UniProtKB - Q9P1Q0 (VPS54_HUMAN)
Vacuolar protein sorting-associated protein 54
VPS54
Functioni
GO - Molecular functioni
- syntaxin binding Source: GO_Central
GO - Biological processi
- Golgi to vacuole transport Source: GO_Central
- homeostasis of number of cells within a tissue Source: Ensembl
- lysosomal transport Source: MGI
- musculoskeletal movement Source: Ensembl
- neurofilament cytoskeleton organization Source: Ensembl
- protein transport Source: UniProtKB-KW
- regulation of growth Source: Ensembl
- retrograde transport, endosome to Golgi Source: MGI
Keywordsi
Biological process | Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q9P1Q0 |
Reactomei | R-HSA-6811440, Retrograde transport at the Trans-Golgi-Network |
Names & Taxonomyi
Protein namesi | Recommended name: Vacuolar protein sorting-associated protein 54Alternative name(s): Hepatocellular carcinoma protein 8 Tumor antigen HOM-HCC-8 Tumor antigen SLP-8p |
Gene namesi | Name:VPS54 Synonyms:HCC8 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000143952.19 |
HGNCi | HGNC:18652, VPS54 |
MIMi | 614633, gene |
neXtProti | NX_Q9P1Q0 |
Subcellular locationi
Golgi apparatus
- trans-Golgi network 2 Publications
Other locations
- Membrane By similarity
Note: Associates with membranes in an EIPR1-independent manner.By similarity
Cytosol
- cytosol Source: GOC
Golgi apparatus
- GARP complex Source: UniProtKB
- Golgi apparatus Source: UniProtKB
- trans-Golgi network Source: UniProtKB
- trans-Golgi network membrane Source: Reactome
Nucleus
- nucleoplasm Source: HPA
Other locations
- membrane Source: UniProtKB
- perinuclear region of cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Golgi apparatus, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 51542 |
OpenTargetsi | ENSG00000143952 |
PharmGKBi | PA134920394 |
Miscellaneous databases
Pharosi | Q9P1Q0, Tbio |
Polymorphism and mutation databases
BioMutai | VPS54 |
DMDMi | 82583721 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000148731 | 1 – 977 | Vacuolar protein sorting-associated protein 54Add BLAST | 977 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 8 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q9P1Q0 |
MassIVEi | Q9P1Q0 |
MaxQBi | Q9P1Q0 |
PaxDbi | Q9P1Q0 |
PeptideAtlasi | Q9P1Q0 |
PRIDEi | Q9P1Q0 |
ProteomicsDBi | 83656 [Q9P1Q0-1] 83657 [Q9P1Q0-2] 83658 [Q9P1Q0-3] 83659 [Q9P1Q0-4] 83660 [Q9P1Q0-5] |
PTM databases
iPTMneti | Q9P1Q0 |
PhosphoSitePlusi | Q9P1Q0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000143952, Expressed in sperm and 229 other tissues |
ExpressionAtlasi | Q9P1Q0, baseline and differential |
Genevisiblei | Q9P1Q0, HS |
Organism-specific databases
HPAi | ENSG00000143952, Low tissue specificity |
Interactioni
Subunit structurei
Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of VPS51, VPS52, VPS53 and VPS54 (PubMed:15878329, PubMed:25799061, PubMed:27440922). EIPR1 interacts with GARP complex and mediates its recruitment to the trans-Golgi network (PubMed:27440922).
Interacts with VPS51 in an EIPR1-independent manner (PubMed:31721635).
4 PublicationsGO - Molecular functioni
- syntaxin binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 119600, 19 interactors |
CORUMi | Q9P1Q0 |
DIPi | DIP-61627N |
IntActi | Q9P1Q0, 12 interactors |
STRINGi | 9606.ENSP00000272322 |
Miscellaneous databases
RNActi | Q9P1Q0, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 240 – 260 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 480 – 507 | Sequence analysisAdd BLAST | 28 | |
Coiled coili | 582 – 603 | Sequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG2115, Eukaryota |
GeneTreei | ENSGT00390000000583 |
HOGENOMi | CLU_005185_1_0_1 |
InParanoidi | Q9P1Q0 |
OMAi | ANGMEMP |
