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Protein

Disks large-associated protein 2

Gene

DLGAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.

GO - Molecular functioni

GO - Biological processi

  • neuron-neuron synaptic transmission Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-HSA-6794361 Neurexins and neuroligins

Names & Taxonomyi

Protein namesi
Recommended name:
Disks large-associated protein 2Curated
Short name:
DAP-2
Alternative name(s):
PSD-95/SAP90-binding protein 2
SAP90/PSD-95-associated protein 2
Short name:
SAPAP2
Gene namesi
Name:DLGAP2Imported
Synonyms:C8orf68Imported, DAP2, ERICH1-AS1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000198010.11
HGNCiHGNC:2906 DLGAP2
MIMi605438 gene
neXtProtiNX_Q9P1A6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi9228
OpenTargetsiENSG00000198010
PharmGKBiPA27362

Polymorphism and mutation databases

DMDMi160395585

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001742911 – 1054Disks large-associated protein 2Add BLAST1054

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei298PhosphoserineBy similarity1
Modified residuei304PhosphoserineBy similarity1
Modified residuei386PhosphoserineBy similarity1
Modified residuei452PhosphoserineBy similarity1
Modified residuei662PhosphoserineBy similarity1
Modified residuei665PhosphoserineBy similarity1
Modified residuei668PhosphoserineBy similarity1
Modified residuei715PhosphoserineBy similarity1
Modified residuei738PhosphothreonineBy similarity1
Modified residuei740PhosphoserineBy similarity1
Modified residuei771PhosphoserineBy similarity1
Modified residuei806PhosphoserineBy similarity1
Modified residuei978PhosphoserineBy similarity1
Modified residuei1007PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9P1A6
PaxDbiQ9P1A6
PeptideAtlasiQ9P1A6
PRIDEiQ9P1A6
ProteomicsDBi83641
83642 [Q9P1A6-2]
83643 [Q9P1A6-3]

PTM databases

iPTMnetiQ9P1A6
PhosphoSitePlusiQ9P1A6

Expressioni

Tissue specificityi

Expressed in brain and kidney.

Gene expression databases

BgeeiENSG00000198010 Expressed in 77 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_DLGAP2
ExpressionAtlasiQ9P1A6 baseline and differential
GenevisibleiQ9P1A6 HS

Organism-specific databases

HPAiHPA030320

Interactioni

Subunit structurei

Interacts with DLG1 and DLG4/PSD-95.By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114659, 17 interactors
IntActiQ9P1A6, 15 interactors
STRINGi9606.ENSP00000400258

Structurei

3D structure databases

ProteinModelPortaliQ9P1A6
SMRiQ9P1A6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAPAP family.Curated

Phylogenomic databases

eggNOGiKOG3971 Eukaryota
ENOG4111JKV LUCA
GeneTreeiENSGT00550000074473
HOGENOMiHOG000015346
HOVERGENiHBG018957
InParanoidiQ9P1A6
PhylomeDBiQ9P1A6
TreeFamiTF321382

Family and domain databases

InterProiView protein in InterPro
IPR030525 DLGAP2
IPR005026 SAPAP
PANTHERiPTHR12353:SF3 PTHR12353:SF3, 1 hit
PfamiView protein in Pfam
PF03359 GKAP, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9P1A6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGTAQVLPGI LQKHCCILPD RNTESQCTLC GEPEEEEAGD LVQPGISFPG
60 70 80 90 100
PAEEDLDPQY SWSPTQHFNE ERYSPAPRSM KGLSGSRTQP PLCSGHTCGL
110 120 130 140 150
APPEDCEHLH HGPDARPPYL LSPADSCPGG RHRCSPRSSV HSECVMMPVV
160 170 180 190 200
LGDHVSSSTF PRMHYSSHYD TRDDCAVAHA GAKINRIPAN LLDQFEKQLP
210 220 230 240 250
LHRDGFHTLQ YQRTSAAAEQ RSESPGRIRH LVHSVQKLFT KSHSLEGSSK
260 270 280 290 300
SNANGTKADG RADDHHHAHH AKHSKRSKSK ERKPEGKPRP GMSSWWSSDD
310 320 330 340 350
NLDSDSTYRT PSVLNRHHLG PVAHCYPDAL QSPFGDLSLK TSKSNNDVKC
360 370 380 390 400
SACEGLALTP DAKYLKRSSW STLTVSQAKE AYRKSSLNLD KPLLHQDAKP
410 420 430 440 450
ALRPCHYLQV PQDEWGGYPT GGKDEEIPCR RMRSGSYIKA MGDEESGESD
460 470 480 490 500
SSPKTSPKSA ILPEPLLKSI GQRPLGEHQT QTYLQAASDV PVGHSLDPAA
510 520 530 540 550
NYNSPKFRSR NQSYMRAVST LSQASCVSQV SEAEINGQFE SVCESVFSEV
560 570 580 590 600
ESQAMDALDL PGCFRTRSHS YLRAIQAGYS QDDECIPMMT PSDITSTIRS
610 620 630 640 650
TAAVSYTNYK KTPPPVPPRT TSKPLISVTA QSSTESTQDA YQDSRAQRMS
660 670 680 690 700
PWPQDSRGLY NSTDSLDSNK AMNLALETAA AQRHLPESQS SSVRTSDKAI
710 720 730 740 750
LVSKAEELLK SRCSSIGIQD SEFPEHQPYP RSDVETATDS DTESRGLREY
760 770 780 790 800
HSVGVQVEDE KRHGRFKRSN SVTAAVQADL ELEGFPGHIT TEDKGLQFGS
810 820 830 840 850
SFQRHSEPST PTQYSAVRTV RTQGLFSYRE DYRTQVDTST LPPPDPWLEP
860 870 880 890 900
AIDTVETGRM SPCRRDGSWF LKLLHAETKR MEGWCKEMER EAEENDLSEE
910 920 930 940 950
ILGKIRSAVG SAQLLMSQKF QQFYWLCQQN MDPSAMPRPT SQDLAGYWDM
960 970 980 990 1000
LQLSIEDVSM KFDELQRLRL NDWKMMESPE RKEERKVPPP IPKKPPKGKF
1010 1020 1030 1040 1050
PITREKSLDL PDRQRQEARR RLMAAKRAAS FRQNSASERA DSIEIYIPEA

QTRL
Length:1,054
Mass (Da):117,620
Last modified:October 23, 2007 - v4
Checksum:iC03A1240B32442AA
GO
Isoform 2 (identifier: Q9P1A6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     720-733: Missing.

Show »
Length:1,040
Mass (Da):115,934
Checksum:iB7D05C8A6A3FBCEE
GO
Isoform 3 (identifier: Q9P1A6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.

Show »
Length:975
Mass (Da):108,908
Checksum:i1E65227B3E3FA7DC
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YBY6H0YBY6_HUMAN
Disks large-associated protein 2
DLGAP2
978Annotation score:
A0A1B0GTN4A0A1B0GTN4_HUMAN
Disks large-associated protein 2
DLGAP2
1,055Annotation score:
A0A1B0GXK6A0A1B0GXK6_HUMAN
Disks large-associated protein 2
DLGAP2
961Annotation score:
A0A0J9YY16A0A0J9YY16_HUMAN
Disks large-associated protein 2
DLGAP2
176Annotation score:
A0A0J9YWL8A0A0J9YWL8_HUMAN
Disks large-associated protein 2
DLGAP2
158Annotation score:
A0A0G2JLW6A0A0G2JLW6_HUMAN
Disks large-associated protein 2
DLGAP2
975Annotation score:
A0A0J9YX70A0A0J9YX70_HUMAN
Disks large-associated protein 2
DLGAP2
561Annotation score:
A0A0J9YY63A0A0J9YY63_HUMAN
Disks large-associated protein 2
DLGAP2
575Annotation score:
A0A0G2JPE0A0A0G2JPE0_HUMAN
Disks large-associated protein 2
DLGAP2
961Annotation score:
A0A0J9YVY4A0A0J9YVY4_HUMAN
Disks large-associated protein 2
DLGAP2
400Annotation score:

