UniProtKB - Q9P126 (CLC1B_HUMAN)
C-type lectin domain family 1 member B
CLEC1B
Functioni
GO - Molecular functioni
- carbohydrate binding Source: UniProtKB-KW
- transmembrane signaling receptor activity Source: UniProtKB
GO - Biological processi
- cell surface receptor signaling pathway Source: ProtInc
- defense response Source: ProtInc
- platelet activation Source: Reactome
- platelet formation Source: Ensembl
- signal transduction by protein phosphorylation Source: UniProtKB
- viral process Source: UniProtKB-KW
Keywordsi
Molecular function | Receptor |
Biological process | Host-virus interaction |
Ligand | Lectin |
Enzyme and pathway databases
PathwayCommonsi | Q9P126 |
Reactomei | R-HSA-114604, GPVI-mediated activation cascade |
Names & Taxonomyi
Protein namesi | Recommended name: C-type lectin domain family 1 member BAlternative name(s): C-type lectin-like receptor 2 Short name: CLEC-2 |
Gene namesi | Name:CLEC1B Synonyms:CLEC2 ORF Names:UNQ721/PRO1384 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000165682.14 |
HGNCi | HGNC:24356, CLEC1B |
MIMi | 606783, gene |
neXtProti | NX_Q9P126 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type II membrane protein Curated
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 33 | CytoplasmicSequence analysisAdd BLAST | 33 | |
Transmembranei | 34 – 54 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 55 – 229 | ExtracellularSequence analysisAdd BLAST | 175 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 7 | Y → F: Loss of activation upon podoplanin or rhodocytin stimulation. 1 Publication | 1 | |
Mutagenesisi | 150 | K → A: Substantial reduction in rhodocytin binding. 1 Publication | 1 | |
Mutagenesisi | 171 | K → A: Significant reduction in rhodocytin binding. 1 Publication | 1 | |
Mutagenesisi | 184 | E → A: Significant reduction in rhodocytin binding. 1 Publication | 1 | |
Mutagenesisi | 187 | E → A: Significant reduction in rhodocytin binding. 1 Publication | 1 | |
Mutagenesisi | 188 | D → A: Significant reduction in rhodocytin binding. 1 Publication | 1 | |
Mutagenesisi | 190 | K → A: Significant reduction in rhodocytin binding. 1 Publication | 1 | |
Mutagenesisi | 192 | N → A: Significant reduction in rhodocytin binding. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 51266 |
OpenTargetsi | ENSG00000165682 |
PharmGKBi | PA142672098 |
Miscellaneous databases
Pharosi | Q9P126, Tbio |
Polymorphism and mutation databases
BioMutai | CLEC1B |
DMDMi | 134035066 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000280043 | 1 – 229 | C-type lectin domain family 1 member BAdd BLAST | 229 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 7 | Phosphotyrosine1 Publication | 1 | |
Glycosylationi | 68 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 102 ↔ 113 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 120 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 130 ↔ 216 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 134 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 195 ↔ 208 | PROSITE-ProRule annotation1 Publication |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
MassIVEi | Q9P126 |
PaxDbi | Q9P126 |
PeptideAtlasi | Q9P126 |
PRIDEi | Q9P126 |
ProteomicsDBi | 83635 [Q9P126-1] 83636 [Q9P126-2] |
PTM databases
GlyGeni | Q9P126, 3 sites |
iPTMneti | Q9P126 |
PhosphoSitePlusi | Q9P126 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000165682, Expressed in monocyte and 97 other tissues |
ExpressionAtlasi | Q9P126, baseline and differential |
Genevisiblei | Q9P126, HS |
Organism-specific databases
HPAi | ENSG00000165682, Group enriched (blood, liver) |
Interactioni
Subunit structurei
Homodimer.
Interacts (via cytoplasmic domain) with RACK1; promotes CLEC1B ubiquitination and proteasome-mediated degradation.
Interacts (dimer) with SYK (via SH2 domains).
Interacts with PDPN; the interaction is independent of CLEC1B glycosylation and activates CLEC1B (PubMed:18215137).
5 PublicationsBinary interactionsi
Isoform 1 [Q9P126-1]
With | #Exp. | IntAct |
---|---|---|
PDPN [Q86YL7] | 2 | EBI-16130833,EBI-723160 |
Protein-protein interaction databases
BioGRIDi | 119420, 3 interactors |
DIPi | DIP-61332N |
IntActi | Q9P126, 4 interactors |
STRINGi | 9606.ENSP00000298527 |
Miscellaneous databases
RNActi | Q9P126, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9P126 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9P126 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 109 – 217 | C-type lectinPROSITE-ProRule annotationAdd BLAST | 109 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 7 – 10 | ITAM1 Publication | 4 |
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4297, Eukaryota |
GeneTreei | ENSGT00940000162140 |
HOGENOMi | CLU_049894_9_0_1 |
InParanoidi | Q9P126 |
OMAi | CKNKHYL |
OrthoDBi | 1201127at2759 |
PhylomeDBi | Q9P126 |
TreeFami | TF336674 |
Family and domain databases
CDDi | cd03593, CLECT_NK_receptors_like, 1 hit |
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR016187, CTDL_fold IPR033992, NKR-like_CTLD |
Pfami | View protein in Pfam PF00059, Lectin_C, 1 hit |
SMARTi | View protein in SMART SM00034, CLECT, 1 hit |
SUPFAMi | SSF56436, SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS50041, C_TYPE_LECTIN_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MQDEDGYITL NIKTRKPALI SVGSASSSWW RVMALILLIL CVGMVVGLVA
60 70 80 90 100
LGIWSVMQRN YLQGENENRT GTLQQLAKRF CQYVVKQSEL KGTFKGHKCS
110 120 130 140 150
PCDTNWRYYG DSCYGFFRHN LTWEESKQYC TDMNATLLKI DNRNIVEYIK
160 170 180 190 200
ARTHLIRWVG LSRQKSNEVW KWEDGSVISE NMFEFLEDGK GNMNCAYFHN
210 220
GKMHPTFCEN KHYLMCERKA GMTKVDQLP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH7BYT7 | H7BYT7_HUMAN | C-type lectin domain family 1 membe... | CLEC1B | 96 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 41 | C → Y in AAF36777 (PubMed:10671229).Curated | 1 | |
Sequence conflicti | 41 | C → Y (PubMed:16940507).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_031047 | 20 | I → V4 PublicationsCorresponds to variant dbSNP:rs612593Ensembl. | 1 | |
Natural variantiVAR_031048 | 24 | S → P1 PublicationCorresponds to variant dbSNP:rs2273986Ensembl. | 1 | |
Natural variantiVAR_031049 | 28 | S → F. Corresponds to variant dbSNP:rs2273987Ensembl. | 1 | |
Natural variantiVAR_031050 | 64 | G → D4 PublicationsCorresponds to variant dbSNP:rs583903Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_023515 | 22 – 55 | VGSAS…LGIWS → A in isoform 2. 1 PublicationAdd BLAST | 34 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF124841 mRNA Translation: AAF36777.1 AY358599 mRNA Translation: AAQ88962.1 AC091814 Genomic DNA No translation available. BC029554 mRNA Translation: AAH29554.1 |
CCDSi | CCDS41751.1 [Q9P126-2] CCDS41752.1 [Q9P126-1] |
RefSeqi | NP_001092901.1, NM_001099431.1 [Q9P126-2] NP_057593.3, NM_016509.3 [Q9P126-1] XP_005253439.1, XM_005253382.4 [Q9P126-1] XP_011518987.1, XM_011520685.2 [Q9P126-2] XP_016874884.1, XM_017019395.1 [Q9P126-1] |
Genome annotation databases
Ensembli | ENST00000298527; ENSP00000298527; ENSG00000165682 [Q9P126-1] ENST00000348658; ENSP00000327169; ENSG00000165682 [Q9P126-2] ENST00000428126; ENSP00000406338; ENSG00000165682 [Q9P126-2] |
GeneIDi | 51266 |
KEGGi | hsa:51266 |
UCSCi | uc001qwu.5, human [Q9P126-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Functional Glycomics Gateway - Glycan Binding CLEC-2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF124841 mRNA Translation: AAF36777.1 AY358599 mRNA Translation: AAQ88962.1 AC091814 Genomic DNA No translation available. BC029554 mRNA Translation: AAH29554.1 |
CCDSi | CCDS41751.1 [Q9P126-2] CCDS41752.1 [Q9P126-1] |
RefSeqi | NP_001092901.1, NM_001099431.1 [Q9P126-2] NP_057593.3, NM_016509.3 [Q9P126-1] XP_005253439.1, XM_005253382.4 [Q9P126-1] XP_011518987.1, XM_011520685.2 [Q9P126-2] XP_016874884.1, XM_017019395.1 [Q9P126-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2C6U | X-ray | 1.60 | A | 100-221 | [»] | |
3WSR | X-ray | 1.91 | A/B | 96-221 | [»] | |
3WWK | X-ray | 2.98 | C/F/I/L | 96-221 | [»] | |
SMRi | Q9P126 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119420, 3 interactors |
DIPi | DIP-61332N |
IntActi | Q9P126, 4 interactors |
STRINGi | 9606.ENSP00000298527 |
PTM databases
GlyGeni | Q9P126, 3 sites |
iPTMneti | Q9P126 |
PhosphoSitePlusi | Q9P126 |
Polymorphism and mutation databases
BioMutai | CLEC1B |
DMDMi | 134035066 |
Proteomic databases
MassIVEi | Q9P126 |
PaxDbi | Q9P126 |
PeptideAtlasi | Q9P126 |
PRIDEi | Q9P126 |
ProteomicsDBi | 83635 [Q9P126-1] 83636 [Q9P126-2] |
Protocols and materials databases
Antibodypediai | 23211, 349 antibodies |
DNASUi | 51266 |
Genome annotation databases
Ensembli | ENST00000298527; ENSP00000298527; ENSG00000165682 [Q9P126-1] ENST00000348658; ENSP00000327169; ENSG00000165682 [Q9P126-2] ENST00000428126; ENSP00000406338; ENSG00000165682 [Q9P126-2] |
GeneIDi | 51266 |
KEGGi | hsa:51266 |
UCSCi | uc001qwu.5, human [Q9P126-1] |
Organism-specific databases
CTDi | 51266 |
DisGeNETi | 51266 |
EuPathDBi | HostDB:ENSG00000165682.14 |
GeneCardsi | CLEC1B |
HGNCi | HGNC:24356, CLEC1B |
HPAi | ENSG00000165682, Group enriched (blood, liver) |
MIMi | 606783, gene |
neXtProti | NX_Q9P126 |
OpenTargetsi | ENSG00000165682 |
PharmGKBi | PA142672098 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4297, Eukaryota |
GeneTreei | ENSGT00940000162140 |
HOGENOMi | CLU_049894_9_0_1 |
InParanoidi | Q9P126 |
OMAi | CKNKHYL |
OrthoDBi | 1201127at2759 |
PhylomeDBi | Q9P126 |
TreeFami | TF336674 |
Enzyme and pathway databases
PathwayCommonsi | Q9P126 |
Reactomei | R-HSA-114604, GPVI-mediated activation cascade |
Miscellaneous databases
BioGRID-ORCSi | 51266, 3 hits in 843 CRISPR screens |
ChiTaRSi | CLEC1B, human |
EvolutionaryTracei | Q9P126 |
GeneWikii | CLEC1B |
GenomeRNAii | 51266 |
Pharosi | Q9P126, Tbio |
PROi | PR:Q9P126 |
RNActi | Q9P126, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000165682, Expressed in monocyte and 97 other tissues |
ExpressionAtlasi | Q9P126, baseline and differential |
Genevisiblei | Q9P126, HS |
Family and domain databases
CDDi | cd03593, CLECT_NK_receptors_like, 1 hit |
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR016187, CTDL_fold IPR033992, NKR-like_CTLD |
Pfami | View protein in Pfam PF00059, Lectin_C, 1 hit |
SMARTi | View protein in SMART SM00034, CLECT, 1 hit |
SUPFAMi | SSF56436, SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS50041, C_TYPE_LECTIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CLC1B_HUMAN | |
Accessioni | Q9P126Primary (citable) accession number: Q9P126 Secondary accession number(s): Q6UWX7, Q8NHR6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 6, 2007 |
Last sequence update: | March 6, 2007 | |
Last modified: | December 2, 2020 | |
This is version 139 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations