CLEC1B

Functionⁱ

C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN (PubMed:18215137). After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2 (PubMed:18955485).2 Publications

(Microbial infection) Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (SYK) and initiation of downstream tyrosine phosphorylation events and activation of PLCG2 (PubMed:16174766, PubMed:18955485).1 Publication1 Publication

GO - Molecular functionⁱ

carbohydrate binding Source: UniProtKB-KW
transmembrane signaling receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 18955485

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell surface receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 10671229
defense response
Source: ProtInc
Traceable author statementⁱ
- 10671229
platelet activation Source: Reactome
platelet formation Source: Ensembl
signal transduction by protein phosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 18955485

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor
Ligand	Lectin

Enzyme and pathway databases

Reactomeⁱ	R-HSA-114604 GPVI-mediated activation cascade

Reactomeⁱ

R-HSA-114604 GPVI-mediated activation cascade

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: C-type lectin domain family 1 member B Alternative name(s): C-type lectin-like receptor 2 Short name: CLEC-2
Gene namesⁱ	Name:CLEC1B Synonyms:CLEC2 ORF Names:UNQ721/PRO1384
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000165682.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24356 CLEC1B
MIMⁱ	606783 gene
neXtProtⁱ	NX_Q9P126

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 33	CytoplasmicSequence analysisAdd BLAST	33
Transmembraneⁱ	34 – 54	Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST	21
Topological domainⁱ	55 – 229	ExtracellularSequence analysisAdd BLAST	175

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	7	Y → F: Loss of activation upon podoplanin or rhodocytin stimulation. 1 Publication	1
Mutagenesisⁱ	150	K → A: Substantial reduction in rhodocytin binding. 1 Publication	1
Mutagenesisⁱ	171	K → A: Significant reduction in rhodocytin binding. 1 Publication	1
Mutagenesisⁱ	184	E → A: Significant reduction in rhodocytin binding. 1 Publication	1
Mutagenesisⁱ	187	E → A: Significant reduction in rhodocytin binding. 1 Publication	1
Mutagenesisⁱ	188	D → A: Significant reduction in rhodocytin binding. 1 Publication	1
Mutagenesisⁱ	190	K → A: Significant reduction in rhodocytin binding. 1 Publication	1
Mutagenesisⁱ	192	N → A: Significant reduction in rhodocytin binding. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	51266
Open Targets More...OpenTargetsⁱ	ENSG00000165682
PharmGKBⁱ	PA142672098

Polymorphism and mutation databases

BioMutaⁱ	CLEC1B
DMDMⁱ	134035066

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000280043	1 – 229	C-type lectin domain family 1 member BAdd BLAST		229

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	7	Phosphotyrosine1 Publication	1
Glycosylationⁱ	68	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	102 ↔ 113	PROSITE-ProRule annotation1 Publication
Glycosylationⁱ	120	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	130 ↔ 216	PROSITE-ProRule annotation1 Publication
Glycosylationⁱ	134	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	195 ↔ 208	PROSITE-ProRule annotation1 Publication

Post-translational modificationⁱ

Glycosylated.2 Publications

Phosphorylated on tyrosine residue in response to rhodocytin binding.2 Publications

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q9P126
PeptideAtlas More...PeptideAtlasⁱ	Q9P126
PRIDEⁱ	Q9P126
ProteomicsDBⁱ	83635 83636 [Q9P126-2]

PTM databases

iPTMnetⁱ	Q9P126
PhosphoSitePlusⁱ	Q9P126

Expressionⁱ

Tissue specificityⁱ

Expressed preferentially in the liver. Also expressed in immune cells of myeloid origin and on the surface of platelets.3 Publications

Gene expression databases

Bgeeⁱ	ENSG00000165682 Expressed in 69 organ(s), highest expression level in liver
CleanExⁱ	HS_CLEC1B
ExpressionAtlasⁱ	Q9P126 baseline and differential
Genevisibleⁱ	Q9P126 HS

Interactionⁱ

Subunit structureⁱ

Homodimer. Interacts (via cytoplasmic domain) with RACK1; promotes CLEC1B ubiquitination and proteasome-mediated degradation. Interacts (dimer) with SYK (via SH2 domains). Interacts with PDPN; the interaction is independent of CLEC1B glycosylation and activates CLEC1B (PubMed:18215137).5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
PDPN	Q86YL7	2	EBI-16130833,EBI-723160

With

Entry

#Exp.

IntAct

Notes

PDPN

Q86YL7

2

EBI-16130833,EBI-723160

Protein-protein interaction databases

BioGridⁱ	119420, 3 interactors
Database of interacting proteins More...DIPⁱ	DIP-61332N
IntActⁱ	Q9P126, 4 interactors
STRINGⁱ	9606.ENSP00000298527

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	106 – 109	Combined sources	4
Beta strandⁱ	112 – 121	Combined sources	10
Helixⁱ	123 – 132	Combined sources	10
Helixⁱ	143 – 150	Combined sources	8
Beta strandⁱ	157 – 162	Combined sources	6
Helixⁱ	180 – 185	Combined sources	6
Beta strandⁱ	195 – 199	Combined sources	5
Beta strandⁱ	202 – 206	Combined sources	5
Beta strandⁱ	212 – 219	Combined sources	8

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9P126
SMRⁱ	Q9P126
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9P126

EvolutionaryTraceⁱ

Q9P126

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	109 – 217	C-type lectinPROSITE-ProRule annotationAdd BLAST		109

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	7 – 10	ITAM1 Publication		4

Keywords - Domainⁱ

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4297 Eukaryota ENOG410XPJ1 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00700000104266
HOGENOMⁱ	HOG000111777
HOVERGENⁱ	HBG094936
InParanoidⁱ	Q9P126
KEGG Orthology (KO) More...KOⁱ	K10070
OMAⁱ	EVWKWED
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0OAQ
PhylomeDBⁱ	Q9P126
TreeFamⁱ	TF336674

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd03593 CLECT_NK_receptors_like, 1 hit
Gene3Dⁱ	3.10.100.10, 1 hit
InterProⁱ	View protein in InterPro IPR001304 C-type_lectin-like IPR016186 C-type_lectin-like/link_sf IPR016187 CTDL_fold IPR033992 NKR-like_CTLD
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00059 Lectin_C, 1 hit
SMARTⁱ	View protein in SMART SM00034 CLECT, 1 hit
SUPFAMⁱ	SSF56436 SSF56436, 1 hit
PROSITEⁱ	View protein in PROSITE PS50041 C_TYPE_LECTIN_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q9P126-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQDEDGYITL NIKTRKPALI SVGSASSSWW RVMALILLIL CVGMVVGLVA 
        60         70         80         90        100
LGIWSVMQRN YLQGENENRT GTLQQLAKRF CQYVVKQSEL KGTFKGHKCS 
       110        120        130        140        150
PCDTNWRYYG DSCYGFFRHN LTWEESKQYC TDMNATLLKI DNRNIVEYIK 
       160        170        180        190        200
ARTHLIRWVG LSRQKSNEVW KWEDGSVISE NMFEFLEDGK GNMNCAYFHN 
       210        220 
GKMHPTFCEN KHYLMCERKA GMTKVDQLP

Length:229

Mass (Da):26,596

Last modified:March 6, 2007 - v2

Checksum:ⁱB39BF202AAE6DDD9

GO

Isoform 2 (identifier: Q9P126-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
22-55: VGSASSSWWRVMALILLILCVGMVVGLVALGIWS → A

« Hide

        10         20         30         40         50
MQDEDGYITL NIKTRKPALI SAVMQRNYLQ GENENRTGTL QQLAKRFCQY 
        60         70         80         90        100
VVKQSELKGT FKGHKCSPCD TNWRYYGDSC YGFFRHNLTW EESKQYCTDM 
       110        120        130        140        150
NATLLKIDNR NIVEYIKART HLIRWVGLSR QKSNEVWKWE DGSVISENMF 
       160        170        180        190 
EFLEDGKGNM NCAYFHNGKM HPTFCENKHY LMCERKAGMT KVDQLP

