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Protein

CXXC-type zinc finger protein 1

Gene

CXXC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri28 – 76PHD-typePROSITE-ProRule annotationAdd BLAST49
Zinc fingeri160 – 209CXXC-typePROSITE-ProRule annotationAdd BLAST50

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-381038 XBP1(S) activates chaperone genes

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CXXC-type zinc finger protein 1
Alternative name(s):
CpG-binding protein
PHD finger and CXXC domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CXXC1
Synonyms:CFP1, CGBP, PCCX1, PHF18
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000154832.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24343 CXXC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609150 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9P0U4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi169C → A: Complete loss of DNA binding activity. No effect on localization in nuclear speckles. 1 Publication1
Mutagenesisi208C → A: Complete loss of DNA binding activity. No effect on localization in nuclear speckles. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
30827

Open Targets

More...
OpenTargetsi
ENSG00000154832

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134908762

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CXXC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20138037

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000797431 – 656CXXC-type zinc finger protein 1Add BLAST656

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei6PhosphoserineCombined sources1
Modified residuei19PhosphoserineCombined sources1
Modified residuei124PhosphoserineCombined sources1
Modified residuei224PhosphoserineCombined sources1
Modified residuei227PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki250Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

May be regulated by proteolysis.

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9P0U4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9P0U4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9P0U4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9P0U4

PeptideAtlas

More...
PeptideAtlasi
Q9P0U4

PRoteomics IDEntifications database

More...
PRIDEi
Q9P0U4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
83600
83601 [Q9P0U4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9P0U4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9P0U4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000154832 Expressed in 224 organ(s), highest expression level in right hemisphere of cerebellum

CleanEx database of gene expression profiles

More...
CleanExi
HS_CXXC1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9P0U4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9P0U4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA044511

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1 HCFC1 and DPY30. Interacts with SETD1A. Interacts with ZNF335.6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
119045, 55 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9P0U4

Database of interacting proteins

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DIPi
DIP-50001N

Protein interaction database and analysis system

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IntActi
Q9P0U4, 27 interactors

Molecular INTeraction database

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MINTi
Q9P0U4

STRING: functional protein association networks

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STRINGi
9606.ENSP00000390475

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1656
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3QMBX-ray2.06A161-222[»]
3QMCX-ray2.10A161-222[»]
3QMDX-ray1.90A161-222[»]
3QMGX-ray2.30A161-222[»]
3QMHX-ray2.50A161-222[»]
3QMIX-ray2.10A161-222[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9P0U4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9P0U4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9P0U4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili422 – 474Sequence analysisAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi256 – 317Asp/Glu-rich (acidic)Add BLAST62
Compositional biasi321 – 359Arg/Lys-rich (basic)Add BLAST39

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The acidic domain carries the potential to activate transcription.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri28 – 76PHD-typePROSITE-ProRule annotationAdd BLAST49
Zinc fingeri160 – 209CXXC-typePROSITE-ProRule annotationAdd BLAST50

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1632 Eukaryota
ENOG410YG6P LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00730000111044

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000116258

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG051274

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9P0U4

KEGG Orthology (KO)

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KOi
K14960

Identification of Orthologs from Complete Genome Data

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OMAi
CINITEK

Database of Orthologous Groups

More...
OrthoDBi
463371at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9P0U4

TreeFam database of animal gene trees

More...
TreeFami
TF320326

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022056 CpG-bd_C
IPR037852 CXXC1
IPR019786 Zinc_finger_PHD-type_CS
IPR002857 Znf_CXXC
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger

The PANTHER Classification System

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PANTHERi
PTHR12321:SF58 PTHR12321:SF58, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00628 PHD, 1 hit
PF12269 zf-CpG_bind_C, 1 hit
PF02008 zf-CXXC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00249 PHD, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51058 ZF_CXXC, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9P0U4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGDGSDPEP PDAGEDSKSE NGENAPIYCI CRKPDINCFM IGCDNCNEWF
60 70 80 90 100
HGDCIRITEK MAKAIREWYC RECREKDPKL EIRYRHKKSR ERDGNERDSS
110 120 130 140 150
EPRDEGGGRK RPVPDPDLQR RAGSGTGVGA MLARGSASPH KSSPQPLVAT
160 170 180 190 200
PSQHHQQQQQ QIKRSARMCG ECEACRRTED CGHCDFCRDM KKFGGPNKIR
210 220 230 240 250
QKCRLRQCQL RARESYKYFP SSLSPVTPSE SLPRPRRPLP TQQQPQPSQK
260 270 280 290 300
LGRIREDEGA VASSTVKEPP EATATPEPLS DEDLPLDPDL YQDFCAGAFD
310 320 330 340 350
DHGLPWMSDT EESPFLDPAL RKRAVKVKHV KRREKKSEKK KEERYKRHRQ
360 370 380 390 400
KQKHKDKWKH PERADAKDPA SLPQCLGPGC VRPAQPSSKY CSDDCGMKLA
410 420 430 440 450
ANRIYEILPQ RIQQWQQSPC IAEEHGKKLL ERIRREQQSA RTRLQEMERR
460 470 480 490 500
FHELEAIILR AKQQAVREDE ESNEGDSDDT DLQIFCVSCG HPINPRVALR
510 520 530 540 550
HMERCYAKYE SQTSFGSMYP TRIEGATRLF CDVYNPQSKT YCKRLQVLCP
560 570 580 590 600
EHSRDPKVPA DEVCGCPLVR DVFELTGDFC RLPKRQCNRH YCWEKLRRAE
610 620 630 640 650
VDLERVRVWY KLDELFEQER NVRTAMTNRA GLLALMLHQT IQHDPLTTDL

RSSADR
Length:656
Mass (Da):75,712
Last modified:March 27, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6D2376E449905A18
GO
Isoform 2 (identifier: Q9P0U4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     340-340: K → KVMER

Show »
Length:660
Mass (Da):76,227
Checksum:i502AD163711D50E7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EQ21K7EQ21_HUMAN
CXXC finger 1 (PHD domain), isoform...
CXXC1 hCG_23689
613Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKZ6K7EKZ6_HUMAN
CXXC-type zinc finger protein 1
CXXC1
250Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJR0K7EJR0_HUMAN
CXXC-type zinc finger protein 1
CXXC1
231Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQZ1K7EQZ1_HUMAN
CXXC-type zinc finger protein 1
CXXC1
252Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti117D → N in AAF37799 (PubMed:10688657).Curated1
Sequence conflicti175C → R in BAG37400 (PubMed:14702039).Curated1
Sequence conflicti235P → S in BAG37400 (PubMed:14702039).Curated1
Sequence conflicti302H → N in AAF37799 (PubMed:10688657).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_040132340K → KVMER in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF149758 mRNA Translation: AAF37799.1
AB031069 mRNA Translation: BAA96307.1
AL136862 mRNA Translation: CAB66796.1
AK314886 mRNA Translation: BAG37400.1
AC090246 Genomic DNA No translation available.
BC014940 mRNA Translation: AAH14940.1
BC015733 mRNA Translation: AAH15733.1
BC029922 mRNA Translation: AAH29922.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11945.1 [Q9P0U4-1]
CCDS45866.1 [Q9P0U4-2]

NCBI Reference Sequences

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RefSeqi
NP_001095124.1, NM_001101654.1 [Q9P0U4-2]
NP_055408.2, NM_014593.3 [Q9P0U4-1]
XP_011524242.1, XM_011525940.2 [Q9P0U4-2]
XP_016881207.1, XM_017025718.1 [Q9P0U4-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.180933

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000285106; ENSP00000285106; ENSG00000154832 [Q9P0U4-1]
ENST00000412036; ENSP00000390475; ENSG00000154832 [Q9P0U4-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
30827

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:30827

UCSC genome browser

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UCSCi
uc002leq.5 human [Q9P0U4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF149758 mRNA Translation: AAF37799.1
AB031069 mRNA Translation: BAA96307.1
AL136862 mRNA Translation: CAB66796.1
AK314886 mRNA Translation: BAG37400.1
AC090246 Genomic DNA No translation available.
BC014940 mRNA Translation: AAH14940.1
BC015733 mRNA Translation: AAH15733.1
BC029922 mRNA Translation: AAH29922.1
CCDSiCCDS11945.1 [Q9P0U4-1]
CCDS45866.1 [Q9P0U4-2]
RefSeqiNP_001095124.1, NM_001101654.1 [Q9P0U4-2]
NP_055408.2, NM_014593.3 [Q9P0U4-1]
XP_011524242.1, XM_011525940.2 [Q9P0U4-2]
XP_016881207.1, XM_017025718.1 [Q9P0U4-1]
UniGeneiHs.180933

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3QMBX-ray2.06A161-222[»]
3QMCX-ray2.10A161-222[»]
3QMDX-ray1.90A161-222[»]
3QMGX-ray2.30A161-222[»]
3QMHX-ray2.50A161-222[»]
3QMIX-ray2.10A161-222[»]
ProteinModelPortaliQ9P0U4
SMRiQ9P0U4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119045, 55 interactors
CORUMiQ9P0U4
DIPiDIP-50001N
IntActiQ9P0U4, 27 interactors
MINTiQ9P0U4
STRINGi9606.ENSP00000390475

PTM databases

iPTMnetiQ9P0U4
PhosphoSitePlusiQ9P0U4

Polymorphism and mutation databases

BioMutaiCXXC1
DMDMi20138037

Proteomic databases

EPDiQ9P0U4
jPOSTiQ9P0U4
MaxQBiQ9P0U4
PaxDbiQ9P0U4
PeptideAtlasiQ9P0U4
PRIDEiQ9P0U4
ProteomicsDBi83600
83601 [Q9P0U4-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
30827
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000285106; ENSP00000285106; ENSG00000154832 [Q9P0U4-1]
ENST00000412036; ENSP00000390475; ENSG00000154832 [Q9P0U4-2]
GeneIDi30827
KEGGihsa:30827
UCSCiuc002leq.5 human [Q9P0U4-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
30827
DisGeNETi30827
EuPathDBiHostDB:ENSG00000154832.14

GeneCards: human genes, protein and diseases

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GeneCardsi
CXXC1
HGNCiHGNC:24343 CXXC1
HPAiHPA044511
MIMi609150 gene
neXtProtiNX_Q9P0U4
OpenTargetsiENSG00000154832
PharmGKBiPA134908762

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1632 Eukaryota
ENOG410YG6P LUCA
GeneTreeiENSGT00730000111044
HOGENOMiHOG000116258
HOVERGENiHBG051274
InParanoidiQ9P0U4
KOiK14960
OMAiCINITEK
OrthoDBi463371at2759
PhylomeDBiQ9P0U4
TreeFamiTF320326

Enzyme and pathway databases

ReactomeiR-HSA-381038 XBP1(S) activates chaperone genes

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CXXC1 human
EvolutionaryTraceiQ9P0U4

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CXXC1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
30827

Protein Ontology

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PROi
PR:Q9P0U4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000154832 Expressed in 224 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_CXXC1
ExpressionAtlasiQ9P0U4 baseline and differential
GenevisibleiQ9P0U4 HS

Family and domain databases

InterProiView protein in InterPro
IPR022056 CpG-bd_C
IPR037852 CXXC1
IPR019786 Zinc_finger_PHD-type_CS
IPR002857 Znf_CXXC
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
PANTHERiPTHR12321:SF58 PTHR12321:SF58, 1 hit
PfamiView protein in Pfam
PF00628 PHD, 1 hit
PF12269 zf-CpG_bind_C, 1 hit
PF02008 zf-CXXC, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51058 ZF_CXXC, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCXXC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P0U4
Secondary accession number(s): B2RC03
, Q8N2W4, Q96BC8, Q9P2V7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: January 16, 2019
This is version 162 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
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