UniProtKB - Q9P0W0 (IFNK_HUMAN)
Protein
Interferon kappa
Gene
IFNK
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon-stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin.2 Publications
GO - Molecular functioni
- cytokine activity Source: GO_Central
- type I interferon receptor binding Source: UniProtKB
GO - Biological processi
- adaptive immune response Source: GO_Central
- B cell differentiation Source: GO_Central
- B cell proliferation Source: GO_Central
- cytokine-mediated signaling pathway Source: UniProtKB
- defense response to virus Source: UniProtKB-KW
- humoral immune response Source: GO_Central
- natural killer cell activation Source: UniProtKB
- natural killer cell activation involved in immune response Source: GO_Central
- negative regulation of cell population proliferation Source: UniProtKB
- positive regulation of innate immune response Source: UniProtKB
- positive regulation of peptidyl-serine phosphorylation of STAT protein Source: GO_Central
- regulation of transcription, DNA-templated Source: UniProtKB
- response to exogenous dsRNA Source: GO_Central
- response to virus Source: UniProtKB
- T cell activation involved in immune response Source: GO_Central
Keywordsi
Molecular function | Cytokine |
Biological process | Antiviral defense |
Enzyme and pathway databases
PathwayCommonsi | Q9P0W0 |
SignaLinki | Q9P0W0 |
Names & Taxonomyi
Protein namesi | Recommended name: Interferon kappaShort name: IFN-kappa |
Gene namesi | Name:IFNK ORF Names:UNQ6124/PRO20084 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000147896.3 |
HGNCi | HGNC:21714, IFNK |
MIMi | 615326, gene |
neXtProti | NX_Q9P0W0 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 56832 |
OpenTargetsi | ENSG00000147896 |
PharmGKBi | PA134970126 |
Miscellaneous databases
Pharosi | Q9P0W0, Tbio |
Polymorphism and mutation databases
BioMutai | IFNK |
DMDMi | 317373367 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | 1 PublicationAdd BLAST | 27 | |
ChainiPRO_0000016410 | 28 – 207 | Interferon kappaAdd BLAST | 180 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 30 ↔ 128 | By similarity | ||
Disulfide bondi | 59 ↔ 181 | By similarity |
Keywords - PTMi
Disulfide bondProteomic databases
EPDi | Q9P0W0 |
MassIVEi | Q9P0W0 |
PaxDbi | Q9P0W0 |
PeptideAtlasi | Q9P0W0 |
PRIDEi | Q9P0W0 |
ProteomicsDBi | 83609 |
PTM databases
iPTMneti | Q9P0W0 |
Expressioni
Tissue specificityi
Expressed in keratinocytes, monocytes and in resting dendritic cells.2 Publications
Inductioni
By viral infection, upon exposure to double-stranded RNA, or upon treatment with either interferon-gamma or interferon-beta.1 Publication
Gene expression databases
Bgeei | ENSG00000147896, Expressed in intestine and 36 other tissues |
Genevisiblei | Q9P0W0, HS |
Organism-specific databases
HPAi | ENSG00000147896, Tissue enhanced (brain, skin) |
Interactioni
GO - Molecular functioni
- cytokine activity Source: GO_Central
- type I interferon receptor binding Source: UniProtKB
Protein-protein interaction databases
STRINGi | 9606.ENSP00000276943 |
Miscellaneous databases
RNActi | Q9P0W0, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 118 – 148 | Sequence analysisAdd BLAST | 31 |
Sequence similaritiesi
Belongs to the alpha/beta interferon family.Curated
Keywords - Domaini
Coiled coil, SignalPhylogenomic databases
eggNOGi | ENOG502SQGR, Eukaryota |
GeneTreei | ENSGT01000000214430 |
HOGENOMi | CLU_109427_1_0_1 |
InParanoidi | Q9P0W0 |
OMAi | QIGLDQQ |
OrthoDBi | 1358010at2759 |
PhylomeDBi | Q9P0W0 |
TreeFami | TF336177 |
Family and domain databases
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR000471, Interferon_alpha/beta/delta |
PANTHERi | PTHR11691, PTHR11691, 1 hit |
Pfami | View protein in Pfam PF00143, Interferon, 1 hit |
PRINTSi | PR00266, INTERFERONAB |
