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Entry version 145 (08 May 2019)
Sequence version 1 (01 Oct 2000)
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Protein

SH3 domain-binding protein 4

Gene

SH3BP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy.2 Publications

Miscellaneous

Overexpression or depletion of SH3BP4 result in a specific decrease of the transferrin receptor endocytosis that can be rescued by DNM2 overexpression.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processEndocytosis

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9P0V3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SH3 domain-binding protein 4
Alternative name(s):
EH-binding protein 10
Transferrin receptor-trafficking protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SH3BP4
Synonyms:BOG25, EHB10, TTP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10826 SH3BP4

Online Mendelian Inheritance in Man (OMIM)

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MIMi
605611 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9P0V3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Coated pit, Cytoplasmic vesicle, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi92W → A: Loss of function. Loss of targeting to the clathrin-coated pits and vesicles. Loss of interaction with DNM2, RRAGB and RRAGC. No effect on localization to the plasma membrane. 2 Publications1

Organism-specific databases

DisGeNET

More...
DisGeNETi
23677

Open Targets

More...
OpenTargetsi
ENSG00000130147

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35734

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SH3BP4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74753102

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002745741 – 963SH3 domain-binding protein 4Add BLAST963

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei131PhosphoserineCombined sources1
Modified residuei246PhosphoserineCombined sources1
Modified residuei251PhosphoserineBy similarity1
Modified residuei279PhosphoserineCombined sources1
Modified residuei296PhosphoserineCombined sources1
Modified residuei637PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated upon EGF stimulation. Phosphorylation prevents interaction with DNM2.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9P0V3

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9P0V3

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9P0V3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9P0V3

PeptideAtlas

More...
PeptideAtlasi
Q9P0V3

PRoteomics IDEntifications database

More...
PRIDEi
Q9P0V3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
83602
83603 [Q9P0V3-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9P0V3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9P0V3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all tissues tested with higher expression in pancreas. Expressed by retinal pigment epithelial cells (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000130147 Expressed in 221 organ(s), highest expression level in parotid gland

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9P0V3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9P0V3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA037533
HPA037534

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer or homooligomer. Interacts with DNM2, EPS15, clathrin, the adapter protein complex 2/AP-2 and TFRC. Interacts with the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; the interaction is most probably direct, preferentially occurs with their inactive GDP-bound form and is negatively regulated by amino acids.3 Publications
(Microbial infection) Interacts with molluscum contagiosum virus protein MC159L; this interaction is important for the suppression of autophagy.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
117194, 75 interactors

Protein interaction database and analysis system

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IntActi
Q9P0V3, 37 interactors

Molecular INTeraction database

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MINTi
Q9P0V3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000386862

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9P0V3

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini55 – 114SH3 1PROSITE-ProRule annotationAdd BLAST60
Domaini317 – 454ZU5PROSITE-ProRule annotationAdd BLAST138
Domaini654 – 724SH3 2PROSITE-ProRule annotationAdd BLAST71

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SH3 domain mediates localization to the clathrin-coated pits and vesicles. The SH3 domain mediates interaction with DNM2 and the cytoplasmic part of TFRC with a lower affinity. The SH3 domain also mediates interaction with RRAGB, RRAGC and is required for the negative regulation of mTORC1.

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IEE9 Eukaryota
ENOG41118AI LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013151

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000015297

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9P0V3

KEGG Orthology (KO)

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KOi
K20066

Identification of Orthologs from Complete Genome Data

More...
OMAi
AIVAHGP

Database of Orthologous Groups

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OrthoDBi
1123658at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9P0V3

TreeFam database of animal gene trees

More...
TreeFami
TF105572

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11757 SH3_SH3BP4, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR035455 SH3BP4
IPR035456 SH3BP4_SH3
IPR000906 ZU5_dom

