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Protein

CXXC-type zinc finger protein 1

Gene

CXXC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri28 – 76PHD-typePROSITE-ProRule annotationAdd BLAST49
Zinc fingeri160 – 209CXXC-typePROSITE-ProRule annotationAdd BLAST50

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-381038 XBP1(S) activates chaperone genes

Names & Taxonomyi

Protein namesi
Recommended name:
CXXC-type zinc finger protein 1
Alternative name(s):
CpG-binding protein
PHD finger and CXXC domain-containing protein 1
Gene namesi
Name:CXXC1
Synonyms:CFP1, CGBP, PCCX1, PHF18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000154832.14
HGNCiHGNC:24343 CXXC1
MIMi609150 gene
neXtProtiNX_Q9P0U4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi169C → A: Complete loss of DNA binding activity. No effect on localization in nuclear speckles. 1 Publication1
Mutagenesisi208C → A: Complete loss of DNA binding activity. No effect on localization in nuclear speckles. 1 Publication1

Organism-specific databases

DisGeNETi30827
OpenTargetsiENSG00000154832
PharmGKBiPA134908762

Polymorphism and mutation databases

BioMutaiCXXC1
DMDMi20138037

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000797431 – 656CXXC-type zinc finger protein 1Add BLAST656

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei6PhosphoserineCombined sources1
Modified residuei19PhosphoserineCombined sources1
Modified residuei124PhosphoserineCombined sources1
Modified residuei224PhosphoserineCombined sources1
Modified residuei227PhosphothreonineCombined sources1
Cross-linki250Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationi

May be regulated by proteolysis.

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9P0U4
MaxQBiQ9P0U4
PaxDbiQ9P0U4
PeptideAtlasiQ9P0U4
PRIDEiQ9P0U4
ProteomicsDBi83600
83601 [Q9P0U4-2]

PTM databases

iPTMnetiQ9P0U4
PhosphoSitePlusiQ9P0U4

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000154832 Expressed in 224 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_CXXC1
ExpressionAtlasiQ9P0U4 baseline and differential
GenevisibleiQ9P0U4 HS

Organism-specific databases

HPAiHPA044511

Interactioni

Subunit structurei

Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1 HCFC1 and DPY30. Interacts with SETD1A. Interacts with ZNF335.6 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi119045, 54 interactors
CORUMiQ9P0U4
DIPiDIP-50001N
IntActiQ9P0U4, 26 interactors
MINTiQ9P0U4
STRINGi9606.ENSP00000390475

Structurei

Secondary structure

1656
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9P0U4
SMRiQ9P0U4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9P0U4

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili422 – 474Sequence analysisAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi256 – 317Asp/Glu-rich (acidic)Add BLAST62
Compositional biasi321 – 359Arg/Lys-rich (basic)Add BLAST39

Domaini

The acidic domain carries the potential to activate transcription.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri28 – 76PHD-typePROSITE-ProRule annotationAdd BLAST49
Zinc fingeri160 – 209CXXC-typePROSITE-ProRule annotationAdd BLAST50

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG1632 Eukaryota
ENOG410YG6P LUCA
GeneTreeiENSGT00730000111044
HOGENOMiHOG000116258
HOVERGENiHBG051274
InParanoidiQ9P0U4
KOiK14960
OMAiCINITEK
OrthoDBiEOG091G05JX
PhylomeDBiQ9P0U4
TreeFamiTF320326

Family and domain databases

InterProiView protein in InterPro
IPR022056 CpG-bd_C
IPR037852 CXXC1
IPR019786 Zinc_finger_PHD-type_CS
IPR002857 Znf_CXXC
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
PANTHERiPTHR12321:SF58 PTHR12321:SF58, 1 hit
PfamiView protein in Pfam
PF00628 PHD, 1 hit
PF12269 zf-CpG_bind_C, 1 hit
PF02008 zf-CXXC, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51058 ZF_CXXC, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9P0U4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGDGSDPEP PDAGEDSKSE NGENAPIYCI CRKPDINCFM IGCDNCNEWF
60 70 80 90 100
HGDCIRITEK MAKAIREWYC RECREKDPKL EIRYRHKKSR ERDGNERDSS
110 120 130 140 150
EPRDEGGGRK RPVPDPDLQR RAGSGTGVGA MLARGSASPH KSSPQPLVAT
160 170 180 190 200
PSQHHQQQQQ QIKRSARMCG ECEACRRTED CGHCDFCRDM KKFGGPNKIR
210 220 230 240 250
QKCRLRQCQL RARESYKYFP SSLSPVTPSE SLPRPRRPLP TQQQPQPSQK
260 270 280 290 300
LGRIREDEGA VASSTVKEPP EATATPEPLS DEDLPLDPDL YQDFCAGAFD
310 320 330 340 350
DHGLPWMSDT EESPFLDPAL RKRAVKVKHV KRREKKSEKK KEERYKRHRQ
360 370 380 390 400
KQKHKDKWKH PERADAKDPA SLPQCLGPGC VRPAQPSSKY CSDDCGMKLA
410 420 430 440 450
ANRIYEILPQ RIQQWQQSPC IAEEHGKKLL ERIRREQQSA RTRLQEMERR
460 470 480 490 500
FHELEAIILR AKQQAVREDE ESNEGDSDDT DLQIFCVSCG HPINPRVALR
510 520 530 540 550
HMERCYAKYE SQTSFGSMYP TRIEGATRLF CDVYNPQSKT YCKRLQVLCP
560 570 580 590 600
EHSRDPKVPA DEVCGCPLVR DVFELTGDFC RLPKRQCNRH YCWEKLRRAE
610 620 630 640 650
VDLERVRVWY KLDELFEQER NVRTAMTNRA GLLALMLHQT IQHDPLTTDL

RSSADR
Length:656
Mass (Da):75,712
Last modified:March 27, 2002 - v2
Checksum:i6D2376E449905A18
GO
Isoform 2 (identifier: Q9P0U4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     340-340: K → KVMER

Show »
Length:660
Mass (Da):76,227
Checksum:i502AD163711D50E7
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EQ21K7EQ21_HUMAN
CXXC finger 1 (PHD domain), isoform...
CXXC1 hCG_23689
613Annotation score:
K7EKZ6K7EKZ6_HUMAN
CXXC-type zinc finger protein 1
CXXC1
250Annotation score:
K7EJR0K7EJR0_HUMAN
CXXC-type zinc finger protein 1
CXXC1
231Annotation score:
K7EQZ1K7EQZ1_HUMAN
CXXC-type zinc finger protein 1
CXXC1
252Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti117D → N in AAF37799 (PubMed:10688657).Curated1
Sequence conflicti175C → R in BAG37400 (PubMed:14702039).Curated1
Sequence conflicti235P → S in BAG37400 (PubMed:14702039).Curated1
Sequence conflicti302H → N in AAF37799 (PubMed:10688657).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040132340K → KVMER in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF149758 mRNA Translation: AAF37799.1
AB031069 mRNA Translation: BAA96307.1
AL136862 mRNA Translation: CAB66796.1
AK314886 mRNA Translation: BAG37400.1
AC090246 Genomic DNA No translation available.
BC014940 mRNA Translation: AAH14940.1
BC015733 mRNA Translation: AAH15733.1
BC029922 mRNA Translation: AAH29922.1
CCDSiCCDS11945.1 [Q9P0U4-1]
CCDS45866.1 [Q9P0U4-2]
RefSeqiNP_001095124.1, NM_001101654.1 [Q9P0U4-2]
NP_055408.2, NM_014593.3 [Q9P0U4-1]
XP_011524242.1, XM_011525940.2 [Q9P0U4-2]
XP_016881207.1, XM_017025718.1 [Q9P0U4-1]
UniGeneiHs.180933

