TMEM9

Functionⁱ

May be involved in intracellular transport.

Keywordsⁱ

Biological process	Transport

Biological process

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transmembrane protein 9 Alternative name(s): Dermal papilla-derived protein 4
Gene namesⁱ	Name:TMEM9 Synonyms:DERP41 Publication, TMEM9A ORF Names:HSPC186, PSEC0012, UNQ631/PRO1248
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000116857.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18823 TMEM9
MIMⁱ	616877 gene
neXtProtⁱ	NX_Q9P0T7

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	21 – 89	ExtracellularSequence analysisAdd BLAST	69
Transmembraneⁱ	90 – 110	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	111 – 183	CytoplasmicSequence analysisAdd BLAST	73

Keywords - Cellular componentⁱ

Endosome, Lysosome, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	252839
Open Targets More...OpenTargetsⁱ	ENSG00000116857
PharmGKBⁱ	PA38696

Polymorphism and mutation databases

DMDMⁱ	20532090

DMDMⁱ

20532090

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 20	Sequence analysisAdd BLAST		20
ChainⁱPRO_0000034374	21 – 183	Transmembrane protein 9Add BLAST		163

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	21	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	38	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	47	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	137	PhosphoserineCombined sources	1
Modified residueⁱ	144	PhosphoserineCombined sources	1

Post-translational modificationⁱ

N-glycosylated.

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	Q9P0T7
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9P0T7
PaxDbⁱ	Q9P0T7
PeptideAtlas More...PeptideAtlasⁱ	Q9P0T7
PRIDEⁱ	Q9P0T7
ProteomicsDBⁱ	83596

PTM databases

GlyConnectⁱ	1857
iPTMnetⁱ	Q9P0T7
PhosphoSitePlusⁱ	Q9P0T7

Expressionⁱ

Tissue specificityⁱ

Highly expressed in adrenal gland, thyroid gland, testis, ovary and prostate. Moderate expression in trachea, spinal cord, stomach, colon, small intestine and spleen. Low expression in bone marrow, lymph node, thymus and peripheral blood lymphocytes. Expression was detected in hematopoietic cell lines including those of myeloid, erythroid, B- and T-cell origin.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000116857 Expressed in 203 organ(s), highest expression level in hypothalamus
CleanExⁱ	HS_TMEM9
ExpressionAtlasⁱ	Q9P0T7 baseline and differential
Genevisibleⁱ	Q9P0T7 HS

Interactionⁱ

Subunit structureⁱ

Dimer.Curated

Protein-protein interaction databases

BioGridⁱ	128927, 98 interactors
IntActⁱ	Q9P0T7, 18 interactors
STRINGⁱ	9606.ENSP00000356298

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9P0T7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the TMEM9 family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4007 Eukaryota ENOG4111KV2 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000819
HOVERGENⁱ	HBG050972
InParanoidⁱ	Q9P0T7
PhylomeDBⁱ	Q9P0T7
TreeFamⁱ	TF315146

Family and domain databases

InterProⁱ	View protein in InterPro IPR008853 TMEM9
PANTHERⁱ	PTHR13064 PTHR13064, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05434 Tmemb_9, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show all Align All

Q9P0T7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKLLSLVAVV GCLLVPPAEA NKSSEDIRCK CICPPYRNIS GHIYNQNVSQ 
        60         70         80         90        100
KDCNCLHVVE PMPVPGHDVE AYCLLCECRY EERSTTTIKV IIVIYLSVVG 
       110        120        130        140        150
ALLLYMAFLM LVDPLIRKPD AYTEQLHNEE ENEDARSMAA AAASLGGPRA 
       160        170        180 
NTVLERVEGA QQRWKLQVQE QRKTVFDRHK MLS

Length:183

Mass (Da):20,574

Last modified:October 1, 2000 - v1

Checksum:ⁱ6BC020EC9FE7F70E

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

B1ALM5	B1ALM5_HUMAN	Transmembrane protein 9 Transmembrane protein 9	TMEM9	186	Annotation score:
B1ALM7	B1ALM7_HUMAN	Transmembrane protein 9 Transmembrane protein 9	TMEM9	138	Annotation score:
B1ALM8	B1ALM8_HUMAN	Transmembrane protein 9 Transmembrane protein 9	TMEM9	151	Annotation score:
B1ALM4	B1ALM4_HUMAN	Transmembrane protein 9 Transmembrane protein 9	TMEM9	163	Annotation score:
F2Z389	F2Z389_HUMAN	Transmembrane protein 9 Transmembrane protein 9	TMEM9	98	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	22	K → KVRE in BAB70820 (PubMed:14702039).Curated		1
Sequence conflictⁱ	53	C → CCS in CAB66535 (PubMed:11230166).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY138587 mRNA Translation: AAN15925.1 AB013909 mRNA Translation: BAB87799.1 AF151020 mRNA Translation: AAF36106.1 AL136600 mRNA Translation: CAB66535.1 AY359012 mRNA Translation: AAQ89371.1 AK054883 mRNA Translation: BAB70820.1 AK075335 mRNA Translation: BAC11554.1 AL139159 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW91338.1 BC001106 mRNA Translation: AAH01106.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1408.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001275493.1, NM_001288564.1 NP_001275494.1, NM_001288565.1 NP_001275495.1, NM_001288566.1 NP_001275496.1, NM_001288567.1 NP_001275497.1, NM_001288568.1 NP_001275498.1, NM_001288569.1 NP_001275499.1, NM_001288570.1 NP_001275500.1, NM_001288571.1 NP_057540.1, NM_016456.4 XP_011507687.1, XM_011509385.1 XP_011507688.1, XM_011509386.2 XP_011507689.1, XM_011509387.2
UniGeneⁱ	Hs.181444

