG00000089012 [Q9P1W8-2]
ENST00000381583; ENSP00000370995; ENSG00000089012 [Q9P1W8-4]
GeneIDi55423
KEGGihsa:55423
UCSCiuc002wfm.1 human [Q9P1W8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042624 mRNA Translation: BAA95692.1
AY748247 mRNA Translation: AAV88530.1
AY748248 mRNA Translation: AAV88531.1
AL109809 Genomic DNA No translation available.
AL138804 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10616.1
BC020629 mRNA Translation: AAH20629.2
BC064532 mRNA Translation: AAH64532.1
CCDSiCCDS13020.2 [Q9P1W8-1]
CCDS13021.2 [Q9P1W8-3]
CCDS33434.1 [Q9P1W8-4]
RefSeqiNP_001034597.1, NM_001039508.1 [Q9P1W8-4]
NP_061026.2, NM_018556.3 [Q9P1W8-1]
NP_543006.2, NM_080816.2 [Q9P1W8-3]
XP_011527588.1, XM_011529286.2 [Q9P1W8-2]
UniGeneiHs.590883

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JJWX-ray1.70A29-147[»]
4I2XX-ray2.48E/F29-347[»]
ProteinModelPortaliQ9P1W8
SMRiQ9P1W8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120664, 3 interactors
IntActiQ9P1W8, 1 interactor
STRINGi9606.ENSP00000305529

PTM databases

iPTMnetiQ9P1W8
PhosphoSitePlusiQ9P1W8

Polymorphism and mutation databases

BioMutaiSIRPG
DMDMi124053651

Proteomic databases

EPDiQ9P1W8
MaxQBiQ9P1W8
PaxDbiQ9P1W8
PeptideAtlasiQ9P1W8
PRIDEiQ9P1W8
ProteomicsDBi83672
83673 [Q9P1W8-2]
83674 [Q9P1W8-3]
83675 [Q9P1W8-4]

Protocols and materials databases

DNASUi55423
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216927; ENSP00000216927; ENSG00000089012 [Q9P1W8-4]
ENST00000303415; ENSP00000305529; ENSG00000089012 [Q9P1W8-1]
ENST00000344103; ENSP00000342759; ENSG00000089012 [Q9P1W8-3]
ENST00000381580; ENSP00000370992; ENSG00000089012 [Q9P1W8-2]
ENST00000381583; ENSP00000370995; ENSG00000089012 [Q9P1W8-4]
GeneIDi55423
KEGGihsa:55423
UCSCiuc002wfm.1 human [Q9P1W8-1]

Organism-specific databases

CTDi55423
DisGeNETi55423
EuPathDBiHostDB:ENSG00000089012.14
GeneCardsiSIRPG
HGNCiHGNC:15757 SIRPG
MIMi605466 gene
neXtProtiNX_Q9P1W8
OpenTargetsiENSG00000089012
PharmGKBiPA38034
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKYM Eukaryota
ENOG410YKK2 LUCA
GeneTreeiENSGT00440000033339
HOVERGENiHBG056632
InParanoidiQ9P1W8
KOiK06551
OMAiSWFLVNV
OrthoDBiEOG091G05RP
PhylomeDBiQ9P1W8
TreeFamiTF341862

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-391160 Signal regulatory protein family interactions

Miscellaneous databases

EvolutionaryTraceiQ9P1W8
GeneWikiiSIRPG
GenomeRNAii55423
PROiPR:Q9P1W8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000089012 Expressed in 97 organ(s), highest expression level in amniotic fluid
CleanExiHS_SIRPG
GenevisibleiQ9P1W8 HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003597 Ig_C1-set
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07654 C1-set, 2 hits
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00407 IGc1, 2 hits
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSIRPG_HUMAN
AccessioniPrimary (citable) accession number: Q9P1W8
Secondary accession number(s): B1AKP6
, Q5D051, Q5JV25, Q5MKL4, Q8WWA5, Q9NQK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 149 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again