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Entry version 145 (02 Dec 2020)
Sequence version 2 (10 May 2005)
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Protein

Vacuolar protein sorting-associated protein 54

Gene

VPS54

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:18367545). Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling (PubMed:25799061).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • syntaxin binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9P1Q0

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6811440, Retrograde transport at the Trans-Golgi-Network

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 54
Alternative name(s):
Hepatocellular carcinoma protein 8
Tumor antigen HOM-HCC-8
Tumor antigen SLP-8p
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VPS54
Synonyms:HCC8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

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EuPathDBi
HostDB:ENSG00000143952.19

Human Gene Nomenclature Database

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HGNCi
HGNC:18652, VPS54

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614633, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9P1Q0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
51542

Open Targets

More...
OpenTargetsi
ENSG00000143952

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134920394

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9P1Q0, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
VPS54

Domain mapping of disease mutations (DMDM)

More...
DMDMi
82583721

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001487311 – 977Vacuolar protein sorting-associated protein 54Add BLAST977

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei8PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9P1Q0

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9P1Q0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9P1Q0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9P1Q0

PeptideAtlas

More...
PeptideAtlasi
Q9P1Q0

PRoteomics IDEntifications database

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PRIDEi
Q9P1Q0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
83656 [Q9P1Q0-1]
83657 [Q9P1Q0-2]
83658 [Q9P1Q0-3]
83659 [Q9P1Q0-4]
83660 [Q9P1Q0-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9P1Q0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9P1Q0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000143952, Expressed in sperm and 229 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9P1Q0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9P1Q0, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000143952, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of VPS51, VPS52, VPS53 and VPS54 (PubMed:15878329, PubMed:25799061, PubMed:27440922). EIPR1 interacts with GARP complex and mediates its recruitment to the trans-Golgi network (PubMed:27440922).

Interacts with VPS51 in an EIPR1-independent manner (PubMed:31721635).

4 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
119600, 19 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9P1Q0

Database of interacting proteins

More...
DIPi
DIP-61627N

Protein interaction database and analysis system

More...
IntActi
Q9P1Q0, 12 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000272322

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9P1Q0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9P1Q0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili240 – 260Sequence analysisAdd BLAST21
Coiled coili480 – 507Sequence analysisAdd BLAST28
Coiled coili582 – 603Sequence analysisAdd BLAST22

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the VPS54 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2115, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000000583

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005185_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9P1Q0

Identification of Orthologs from Complete Genome Data

More...
OMAi
ANGMEMP

Database of Orthologous Groups

More...
OrthoDBi
449680at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9P1Q0

TreeFam database of animal gene trees

More...
TreeFami
TF313700

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039745, Vps54
IPR012501, Vps54_C
IPR019515, VPS54_N

The PANTHER Classification System

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PANTHERi
PTHR12965, PTHR12965, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07928, Vps54, 1 hit
PF10475, Vps54_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9P1Q0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASSHSSSPV PQGSSSDVFF KIEVDPSKHI RPVPSLPDVC PKEPTGDSHS
60 70 80 90 100
LYVAPSLVTD QHRWTVYHSK VNLPAALNDP RLAKRESDFF TKTWGLDFVD
110 120 130 140 150
TEVIPSFYLP QISKEHFTVY QQEISQREKI HERCKNICPP KDTFERTLLH
160 170 180 190 200
THDKSRTDLE QVPKIFMKPD FALDDSLTFN SVLPWSHFNT AGGKGNRDAA
210 220 230 240 250
SSKLLQEKLS HYLDIVEVNI AHQISLRSEA FFHAMTSQHE LQDYLRKTSQ
260 270 280 290 300
AVKMLRDKIA QIDKVMCEGS LHILRLALTR NNCVKVYNKL KLMATVHQTQ
310 320 330 340 350
PTVQVLLSTS EFVGALDLIA TTQEVLQQEL QGIHSFRHLG SQLCELEKLI
360 370 380 390 400
DKMMIAEFST YSHSDLNRPL EDDCQVLEEE RLISLVFGLL KQRKLNFLEI
410 420 430 440 450
YGEKMVITAK NIIKQCVINK VSQTEEIDTD VVVKLADQMR MLNFPQWFDL
460 470 480 490 500
LKDIFSKFTI FLQRVKATLN IIHSVVLSVL DKNQRTRELE EISQQKNAAK
510 520 530 540 550
DNSLDTEVAY LIHEGMFISD AFGEGELTPI AVDTTSQRNA SPNSEPCSSD
560 570 580 590 600
SVSEPECTTD SSSSKEHTSS SAIPGGVDIM VSEDMKLTDS ELGKLANNIQ
610 620 630 640 650
ELLYSASDIC HDRAVKFLMS RAKDGFLEKL NSMEFITLSR LMETFILDTE
660 670 680 690 700
QICGRKSTSL LGALQSQAIK FVNRFHEERK TKLSLLLDNE RWKQADVPAE
710 720 730 740 750
FQDLVDSLSD GKIALPEKKS GATEERKPAE VLIVEGQQYA VVGTVLLLIR
760 770 780 790 800
IILEYCQCVD NIPSVTTDML TRLSDLLKYF NSRSCQLVLG AGALQVVGLK
810 820 830 840 850
TITTKNLALS SRCLQLIVHY IPVIRAHFEA RLPPKQYSML RHFDHITKDY
860 870 880 890 900
HDHIAEISAK LVAIMDSLFD KLLSKYEVKA PVPSACFRNI CKQMTKMHEA
910 920 930 940 950
IFDLLPEEQT QMLFLRINAS YKLHLKKQLS HLNVINDGGP QNGLVTADVA
960 970
FYTGNLQALK GLKDLDLNMA EIWEQKR
Length:977
Mass (Da):110,589
Last modified:May 10, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3290160E3460C836
GO
Isoform 2 (identifier: Q9P1Q0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     964-977: DLDLNMAEIWEQKR → IWT