Genome annotation databases

Ensemblⁱ	ENST00000367330; ENSP00000356299; ENSG00000116857 ENST00000367333; ENSP00000356302; ENSG00000116857 ENST00000367334; ENSP00000356303; ENSG00000116857 ENST00000485839; ENSP00000476893; ENSG00000116857
GeneIDⁱ	252839
KEGGⁱ	hsa:252839
UCSC genome browser More...UCSCⁱ	uc001gvx.5 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9P0T7	Transmembrane protein 9, isoform CRA_b		HUMAN		183	UniRef100_Q9P0T7
TMEM9 isoform 1		PANTR		183
Transmembrane protein 9		MACMU		183
Transmembrane protein 9		RHIRO		183
Uncharacterized protein		COLAP		183
+11

Protein	Similar proteins		Species	Score	Length	Source
Q9P0T7	Transmembrane protein 9, isoform CRA_b		HUMAN		183	UniRef90_Q9P0T7
TMEM9 isoform 1		PANTR		183
Transmembrane protein 9		MACMU		183
Transmembrane protein 9		RHIRO		183
Uncharacterized protein		COLAP		183
+45

Protein	Similar proteins		Species	Score	Length	Source
Q9P0T7	Transmembrane protein 9, isoform CRA_b		HUMAN		183	UniRef50_Q9P0T7
TMEM9 isoform 1		PANTR		183
Transmembrane protein 9		MACMU		183
Transmembrane protein 9		RHIRO		183
Uncharacterized protein		COLAP		183
+239

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY138587 mRNA Translation: AAN15925.1 AB013909 mRNA Translation: BAB87799.1 AF151020 mRNA Translation: AAF36106.1 AL136600 mRNA Translation: CAB66535.1 AY359012 mRNA Translation: AAQ89371.1 AK054883 mRNA Translation: BAB70820.1 AK075335 mRNA Translation: BAC11554.1 AL139159 Genomic DNA No translation available. CH471067 Genomic DNA Translation: EAW91338.1 BC001106 mRNA Translation: AAH01106.1
CCDSⁱ	CCDS1408.1
RefSeqⁱ	NP_001275493.1, NM_001288564.1 NP_001275494.1, NM_001288565.1 NP_001275495.1, NM_001288566.1 NP_001275496.1, NM_001288567.1 NP_001275497.1, NM_001288568.1 NP_001275498.1, NM_001288569.1 NP_001275499.1, NM_001288570.1 NP_001275500.1, NM_001288571.1 NP_057540.1, NM_016456.4 XP_011507687.1, XM_011509385.1 XP_011507688.1, XM_011509386.2 XP_011507689.1, XM_011509387.2
UniGeneⁱ	Hs.181444

3D structure databases

ProteinModelPortalⁱ	Q9P0T7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	128927, 98 interactors
IntActⁱ	Q9P0T7, 18 interactors
STRINGⁱ	9606.ENSP00000356298

PTM databases

GlyConnectⁱ	1857
iPTMnetⁱ	Q9P0T7
PhosphoSitePlusⁱ	Q9P0T7

Polymorphism and mutation databases

DMDMⁱ	20532090

DMDMⁱ

20532090

Proteomic databases

EPDⁱ	Q9P0T7
MaxQBⁱ	Q9P0T7
PaxDbⁱ	Q9P0T7
PeptideAtlasⁱ	Q9P0T7
PRIDEⁱ	Q9P0T7
ProteomicsDBⁱ	83596

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	252839
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000367330; ENSP00000356299; ENSG00000116857 ENST00000367333; ENSP00000356302; ENSG00000116857 ENST00000367334; ENSP00000356303; ENSG00000116857 ENST00000485839; ENSP00000476893; ENSG00000116857
GeneIDⁱ	252839
KEGGⁱ	hsa:252839
UCSCⁱ	uc001gvx.5 human

Organism-specific databases

CTDⁱ	252839
DisGeNETⁱ	252839
EuPathDBⁱ	HostDB:ENSG00000116857.16
GeneCardsⁱ	TMEM9
HGNCⁱ	HGNC:18823 TMEM9
MIMⁱ	616877 gene
neXtProtⁱ	NX_Q9P0T7
OpenTargetsⁱ	ENSG00000116857
PharmGKBⁱ	PA38696
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4007 Eukaryota ENOG4111KV2 LUCA
GeneTreeⁱ	ENSGT00390000000819
HOVERGENⁱ	HBG050972
InParanoidⁱ	Q9P0T7
PhylomeDBⁱ	Q9P0T7
TreeFamⁱ	TF315146

Miscellaneous databases

ChiTaRSⁱ	TMEM9 human
GeneWikiⁱ	TMEM9
GenomeRNAiⁱ	252839
Protein Ontology More...PROⁱ	PR:Q9P0T7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000116857 Expressed in 203 organ(s), highest expression level in hypothalamus
CleanExⁱ	HS_TMEM9
ExpressionAtlasⁱ	Q9P0T7 baseline and differential
Genevisibleⁱ	Q9P0T7 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR008853 TMEM9
PANTHERⁱ	PTHR13064 PTHR13064, 1 hit
Pfamⁱ	View protein in Pfam PF05434 Tmemb_9, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TMEM9_HUMAN
Accessionⁱ	Q9P0T7Primary (citable) accession number: Q9P0T7 Secondary accession number(s): B1ALM6, Q96NQ9, Q9BQF5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 10, 2002
	Last sequence update:	October 1, 2000
	Last modified:	October 10, 2018
	This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries

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UniParc

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UniRef

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UniProtKB - Q9P0T7 (TMEM9_HUMAN)

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Transmembrane protein 9

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Lysosome

Endosome

Endosome

Lysosome

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