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UniProtKB - Q9P1Q0 (VPS54_HUMAN)

Entry version 149 (29 Sep 2021)
Sequence version 2 (10 May 2005)
Previous versions | rss
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Protein

Vacuolar protein sorting-associated protein 54

Gene

VPS54

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:18367545).

Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling (PubMed:25799061).

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • syntaxin binding Source: GO_Central
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9P1Q0

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6811440, Retrograde transport at the Trans-Golgi-Network

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 54
Alternative name(s):
Hepatocellular carcinoma protein 8
Tumor antigen HOM-HCC-8
Tumor antigen SLP-8p
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VPS54
Synonyms:HCC8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18652, VPS54

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		614633, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9P1Q0

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000143952

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		51542

Open Targets

More...OpenTargetsi		ENSG00000143952

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134920394

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9P1Q0, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		VPS54

Domain mapping of disease mutations (DMDM)

More...DMDMi		82583721

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001487311 – 977Vacuolar protein sorting-associated protein 54Add BLAST977

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei8PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9P1Q0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9P1Q0

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9P1Q0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9P1Q0

PeptideAtlas

More...PeptideAtlasi		Q9P1Q0

PRoteomics IDEntifications database

More...PRIDEi		Q9P1Q0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		83656 [Q9P1Q0-1]
83657 [Q9P1Q0-2]
83658 [Q9P1Q0-3]
83659 [Q9P1Q0-4]
83660 [Q9P1Q0-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9P1Q0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9P1Q0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000143952, Expressed in sperm and 230 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9P1Q0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9P1Q0, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000143952, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of VPS51, VPS52, VPS53 and VPS54 (PubMed:15878329, PubMed:25799061, PubMed:27440922). EIPR1 interacts with GARP complex and mediates its recruitment to the trans-Golgi network (PubMed:27440922).

Interacts with VPS51 in an EIPR1-independent manner (PubMed:31721635).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119600, 27 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-6208, GARP tethering complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9P1Q0

Database of interacting proteins

More...DIPi		DIP-61627N

Protein interaction database and analysis system

More...IntActi		Q9P1Q0, 23 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000272322

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9P1Q0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9P1Q0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni535 – 575DisorderedSequence analysisAdd BLAST41

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili240 – 260Sequence analysisAdd BLAST21
Coiled coili480 – 507Sequence analysisAdd BLAST28
Coiled coili582 – 603Sequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi535 – 571Polar residuesSequence analysisAdd BLAST37

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the VPS54 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2115, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000000583

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005185_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9P1Q0

Identification of Orthologs from Complete Genome Data

More...OMAi		ESEQCLD

Database of Orthologous Groups

More...OrthoDBi		449680at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9P1Q0

TreeFam database of animal gene trees

More...TreeFami		TF313700

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039745, Vps54
IPR012501, Vps54_C
IPR019515, VPS54_N

The PANTHER Classification System

More...PANTHERi		PTHR12965, PTHR12965, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07928, Vps54, 1 hit
PF10475, Vps54_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9P1Q0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASSHSSSPV PQGSSSDVFF KIEVDPSKHI RPVPSLPDVC PKEPTGDSHS 
        60         70         80         90        100
LYVAPSLVTD QHRWTVYHSK VNLPAALNDP RLAKRESDFF TKTWGLDFVD 
       110        120        130        140        150
TEVIPSFYLP QISKEHFTVY QQEISQREKI HERCKNICPP KDTFERTLLH 
       160        170        180        190        200
THDKSRTDLE QVPKIFMKPD FALDDSLTFN SVLPWSHFNT AGGKGNRDAA 
       210        220        230        240        250
SSKLLQEKLS HYLDIVEVNI AHQISLRSEA FFHAMTSQHE LQDYLRKTSQ 
       260        270        280        290        300
AVKMLRDKIA QIDKVMCEGS LHILRLALTR NNCVKVYNKL KLMATVHQTQ 
       310        320        330        340        350
PTVQVLLSTS EFVGALDLIA TTQEVLQQEL QGIHSFRHLG SQLCELEKLI 
       360        370        380        390        400
DKMMIAEFST YSHSDLNRPL EDDCQVLEEE RLISLVFGLL KQRKLNFLEI 
       410        420        430        440        450
YGEKMVITAK NIIKQCVINK VSQTEEIDTD VVVKLADQMR MLNFPQWFDL 
       460        470        480        490        500
LKDIFSKFTI FLQRVKATLN IIHSVVLSVL DKNQRTRELE EISQQKNAAK 
       510        520        530        540        550
DNSLDTEVAY LIHEGMFISD AFGEGELTPI AVDTTSQRNA SPNSEPCSSD 
       560        570        580        590        600
SVSEPECTTD SSSSKEHTSS SAIPGGVDIM VSEDMKLTDS ELGKLANNIQ 
       610        620        630        640        650
ELLYSASDIC HDRAVKFLMS RAKDGFLEKL NSMEFITLSR LMETFILDTE 
       660        670        680        690        700
QICGRKSTSL LGALQSQAIK FVNRFHEERK TKLSLLLDNE RWKQADVPAE 
       710        720        730        740        750
FQDLVDSLSD GKIALPEKKS GATEERKPAE VLIVEGQQYA VVGTVLLLIR 
       760        770        780        790        800
IILEYCQCVD NIPSVTTDML TRLSDLLKYF NSRSCQLVLG AGALQVVGLK 
       810        820        830        840        850
TITTKNLALS SRCLQLIVHY IPVIRAHFEA RLPPKQYSML RHFDHITKDY 
       860        870        880        890        900
HDHIAEISAK LVAIMDSLFD KLLSKYEVKA PVPSACFRNI CKQMTKMHEA 
       910        920        930        940        950
IFDLLPEEQT QMLFLRINAS YKLHLKKQLS HLNVINDGGP QNGLVTADVA 
       960        970 
FYTGNLQALK GLKDLDLNMA EIWEQKR
Length:977
Mass (Da):110,589
Last modified:May 10, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3290160E3460C836
GO
Isoform 2 (identifier: Q9P1Q0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     964-977: DLDLNMAEIWEQKR → IWT

