IFNK

Functionⁱ

May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon-stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin.2 Publications

GO - Molecular functionⁱ

cytokine activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
type I interferon receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 11514542

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adaptive immune response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
B cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
B cell proliferation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cytokine-mediated signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 11514542
defense response to virus Source: UniProtKB-KW
humoral immune response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
natural killer cell activation
Source: UniProtKB
Non-traceable author statementⁱ
- 11514542
natural killer cell activation involved in immune response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of cell proliferation
Source: UniProtKB
Non-traceable author statementⁱ
- 11514542
positive regulation of innate immune response
Source: UniProtKB
Traceable author statementⁱ
- 11514542
positive regulation of peptidyl-serine phosphorylation of STAT protein
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 11514542
response to exogenous dsRNA
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
response to virus
Source: UniProtKB
Inferred from expression patternⁱ
- 11514542
T cell activation involved in immune response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cytokine
Biological process	Antiviral defense

Enzyme and pathway databases

SignaLinkⁱ	Q9P0W0

SignaLinkⁱ

Q9P0W0

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Interferon kappa Short name: IFN-kappa
Gene namesⁱ	Name:IFNK ORF Names:UNQ6124/PRO20084
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000147896.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21714 IFNK
MIMⁱ	615326 gene
neXtProtⁱ	NX_Q9P0W0

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	56832
Open Targets More...OpenTargetsⁱ	ENSG00000147896
PharmGKBⁱ	PA134970126

Polymorphism and mutation databases

BioMutaⁱ	IFNK
DMDMⁱ	317373367

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 27	1 PublicationAdd BLAST		27
ChainⁱPRO_0000016410	28 – 207	Interferon kappaAdd BLAST		180

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	30 ↔ 128	By similarity
Disulfide bondⁱ	59 ↔ 181	By similarity

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

EPDⁱ	Q9P0W0
PaxDbⁱ	Q9P0W0
PeptideAtlas More...PeptideAtlasⁱ	Q9P0W0
PRIDEⁱ	Q9P0W0
ProteomicsDBⁱ	83609

Expressionⁱ

Tissue specificityⁱ

Expressed in keratinocytes, monocytes and in resting dendritic cells.2 Publications

Inductionⁱ

By viral infection, upon exposure to double-stranded RNA, or upon treatment with either interferon-gamma or interferon-beta.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000147896 Expressed in 21 organ(s), highest expression level in intestine
CleanExⁱ	HS_IFNK
Genevisibleⁱ	Q9P0W0 HS

Interactionⁱ

GO - Molecular functionⁱ

cytokine activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
type I interferon receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 11514542

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000276943

STRINGⁱ

9606.ENSP00000276943

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9P0W0
SMRⁱ	Q9P0W0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	118 – 148	Sequence analysisAdd BLAST		31

Sequence similaritiesⁱ

Belongs to the alpha/beta interferon family.Curated

Keywords - Domainⁱ

Coiled coil, Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J1FR Eukaryota ENOG41114KE LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119150
HOGENOMⁱ	HOG000230501
HOVERGENⁱ	HBG052086
InParanoidⁱ	Q9P0W0
KEGG Orthology (KO) More...KOⁱ	K05441
OMAⁱ	RVTWQNL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0R88
PhylomeDBⁱ	Q9P0W0
TreeFamⁱ	TF336177

Family and domain databases

InterProⁱ	View protein in InterPro IPR009079 4_helix_cytokine-like_core IPR000471 Interferon_alpha/beta/delta
PANTHERⁱ	PTHR11691 PTHR11691, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00143 Interferon, 1 hit
PRINTSⁱ	PR00266 INTERFERONAB
SMARTⁱ	View protein in SMART SM00076 IFabd, 1 hit
SUPFAMⁱ	SSF47266 SSF47266, 1 hit
PROSITEⁱ	View protein in PROSITE PS00252 INTERFERON_A_B_D, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9P0W0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSTKPDMIQK CLWLEILMGI FIAGTLSLDC NLLNVHLRRV TWQNLRHLSS 
        60         70         80         90        100
MSNSFPVECL RENIAFELPQ EFLQYTQPMK RDIKKAFYEM SLQAFNIFSQ 
       110        120        130        140        150
HTFKYWKERH LKQIQIGLDQ QAEYLNQCLE EDKNENEDMK EMKENEMKPS 
       160        170        180        190        200
EARVPQLSSL ELRRYFHRID NFLKEKKYSD CAWEIVRVEI RRCLYYFYKF 

TALFRRK

Length:207

Mass (Da):25,218

Last modified:January 11, 2011 - v2

Checksum:ⁱ49CF4CB5785F0E21

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_032710	97	I → N. Corresponds to variant dbSNP:rs34933275Ensembl.		1
Natural variantⁱVAR_021303	133	K → E3 PublicationsCorresponds to variant dbSNP:rs700785Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF146759 mRNA Translation: AAF67468.1 AF315688 mRNA Translation: AAK01623.1 AF384048 Genomic DNA Translation: AAK63835.1 AY358855 mRNA Translation: AAQ89214.1 AL451123 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6521.1
NCBI Reference Sequences More...RefSeqⁱ	NP_064509.2, NM_020124.2
UniGeneⁱ	Hs.591083

Genome annotation databases

Ensemblⁱ	ENST00000276943; ENSP00000276943; ENSG00000147896
GeneIDⁱ	56832
KEGGⁱ	hsa:56832
UCSC genome browser More...UCSCⁱ	uc003zqp.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9P0W0	Interferon kappa		PANTR		208	UniRef90_Q9P0W0
Interferon kappa		GORGO		207
Interferon kappa		CHLSB		207
Interferon kappa		MACMU		207
Interferon kappa		MACFA		207
+12

Protein	Similar proteins		Species	Score	Length	Source
Q9P0W0	Interferon kappa		PANTR		208	UniRef50_Q9P0W0
Interferon kappa		MACMU		207
Interferon kappa		MACFA		207
Interferon kappa		CHLSB		207
IFNK isoform 1		PONAB		207
+64

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF146759 mRNA Translation: AAF67468.1 AF315688 mRNA Translation: AAK01623.1 AF384048 Genomic DNA Translation: AAK63835.1 AY358855 mRNA Translation: AAQ89214.1 AL451123 Genomic DNA No translation available.
CCDSⁱ	CCDS6521.1
RefSeqⁱ	NP_064509.2, NM_020124.2
UniGeneⁱ	Hs.591083

3D structure databases

ProteinModelPortalⁱ	Q9P0W0
SMRⁱ	Q9P0W0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000276943

STRINGⁱ

9606.ENSP00000276943

Polymorphism and mutation databases

BioMutaⁱ	IFNK
DMDMⁱ	317373367

Proteomic databases

EPDⁱ	Q9P0W0
PaxDbⁱ	Q9P0W0
PeptideAtlasⁱ	Q9P0W0
PRIDEⁱ	Q9P0W0
ProteomicsDBⁱ	83609

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	56832
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000276943; ENSP00000276943; ENSG00000147896
GeneIDⁱ	56832
KEGGⁱ	hsa:56832
UCSCⁱ	uc003zqp.3 human

Organism-specific databases

CTDⁱ	56832
DisGeNETⁱ	56832
EuPathDBⁱ	HostDB:ENSG00000147896.3
GeneCardsⁱ	IFNK
H-InvDBⁱ	HIX0034769
HGNCⁱ	HGNC:21714 IFNK
MIMⁱ	615326 gene
neXtProtⁱ	NX_Q9P0W0
OpenTargetsⁱ	ENSG00000147896
PharmGKBⁱ	PA134970126
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J1FR Eukaryota ENOG41114KE LUCA
GeneTreeⁱ	ENSGT00760000119150
HOGENOMⁱ	HOG000230501
HOVERGENⁱ	HBG052086
InParanoidⁱ	Q9P0W0
KOⁱ	K05441
OMAⁱ	RVTWQNL
OrthoDBⁱ	EOG091G0R88
PhylomeDBⁱ	Q9P0W0
TreeFamⁱ	TF336177

Enzyme and pathway databases

SignaLinkⁱ	Q9P0W0

SignaLinkⁱ

Q9P0W0

Miscellaneous databases

GeneWikiⁱ	IFNK
GenomeRNAiⁱ	56832
Protein Ontology More...PROⁱ	PR:Q9P0W0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000147896 Expressed in 21 organ(s), highest expression level in intestine
CleanExⁱ	HS_IFNK
Genevisibleⁱ	Q9P0W0 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR009079 4_helix_cytokine-like_core IPR000471 Interferon_alpha/beta/delta
PANTHERⁱ	PTHR11691 PTHR11691, 1 hit
Pfamⁱ	View protein in Pfam PF00143 Interferon, 1 hit
PRINTSⁱ	PR00266 INTERFERONAB
SMARTⁱ	View protein in SMART SM00076 IFabd, 1 hit
SUPFAMⁱ	SSF47266 SSF47266, 1 hit
PROSITEⁱ	View protein in PROSITE PS00252 INTERFERON_A_B_D, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IFNK_HUMAN
Accessionⁱ	Q9P0W0Primary (citable) accession number: Q9P0W0 Secondary accession number(s): Q5T166
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
	Last sequence update:	January 11, 2011
	Last modified:	November 7, 2018
	This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - Q9P0W0 (IFNK_HUMAN)

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Interferon kappa

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