Show »

Length:196

Mass (Da):23,096

Checksum:ⁱ0BFA3D427640C3F5

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	H7BYT7	H7BYT7_HUMAN		C-type lectin domain family 1 membe... C-type lectin domain family 1 member B	CLEC1B	96	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	41	C → Y in AAF36777 (PubMed:10671229).Curated		1
Sequence conflictⁱ	41	C → Y (PubMed:16940507).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_031047	20	I → V4 PublicationsCorresponds to variant dbSNP:rs612593Ensembl.	1
Natural variantⁱVAR_031048	24	S → P1 PublicationCorresponds to variant dbSNP:rs2273986Ensembl.	1
Natural variantⁱVAR_031049	28	S → F. Corresponds to variant dbSNP:rs2273987Ensembl.	1
Natural variantⁱVAR_031050	64	G → D4 PublicationsCorresponds to variant dbSNP:rs583903Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_023515	22 – 55	VGSAS…LGIWS → A in isoform 2. 1 PublicationAdd BLAST		34

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF124841 mRNA Translation: AAF36777.1 AY358599 mRNA Translation: AAQ88962.1 AC091814 Genomic DNA No translation available. BC029554 mRNA Translation: AAH29554.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS41751.1 [Q9P126-2] CCDS41752.1 [Q9P126-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001092901.1, NM_001099431.1 [Q9P126-2] NP_057593.3, NM_016509.3 [Q9P126-1] XP_005253439.1, XM_005253382.4 [Q9P126-1] XP_011518987.1, XM_011520685.2 [Q9P126-2] XP_016874884.1, XM_017019395.1 [Q9P126-1]
UniGeneⁱ	Hs.409794

Genome annotation databases

Ensemblⁱ	ENST00000298527; ENSP00000298527; ENSG00000165682 [Q9P126-1] ENST00000348658; ENSP00000327169; ENSG00000165682 [Q9P126-2] ENST00000428126; ENSP00000406338; ENSG00000165682 [Q9P126-2]
GeneIDⁱ	51266
KEGGⁱ	hsa:51266
UCSC genome browser More...UCSCⁱ	uc001qwu.5 human [Q9P126-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9P126	C-type lectin domain family 1 member B		RHIBE		229	UniRef90_Q9P126
Uncharacterized protein		RHIRO		229
C-type lectin domain family 1 member B		PONAB		229
Uncharacterized protein		MACMU		229
Uncharacterized protein		MANLE		229
+20

Protein	Similar proteins		Species	Score	Length	Source
Q9P126	C-type lectin domain family 1 member B		PONAB		229	UniRef50_Q9P126
C-type lectin-like receptor 2		MACFA		229
Uncharacterized protein		CHLSB		229
Uncharacterized protein		COLAP		229
C-type lectin domain family 1 member B		RHIBE		229
+91

Cross-referencesⁱ

Web resourcesⁱ

Functional Glycomics Gateway - Glycan Binding

CLEC-2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF124841 mRNA Translation: AAF36777.1 AY358599 mRNA Translation: AAQ88962.1 AC091814 Genomic DNA No translation available. BC029554 mRNA Translation: AAH29554.1
CCDSⁱ	CCDS41751.1 [Q9P126-2] CCDS41752.1 [Q9P126-1]
RefSeqⁱ	NP_001092901.1, NM_001099431.1 [Q9P126-2] NP_057593.3, NM_016509.3 [Q9P126-1] XP_005253439.1, XM_005253382.4 [Q9P126-1] XP_011518987.1, XM_011520685.2 [Q9P126-2] XP_016874884.1, XM_017019395.1 [Q9P126-1]
UniGeneⁱ	Hs.409794