Show »
Length:966
Mass (Da):109,246
Checksum:i7FA7C844A6026471
GO
Isoform 3 (identifier: Q9P1Q0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-117: Missing.
     118-126: TVYQQEISQ → MLPTKNRIK
     380-415: Missing.

Show »
Length:824
Mass (Da):93,274
Checksum:i9EF51F039A9AD46A
GO
Isoform 4 (identifier: Q9P1Q0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     46-57: Missing.

Show »
Length:965
Mass (Da):109,362
Checksum:iD91F94CD6CDC72D3
GO
Isoform 5 (identifier: Q9P1Q0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-838: Missing.

Show »
Length:139
Mass (Da):15,982
Checksum:iF6AFBCDA077C7BB4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MT48A0A0A0MT48_HUMAN
Vacuolar protein sorting-associated...
VPS54
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA92134 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti130I → V in AAF37319 (Ref. 1) Curated1
Sequence conflicti526E → K in AAF37319 (Ref. 1) Curated1
Sequence conflicti601E → G in AAF37319 (Ref. 1) Curated1
Sequence conflicti643E → G in AAF37319 (Ref. 1) Curated1
Sequence conflicti650E → A in AAF37319 (Ref. 1) Curated1
Sequence conflicti677 – 679EER → VGG in AAF37319 (Ref. 1) Curated3
Sequence conflicti727K → E in BAA92134 (PubMed:14702039).Curated1
Sequence conflicti844D → G in AAH41868 (PubMed:15489334).Curated1
Sequence conflicti904L → H in AAH41868 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052944561S → C. Corresponds to variant dbSNP:rs34015596EnsemblClinVar.1
Natural variantiVAR_061983912M → I. Corresponds to variant dbSNP:rs11558741Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0137511 – 838Missing in isoform 5. 1 PublicationAdd BLAST838
Alternative sequenceiVSP_0137521 – 117Missing in isoform 3. 1 PublicationAdd BLAST117
Alternative sequenceiVSP_01375346 – 57Missing in isoform 4. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_013754118 – 126TVYQQEISQ → MLPTKNRIK in isoform 3. 1 Publication9
Alternative sequenceiVSP_013755380 – 415Missing in isoform 3. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_013756964 – 977DLDLN…WEQKR → IWT in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF102177 mRNA Translation: AAF37319.1
AY444798 mRNA Translation: AAS20945.1
AL137604 mRNA Translation: CAB70837.1
AL359939 mRNA Translation: CAB95772.1
CR749701 mRNA Translation: CAH18479.1
BC030275 mRNA Translation: AAH30275.1
BC041868 mRNA Translation: AAH41868.1
AK002205 mRNA Translation: BAA92134.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33208.1 [Q9P1Q0-1]
CCDS46302.1 [Q9P1Q0-4]

