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Entry version 150 (12 Aug 2020)
Sequence version 2 (22 Jul 2008)
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Protein

GEM-interacting protein

Gene

GMIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Stimulates, in vitro and in vivo, the GTPase activity of RhoA.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri493 – 537Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST45

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9P107

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-194840, Rho GTPase cycle

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9P107

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GEM-interacting protein
Short name:
GMIP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GMIP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000089639.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24852, GMIP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609694, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9P107

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
51291

Open Targets

More...
OpenTargetsi
ENSG00000089639

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134963566

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9P107, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GMIP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
212286192

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000567251 – 970GEM-interacting proteinAdd BLAST970

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei19PhosphoserineCombined sources1
Modified residuei71PhosphoserineBy similarity1
Modified residuei231PhosphoserineCombined sources1
Modified residuei234PhosphoserineCombined sources1
Modified residuei243PhosphoserineCombined sources1
Modified residuei437PhosphoserineCombined sources1
Modified residuei441PhosphoserineCombined sources1
Modified residuei660PhosphothreonineCombined sources1
Modified residuei885PhosphoserineCombined sources1
Modified residuei907PhosphoserineCombined sources1
Modified residuei914PhosphoserineCombined sources1
Modified residuei919PhosphoserineCombined sources1
Modified residuei923PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9P107

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9P107

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9P107

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9P107

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9P107

PeptideAtlas

More...
PeptideAtlasi
Q9P107

PRoteomics IDEntifications database

More...
PRIDEi
Q9P107

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
83629 [Q9P107-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9P107

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9P107

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000089639, Expressed in blood and 189 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9P107, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9P107, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000089639, Tissue enhanced (blood, bone marrow, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GEM through its N-terminal.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
119442, 7 interactors

Protein interaction database and analysis system

More...
IntActi
Q9P107, 9 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000203556

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9P107, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1970
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9P107

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9P107

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini81 – 344F-BARPROSITE-ProRule annotationAdd BLAST264
Domaini554 – 757Rho-GAPPROSITE-ProRule annotationAdd BLAST204

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi252 – 257Poly-Arg6
Compositional biasi354 – 419Pro-richAdd BLAST66
Compositional biasi763 – 828Pro-richAdd BLAST66

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri493 – 537Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST45

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1453, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00950000183110

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006236_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9P107

KEGG Orthology (KO)

More...
KOi
K20653

Identification of Orthologs from Complete Genome Data

More...
OMAi
HRKCMEV

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9P107

TreeFam database of animal gene trees

More...
TreeFami
TF351450

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.555.10, 1 hit
1.20.1270.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027267, AH/BAR_dom_sf
IPR031160, F_BAR
IPR002219, PE/DAG-bd
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00620, RhoGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00109, C1, 1 hit
SM00324, RhoGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103657, SSF103657, 1 hit
SSF48350, SSF48350, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51741, F_BAR, 1 hit
PS50238, RHOGAP, 1 hit
PS00479, ZF_DAG_PE_1, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9P107-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDAAEPGLPP GPEGRKRYSD IFRSLDNLEI SLGNVTLEML AGDPLLSEDP
60 70 80 90 100
EPDKTPTATV TNEASCWSGP SPEGPVPLTG EELDLRLIRT KGGVDAALEY
110 120 130 140 150
AKTWSRYAKE LLAWTEKRAS YELEFAKSTM KIAEAGKVSI QQQSHMPLQY
160 170 180 190 200
IYTLFLEHDL SLGTLAMETV AQQKRDYYQP LAAKRTEIEK WRKEFKEQWM
210 220 230 240 250
KEQKRMNEAV QALRRAQLQY VQRSEDLRAR SQGSPEDSAP QASPGPSKQQ
260 270 280 290 300
ERRRRSREEA QAKAQEAEAL YQACVREANA RQQDLEIAKQ RIVSHVRKLV
310 320 330 340 350
FQGDEVLRRV TLSLFGLRGA QAERGPRAFA ALAECCAPFE PGQRYQEFVR
360 370 380 390 400
ALRPEAPPPP PPAFSFQEFL PSLNSSPLDI RKKLSGPLPP RLDENSAEPG
410 420 430 440 450
PWEDPGTGWR WQGTPGPTPG SDVDSVGGGS ESRSLDSPTS SPGAGTRQLV
460 470 480 490 500
KASSTGTESS DDFEERDPDL GDGLENGLGS PFGKWTLSSA AQTHQLRRLR
510 520 530 540 550
GPAKCRECEA FMVSGTECEE CFLTCHKRCL ETLLILCGHR RLPARTPLFG
560 570 580 590 600
VDFLQLPRDF PEEVPFVVTK CTAEIEHRAL DVQGIYRVSG SRVRVERLCQ
610 620 630 640 650
AFENGRALVE LSGNSPHDVS SVLKRFLQEL TEPVIPFHLY DAFISLAKTL
660 670 680 690 700
HADPGDDPGT PSPSPEVIRS LKTLLVQLPD SNYNTLRHLV AHLFRVAARF
710 720 730 740 750
MENKMSANNL GIVFGPTLLR PPDGPRAASA IPVTCLLDSG HQAQLVEFLI
760 770 780 790 800
VHYEQIFGMD ELPQATEPPP QDSSPAPGPL TTSSQPPPPH LDPDSQPPVL
810 820 830 840 850
ASDPGPDPQH HSTLEQHPTA TPTEIPTPQS DQREDVAEDT KDGGGEVSSQ
860 870 880 890 900
GPEDSLLGTQ SRGHFSRQPV KYPRGGVRPV THQLSSLALV ASKLCEETPI
910 920 930 940 950
TSVPRGSLRG RGPSPAAASP EGSPLRRTPL PKHFEITQET ARLLSKLDSE
960 970
AVPRATCCPD VQPEEAEDHL
Length:970
Mass (Da):106,683
Last modified:July 22, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8163EF62F85EB2EE
GO
Isoform 2 (identifier: Q9P107-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     442-467: Missing.

Show »
Length:944
Mass (Da):103,960
Checksum:iF74C3C7AD265BEBE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EJC2K7EJC2_HUMAN
GEM-interacting protein
GMIP
303Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQR5K7EQR5_HUMAN
GEM-interacting protein
GMIP
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ELE8K7ELE8_HUMAN
GEM-interacting protein
GMIP
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti666E → D in AAF61330 (PubMed:12093360).Curated1
Sequence conflicti773S → F in AAF61330 (PubMed:12093360).Curated1
Sequence conflicti870V → C in AAF61330 (PubMed:12093360).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_044518641D → N. Corresponds to variant dbSNP:rs12003Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_056142442 – 467Missing in isoform 2. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF132541 mRNA Translation: AAF61330.1
AC011458 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84839.1
BC126436 mRNA Translation: AAI26437.1
BC144142 mRNA Translation: AAI44143.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12408.1 [Q9P107-1]
CCDS74318.1 [Q9P107-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
D59435

NCBI Reference Sequences

More...
RefSeqi
NP_001275927.1, NM_001288998.1
NP_001275928.1, NM_001288999.1 [Q9P107-2]
NP_057657.2, NM_016573.3 [Q9P107-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000203556; ENSP00000203556; ENSG00000089639 [Q9P107-1]
ENST00000587238; ENSP00000467054; ENSG00000089639 [Q9P107-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
51291

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51291

UCSC genome browser

More...
UCSCi
uc002nnd.5, human [Q9P107-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132541 mRNA Translation: AAF61330.1
AC011458 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84839.1
BC126436 mRNA Translation: AAI26437.1
BC144142 mRNA Translation: AAI44143.1
CCDSiCCDS12408.1 [Q9P107-1]
CCDS74318.1 [Q9P107-2]
PIRiD59435
RefSeqiNP_001275927.1, NM_001288998.1
NP_001275928.1, NM_001288999.1 [Q9P107-2]
NP_057657.2, NM_016573.3 [Q9P107-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3QWEX-ray2.40A80-357[»]
SMRiQ9P107
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi119442, 7 interactors
IntActiQ9P107, 9 interactors
STRINGi9606.ENSP00000203556

PTM databases

iPTMnetiQ9P107
PhosphoSitePlusiQ9P107

Polymorphism and mutation databases

BioMutaiGMIP
DMDMi212286192

Proteomic databases

EPDiQ9P107
jPOSTiQ9P107
MassIVEiQ9P107
MaxQBiQ9P107
PaxDbiQ9P107
PeptideAtlasiQ9P107
PRIDEiQ9P107
ProteomicsDBi83629 [Q9P107-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
61622, 72 antibodies

Genome annotation databases

EnsembliENST00000203556; ENSP00000203556; ENSG00000089639 [Q9P107-1]
ENST00000587238; ENSP00000467054; ENSG00000089639 [Q9P107-2]
GeneIDi51291
KEGGihsa:51291
UCSCiuc002nnd.5, human [Q9P107-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51291
DisGeNETi51291
EuPathDBiHostDB:ENSG00000089639.10

GeneCards: human genes, protein and diseases

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GeneCardsi
GMIP
HGNCiHGNC:24852, GMIP
HPAiENSG00000089639, Tissue enhanced (blood, bone marrow, lymphoid tissue)
MIMi609694, gene
neXtProtiNX_Q9P107
OpenTargetsiENSG00000089639
PharmGKBiPA134963566

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1453, Eukaryota
GeneTreeiENSGT00950000183110
HOGENOMiCLU_006236_1_0_1
InParanoidiQ9P107
KOiK20653
OMAiHRKCMEV
PhylomeDBiQ9P107
TreeFamiTF351450

Enzyme and pathway databases

PathwayCommonsiQ9P107
ReactomeiR-HSA-194840, Rho GTPase cycle
SIGNORiQ9P107

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
51291, 10 hits in 873 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GMIP, human
EvolutionaryTraceiQ9P107

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51291
PharosiQ9P107, Tbio

Protein Ontology

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PROi
PR:Q9P107
RNActiQ9P107, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000089639, Expressed in blood and 189 other tissues
ExpressionAtlasiQ9P107, baseline and differential
GenevisibleiQ9P107, HS

Family and domain databases

Gene3Di1.10.555.10, 1 hit
1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267, AH/BAR_dom_sf
IPR031160, F_BAR
IPR002219, PE/DAG-bd
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom
PfamiView protein in Pfam
PF00620, RhoGAP, 1 hit
SMARTiView protein in SMART
SM00109, C1, 1 hit
SM00324, RhoGAP, 1 hit
SUPFAMiSSF103657, SSF103657, 1 hit
SSF48350, SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS51741, F_BAR, 1 hit
PS50238, RHOGAP, 1 hit
PS00479, ZF_DAG_PE_1, 1 hit
PS50081, ZF_DAG_PE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGMIP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P107
Secondary accession number(s): A0AVN9, B7ZLZ0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: July 22, 2008
Last modified: August 12, 2020
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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