UniProtKB - Q9P127 (LUZP4_HUMAN)
Protein
Leucine zipper protein 4
Gene
LUZP4
Organism
Homo sapiens (Human)
Status
Functioni
Export adapter involved in mRNA nuclear export in cancer cells. Binds and enhances the RNA-binding activity of the nuclear RNA export factor NXF1. Can restore mRNA export function in cells compromised by loss of mRNA export adapters (PubMed:25662211).1 Publication
GO - Molecular functioni
- RNA binding Source: UniProtKB-KW
GO - Biological processi
- mRNA transport Source: UniProtKB-KW
Keywordsi
Molecular function | RNA-binding |
Biological process | mRNA transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q9P127 |
Reactomei | R-HSA-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72187, mRNA 3'-end processing R-HSA-73856, RNA Polymerase II Transcription Termination |
Names & Taxonomyi
Protein namesi | Recommended name: Leucine zipper protein 4Alternative name(s): Cancer/testis antigen 28 Short name: CT-28 Short name: CT28 Tumor antigen HOM-TES-85 |
Gene namesi | Name:LUZP4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000102021.10 |
HGNCi | HGNC:24971, LUZP4 |
MIMi | 300616, gene |
neXtProti | NX_Q9P127 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 51213 |
OpenTargetsi | ENSG00000102021 |
PharmGKBi | PA134920076 |
Miscellaneous databases
Pharosi | Q9P127, Tbio |
Polymorphism and mutation databases
BioMutai | LUZP4 |
DMDMi | 74753106 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000288649 | 1 – 313 | Leucine zipper protein 4Add BLAST | 313 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 234 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MassIVEi | Q9P127 |
PaxDbi | Q9P127 |
PeptideAtlasi | Q9P127 |
PRIDEi | Q9P127 |
ProteomicsDBi | 3632 83637 [Q9P127-1] |
PTM databases
iPTMneti | Q9P127 |
PhosphoSitePlusi | Q9P127 |
Expressioni
Tissue specificityi
Expressed specifically in testis. Also expressed in a wide variety of cancer types, but particularly high levels of expression observed in melanoma cells.2 Publications
Gene expression databases
Bgeei | ENSG00000102021, Expressed in testis and 8 other tissues |
ExpressionAtlasi | Q9P127, baseline and differential |
Genevisiblei | Q9P127, HS |
Organism-specific databases
HPAi | ENSG00000102021, Tissue enriched (testis) |
Interactioni
Subunit structurei
Interacts NXF1, NXF2, THOC1, THOC5, DDX39B/UAP56 and SRRT.
1 PublicationBinary interactionsi
Hide detailsQ9P127
Protein-protein interaction databases
BioGRIDi | 119383, 99 interactors |
IntActi | Q9P127, 20 interactors |
STRINGi | 9606.ENSP00000360988 |
Miscellaneous databases
RNActi | Q9P127, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 119 | Interaction with DDX39B/UAP561 PublicationAdd BLAST | 119 | |
Regioni | 51 – 80 | Arg-rich; required for RNA-binding1 PublicationAdd BLAST | 30 | |
Regioni | 178 – 236 | RS-containing His-rich (RS-H); necessary for nuclear localization1 PublicationAdd BLAST | 59 | |
Regioni | 238 – 287 | Leucine-zipper; required for RNA-binding and for its relocalization to the cytoplasm during cell division1 PublicationAdd BLAST | 50 | |
Regioni | 241 – 313 | Interaction with NXF11 PublicationAdd BLAST | 73 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 22 – 40 | UAP56-binding motif (UBM); required for proper nuclear localization1 PublicationAdd BLAST | 19 |
Phylogenomic databases
eggNOGi | ENOG502STD9, Eukaryota |
GeneTreei | ENSGT00950000183340 |
HOGENOMi | CLU_082916_0_0_1 |
InParanoidi | Q9P127 |
OMAi | HRQSERS |
OrthoDBi | 1408618at2759 |
PhylomeDBi | Q9P127 |
TreeFami | TF350091 |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9P127-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASFRKLTLS EKVPPNHPSR KKVNFLDMSL DDIIIYKELE GTNAEEEKNK
60 70 80 90 100
RQNHSKKESP SRQQSKAHRH RHRRGYSRCR SNSEEGNHDK KPSQKPSGFK
110 120 130 140 150
SGQHPLNGQP LIEQEKCSDN YEAQAEKNQG QSEGNQHQSE GNPDKSEESQ
160 170 180 190 200