Sequence cautioni

The sequence EAW51475 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti463P → Q in EAW51474 (Ref. 3) Curated1
Sequence conflicti463P → Q in EAW51475 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023073419P → Q. Corresponds to variant dbSNP:rs2301963Ensembl.1
Natural variantiVAR_036750620T → M. Corresponds to variant dbSNP:rs7463888Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0060111 – 79Missing in isoform 3. 3 PublicationsAdd BLAST79
Alternative sequenceiVSP_006012720 – 733Missing in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF119817 mRNA Translation: AAF34344.1
AF119818 mRNA Translation: AAF34345.1
AF009204 mRNA Translation: AAB71661.1
AC100797 Genomic DNA No translation available.
AC026950 Genomic DNA No translation available.
AC110288 Genomic DNA No translation available.
CH471181 Genomic DNA Translation: EAW51474.1
CH471181 Genomic DNA Translation: EAW51475.1 Sequence problems.
BC141862 mRNA Translation: AAI41863.1
AB000275 mRNA Translation: BAA23256.1
PIRiT03306
RefSeqiNP_004736.2, NM_004745.4
UniGeneiHs.113287
Hs.667939
Hs.722154

Genome annotation databases

EnsembliENST00000421627; ENSP00000400258; ENSG00000198010 [Q9P1A6-1]
UCSCiuc003wpl.4 human [Q9P1A6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF119817 mRNA Translation: AAF34344.1
AF119818 mRNA Translation: AAF34345.1
AF009204 mRNA Translation: AAB71661.1
AC100797 Genomic DNA No translation available.
AC026950 Genomic DNA No translation available.
AC110288 Genomic DNA No translation available.
CH471181 Genomic DNA Translation: EAW51474.1
CH471181 Genomic DNA Translation: EAW51475.1 Sequence problems.
BC141862 mRNA Translation: AAI41863.1
AB000275 mRNA Translation: BAA23256.1
PIRiT03306
RefSeqiNP_004736.2, NM_004745.4
UniGeneiHs.113287
Hs.667939
Hs.722154

3D structure databases

ProteinModelPortaliQ9P1A6
SMRiQ9P1A6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114659, 17 interactors
IntActiQ9P1A6, 15 interactors
STRINGi9606.ENSP00000400258

PTM databases

iPTMnetiQ9P1A6
PhosphoSitePlusiQ9P1A6

Polymorphism and mutation databases

DMDMi160395585

Proteomic databases

MaxQBiQ9P1A6
PaxDbiQ9P1A6
PeptideAtlasiQ9P1A6
PRIDEiQ9P1A6
ProteomicsDBi83641
83642 [Q9P1A6-2]
83643 [Q9P1A6-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000421627; ENSP00000400258; ENSG00000198010 [Q9P1A6-1]
UCSCiuc003wpl.4 human [Q9P1A6-1]

Organism-specific databases

DisGeNETi9228
EuPathDBiHostDB:ENSG00000198010.11
GeneCardsiDLGAP2
H-InvDBiHIX0021309
HIX0034229
HGNCiHGNC:2906 DLGAP2
HPAiHPA030320
MIMi605438 gene
neXtProtiNX_Q9P1A6
OpenTargetsiENSG00000198010
PharmGKBiPA27362
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3971 Eukaryota
ENOG4111JKV LUCA
GeneTreeiENSGT00550000074473
HOGENOMiHOG000015346
HOVERGENiHBG018957
InParanoidiQ9P1A6
PhylomeDBiQ9P1A6
TreeFamiTF321382

Enzyme and pathway databases

ReactomeiR-HSA-6794361 Neurexins and neuroligins

Miscellaneous databases

ChiTaRSiDLGAP2 human
GeneWikiiDLGAP2
GenomeRNAii9228
PROiPR:Q9P1A6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198010 Expressed in 77 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_DLGAP2
ExpressionAtlasiQ9P1A6 baseline and differential
GenevisibleiQ9P1A6 HS

Family and domain databases

InterProiView protein in InterPro
IPR030525 DLGAP2
IPR005026 SAPAP
PANTHERiPTHR12353:SF3 PTHR12353:SF3, 1 hit
PfamiView protein in Pfam
PF03359 GKAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDLGP2_HUMAN
AccessioniPrimary (citable) accession number: Q9P1A6
Secondary accession number(s): A1QCF8
, A1QCF9, A5D8Y2, O14488, O14664, Q9P1A7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 23, 2007
Last modified: September 12, 2018
This is version 137 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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