Genome annotation databases

EnsembliENST00000285106; ENSP00000285106; ENSG00000154832 [Q9P0U4-1]
ENST00000412036; ENSP00000390475; ENSG00000154832 [Q9P0U4-2]
GeneIDi30827
KEGGihsa:30827
UCSCiuc002leq.5 human [Q9P0U4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF149758 mRNA Translation: AAF37799.1
AB031069 mRNA Translation: BAA96307.1
AL136862 mRNA Translation: CAB66796.1
AK314886 mRNA Translation: BAG37400.1
AC090246 Genomic DNA No translation available.
BC014940 mRNA Translation: AAH14940.1
BC015733 mRNA Translation: AAH15733.1
BC029922 mRNA Translation: AAH29922.1
CCDSiCCDS11945.1 [Q9P0U4-1]
CCDS45866.1 [Q9P0U4-2]
RefSeqiNP_001095124.1, NM_001101654.1 [Q9P0U4-2]
NP_055408.2, NM_014593.3 [Q9P0U4-1]
XP_011524242.1, XM_011525940.2 [Q9P0U4-2]
XP_016881207.1, XM_017025718.1 [Q9P0U4-1]
UniGeneiHs.180933

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3QMBX-ray2.06A161-222[»]
3QMCX-ray2.10A161-222[»]
3QMDX-ray1.90A161-222[»]
3QMGX-ray2.30A161-222[»]
3QMHX-ray2.50A161-222[»]
3QMIX-ray2.10A161-222[»]
ProteinModelPortaliQ9P0U4
SMRiQ9P0U4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119045, 54 interactors
CORUMiQ9P0U4
DIPiDIP-50001N
IntActiQ9P0U4, 26 interactors
MINTiQ9P0U4
STRINGi9606.ENSP00000390475

PTM databases

iPTMnetiQ9P0U4
PhosphoSitePlusiQ9P0U4

Polymorphism and mutation databases

BioMutaiCXXC1
DMDMi20138037

Proteomic databases

EPDiQ9P0U4
MaxQBiQ9P0U4
PaxDbiQ9P0U4
PeptideAtlasiQ9P0U4
PRIDEiQ9P0U4
ProteomicsDBi83600
83601 [Q9P0U4-2]

Protocols and materials databases

DNASUi30827
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000285106; ENSP00000285106; ENSG00000154832 [Q9P0U4-1]
ENST00000412036; ENSP00000390475; ENSG00000154832 [Q9P0U4-2]
GeneIDi30827
KEGGihsa:30827
UCSCiuc002leq.5 human [Q9P0U4-1]

Organism-specific databases

CTDi30827
DisGeNETi30827
EuPathDBiHostDB:ENSG00000154832.14
GeneCardsiCXXC1
HGNCiHGNC:24343 CXXC1
HPAiHPA044511
MIMi609150 gene
neXtProtiNX_Q9P0U4
OpenTargetsiENSG00000154832
PharmGKBiPA134908762
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1632 Eukaryota
ENOG410YG6P LUCA
GeneTreeiENSGT00730000111044
HOGENOMiHOG000116258
HOVERGENiHBG051274
InParanoidiQ9P0U4
KOiK14960
OMAiCINITEK
OrthoDBiEOG091G05JX
PhylomeDBiQ9P0U4
TreeFamiTF320326

Enzyme and pathway databases

ReactomeiR-HSA-381038 XBP1(S) activates chaperone genes

Miscellaneous databases

ChiTaRSiCXXC1 human
EvolutionaryTraceiQ9P0U4
GeneWikiiCXXC1
GenomeRNAii30827
PROiPR:Q9P0U4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000154832 Expressed in 224 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_CXXC1
ExpressionAtlasiQ9P0U4 baseline and differential
GenevisibleiQ9P0U4 HS

Family and domain databases

InterProiView protein in InterPro
IPR022056 CpG-bd_C
IPR037852 CXXC1
IPR019786 Zinc_finger_PHD-type_CS
IPR002857 Znf_CXXC
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
PANTHERiPTHR12321:SF58 PTHR12321:SF58, 1 hit
PfamiView protein in Pfam
PF00628 PHD, 1 hit
PF12269 zf-CpG_bind_C, 1 hit
PF02008 zf-CXXC, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51058 ZF_CXXC, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCXXC1_HUMAN
AccessioniPrimary (citable) accession number: Q9P0U4
Secondary accession number(s): B2RC03
, Q8N2W4, Q96BC8, Q9P2V7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: November 7, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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