The PANTHER Classification System

More...
PANTHERi
PTHR15603:SF3 PTHR15603:SF3, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF07653 SH3_2, 1 hit
PF14604 SH3_9, 1 hit
PF00791 ZU5, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044 SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50002 SH3, 2 hits
PS51145 ZU5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9P0V3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAQRIRAAN SNGLPRCKSE GTLIDLSEGF SETSFNDIKV PSPSALLVDN
60 70 80 90 100
PTPFGNAKEV IAIKDYCPTN FTTLKFSKGD HLYVLDTSGG EWWYAHNTTE
110 120 130 140 150
MGYIPSSYVQ PLNYRNSTLS DSGMIDNLPD SPDEVAKELE LLGGWTDDKK
160 170 180 190 200
VPGRMYSNNP FWNGVQTNPF LNGNVPVMPS LDELNPKSTV DLLLFDAGTS
210 220 230 240 250
SFTESSSATT NSTGNIFDEL PVTNGLHAEP PVRRDNPFFR SKRSYSLSEL
260 270 280 290 300
SVLQAKSDAP TSSSFFTGLK SPAPEQFQSR EDFRTAWLNH RKLARSCHDL
310 320 330 340 350
DLLGQSPGWG QTQAVETNIV CKLDSSGGAV QLPDTSISIH VPEGHVAPGE
360 370 380 390 400
TQQISMKALL DPPLELNSDR SCSISPVLEV KLSNLEVKTS IILEMKVSAE
410 420 430 440 450
IKNDLFSKST VGLQCLRSDS KEGPYVSVPL NCSCGDTVQA QLHNLEPCMY
460 470 480 490 500
VAVVAHGPSI LYPSTVWDFI NKKVTVGLYG PKHIHPSFKT VVTIFGHDCA
510 520 530 540 550
PKTLLVSEVT RQAPNPAPVA LQLWGKHQFV LSRPQDLKVC MFSNMTNYEV
560 570 580 590 600
KASEQAKVVR GFQLKLGKVS RLIFPITSQN PNELSDFTLR VQVKDDQEAI
610 620 630 640 650
LTQFCVQTPQ PPPKSAIKPS GQRRFLKKNE VGKIILSPFA TTTKYPTFQD
660 670 680 690 700
RPVSSLKFGK LLKTVVRQNK NHYLLEYKKG DGIALLSEER VRLRGQLWTK
710 720 730 740 750
EWYIGYYQGR VGLVHTKNVL VVGRARPSLC SGPELSTSVL LEQILRPCKF
760 770 780 790 800
LTYIYASVRT LLMENISSWR SFADALGYVN LPLTFFCRAE LDSEPERVAS
810 820 830 840 850
VLEKLKEDCN NTENKERKSF QKELVMALLK MDCQGLVVRL IQDFVLLTTA
860 870 880 890 900
VEVAQRWREL AEKLAKVSKQ QMDAYESPHR DRNGVVDSEA MWKPAYDFLL
910 920 930 940 950
TWSHQIGDSY RDVIQELHLG LDKMKNPITK RWKHLTGTLI LVNSLDVLRA
960
AAFSPADQDD FVI
Length:963
Mass (Da):107,496
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7F98200AC420F3D5
GO
Isoform 2 (identifier: Q9P0V3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     515-925: Missing.

Note: No experimental confirmation available. Dubious isoform produced through aberrant splice sites.
Show »
Length:552
Mass (Da):60,337
Checksum:i1C9C5ABE339BFD7D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JED2C9JED2_HUMAN
SH3 domain-binding protein 4
SH3BP4
173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JF25C9JF25_HUMAN
SH3 domain-binding protein 4
SH3BP4
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JWW6C9JWW6_HUMAN
SH3 domain-binding protein 4
SH3BP4
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JRG1C9JRG1_HUMAN
SH3 domain-binding protein 4
SH3BP4
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti235D → N in ABB18377 (PubMed:16325581).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_030330155M → T1 PublicationCorresponds to variant dbSNP:rs3731644Ensembl.1
Natural variantiVAR_030331197A → T1 PublicationCorresponds to variant dbSNP:rs3731646Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_022823515 – 925Missing in isoform 2. 1 PublicationAdd BLAST411

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF147747 mRNA Translation: AAF33022.1
DQ232895 mRNA Translation: ABB18377.1
AC010148 Genomic DNA Translation: AAY14916.1
AC114814 Genomic DNA Translation: AAY24025.1
BC057396 mRNA Translation: AAH57396.1
AF015043 mRNA Translation: AAD01551.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2513.1 [Q9P0V3-1]

NCBI Reference Sequences

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RefSeqi
NP_055336.1, NM_014521.2 [Q9P0V3-1]
XP_011509193.1, XM_011510891.2 [Q9P0V3-1]
XP_011509194.1, XM_011510892.1 [Q9P0V3-1]
XP_011509195.1, XM_011510893.1 [Q9P0V3-1]
XP_011509196.1, XM_011510894.2 [Q9P0V3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000344528; ENSP00000340237; ENSG00000130147 [Q9P0V3-1]
ENST00000392011; ENSP00000375867; ENSG00000130147 [Q9P0V3-1]
ENST00000409212; ENSP00000386862; ENSG00000130147 [Q9P0V3-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23677

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23677

UCSC genome browser

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UCSCi
uc002vvp.4 human [Q9P0V3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF147747 mRNA Translation: AAF33022.1
DQ232895 mRNA Translation: ABB18377.1
AC010148 Genomic DNA Translation: AAY14916.1
AC114814 Genomic DNA Translation: AAY24025.1
BC057396 mRNA Translation: AAH57396.1
AF015043 mRNA Translation: AAD01551.1
CCDSiCCDS2513.1 [Q9P0V3-1]
RefSeqiNP_055336.1, NM_014521.2 [Q9P0V3-1]
XP_011509193.1, XM_011510891.2 [Q9P0V3-1]
XP_011509194.1, XM_011510892.1 [Q9P0V3-1]
XP_011509195.1, XM_011510893.1 [Q9P0V3-1]
XP_011509196.1, XM_011510894.2 [Q9P0V3-1]

3D structure databases

SMRiQ9P0V3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117194, 75 interactors
IntActiQ9P0V3, 37 interactors
MINTiQ9P0V3
STRINGi9606.ENSP00000386862

PTM databases

iPTMnetiQ9P0V3
PhosphoSitePlusiQ9P0V3

Polymorphism and mutation databases

BioMutaiSH3BP4
DMDMi74753102

Proteomic databases

EPDiQ9P0V3
jPOSTiQ9P0V3
MaxQBiQ9P0V3
PaxDbiQ9P0V3
PeptideAtlasiQ9P0V3
PRIDEiQ9P0V3
ProteomicsDBi83602
83603 [Q9P0V3-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344528; ENSP00000340237; ENSG00000130147 [Q9P0V3-1]
ENST00000392011; ENSP00000375867; ENSG00000130147 [Q9P0V3-1]
ENST00000409212; ENSP00000386862; ENSG00000130147 [Q9P0V3-1]
GeneIDi23677
KEGGihsa:23677
UCSCiuc002vvp.4 human [Q9P0V3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23677
DisGeNETi23677

GeneCards: human genes, protein and diseases

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GeneCardsi
SH3BP4
HGNCiHGNC:10826 SH3BP4
HPAiHPA037533
HPA037534
MIMi605611 gene
neXtProtiNX_Q9P0V3
OpenTargetsiENSG00000130147
PharmGKBiPA35734

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEE9 Eukaryota
ENOG41118AI LUCA
GeneTreeiENSGT00390000013151
HOGENOMiHOG000015297
InParanoidiQ9P0V3
KOiK20066
OMAiAIVAHGP
OrthoDBi1123658at2759
PhylomeDBiQ9P0V3
TreeFamiTF105572

Enzyme and pathway databases

SIGNORiQ9P0V3

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SH3BP4 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SH3BP4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23677

Protein Ontology

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PROi
PR:Q9P0V3

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000130147 Expressed in 221 organ(s), highest expression level in parotid gland
ExpressionAtlasiQ9P0V3 baseline and differential
GenevisibleiQ9P0V3 HS

Family and domain databases

CDDicd11757 SH3_SH3BP4, 1 hit
InterProiView protein in InterPro
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR035455 SH3BP4
IPR035456 SH3BP4_SH3
IPR000906 ZU5_dom
PANTHERiPTHR15603:SF3 PTHR15603:SF3, 1 hit
PfamiView protein in Pfam
PF07653 SH3_2, 1 hit
PF14604 SH3_9, 1 hit
PF00791 ZU5, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 2 hits
PS51145 ZU5, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSH3B4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P0V3
Secondary accession number(s): O95082
, Q309A3, Q53QD0, Q53TD1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 1, 2000
Last modified: May 8, 2019
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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