GQPEENHHSE RSRNHLERSL SQSDRSQGQL KRHHPQYERS HGQYKRSHGQ
210 220 230 240 250
SERSHGHSER SHGHSERSHG HSERSHGHSK RSRSQGDLVD TQSDLIATQR
260 270 280 290 300
DLIATQKDLI ATQRDLIATQ RDLIVTQRDL VATERDLINQ SGRSHGQSER
310
HQRYSTGKNT ITT
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ5JX98 | Q5JX98_HUMAN | Leucine zipper protein 4 | LUZP4 RP1-237H22.1-002 | 78 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051146 | 14 | P → S. Corresponds to variant dbSNP:rs10482480Ensembl. | 1 | |
Natural variantiVAR_051147 | 306 | T → A. Corresponds to variant dbSNP:rs35314601Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_053926 | 1 – 32 | MASFR…MSLDD → MLKKKRIKDRTIVKRNRLQD SNQKLIDIAIGE in isoform 2. 1 PublicationAdd BLAST | 32 | |
Alternative sequenceiVSP_053927 | 33 – 114 | Missing in isoform 2. 1 PublicationAdd BLAST | 82 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF124430 mRNA Translation: AAF28870.1 AK093369 mRNA Translation: BAG52698.1 AL109751 Genomic DNA Translation: CAC09922.1 BC128134 mRNA Translation: AAI28135.1 |
CCDSi | CCDS14567.1 [Q9P127-1] |
RefSeqi | NP_001305769.1, NM_001318840.1 [Q9P127-2] NP_057467.1, NM_016383.4 [Q9P127-1] |
Genome annotation databases
Ensembli | ENST00000371920; ENSP00000360988; ENSG00000102021 [Q9P127-1] |
GeneIDi | 51213 |
KEGGi | hsa:51213 |
UCSCi | uc004eqa.4, human [Q9P127-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF124430 mRNA Translation: AAF28870.1 AK093369 mRNA Translation: BAG52698.1 AL109751 Genomic DNA Translation: CAC09922.1 BC128134 mRNA Translation: AAI28135.1 |
CCDSi | CCDS14567.1 [Q9P127-1] |
RefSeqi | NP_001305769.1, NM_001318840.1 [Q9P127-2] NP_057467.1, NM_016383.4 [Q9P127-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 119383, 99 interactors |
IntActi | Q9P127, 20 interactors |
STRINGi | 9606.ENSP00000360988 |
PTM databases
iPTMneti | Q9P127 |
PhosphoSitePlusi | Q9P127 |
Polymorphism and mutation databases
BioMutai | LUZP4 |
DMDMi | 74753106 |
Proteomic databases
MassIVEi | Q9P127 |
PaxDbi | Q9P127 |
PeptideAtlasi | Q9P127 |
PRIDEi | Q9P127 |
ProteomicsDBi | 3632 83637 [Q9P127-1] |
Protocols and materials databases
Antibodypediai | 52074, 140 antibodies |
Genome annotation databases
Ensembli | ENST00000371920; ENSP00000360988; ENSG00000102021 [Q9P127-1] |
GeneIDi | 51213 |
KEGGi | hsa:51213 |
UCSCi | uc004eqa.4, human [Q9P127-1] |
Organism-specific databases
CTDi | 51213 |
DisGeNETi | 51213 |
EuPathDBi | HostDB:ENSG00000102021.10 |
GeneCardsi | LUZP4 |
HGNCi | HGNC:24971, LUZP4 |
HPAi | ENSG00000102021, Tissue enriched (testis) |
MIMi | 300616, gene |
neXtProti | NX_Q9P127 |
OpenTargetsi | ENSG00000102021 |
PharmGKBi | PA134920076 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502STD9, Eukaryota |
GeneTreei | ENSGT00950000183340 |
HOGENOMi | CLU_082916_0_0_1 |
InParanoidi | Q9P127 |
OMAi | HRQSERS |
OrthoDBi | 1408618at2759 |
PhylomeDBi | Q9P127 |
TreeFami | TF350091 |
Enzyme and pathway databases
PathwayCommonsi | Q9P127 |
Reactomei | R-HSA-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72187, mRNA 3'-end processing R-HSA-73856, RNA Polymerase II Transcription Termination |
Miscellaneous databases
BioGRID-ORCSi | 51213, 4 hits in 472 CRISPR screens |
GenomeRNAii | 51213 |
Pharosi | Q9P127, Tbio |
PROi | PR:Q9P127 |
RNActi | Q9P127, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000102021, Expressed in testis and 8 other tissues |
ExpressionAtlasi | Q9P127, baseline and differential |
Genevisiblei | Q9P127, HS |
Family and domain databases
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LUZP4_HUMAN | |
Accessioni | Q9P127Primary (citable) accession number: Q9P127 Secondary accession number(s): B3KSD6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 29, 2007 |
Last sequence update: | October 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 117 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations