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Protein

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related

Gene

HMG20B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi70 – 138HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, DNA-binding
Biological processCell cycle, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-3214815 HDACs deacetylate histones
R-HSA-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related
Short name:
SMARCE1-related protein
Alternative name(s):
BRCA2-associated factor 35
HMG box-containing protein 20B
HMG domain-containing protein 2
HMG domain-containing protein HMGX2
Sox-like transcriptional factor
Structural DNA-binding protein BRAF35
Gene namesi
Name:HMG20B
Synonyms:BRAF35, HMGX2, HMGXB2, SMARCE1R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000064961.18
HGNCiHGNC:5002 HMG20B
MIMi605535 gene
neXtProtiNX_Q9P0W2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi116K → I: Loss of DNA binding activity of the BHC histone deacetylase complex. 1 Publication1

Organism-specific databases

DisGeNETi10362
OpenTargetsiENSG00000064961
PharmGKBiPA29332

Polymorphism and mutation databases

BioMutaiHMG20B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000485751 – 317SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-relatedAdd BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki31Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei160PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9P0W2
MaxQBiQ9P0W2
PaxDbiQ9P0W2
PeptideAtlasiQ9P0W2
PRIDEiQ9P0W2
ProteomicsDBi83610
83611 [Q9P0W2-2]
83612 [Q9P0W2-3]

PTM databases

iPTMnetiQ9P0W2
PhosphoSitePlusiQ9P0W2

Expressioni

Tissue specificityi

Ubiquitously expressed in adult tissues.2 Publications

Gene expression databases

BgeeiENSG00000064961 Expressed in 210 organ(s), highest expression level in lower esophagus muscularis layer
CleanExiHS_HMG20B
ExpressionAtlasiQ9P0W2 baseline and differential
GenevisibleiQ9P0W2 HS

Organism-specific databases

HPAiHPA050220
HPA053157
HPA069832

Interactioni

Subunit structurei

Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with the BRCA2 tumor suppressor protein.2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115642, 32 interactors
CORUMiQ9P0W2
IntActiQ9P0W2, 26 interactors
MINTiQ9P0W2
STRINGi9606.ENSP00000328269

Structurei

3D structure databases

ProteinModelPortaliQ9P0W2
SMRiQ9P0W2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili190 – 257Sequence analysisAdd BLAST68

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0381 Eukaryota
COG5648 LUCA
GeneTreeiENSGT00730000110938
HOVERGENiHBG059870
InParanoidiQ9P0W2
OMAiHNRSTEN
OrthoDBiEOG091G0IHZ
PhylomeDBiQ9P0W2
TreeFamiTF106440

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9P0W2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSHGPKQPGA AAAPAGGKAP GQHGGFVVTV KQERGEGPRA GEKGSHEEEP
60 70 80 90 100
VKKRGWPKGK KRKKILPNGP KAPVTGYVRF LNERREQIRT RHPDLPFPEI
110 120 130 140 150
TKMLGAEWSK LQPTEKQRYL DEAEREKQQY MKELRAYQQS EAYKMCTEKI
160 170 180 190 200
QEKKIKKEDS SSGLMNTLLN GHKGGDCDGF STFDVPIFTE EFLDQNKARE
210 220 230 240 250
AELRRLRKMN VAFEEQNAVL QRHTQSMSSA RERLEQELAL EERRTLALQQ
260 270 280 290 300
QLQAVRQALT ASFASLPVPG TGETPTLGTL DFYMARLHGA IERDPAQHEK
310
LIVRIKEILA QVASEHL
Length:317
Mass (Da):35,813
Last modified:October 1, 2000 - v1
Checksum:iADFCF71C47F8CD2D
GO
Isoform 2 (identifier: Q9P0W2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-102: Missing.

Show »
Length:215
Mass (Da):24,713
Checksum:iF4730ECC889B01B6
GO
Isoform 3 (identifier: Q9P0W2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-106: Missing.

Show »
Length:293
Mass (Da):32,939
Checksum:iFD6967D1DDDD4463
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J8X5C9J8X5_HUMAN
SWI/SNF-related matrix-associated a...
HMG20B
215Annotation score:
B5MDG7B5MDG7_HUMAN
SWI/SNF-related matrix-associated a...
HMG20B
286Annotation score:
C9K049C9K049_HUMAN
SWI/SNF-related matrix-associated a...
HMG20B
165Annotation score:
C9JQA7C9JQA7_HUMAN
SWI/SNF-related matrix-associated a...
HMG20B
142Annotation score:
K7EJR8K7EJR8_HUMAN
SWI/SNF-related matrix-associated a...
HMG20B
184Annotation score:
F8WES5F8WES5_HUMAN
SWI/SNF-related matrix-associated a...
HMG20B
125Annotation score:

Sequence cautioni

The sequence AAC26860 differs from that shown. Reason: Frameshift at position 223.Curated
The sequence AAC26860 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH21585 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11 – 12AA → SS in AAG01174 (PubMed:11997092).Curated2
Sequence conflicti174G → D in CAG33035 (Ref. 10) Curated1
Sequence conflicti223H → Q in AAC26860 (Ref. 9) Curated1
Sequence conflicti270G → D in BAC03510 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0371311 – 102Missing in isoform 2. 1 PublicationAdd BLAST102
Alternative sequenceiVSP_03713283 – 106Missing in isoform 3. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146223 mRNA Translation: AAF66707.1
AL355709 mRNA Translation: CAB90809.2
AF331191 mRNA Translation: AAG60060.1
AF288679 mRNA Translation: AAG01174.1
AF072165 mRNA Translation: AAF76253.1
AK090733 mRNA Translation: BAC03510.1
AC005786 Genomic DNA Translation: AAC62837.1
CH471139 Genomic DNA Translation: EAW69306.1
CH471139 Genomic DNA Translation: EAW69307.1
CH471139 Genomic DNA Translation: EAW69308.1
BC002552 mRNA Translation: AAH02552.1
BC003505 mRNA Translation: AAH03505.2
BC004408 mRNA Translation: AAH04408.2
BC021585 mRNA Translation: AAH21585.1 Different initiation.
AF072836 mRNA Translation: AAC26860.1 Sequence problems.
CR456754 mRNA Translation: CAG33035.1
CCDSiCCDS45919.1 [Q9P0W2-1]
RefSeqiNP_006330.2, NM_006339.2 [Q9P0W2-1]
UniGeneiHs.406534

Genome annotation databases

EnsembliENST00000333651; ENSP00000328269; ENSG00000064961 [Q9P0W2-1]
GeneIDi10362
KEGGihsa:10362
UCSCiuc002lya.4 human [Q9P0W2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146223 mRNA Translation: AAF66707.1
AL355709 mRNA Translation: CAB90809.2
AF331191 mRNA Translation: AAG60060.1
AF288679 mRNA Translation: AAG01174.1
AF072165 mRNA Translation: AAF76253.1
AK090733 mRNA Translation: BAC03510.1
AC005786 Genomic DNA Translation: AAC62837.1
CH471139 Genomic DNA Translation: EAW69306.1
CH471139 Genomic DNA Translation: EAW69307.1
CH471139 Genomic DNA Translation: EAW69308.1
BC002552 mRNA Translation: AAH02552.1
BC003505 mRNA Translation: AAH03505.2
BC004408 mRNA Translation: AAH04408.2
BC021585 mRNA Translation: AAH21585.1 Different initiation.
AF072836 mRNA Translation: AAC26860.1 Sequence problems.
CR456754 mRNA Translation: CAG33035.1
CCDSiCCDS45919.1 [Q9P0W2-1]
RefSeqiNP_006330.2, NM_006339.2 [Q9P0W2-1]
UniGeneiHs.406534

3D structure databases

ProteinModelPortaliQ9P0W2
SMRiQ9P0W2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115642, 32 interactors
CORUMiQ9P0W2
IntActiQ9P0W2, 26 interactors
MINTiQ9P0W2
STRINGi9606.ENSP00000328269

PTM databases

iPTMnetiQ9P0W2
PhosphoSitePlusiQ9P0W2

Polymorphism and mutation databases

BioMutaiHMG20B

Proteomic databases

EPDiQ9P0W2
MaxQBiQ9P0W2
PaxDbiQ9P0W2
PeptideAtlasiQ9P0W2
PRIDEiQ9P0W2
ProteomicsDBi83610
83611 [Q9P0W2-2]
83612 [Q9P0W2-3]

Protocols and materials databases

DNASUi10362
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333651; ENSP00000328269; ENSG00000064961 [Q9P0W2-1]
GeneIDi10362
KEGGihsa:10362
UCSCiuc002lya.4 human [Q9P0W2-1]

Organism-specific databases

CTDi10362
DisGeNETi10362
EuPathDBiHostDB:ENSG00000064961.18
GeneCardsiHMG20B
HGNCiHGNC:5002 HMG20B
HPAiHPA050220
HPA053157
HPA069832
MIMi605535 gene
neXtProtiNX_Q9P0W2
OpenTargetsiENSG00000064961
PharmGKBiPA29332
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0381 Eukaryota
COG5648 LUCA
GeneTreeiENSGT00730000110938
HOVERGENiHBG059870
InParanoidiQ9P0W2
OMAiHNRSTEN
OrthoDBiEOG091G0IHZ
PhylomeDBiQ9P0W2
TreeFamiTF106440

Enzyme and pathway databases

ReactomeiR-HSA-3214815 HDACs deacetylate histones
R-HSA-983231 Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

ChiTaRSiHMG20B human
GeneWikiiHMG20B
GenomeRNAii10362
PROiPR:Q9P0W2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000064961 Expressed in 210 organ(s), highest expression level in lower esophagus muscularis layer
CleanExiHS_HMG20B
ExpressionAtlasiQ9P0W2 baseline and differential
GenevisibleiQ9P0W2 HS

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHM20B_HUMAN
AccessioniPrimary (citable) accession number: Q9P0W2
Secondary accession number(s): A6NMS5
, D6W616, Q6IBP8, Q8NBD5, Q9HD21, Q9Y491, Q9Y4A2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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