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Protein

Neurotrimin

Gene

NTM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Neural cell adhesion molecule.

GO - Biological processi

  • cell adhesion Source: ProtInc
  • neuron recognition Source: ProtInc

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotrimin
Short name:
hNT
Alternative name(s):
IgLON family member 2
Gene namesi
Name:NTM
Synonyms:IGLON2, NT
ORF Names:UNQ297/PRO337
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000182667.14
HGNCiHGNC:17941 NTM
MIMi607938 gene
neXtProtiNX_Q9P121

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi50863
OpenTargetsiENSG00000182667
PharmGKBiPA164724212

Polymorphism and mutation databases

BioMutaiNTM
DMDMi27151645

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 331 PublicationAdd BLAST33
ChainiPRO_000001511034 – 321NeurotriminAdd BLAST288
PropeptideiPRO_0000015111322 – 344Removed in mature formSequence analysisAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi44N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi57 ↔ 115PROSITE-ProRule annotation
Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi152N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi157 ↔ 201PROSITE-ProRule annotation
Disulfide bondi243 ↔ 295PROSITE-ProRule annotation
Glycosylationi284N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi292N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi305N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi321GPI-anchor amidated asparagineSequence analysis1
Glycosylationi321N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiQ9P121
MaxQBiQ9P121
PaxDbiQ9P121
PeptideAtlasiQ9P121
PRIDEiQ9P121
ProteomicsDBi83631
83632 [Q9P121-2]
83633 [Q9P121-3]
83634 [Q9P121-4]

PTM databases

iPTMnetiQ9P121
PhosphoSitePlusiQ9P121

Expressioni

Gene expression databases

BgeeiENSG00000182667 Expressed in 183 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ9P121 baseline and differential
GenevisibleiQ9P121 HS

Organism-specific databases

HPAiCAB024875

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi119163, 16 interactors
IntActiQ9P121, 20 interactors
STRINGi9606.ENSP00000396722

Structurei

3D structure databases

ProteinModelPortaliQ9P121
SMRiQ9P121
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 126Ig-like C2-type 1Add BLAST88
Domaini136 – 218Ig-like C2-type 2Add BLAST83
Domaini222 – 309Ig-like C2-type 3Add BLAST88

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IQJF Eukaryota
ENOG4111SM8 LUCA
GeneTreeiENSGT00860000133697
HOGENOMiHOG000019085
HOVERGENiHBG017341
InParanoidiQ9P121
KOiK06774
OMAiASMILYE
OrthoDBiEOG091G0B5D
PhylomeDBiQ9P121
TreeFamiTF325565

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF00047 ig, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9P121-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGVCGYLFLP WKCLVVVSLR LLFLVPTGVP VRSGDATFPK AMDNVTVRQG
60 70 80 90 100
ESATLRCTID NRVTRVAWLN RSTILYAGND KWCLDPRVVL LSNTQTQYSI
110 120 130 140 150
EIQNVDVYDE GPYTCSVQTD NHPKTSRVHL IVQVSPKIVE ISSDISINEG
160 170 180 190 200
NNISLTCIAT GRPEPTVTWR HISPKAVGFV SEDEYLEIQG ITREQSGDYE
210 220 230 240 250
CSASNDVAAP VVRRVKVTVN YPPYISEAKG TGVPVGQKGT LQCEASAVPS
260 270 280 290 300
AEFQWYKDDK RLIEGKKGVK VENRPFLSKL IFFNVSEHDY GNYTCVASNK
310 320 330 340
LGHTNASIML FGPGAVSEVS NGTSRRAGCV WLLPLLVLHL LLKF
Length:344
Mass (Da):37,971
Last modified:October 1, 2000 - v1
Checksum:iDA4D12C295ABBE3A
GO
Isoform 2 (identifier: Q9P121-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MGVCGYLFLPWKCLVVVSLRLLFLVPT → MKTIQPKMHNSISWAIFTGLAALCLFQ

Note: No experimental confirmation available.
Show »
Length:344
Mass (Da):37,954
Checksum:i9423373042A196CD
GO
Isoform 3 (identifier: Q9P121-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     313-316: PGAV → ETVL
     317-344: Missing.

Note: No experimental confirmation available.
Show »
Length:316
Mass (Da):34,985
Checksum:i4AA281427476437F
GO
Isoform 4 (identifier: Q9P121-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     311-311: F → FEVKTTALTPWK

Show »
Length:355
Mass (Da):39,227
Checksum:iBF3350144F424D27
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VTR5F8VTR5_HUMAN
Neurotrimin
NTM
191Annotation score:
F8W8Y1F8W8Y1_HUMAN
Neurotrimin
NTM
179Annotation score:
F6WFR7F6WFR7_HUMAN
Neurotrimin
NTM
168Annotation score:
H7BZ62H7BZ62_HUMAN
Neurotrimin
NTM
119Annotation score:
C9JK95C9JK95_HUMAN
Neurotrimin
NTM
36Annotation score:
C9J0V2C9J0V2_HUMAN
Neurotrimin
NTM
18Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0109391 – 27MGVCG…FLVPT → MKTIQPKMHNSISWAIFTGL AALCLFQ in isoform 2. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_041165311F → FEVKTTALTPWK in isoform 4. Curated1
Alternative sequenceiVSP_010940313 – 316PGAV → ETVL in isoform 3. 2 Publications4
Alternative sequenceiVSP_010941317 – 344Missing in isoform 3. 2 PublicationsAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126426 mRNA Translation: AAF37591.1
EF043567 mRNA Translation: ABK34282.1
AY358331 mRNA Translation: AAQ88697.1
BC050716 mRNA Translation: AAH50716.1
CCDSiCCDS41733.1 [Q9P121-2]
CCDS44777.1 [Q9P121-4]
CCDS44778.1 [Q9P121-3]
CCDS8491.1 [Q9P121-1]
RefSeqiNP_001041674.1, NM_001048209.1 [Q9P121-2]
NP_001137530.1, NM_001144058.1 [Q9P121-4]
NP_001137531.1, NM_001144059.1 [Q9P121-3]
NP_057606.1, NM_016522.2 [Q9P121-1]
UniGeneiHs.504352

Genome annotation databases

EnsembliENST00000374784; ENSP00000363916; ENSG00000182667 [Q9P121-3]
ENST00000374786; ENSP00000363918; ENSG00000182667 [Q9P121-1]
ENST00000374791; ENSP00000363923; ENSG00000182667 [Q9P121-2]
ENST00000425719; ENSP00000396722; ENSG00000182667 [Q9P121-4]
GeneIDi50863
KEGGihsa:50863
UCSCiuc001qgm.4 human [Q9P121-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126426 mRNA Translation: AAF37591.1
EF043567 mRNA Translation: ABK34282.1
AY358331 mRNA Translation: AAQ88697.1
BC050716 mRNA Translation: AAH50716.1
CCDSiCCDS41733.1 [Q9P121-2]
CCDS44777.1 [Q9P121-4]
CCDS44778.1 [Q9P121-3]
CCDS8491.1 [Q9P121-1]
RefSeqiNP_001041674.1, NM_001048209.1 [Q9P121-2]
NP_001137530.1, NM_001144058.1 [Q9P121-4]
NP_001137531.1, NM_001144059.1 [Q9P121-3]
NP_057606.1, NM_016522.2 [Q9P121-1]
UniGeneiHs.504352

3D structure databases

ProteinModelPortaliQ9P121
SMRiQ9P121
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119163, 16 interactors
IntActiQ9P121, 20 interactors
STRINGi9606.ENSP00000396722

PTM databases

iPTMnetiQ9P121
PhosphoSitePlusiQ9P121

Polymorphism and mutation databases

BioMutaiNTM
DMDMi27151645

Proteomic databases

EPDiQ9P121
MaxQBiQ9P121
PaxDbiQ9P121
PeptideAtlasiQ9P121
PRIDEiQ9P121
ProteomicsDBi83631
83632 [Q9P121-2]
83633 [Q9P121-3]
83634 [Q9P121-4]

Protocols and materials databases

DNASUi50863
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374784; ENSP00000363916; ENSG00000182667 [Q9P121-3]
ENST00000374786; ENSP00000363918; ENSG00000182667 [Q9P121-1]
ENST00000374791; ENSP00000363923; ENSG00000182667 [Q9P121-2]
ENST00000425719; ENSP00000396722; ENSG00000182667 [Q9P121-4]
GeneIDi50863
KEGGihsa:50863
UCSCiuc001qgm.4 human [Q9P121-1]

Organism-specific databases

CTDi50863
DisGeNETi50863
EuPathDBiHostDB:ENSG00000182667.14
GeneCardsiNTM
HGNCiHGNC:17941 NTM
HPAiCAB024875
MIMi607938 gene
neXtProtiNX_Q9P121
OpenTargetsiENSG00000182667
PharmGKBiPA164724212
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQJF Eukaryota
ENOG4111SM8 LUCA
GeneTreeiENSGT00860000133697
HOGENOMiHOG000019085
HOVERGENiHBG017341
InParanoidiQ9P121
KOiK06774
OMAiASMILYE
OrthoDBiEOG091G0B5D
PhylomeDBiQ9P121
TreeFamiTF325565

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

Miscellaneous databases

ChiTaRSiNTM human
GeneWikiiHNT
GenomeRNAii50863
PROiPR:Q9P121
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182667 Expressed in 183 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ9P121 baseline and differential
GenevisibleiQ9P121 HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF00047 ig, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiNTRI_HUMAN
AccessioniPrimary (citable) accession number: Q9P121
Secondary accession number(s): A0MTT2, Q6UXJ3, Q86VJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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