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Protein

SLAM family member 8

Gene

SLAMF8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor.1 Publication

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
SLAM family member 8
Alternative name(s):
B-lymphocyte activator macrophage expressed
BCM-like membrane protein
CD_antigen: CD353
Gene namesi
Name:SLAMF8
Synonyms:BLAME
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000158714.10
HGNCiHGNC:21391 SLAMF8
MIMi606620 gene
neXtProtiNX_Q9P0V8

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 233ExtracellularSequence analysisAdd BLAST211
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Topological domaini255 – 285CytoplasmicSequence analysisAdd BLAST31

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi56833
OpenTargetsiENSG00000158714
PharmGKBiPA134983606

Polymorphism and mutation databases

BioMutaiSLAMF8
DMDMi67461583

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000001496523 – 285SLAM family member 8Add BLAST263

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi85N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi152 ↔ 201PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9P0V8
PeptideAtlasiQ9P0V8
PRIDEiQ9P0V8
ProteomicsDBi83604
83605 [Q9P0V8-2]

Expressioni

Tissue specificityi

Expressed in lymph node, spleen, thymus and bone marrow.1 Publication

Gene expression databases

BgeeiENSG00000158714 Expressed in 155 organ(s), highest expression level in lung
CleanExiHS_SLAMF8
GenevisibleiQ9P0V8 HS

Organism-specific databases

HPAiHPA067601

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121206, 1 interactor
IntActiQ9P0V8, 2 interactors
STRINGi9606.ENSP00000289707

Structurei

3D structure databases

ProteinModelPortaliQ9P0V8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini128 – 215Ig-like C2-typeAdd BLAST88

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVMT Eukaryota
ENOG410Y74Q LUCA
GeneTreeiENSGT00510000048737
HOGENOMiHOG000133036
HOVERGENiHBG083118
InParanoidiQ9P0V8
KOiK16853
OMAiNFSVLMV
OrthoDBiEOG091G0GFI
PhylomeDBiQ9P0V8
TreeFamiTF334964

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9P0V8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVMRPLWSLL LWEALLPITV TGAQVLSKVG GSVLLVAARP PGFQVREAIW
60 70 80 90 100
RSLWPSEELL ATFFRGSLET LYHSRFLGRA QLHSNLSLEL GPLESGDSGN
110 120 130 140 150
FSVLMVDTRG QPWTQTLQLK VYDAVPRPVV QVFIAVERDA QPSKTCQVFL
160 170 180 190 200
SCWAPNISEI TYSWRRETTM DFGMEPHSLF TDGQVLSISL GPGDRDVAYS
210 220 230 240 250
CIVSNPVSWD LATVTPWDSC HHEAAPGKAS YKDVLLVVVP VSLLLMLVTL
260 270 280
FSAWHWCPCS GKKKKDVHAD RVGPETENPL VQDLP
Length:285
Mass (Da):31,670
Last modified:October 1, 2000 - v1
Checksum:i1BA63F4F90739AB2
GO
Isoform 2 (identifier: Q9P0V8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     14-122: Missing.

Note: No experimental confirmation available.
Show »
Length:176
Mass (Da):19,707
Checksum:iA96ABE0AFAEDC4F9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0499405P → T. Corresponds to variant dbSNP:rs2494514Ensembl.1
Natural variantiVAR_04994199G → S1 PublicationCorresponds to variant dbSNP:rs34687326Ensembl.1
Natural variantiVAR_049942129V → M. Corresponds to variant dbSNP:rs3795331Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01389614 – 122Missing in isoform 2. CuratedAdd BLAST109

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146761 mRNA Translation: AAF67470.1
AK074669 mRNA Translation: BAC11123.1
AL590560 Genomic DNA No translation available.
BC109194 mRNA Translation: AAI09195.1
CCDSiCCDS1188.1 [Q9P0V8-1]
CCDS81387.1 [Q9P0V8-2]
RefSeqiNP_001317670.1, NM_001330741.1 [Q9P0V8-2]
NP_064510.1, NM_020125.2 [Q9P0V8-1]
UniGeneiHs.438683

Genome annotation databases

EnsembliENST00000289707; ENSP00000289707; ENSG00000158714 [Q9P0V8-1]
ENST00000368104; ENSP00000357084; ENSG00000158714 [Q9P0V8-2]
GeneIDi56833
KEGGihsa:56833
UCSCiuc001fue.5 human [Q9P0V8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146761 mRNA Translation: AAF67470.1
AK074669 mRNA Translation: BAC11123.1
AL590560 Genomic DNA No translation available.
BC109194 mRNA Translation: AAI09195.1
CCDSiCCDS1188.1 [Q9P0V8-1]
CCDS81387.1 [Q9P0V8-2]
RefSeqiNP_001317670.1, NM_001330741.1 [Q9P0V8-2]
NP_064510.1, NM_020125.2 [Q9P0V8-1]
UniGeneiHs.438683

3D structure databases

ProteinModelPortaliQ9P0V8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121206, 1 interactor
IntActiQ9P0V8, 2 interactors
STRINGi9606.ENSP00000289707

Polymorphism and mutation databases

BioMutaiSLAMF8
DMDMi67461583

Proteomic databases

PaxDbiQ9P0V8
PeptideAtlasiQ9P0V8
PRIDEiQ9P0V8
ProteomicsDBi83604
83605 [Q9P0V8-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289707; ENSP00000289707; ENSG00000158714 [Q9P0V8-1]
ENST00000368104; ENSP00000357084; ENSG00000158714 [Q9P0V8-2]
GeneIDi56833
KEGGihsa:56833
UCSCiuc001fue.5 human [Q9P0V8-1]

Organism-specific databases

CTDi56833
DisGeNETi56833
EuPathDBiHostDB:ENSG00000158714.10
GeneCardsiSLAMF8
HGNCiHGNC:21391 SLAMF8
HPAiHPA067601
MIMi606620 gene
neXtProtiNX_Q9P0V8
OpenTargetsiENSG00000158714
PharmGKBiPA134983606
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVMT Eukaryota
ENOG410Y74Q LUCA
GeneTreeiENSGT00510000048737
HOGENOMiHOG000133036
HOVERGENiHBG083118
InParanoidiQ9P0V8
KOiK16853
OMAiNFSVLMV
OrthoDBiEOG091G0GFI
PhylomeDBiQ9P0V8
TreeFamiTF334964

Miscellaneous databases

GeneWikiiSLAMF8
GenomeRNAii56833
PROiPR:Q9P0V8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158714 Expressed in 155 organ(s), highest expression level in lung
CleanExiHS_SLAMF8
GenevisibleiQ9P0V8 HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSLAF8_HUMAN
AccessioniPrimary (citable) accession number: Q9P0V8
Secondary accession number(s): Q32MC6, Q5VU15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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Main funding by: National Institutes of Health

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