Show »
Length:966
Mass (Da):109,246
Checksum:i7FA7C844A6026471
GO
Isoform 3 (identifier: Q9P1Q0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-117: Missing.
     118-126: TVYQQEISQ → MLPTKNRIK
     380-415: Missing.

Show »
Length:824
Mass (Da):93,274
Checksum:i9EF51F039A9AD46A
GO
Isoform 4 (identifier: Q9P1Q0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     46-57: Missing.

Show »
Length:965
Mass (Da):109,362
Checksum:iD91F94CD6CDC72D3
GO
Isoform 5 (identifier: Q9P1Q0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-838: Missing.

Show »
Length:139
Mass (Da):15,982
Checksum:iF6AFBCDA077C7BB4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MT48A0A0A0MT48_HUMAN
Vacuolar protein sorting-associated...
VPS54
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA92134 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti130I → V in AAF37319 (Ref. 1) Curated1
Sequence conflicti526E → K in AAF37319 (Ref. 1) Curated1
Sequence conflicti601E → G in AAF37319 (Ref. 1) Curated1
Sequence conflicti643E → G in AAF37319 (Ref. 1) Curated1
Sequence conflicti650E → A in AAF37319 (Ref. 1) Curated1
Sequence conflicti677 – 679EER → VGG in AAF37319 (Ref. 1) Curated3
Sequence conflicti727K → E in BAA92134 (PubMed:14702039).Curated1
Sequence conflicti844D → G in AAH41868 (PubMed:15489334).Curated1
Sequence conflicti904L → H in AAH41868 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052944561S → C. Corresponds to variant dbSNP:rs34015596EnsemblClinVar.1
Natural variantiVAR_061983912M → I. Corresponds to variant dbSNP:rs11558741Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0137511 – 838Missing in isoform 5. 1 PublicationAdd BLAST838
Alternative sequenceiVSP_0137521 – 117Missing in isoform 3. 1 PublicationAdd BLAST117
Alternative sequenceiVSP_01375346 – 57Missing in isoform 4. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_013754118 – 126TVYQQEISQ → MLPTKNRIK in isoform 3. 1 Publication9
Alternative sequenceiVSP_013755380 – 415Missing in isoform 3. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_013756964 – 977DLDLN…WEQKR → IWT in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF102177 mRNA Translation: AAF37319.1
AY444798 mRNA Translation: AAS20945.1
AL137604 mRNA Translation: CAB70837.1
AL359939 mRNA Translation: CAB95772.1
CR749701 mRNA Translation: CAH18479.1
BC030275 mRNA Translation: AAH30275.1
BC041868 mRNA Translation: AAH41868.1
AK002205 mRNA Translation: BAA92134.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33208.1 [Q9P1Q0-1]
CCDS46302.1 [Q9P1Q0-4]