SMARTi | View protein in SMART SM00076, IFabd, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00252, INTERFERON_A_B_D, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9P0W0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTKPDMIQK CLWLEILMGI FIAGTLSLDC NLLNVHLRRV TWQNLRHLSS
60 70 80 90 100
MSNSFPVECL RENIAFELPQ EFLQYTQPMK RDIKKAFYEM SLQAFNIFSQ
110 120 130 140 150
HTFKYWKERH LKQIQIGLDQ QAEYLNQCLE EDKNENEDMK EMKENEMKPS
160 170 180 190 200
EARVPQLSSL ELRRYFHRID NFLKEKKYSD CAWEIVRVEI RRCLYYFYKF
TALFRRK
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032710 | 97 | I → N. Corresponds to variant dbSNP:rs34933275Ensembl. | 1 | |
Natural variantiVAR_021303 | 133 | K → E3 PublicationsCorresponds to variant dbSNP:rs700785Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF146759 mRNA Translation: AAF67468.1 AF315688 mRNA Translation: AAK01623.1 AF384048 Genomic DNA Translation: AAK63835.1 AY358855 mRNA Translation: AAQ89214.1 AL451123 Genomic DNA No translation available. |
CCDSi | CCDS6521.1 |
RefSeqi | NP_064509.2, NM_020124.2 |
Genome annotation databases
Ensembli | ENST00000276943; ENSP00000276943; ENSG00000147896 |
GeneIDi | 56832 |
KEGGi | hsa:56832 |
UCSCi | uc003zqp.3, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF146759 mRNA Translation: AAF67468.1 AF315688 mRNA Translation: AAK01623.1 AF384048 Genomic DNA Translation: AAK63835.1 AY358855 mRNA Translation: AAQ89214.1 AL451123 Genomic DNA No translation available. |
CCDSi | CCDS6521.1 |
RefSeqi | NP_064509.2, NM_020124.2 |
3D structure databases
SMRi | Q9P0W0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000276943 |
PTM databases
iPTMneti | Q9P0W0 |
Polymorphism and mutation databases
BioMutai | IFNK |
DMDMi | 317373367 |
Proteomic databases
EPDi | Q9P0W0 |
MassIVEi | Q9P0W0 |
PaxDbi | Q9P0W0 |
PeptideAtlasi | Q9P0W0 |
PRIDEi | Q9P0W0 |
ProteomicsDBi | 83609 |
Protocols and materials databases
Antibodypediai | 25005, 87 antibodies |
DNASUi | 56832 |
Genome annotation databases
Ensembli | ENST00000276943; ENSP00000276943; ENSG00000147896 |
GeneIDi | 56832 |
KEGGi | hsa:56832 |
UCSCi | uc003zqp.3, human |
Organism-specific databases
CTDi | 56832 |
DisGeNETi | 56832 |
EuPathDBi | HostDB:ENSG00000147896.3 |
GeneCardsi | IFNK |
HGNCi | HGNC:21714, IFNK |
HPAi | ENSG00000147896, Tissue enhanced (brain, skin) |
MIMi | 615326, gene |
neXtProti | NX_Q9P0W0 |
OpenTargetsi | ENSG00000147896 |
PharmGKBi | PA134970126 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SQGR, Eukaryota |
GeneTreei | ENSGT01000000214430 |
HOGENOMi | CLU_109427_1_0_1 |
InParanoidi | Q9P0W0 |
OMAi | QIGLDQQ |
OrthoDBi | 1358010at2759 |
PhylomeDBi | Q9P0W0 |
TreeFami | TF336177 |
Enzyme and pathway databases
PathwayCommonsi | Q9P0W0 |
SignaLinki | Q9P0W0 |
Miscellaneous databases
BioGRID-ORCSi | 56832, 2 hits in 815 CRISPR screens |
GeneWikii | IFNK |
GenomeRNAii | 56832 |
Pharosi | Q9P0W0, Tbio |
PROi | PR:Q9P0W0 |
RNActi | Q9P0W0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000147896, Expressed in intestine and 36 other tissues |
Genevisiblei | Q9P0W0, HS |
Family and domain databases
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR000471, Interferon_alpha/beta/delta |
PANTHERi | PTHR11691, PTHR11691, 1 hit |
Pfami | View protein in Pfam PF00143, Interferon, 1 hit |
PRINTSi | PR00266, INTERFERONAB |
SMARTi | View protein in SMART SM00076, IFabd, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00252, INTERFERON_A_B_D, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IFNK_HUMAN | |
Accessioni | Q9P0W0Primary (citable) accession number: Q9P0W0 Secondary accession number(s): Q5T166 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 2005 |
Last sequence update: | January 11, 2011 | |
Last modified: | December 2, 2020 | |
This is version 138 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations