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Entry version 153 (07 Oct 2020)
Sequence version 4 (23 Oct 2007)
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Protein

Disks large-associated protein 2

Gene

DLGAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9P1A6

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6794361, Neurexins and neuroligins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Disks large-associated protein 2Curated
Short name:
DAP-2
Alternative name(s):
PSD-95/SAP90-binding protein 2
SAP90/PSD-95-associated protein 2
Short name:
SAPAP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DLGAP2Imported
Synonyms:C8orf68Imported, DAP2, ERICH1-AS1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000198010.11

Human Gene Nomenclature Database

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HGNCi
HGNC:2906, DLGAP2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605438, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9P1A6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000198010

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27362

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9P1A6, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DLGAP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
160395585

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001742911 – 1054Disks large-associated protein 2Add BLAST1054

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei298PhosphoserineBy similarity1
Modified residuei304PhosphoserineBy similarity1
Modified residuei386PhosphoserineBy similarity1
Modified residuei452PhosphoserineBy similarity1
Modified residuei662PhosphoserineBy similarity1
Modified residuei665PhosphoserineBy similarity1
Modified residuei668PhosphoserineBy similarity1
Modified residuei715PhosphoserineBy similarity1
Modified residuei738PhosphothreonineBy similarity1
Modified residuei740PhosphoserineBy similarity1
Modified residuei771PhosphoserineBy similarity1
Modified residuei806PhosphoserineBy similarity1
Modified residuei978PhosphoserineBy similarity1
Modified residuei1007PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9P1A6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9P1A6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9P1A6

PeptideAtlas

More...
PeptideAtlasi
Q9P1A6

PRoteomics IDEntifications database

More...
PRIDEi
Q9P1A6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
83641 [Q9P1A6-1]
83642 [Q9P1A6-2]
83643 [Q9P1A6-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9P1A6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9P1A6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain and kidney.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198010, Expressed in middle temporal gyrus and 98 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9P1A6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9P1A6, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000198010, Group enriched (brain, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DLG1 and DLG4/PSD-95.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
114659, 22 interactors

Protein interaction database and analysis system

More...
IntActi
Q9P1A6, 19 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000400258

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9P1A6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9P1A6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SAPAP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3971, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000157913

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9P1A6

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9P1A6

TreeFam database of animal gene trees

More...
TreeFami
TF321382

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR030525, DLGAP2
IPR005026, SAPAP

The PANTHER Classification System

More...
PANTHERi
PTHR12353, PTHR12353, 1 hit
PTHR12353:SF3, PTHR12353:SF3, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF03359, GKAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9P1A6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGTAQVLPGI LQKHCCILPD RNTESQCTLC GEPEEEEAGD LVQPGISFPG
60 70 80 90 100
PAEEDLDPQY SWSPTQHFNE ERYSPAPRSM KGLSGSRTQP PLCSGHTCGL
110 120 130 140 150
APPEDCEHLH HGPDARPPYL LSPADSCPGG RHRCSPRSSV HSECVMMPVV
160 170 180 190 200
LGDHVSSSTF PRMHYSSHYD TRDDCAVAHA GAKINRIPAN LLDQFEKQLP
210 220 230 240 250
LHRDGFHTLQ YQRTSAAAEQ RSESPGRIRH LVHSVQKLFT KSHSLEGSSK
260 270 280 290 300
SNANGTKADG RADDHHHAHH AKHSKRSKSK ERKPEGKPRP GMSSWWSSDD
310 320 330 340 350
NLDSDSTYRT PSVLNRHHLG PVAHCYPDAL QSPFGDLSLK TSKSNNDVKC
360 370 380 390 400
SACEGLALTP DAKYLKRSSW STLTVSQAKE AYRKSSLNLD KPLLHQDAKP
410 420 430 440 450
ALRPCHYLQV PQDEWGGYPT GGKDEEIPCR RMRSGSYIKA MGDEESGESD
460 470 480 490 500
SSPKTSPKSA ILPEPLLKSI GQRPLGEHQT QTYLQAASDV PVGHSLDPAA
510 520 530 540 550
NYNSPKFRSR NQSYMRAVST LSQASCVSQV SEAEINGQFE SVCESVFSEV
560 570 580 590 600
ESQAMDALDL PGCFRTRSHS YLRAIQAGYS QDDECIPMMT PSDITSTIRS
610 620 630 640 650
TAAVSYTNYK KTPPPVPPRT TSKPLISVTA QSSTESTQDA YQDSRAQRMS
660 670 680 690 700
PWPQDSRGLY NSTDSLDSNK AMNLALETAA AQRHLPESQS SSVRTSDKAI
710 720 730 740 750
LVSKAEELLK SRCSSIGIQD SEFPEHQPYP RSDVETATDS DTESRGLREY
760 770 780 790 800
HSVGVQVEDE KRHGRFKRSN SVTAAVQADL ELEGFPGHIT TEDKGLQFGS
810 820 830 840 850
SFQRHSEPST PTQYSAVRTV RTQGLFSYRE DYRTQVDTST LPPPDPWLEP
860 870 880 890 900
AIDTVETGRM SPCRRDGSWF LKLLHAETKR MEGWCKEMER EAEENDLSEE
910 920 930 940 950
ILGKIRSAVG SAQLLMSQKF QQFYWLCQQN MDPSAMPRPT SQDLAGYWDM
960 970 980 990 1000
LQLSIEDVSM KFDELQRLRL NDWKMMESPE RKEERKVPPP IPKKPPKGKF
1010 1020 1030 1040 1050
PITREKSLDL PDRQRQEARR RLMAAKRAAS FRQNSASERA DSIEIYIPEA

QTRL
Length:1,054
Mass (Da):117,620
Last modified:October 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC03A1240B32442AA
GO
Isoform 2 (identifier: Q9P1A6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     720-733: Missing.

Show »
Length:1,040
Mass (Da):115,934
Checksum:iB7D05C8A6A3FBCEE
GO
Isoform 3 (identifier: Q9P1A6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.

Show »
Length:975
Mass (Da):108,908
Checksum:i1E65227B3E3FA7DC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GTN4A0A1B0GTN4_HUMAN
Disks large-associated protein 2
DLGAP2
1,055Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBY6H0YBY6_HUMAN
Disks large-associated protein 2
DLGAP2
978Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GXK6A0A1B0GXK6_HUMAN
Disks large-associated protein 2
DLGAP2
961Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YY16A0A0J9YY16_HUMAN
Disks large-associated protein 2
DLGAP2
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JLW6A0A0G2JLW6_HUMAN
Disks large-associated protein 2
DLGAP2
975Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YX70A0A0J9YX70_HUMAN
Disks large-associated protein 2
DLGAP2
561Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YY63A0A0J9YY63_HUMAN
Disks large-associated protein 2
DLGAP2
575Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JPE0A0A0G2JPE0_HUMAN
Disks large-associated protein 2
DLGAP2
961Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YVY4A0A0J9YVY4_HUMAN
Disks large-associated protein 2
DLGAP2
400Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YWL8A0A0J9YWL8_HUMAN
Disks large-associated protein 2
DLGAP2
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence EAW51475 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti463P → Q in EAW51474 (Ref. 3) Curated1
Sequence conflicti463P → Q in EAW51475 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_023073419P → Q. Corresponds to variant dbSNP:rs2301963Ensembl.1
Natural variantiVAR_036750620T → M. Corresponds to variant dbSNP:rs7463888Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0060111 – 79Missing in isoform 3. 3 PublicationsAdd BLAST79
Alternative sequenceiVSP_006012720 – 733Missing in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF119817 mRNA Translation: AAF34344.1
AF119818 mRNA Translation: AAF34345.1
AF009204 mRNA Translation: AAB71661.1
AC100797 Genomic DNA No translation available.
AC026950 Genomic DNA No translation available.
AC110288 Genomic DNA No translation available.
CH471181 Genomic DNA Translation: EAW51474.1
CH471181 Genomic DNA Translation: EAW51475.1 Sequence problems.
BC141862 mRNA Translation: AAI41863.1
AB000275 mRNA Translation: BAA23256.1

Protein sequence database of the Protein Information Resource

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PIRi
T03306

NCBI Reference Sequences

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RefSeqi
NP_004736.2, NM_004745.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000421627; ENSP00000400258; ENSG00000198010 [Q9P1A6-1]

UCSC genome browser

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UCSCi
uc003wpl.4, human [Q9P1A6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF119817 mRNA Translation: AAF34344.1
AF119818 mRNA Translation: AAF34345.1
AF009204 mRNA Translation: AAB71661.1
AC100797 Genomic DNA No translation available.
AC026950 Genomic DNA No translation available.
AC110288 Genomic DNA No translation available.
CH471181 Genomic DNA Translation: EAW51474.1
CH471181 Genomic DNA Translation: EAW51475.1 Sequence problems.
BC141862 mRNA Translation: AAI41863.1
AB000275 mRNA Translation: BAA23256.1
PIRiT03306
RefSeqiNP_004736.2, NM_004745.4

3D structure databases

SMRiQ9P1A6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi114659, 22 interactors
IntActiQ9P1A6, 19 interactors
STRINGi9606.ENSP00000400258

PTM databases

iPTMnetiQ9P1A6
PhosphoSitePlusiQ9P1A6

Polymorphism and mutation databases

BioMutaiDLGAP2
DMDMi160395585

Proteomic databases

MassIVEiQ9P1A6
MaxQBiQ9P1A6
PaxDbiQ9P1A6
PeptideAtlasiQ9P1A6
PRIDEiQ9P1A6
ProteomicsDBi83641 [Q9P1A6-1]
83642 [Q9P1A6-2]
83643 [Q9P1A6-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
21955, 82 antibodies

Genome annotation databases

EnsembliENST00000421627; ENSP00000400258; ENSG00000198010 [Q9P1A6-1]
UCSCiuc003wpl.4, human [Q9P1A6-1]

Organism-specific databases

EuPathDBiHostDB:ENSG00000198010.11

GeneCards: human genes, protein and diseases

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GeneCardsi
DLGAP2
HGNCiHGNC:2906, DLGAP2
HPAiENSG00000198010, Group enriched (brain, testis)
MIMi605438, gene
neXtProtiNX_Q9P1A6
OpenTargetsiENSG00000198010
PharmGKBiPA27362

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3971, Eukaryota
GeneTreeiENSGT00940000157913
InParanoidiQ9P1A6
PhylomeDBiQ9P1A6
TreeFamiTF321382

Enzyme and pathway databases

PathwayCommonsiQ9P1A6
ReactomeiR-HSA-6794361, Neurexins and neuroligins

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
9228, 2 hits in 866 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
DLGAP2, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
DLGAP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9228
PharosiQ9P1A6, Tbio

Protein Ontology

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PROi
PR:Q9P1A6
RNActiQ9P1A6, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000198010, Expressed in middle temporal gyrus and 98 other tissues
ExpressionAtlasiQ9P1A6, baseline and differential
GenevisibleiQ9P1A6, HS

Family and domain databases

InterProiView protein in InterPro
IPR030525, DLGAP2
IPR005026, SAPAP
PANTHERiPTHR12353, PTHR12353, 1 hit
PTHR12353:SF3, PTHR12353:SF3, 1 hit
PfamiView protein in Pfam
PF03359, GKAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDLGP2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P1A6
Secondary accession number(s): A1QCF8
, A1QCF9, A5D8Y2, O14488, O14664, Q9P1A7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 23, 2007
Last modified: October 7, 2020
This is version 153 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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