OrthoDBi | 449680at2759 |
PhylomeDBi | Q9P1Q0 |
TreeFami | TF313700 |
Family and domain databases
InterProi | View protein in InterPro IPR039745, Vps54 IPR012501, Vps54_C IPR019515, VPS54_N |
PANTHERi | PTHR12965, PTHR12965, 1 hit |
Pfami | View protein in Pfam PF07928, Vps54, 1 hit PF10475, Vps54_N, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASSHSSSPV PQGSSSDVFF KIEVDPSKHI RPVPSLPDVC PKEPTGDSHS
60 70 80 90 100
LYVAPSLVTD QHRWTVYHSK VNLPAALNDP RLAKRESDFF TKTWGLDFVD
110 120 130 140 150
TEVIPSFYLP QISKEHFTVY QQEISQREKI HERCKNICPP KDTFERTLLH
160 170 180 190 200
THDKSRTDLE QVPKIFMKPD FALDDSLTFN SVLPWSHFNT AGGKGNRDAA
210 220 230 240 250
SSKLLQEKLS HYLDIVEVNI AHQISLRSEA FFHAMTSQHE LQDYLRKTSQ
260 270 280 290 300
AVKMLRDKIA QIDKVMCEGS LHILRLALTR NNCVKVYNKL KLMATVHQTQ
310 320 330 340 350
PTVQVLLSTS EFVGALDLIA TTQEVLQQEL QGIHSFRHLG SQLCELEKLI
360 370 380 390 400
DKMMIAEFST YSHSDLNRPL EDDCQVLEEE RLISLVFGLL KQRKLNFLEI
410 420 430 440 450
YGEKMVITAK NIIKQCVINK VSQTEEIDTD VVVKLADQMR MLNFPQWFDL
460 470 480 490 500
LKDIFSKFTI FLQRVKATLN IIHSVVLSVL DKNQRTRELE EISQQKNAAK
510 520 530 540 550
DNSLDTEVAY LIHEGMFISD AFGEGELTPI AVDTTSQRNA SPNSEPCSSD
560 570 580 590 600
SVSEPECTTD SSSSKEHTSS SAIPGGVDIM VSEDMKLTDS ELGKLANNIQ
610 620 630 640 650
ELLYSASDIC HDRAVKFLMS RAKDGFLEKL NSMEFITLSR LMETFILDTE
660 670 680 690 700
QICGRKSTSL LGALQSQAIK FVNRFHEERK TKLSLLLDNE RWKQADVPAE
710 720 730 740 750
FQDLVDSLSD GKIALPEKKS GATEERKPAE VLIVEGQQYA VVGTVLLLIR
760 770 780 790 800
IILEYCQCVD NIPSVTTDML TRLSDLLKYF NSRSCQLVLG AGALQVVGLK
810 820 830 840 850
TITTKNLALS SRCLQLIVHY IPVIRAHFEA RLPPKQYSML RHFDHITKDY
860 870 880 890 900
HDHIAEISAK LVAIMDSLFD KLLSKYEVKA PVPSACFRNI CKQMTKMHEA
910 920 930 940 950
IFDLLPEEQT QMLFLRINAS YKLHLKKQLS HLNVINDGGP QNGLVTADVA
960 970
FYTGNLQALK GLKDLDLNMA EIWEQKR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MT48 | A0A0A0MT48_HUMAN | Vacuolar protein sorting-associated... | VPS54 | 81 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 130 | I → V in AAF37319 (Ref. 1) Curated | 1 | |
Sequence conflicti | 526 | E → K in AAF37319 (Ref. 1) Curated | 1 | |
Sequence conflicti | 601 | E → G in AAF37319 (Ref. 1) Curated | 1 | |
Sequence conflicti | 643 | E → G in AAF37319 (Ref. 1) Curated | 1 | |
Sequence conflicti | 650 | E → A in AAF37319 (Ref. 1) Curated | 1 | |
Sequence conflicti | 677 – 679 | EER → VGG in AAF37319 (Ref. 1) Curated | 3 | |
Sequence conflicti | 727 | K → E in BAA92134 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 844 | D → G in AAH41868 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 904 | L → H in AAH41868 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052944 | 561 | S → C. Corresponds to variant dbSNP:rs34015596EnsemblClinVar. | 1 | |
Natural variantiVAR_061983 | 912 | M → I. Corresponds to variant dbSNP:rs11558741Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_013751 | 1 – 838 | Missing in isoform 5. 1 PublicationAdd BLAST | 838 | |
Alternative sequenceiVSP_013752 | 1 – 117 | Missing in isoform 3. 1 PublicationAdd BLAST | 117 | |
Alternative sequenceiVSP_013753 | 46 – 57 | Missing in isoform 4. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_013754 | 118 – 126 | TVYQQEISQ → MLPTKNRIK in isoform 3. 1 Publication | 9 | |
Alternative sequenceiVSP_013755 | 380 – 415 | Missing in isoform 3. 1 PublicationAdd BLAST | 36 | |
Alternative sequenceiVSP_013756 | 964 – 977 | DLDLN…WEQKR → IWT in isoform 2. 1 PublicationAdd BLAST | 14 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF102177 mRNA Translation: AAF37319.1 AY444798 mRNA Translation: AAS20945.1 AL137604 mRNA Translation: CAB70837.1 AL359939 mRNA Translation: CAB95772.1 CR749701 mRNA Translation: CAH18479.1 BC030275 mRNA Translation: AAH30275.1 BC041868 mRNA Translation: AAH41868.1 AK002205 mRNA Translation: BAA92134.1 Different initiation. |