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2C6U	X-ray	1.60	A	100-221	[»]
	3WSR	X-ray	1.91	A/B	96-221	[»]
	3WWK	X-ray	2.98	C/F/I/L	96-221	[»]
ProteinModelPortalⁱ	Q9P126
SMRⁱ	Q9P126
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119420, 3 interactors
DIPⁱ	DIP-61332N
IntActⁱ	Q9P126, 4 interactors
STRINGⁱ	9606.ENSP00000298527

PTM databases

iPTMnetⁱ	Q9P126
PhosphoSitePlusⁱ	Q9P126

Polymorphism and mutation databases

BioMutaⁱ	CLEC1B
DMDMⁱ	134035066

Proteomic databases

PaxDbⁱ	Q9P126
PeptideAtlasⁱ	Q9P126
PRIDEⁱ	Q9P126
ProteomicsDBⁱ	83635 83636 [Q9P126-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	51266
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000298527; ENSP00000298527; ENSG00000165682 [Q9P126-1] ENST00000348658; ENSP00000327169; ENSG00000165682 [Q9P126-2] ENST00000428126; ENSP00000406338; ENSG00000165682 [Q9P126-2]
GeneIDⁱ	51266
KEGGⁱ	hsa:51266
UCSCⁱ	uc001qwu.5 human [Q9P126-1]

Organism-specific databases

CTDⁱ	51266
DisGeNETⁱ	51266
EuPathDBⁱ	HostDB:ENSG00000165682.14
GeneCardsⁱ	CLEC1B
HGNCⁱ	HGNC:24356 CLEC1B
MIMⁱ	606783 gene
neXtProtⁱ	NX_Q9P126
OpenTargetsⁱ	ENSG00000165682
PharmGKBⁱ	PA142672098
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4297 Eukaryota ENOG410XPJ1 LUCA
GeneTreeⁱ	ENSGT00700000104266
HOGENOMⁱ	HOG000111777
HOVERGENⁱ	HBG094936
InParanoidⁱ	Q9P126
KOⁱ	K10070
OMAⁱ	EVWKWED
OrthoDBⁱ	EOG091G0OAQ
PhylomeDBⁱ	Q9P126
TreeFamⁱ	TF336674

Enzyme and pathway databases

Reactomeⁱ	R-HSA-114604 GPVI-mediated activation cascade

Reactomeⁱ

R-HSA-114604 GPVI-mediated activation cascade

Miscellaneous databases

ChiTaRSⁱ	CLEC1B human
EvolutionaryTraceⁱ	Q9P126
GeneWikiⁱ	CLEC1B
GenomeRNAiⁱ	51266
Protein Ontology More...PROⁱ	PR:Q9P126
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000165682 Expressed in 69 organ(s), highest expression level in liver
CleanExⁱ	HS_CLEC1B
ExpressionAtlasⁱ	Q9P126 baseline and differential
Genevisibleⁱ	Q9P126 HS

Family and domain databases

CDDⁱ	cd03593 CLECT_NK_receptors_like, 1 hit
Gene3Dⁱ	3.10.100.10, 1 hit
InterProⁱ	View protein in InterPro IPR001304 C-type_lectin-like IPR016186 C-type_lectin-like/link_sf IPR016187 CTDL_fold IPR033992 NKR-like_CTLD
Pfamⁱ	View protein in Pfam PF00059 Lectin_C, 1 hit
SMARTⁱ	View protein in SMART SM00034 CLECT, 1 hit
SUPFAMⁱ	SSF56436 SSF56436, 1 hit
PROSITEⁱ	View protein in PROSITE PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CLC1B_HUMAN
Accessionⁱ	Q9P126Primary (citable) accession number: Q9P126 Secondary accession number(s): Q6UWX7, Q8NHR6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 6, 2007
	Last sequence update:	March 6, 2007
	Last modified:	September 12, 2018
	This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

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UniProtKB - Q9P126 (CLC1B_HUMAN)

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C-type lectin domain family 1 member B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Plasma Membrane

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

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Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