Protein sequence database of the Protein Information Resource

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PIRi
T46308

NCBI Reference Sequences

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RefSeqi
NP_001005739.1, NM_001005739.1 [Q9P1Q0-4]
NP_057600.2, NM_016516.2 [Q9P1Q0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000272322; ENSP00000272322; ENSG00000143952 [Q9P1Q0-1]
ENST00000354504; ENSP00000346499; ENSG00000143952 [Q9P1Q0-3]
ENST00000409558; ENSP00000386980; ENSG00000143952 [Q9P1Q0-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
51542

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51542

UCSC genome browser

More...
UCSCi
uc002scp.4, human [Q9P1Q0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102177 mRNA Translation: AAF37319.1
AY444798 mRNA Translation: AAS20945.1
AL137604 mRNA Translation: CAB70837.1
AL359939 mRNA Translation: CAB95772.1
CR749701 mRNA Translation: CAH18479.1
BC030275 mRNA Translation: AAH30275.1
BC041868 mRNA Translation: AAH41868.1
AK002205 mRNA Translation: BAA92134.1 Different initiation.
CCDSiCCDS33208.1 [Q9P1Q0-1]
CCDS46302.1 [Q9P1Q0-4]
PIRiT46308
RefSeqiNP_001005739.1, NM_001005739.1 [Q9P1Q0-4]
NP_057600.2, NM_016516.2 [Q9P1Q0-1]

3D structure databases

SMRiQ9P1Q0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi119600, 19 interactors
CORUMiQ9P1Q0
DIPiDIP-61627N
IntActiQ9P1Q0, 12 interactors
STRINGi9606.ENSP00000272322

PTM databases

iPTMnetiQ9P1Q0
PhosphoSitePlusiQ9P1Q0

Polymorphism and mutation databases

BioMutaiVPS54
DMDMi82583721

Proteomic databases

jPOSTiQ9P1Q0
MassIVEiQ9P1Q0
MaxQBiQ9P1Q0
PaxDbiQ9P1Q0
PeptideAtlasiQ9P1Q0
PRIDEiQ9P1Q0
ProteomicsDBi83656 [Q9P1Q0-1]
83657 [Q9P1Q0-2]
83658 [Q9P1Q0-3]
83659 [Q9P1Q0-4]
83660 [Q9P1Q0-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
30808, 140 antibodies

The DNASU plasmid repository

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DNASUi
51542

Genome annotation databases

EnsembliENST00000272322; ENSP00000272322; ENSG00000143952 [Q9P1Q0-1]
ENST00000354504; ENSP00000346499; ENSG00000143952 [Q9P1Q0-3]
ENST00000409558; ENSP00000386980; ENSG00000143952 [Q9P1Q0-4]
GeneIDi51542
KEGGihsa:51542
UCSCiuc002scp.4, human [Q9P1Q0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51542
DisGeNETi51542
EuPathDBiHostDB:ENSG00000143952.19

GeneCards: human genes, protein and diseases

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GeneCardsi
VPS54
HGNCiHGNC:18652, VPS54
HPAiENSG00000143952, Low tissue specificity
MIMi614633, gene
neXtProtiNX_Q9P1Q0
OpenTargetsiENSG00000143952
PharmGKBiPA134920394

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2115, Eukaryota
GeneTreeiENSGT00390000000583
HOGENOMiCLU_005185_1_0_1
InParanoidiQ9P1Q0
OMAiANGMEMP
OrthoDBi449680at2759
PhylomeDBiQ9P1Q0
TreeFamiTF313700

Enzyme and pathway databases

PathwayCommonsiQ9P1Q0
ReactomeiR-HSA-6811440, Retrograde transport at the Trans-Golgi-Network

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
51542, 219 hits in 861 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
VPS54, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51542
PharosiQ9P1Q0, Tbio

Protein Ontology

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PROi
PR:Q9P1Q0
RNActiQ9P1Q0, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000143952, Expressed in sperm and 229 other tissues
ExpressionAtlasiQ9P1Q0, baseline and differential
GenevisibleiQ9P1Q0, HS

Family and domain databases

InterProiView protein in InterPro
IPR039745, Vps54
IPR012501, Vps54_C
IPR019515, VPS54_N
PANTHERiPTHR12965, PTHR12965, 1 hit
PfamiView protein in Pfam
PF07928, Vps54, 1 hit
PF10475, Vps54_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVPS54_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P1Q0
Secondary accession number(s): Q5VIR5
, Q86YF7, Q8N6G3, Q9NPV0, Q9NT07, Q9NUJ0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 10, 2005
Last modified: December 2, 2020
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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