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Protein

Docking protein 5

Gene

DOK5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-8853659 RET signaling
SignaLinkiQ9P104
SIGNORiQ9P104

Names & Taxonomyi

Protein namesi
Recommended name:
Docking protein 5
Alternative name(s):
Downstream of tyrosine kinase 5
Insulin receptor substrate 6
Short name:
IRS-6
Short name:
IRS6
Gene namesi
Name:DOK5
Synonyms:C20orf180
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101134.11
HGNCiHGNC:16173 DOK5
MIMi608334 gene
neXtProtiNX_Q9P104

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi55816
OpenTargetsiENSG00000101134
PharmGKBiPA25724

Polymorphism and mutation databases

BioMutaiDOK5
DMDMi26393190

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001872771 – 306Docking protein 5Add BLAST306

Post-translational modificationi

Phosphorylated on tyrosine residues in response to insulin, IGF1 and GDNF.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9P104
PeptideAtlasiQ9P104
PRIDEiQ9P104
ProteomicsDBi83627
83628 [Q9P104-2]

PTM databases

iPTMnetiQ9P104
PhosphoSitePlusiQ9P104

Expressioni

Tissue specificityi

Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes.2 Publications

Gene expression databases

BgeeiENSG00000101134 Expressed in 187 organ(s), highest expression level in neocortex
CleanExiHS_DOK5
GenevisibleiQ9P104 HS

Organism-specific databases

HPAiHPA054460
HPA065235

Interactioni

Subunit structurei

Interacts with phosphorylated RET. In contrast to other DOK proteins, it does not interact with RASGAP (By similarity).By similarity

Protein-protein interaction databases

BioGridi120926, 15 interactors
IntActiQ9P104, 15 interactors
MINTiQ9P104
STRINGi9606.ENSP00000262593

Structurei

Secondary structure

1306
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9P104
SMRiQ9P104
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9P104

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 112PHAdd BLAST105
Domaini132 – 237IRS-type PTBPROSITE-ProRule annotationAdd BLAST106

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi263 – 273DKFBH motifAdd BLAST11

Domaini

PTB domain mediates receptor interaction.By similarity

Sequence similaritiesi

Belongs to the DOK family. Type B subfamily.Curated

Phylogenomic databases

eggNOGiKOG4047 Eukaryota
ENOG410XS2S LUCA
GeneTreeiENSGT00730000110348
HOVERGENiHBG002356
InParanoidiQ9P104
OMAiHAVGIYF
OrthoDBiEOG091G0M38
PhylomeDBiQ9P104
TreeFamiTF324994

Family and domain databases

CDDicd14678 PH_DOK4_DOK5_DOK6, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR037816 DOK4/5/6_PH
IPR002404 IRS_PTB
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF02174 IRS, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00310 PTBI, 1 hit
PROSITEiView protein in PROSITE
PS51064 IRS_PTB, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9P104-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASNFNDIVK QGYVRIRSRR LGIYQRCWLV FKKASSKGPK RLEKFSDERA
60 70 80 90 100
AYFRCYHKVT ELNNVKNVAR LPKSTKKHAI GIYFNDDTSK TFACESDLEA
110 120 130 140 150
DEWCKVLQME CVGTRINDIS LGEPDLLATG VEREQSERFN VYLMPSPNLD
160 170 180 190 200
VHGECALQIT YEYICLWDVQ NPRVKLISWP LSALRRYGRD TTWFTFEAGR
210 220 230 240 250
MCETGEGLFI FQTRDGEAIY QKVHSAALAI AEQHERLLQS VKNSMLQMKM
260 270 280 290 300
SERAASLSTM VPLPRSAYWQ HITRQHSTGQ LYRLQDVSSP LKLHRTETFP

AYRSEH
Length:306
Mass (Da):35,464
Last modified:December 6, 2002 - v2
Checksum:i2F259529E8B068DB
GO
Isoform 2 (identifier: Q9P104-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: Missing.

Note: No experimental confirmation available.
Show »
Length:198
Mass (Da):22,824
Checksum:i291F9F2A419FE062
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti225 – 234SAALAIAEQH → LLQMKMSERA in AAF66443 (Ref. 1) Curated10

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0038541 – 108Missing in isoform 2. 1 PublicationAdd BLAST108

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132732 mRNA Translation: AAF66443.1
AF466368 mRNA Translation: AAL74194.1
AL118501 Genomic DNA No translation available.
AL162292 Genomic DNA No translation available.
BC008992 mRNA Translation: AAH08992.1
AL050069 mRNA Translation: CAB43255.3
CCDSiCCDS13446.1 [Q9P104-1]
CCDS13447.1 [Q9P104-2]
PIRiT08731
RefSeqiNP_060901.2, NM_018431.4 [Q9P104-1]
NP_808874.1, NM_177959.2 [Q9P104-2]
XP_011527206.1, XM_011528904.1 [Q9P104-2]
UniGeneiHs.473133
Hs.656582

Genome annotation databases

EnsembliENST00000262593; ENSP00000262593; ENSG00000101134 [Q9P104-1]
ENST00000395939; ENSP00000379270; ENSG00000101134 [Q9P104-2]
GeneIDi55816
KEGGihsa:55816
UCSCiuc002xwy.4 human [Q9P104-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132732 mRNA Translation: AAF66443.1
AF466368 mRNA Translation: AAL74194.1
AL118501 Genomic DNA No translation available.
AL162292 Genomic DNA No translation available.
BC008992 mRNA Translation: AAH08992.1
AL050069 mRNA Translation: CAB43255.3
CCDSiCCDS13446.1 [Q9P104-1]
CCDS13447.1 [Q9P104-2]
PIRiT08731
RefSeqiNP_060901.2, NM_018431.4 [Q9P104-1]
NP_808874.1, NM_177959.2 [Q9P104-2]
XP_011527206.1, XM_011528904.1 [Q9P104-2]
UniGeneiHs.473133
Hs.656582

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J0WX-ray2.50A/B133-232[»]
ProteinModelPortaliQ9P104
SMRiQ9P104
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120926, 15 interactors
IntActiQ9P104, 15 interactors
MINTiQ9P104
STRINGi9606.ENSP00000262593

PTM databases

iPTMnetiQ9P104
PhosphoSitePlusiQ9P104

Polymorphism and mutation databases

BioMutaiDOK5
DMDMi26393190

Proteomic databases

PaxDbiQ9P104
PeptideAtlasiQ9P104
PRIDEiQ9P104
ProteomicsDBi83627
83628 [Q9P104-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262593; ENSP00000262593; ENSG00000101134 [Q9P104-1]
ENST00000395939; ENSP00000379270; ENSG00000101134 [Q9P104-2]
GeneIDi55816
KEGGihsa:55816
UCSCiuc002xwy.4 human [Q9P104-1]

Organism-specific databases

CTDi55816
DisGeNETi55816
EuPathDBiHostDB:ENSG00000101134.11
GeneCardsiDOK5
HGNCiHGNC:16173 DOK5
HPAiHPA054460
HPA065235
MIMi608334 gene
neXtProtiNX_Q9P104
OpenTargetsiENSG00000101134
PharmGKBiPA25724
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4047 Eukaryota
ENOG410XS2S LUCA
GeneTreeiENSGT00730000110348
HOVERGENiHBG002356
InParanoidiQ9P104
OMAiHAVGIYF
OrthoDBiEOG091G0M38
PhylomeDBiQ9P104
TreeFamiTF324994

Enzyme and pathway databases

ReactomeiR-HSA-8853659 RET signaling
SignaLinkiQ9P104
SIGNORiQ9P104

Miscellaneous databases

ChiTaRSiDOK5 human
EvolutionaryTraceiQ9P104
GeneWikiiDOK5
GenomeRNAii55816
PROiPR:Q9P104
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101134 Expressed in 187 organ(s), highest expression level in neocortex
CleanExiHS_DOK5
GenevisibleiQ9P104 HS

Family and domain databases

CDDicd14678 PH_DOK4_DOK5_DOK6, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR037816 DOK4/5/6_PH
IPR002404 IRS_PTB
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF02174 IRS, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00310 PTBI, 1 hit
PROSITEiView protein in PROSITE
PS51064 IRS_PTB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDOK5_HUMAN
AccessioniPrimary (citable) accession number: Q9P104
Secondary accession number(s): Q5T7Y0
, Q5TE53, Q8TEW7, Q96H13, Q9BZ24, Q9NQF4, Q9Y411
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: December 6, 2002
Last modified: September 12, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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