Protein sequence database of the Protein Information Resource

More...PIRi		T46308

NCBI Reference Sequences

More...RefSeqi		NP_001005739.1, NM_001005739.1 [Q9P1Q0-4]
NP_057600.2, NM_016516.2 [Q9P1Q0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000272322; ENSP00000272322; ENSG00000143952 [Q9P1Q0-1]
ENST00000354504; ENSP00000346499; ENSG00000143952 [Q9P1Q0-3]
ENST00000409558; ENSP00000386980; ENSG00000143952 [Q9P1Q0-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51542

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51542

UCSC genome browser

More...UCSCi		uc002scp.4, human [Q9P1Q0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102177 mRNA Translation: AAF37319.1
AY444798 mRNA Translation: AAS20945.1
AL137604 mRNA Translation: CAB70837.1
AL359939 mRNA Translation: CAB95772.1
CR749701 mRNA Translation: CAH18479.1
BC030275 mRNA Translation: AAH30275.1
BC041868 mRNA Translation: AAH41868.1
AK002205 mRNA Translation: BAA92134.1 Different initiation.
CCDSiCCDS33208.1 [Q9P1Q0-1]
CCDS46302.1 [Q9P1Q0-4]
PIRiT46308
RefSeqiNP_001005739.1, NM_001005739.1 [Q9P1Q0-4]
NP_057600.2, NM_016516.2 [Q9P1Q0-1]

3D structure databases

SMRiQ9P1Q0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi119600, 27 interactors
ComplexPortaliCPX-6208, GARP tethering complex
CORUMiQ9P1Q0
DIPiDIP-61627N
IntActiQ9P1Q0, 23 interactors
STRINGi9606.ENSP00000272322

PTM databases

iPTMnetiQ9P1Q0
PhosphoSitePlusiQ9P1Q0

Genetic variation databases

BioMutaiVPS54
DMDMi82583721

Proteomic databases

jPOSTiQ9P1Q0
MassIVEiQ9P1Q0
MaxQBiQ9P1Q0
PaxDbiQ9P1Q0
PeptideAtlasiQ9P1Q0
PRIDEiQ9P1Q0
ProteomicsDBi83656 [Q9P1Q0-1]
83657 [Q9P1Q0-2]
83658 [Q9P1Q0-3]
83659 [Q9P1Q0-4]
83660 [Q9P1Q0-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		30808, 150 antibodies

The DNASU plasmid repository

More...DNASUi		51542

Genome annotation databases

EnsembliENST00000272322; ENSP00000272322; ENSG00000143952 [Q9P1Q0-1]
ENST00000354504; ENSP00000346499; ENSG00000143952 [Q9P1Q0-3]
ENST00000409558; ENSP00000386980; ENSG00000143952 [Q9P1Q0-4]
GeneIDi51542
KEGGihsa:51542
UCSCiuc002scp.4, human [Q9P1Q0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51542
DisGeNETi51542

GeneCards: human genes, protein and diseases

More...GeneCardsi		VPS54
HGNCiHGNC:18652, VPS54
HPAiENSG00000143952, Low tissue specificity
MIMi614633, gene
neXtProtiNX_Q9P1Q0
OpenTargetsiENSG00000143952
PharmGKBiPA134920394
VEuPathDBiHostDB:ENSG00000143952

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2115, Eukaryota
GeneTreeiENSGT00390000000583
HOGENOMiCLU_005185_1_0_1
InParanoidiQ9P1Q0
OMAiESEQCLD
OrthoDBi449680at2759
PhylomeDBiQ9P1Q0
TreeFamiTF313700

Enzyme and pathway databases

PathwayCommonsiQ9P1Q0
ReactomeiR-HSA-6811440, Retrograde transport at the Trans-Golgi-Network

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		51542, 234 hits in 1040 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		VPS54, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51542
PharosiQ9P1Q0, Tbio

Protein Ontology

More...PROi		PR:Q9P1Q0
RNActiQ9P1Q0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000143952, Expressed in sperm and 230 other tissues
ExpressionAtlasiQ9P1Q0, baseline and differential
GenevisibleiQ9P1Q0, HS

Family and domain databases

InterProiView protein in InterPro
IPR039745, Vps54
IPR012501, Vps54_C
IPR019515, VPS54_N
PANTHERiPTHR12965, PTHR12965, 1 hit
PfamiView protein in Pfam
PF07928, Vps54, 1 hit
PF10475, Vps54_N, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVPS54_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P1Q0
Secondary accession number(s): Q5VIR5
, Q86YF7, Q8N6G3, Q9NPV0, Q9NT07, Q9NUJ0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 10, 2005
Last modified: September 29, 2021
This is version 149 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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