CCDSi | CCDS33208.1 [Q9P1Q0-1] CCDS46302.1 [Q9P1Q0-4] |
PIRi | T46308 |
RefSeqi | NP_001005739.1, NM_001005739.1 [Q9P1Q0-4] NP_057600.2, NM_016516.2 [Q9P1Q0-1] |
Genome annotation databases
Ensembli | ENST00000272322; ENSP00000272322; ENSG00000143952 [Q9P1Q0-1] ENST00000354504; ENSP00000346499; ENSG00000143952 [Q9P1Q0-3] ENST00000409558; ENSP00000386980; ENSG00000143952 [Q9P1Q0-4] |
GeneIDi | 51542 |
KEGGi | hsa:51542 |
UCSCi | uc002scp.4, human [Q9P1Q0-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF102177 mRNA Translation: AAF37319.1 AY444798 mRNA Translation: AAS20945.1 AL137604 mRNA Translation: CAB70837.1 AL359939 mRNA Translation: CAB95772.1 CR749701 mRNA Translation: CAH18479.1 BC030275 mRNA Translation: AAH30275.1 BC041868 mRNA Translation: AAH41868.1 AK002205 mRNA Translation: BAA92134.1 Different initiation. |
CCDSi | CCDS33208.1 [Q9P1Q0-1] CCDS46302.1 [Q9P1Q0-4] |
PIRi | T46308 |
RefSeqi | NP_001005739.1, NM_001005739.1 [Q9P1Q0-4] NP_057600.2, NM_016516.2 [Q9P1Q0-1] |
3D structure databases
SMRi | Q9P1Q0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119600, 19 interactors |
CORUMi | Q9P1Q0 |
DIPi | DIP-61627N |
IntActi | Q9P1Q0, 12 interactors |
STRINGi | 9606.ENSP00000272322 |
PTM databases
iPTMneti | Q9P1Q0 |
PhosphoSitePlusi | Q9P1Q0 |
Polymorphism and mutation databases
BioMutai | VPS54 |
DMDMi | 82583721 |
Proteomic databases
jPOSTi | Q9P1Q0 |
MassIVEi | Q9P1Q0 |
MaxQBi | Q9P1Q0 |
PaxDbi | Q9P1Q0 |
PeptideAtlasi | Q9P1Q0 |
PRIDEi | Q9P1Q0 |
ProteomicsDBi | 83656 [Q9P1Q0-1] 83657 [Q9P1Q0-2] 83658 [Q9P1Q0-3] 83659 [Q9P1Q0-4] 83660 [Q9P1Q0-5] |
Protocols and materials databases
Antibodypediai | 30808, 140 antibodies |
DNASUi | 51542 |
Genome annotation databases
Ensembli | ENST00000272322; ENSP00000272322; ENSG00000143952 [Q9P1Q0-1] ENST00000354504; ENSP00000346499; ENSG00000143952 [Q9P1Q0-3] ENST00000409558; ENSP00000386980; ENSG00000143952 [Q9P1Q0-4] |
GeneIDi | 51542 |
KEGGi | hsa:51542 |
UCSCi | uc002scp.4, human [Q9P1Q0-1] |
Organism-specific databases
CTDi | 51542 |
DisGeNETi | 51542 |
EuPathDBi | HostDB:ENSG00000143952.19 |
GeneCardsi | VPS54 |
HGNCi | HGNC:18652, VPS54 |
HPAi | ENSG00000143952, Low tissue specificity |
MIMi | 614633, gene |
neXtProti | NX_Q9P1Q0 |
OpenTargetsi | ENSG00000143952 |
PharmGKBi | PA134920394 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2115, Eukaryota |
GeneTreei | ENSGT00390000000583 |
HOGENOMi | CLU_005185_1_0_1 |
InParanoidi | Q9P1Q0 |
OMAi | ANGMEMP |
OrthoDBi | 449680at2759 |
PhylomeDBi | Q9P1Q0 |
TreeFami | TF313700 |
Enzyme and pathway databases
PathwayCommonsi | Q9P1Q0 |
Reactomei | R-HSA-6811440, Retrograde transport at the Trans-Golgi-Network |
Miscellaneous databases
BioGRID-ORCSi | 51542, 219 hits in 861 CRISPR screens |
ChiTaRSi | VPS54, human |
GenomeRNAii | 51542 |
Pharosi | Q9P1Q0, Tbio |
PROi | PR:Q9P1Q0 |
RNActi | Q9P1Q0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000143952, Expressed in sperm and 229 other tissues |
ExpressionAtlasi | Q9P1Q0, baseline and differential |
Genevisiblei | Q9P1Q0, HS |
Family and domain databases
InterProi | View protein in InterPro IPR039745, Vps54 IPR012501, Vps54_C IPR019515, VPS54_N |
PANTHERi | PTHR12965, PTHR12965, 1 hit |
Pfami | View protein in Pfam PF07928, Vps54, 1 hit PF10475, Vps54_N, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VPS54_HUMAN | |
Accessioni | Q9P1Q0Primary (citable) accession number: Q9P1Q0 Secondary accession number(s): Q5VIR5 Q9NUJ0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | December 2, 2020 | |
This is version 145 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations