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Protein

Transmembrane protein 9

Gene

TMEM9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in intracellular transport.

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 9
Alternative name(s):
Dermal papilla-derived protein 4
Gene namesi
Name:TMEM9
Synonyms:DERP41 Publication, TMEM9A
ORF Names:HSPC186, PSEC0012, UNQ631/PRO1248
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116857.16
HGNCiHGNC:18823 TMEM9
MIMi616877 gene
neXtProtiNX_Q9P0T7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 89ExtracellularSequence analysisAdd BLAST69
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Topological domaini111 – 183CytoplasmicSequence analysisAdd BLAST73

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi252839
OpenTargetsiENSG00000116857
PharmGKBiPA38696

Polymorphism and mutation databases

DMDMi20532090

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000003437421 – 183Transmembrane protein 9Add BLAST163

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi21N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei137PhosphoserineCombined sources1
Modified residuei144PhosphoserineCombined sources1

Post-translational modificationi

N-glycosylated.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9P0T7
MaxQBiQ9P0T7
PaxDbiQ9P0T7
PeptideAtlasiQ9P0T7
PRIDEiQ9P0T7
ProteomicsDBi83596

PTM databases

GlyConnecti1857
iPTMnetiQ9P0T7
PhosphoSitePlusiQ9P0T7

Expressioni

Tissue specificityi

Highly expressed in adrenal gland, thyroid gland, testis, ovary and prostate. Moderate expression in trachea, spinal cord, stomach, colon, small intestine and spleen. Low expression in bone marrow, lymph node, thymus and peripheral blood lymphocytes. Expression was detected in hematopoietic cell lines including those of myeloid, erythroid, B- and T-cell origin.1 Publication

Gene expression databases

BgeeiENSG00000116857 Expressed in 203 organ(s), highest expression level in hypothalamus
CleanExiHS_TMEM9
ExpressionAtlasiQ9P0T7 baseline and differential
GenevisibleiQ9P0T7 HS

Interactioni

Subunit structurei

Dimer.Curated

Protein-protein interaction databases

BioGridi128927, 98 interactors
IntActiQ9P0T7, 18 interactors
STRINGi9606.ENSP00000356298

Structurei

3D structure databases

ProteinModelPortaliQ9P0T7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM9 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4007 Eukaryota
ENOG4111KV2 LUCA
GeneTreeiENSGT00390000000819
HOVERGENiHBG050972
InParanoidiQ9P0T7
PhylomeDBiQ9P0T7
TreeFamiTF315146

Family and domain databases

InterProiView protein in InterPro
IPR008853 TMEM9
PANTHERiPTHR13064 PTHR13064, 1 hit
PfamiView protein in Pfam
PF05434 Tmemb_9, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9P0T7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLLSLVAVV GCLLVPPAEA NKSSEDIRCK CICPPYRNIS GHIYNQNVSQ
60 70 80 90 100
KDCNCLHVVE PMPVPGHDVE AYCLLCECRY EERSTTTIKV IIVIYLSVVG
110 120 130 140 150
ALLLYMAFLM LVDPLIRKPD AYTEQLHNEE ENEDARSMAA AAASLGGPRA
160 170 180
NTVLERVEGA QQRWKLQVQE QRKTVFDRHK MLS
Length:183
Mass (Da):20,574
Last modified:October 1, 2000 - v1
Checksum:i6BC020EC9FE7F70E
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1ALM5B1ALM5_HUMAN
Transmembrane protein 9
TMEM9
186Annotation score:
B1ALM7B1ALM7_HUMAN
Transmembrane protein 9
TMEM9
138Annotation score:
B1ALM8B1ALM8_HUMAN
Transmembrane protein 9
TMEM9
151Annotation score:
B1ALM4B1ALM4_HUMAN
Transmembrane protein 9
TMEM9
163Annotation score:
F2Z389F2Z389_HUMAN
Transmembrane protein 9
TMEM9
98Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22K → KVRE in BAB70820 (PubMed:14702039).Curated1
Sequence conflicti53C → CCS in CAB66535 (PubMed:11230166).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY138587 mRNA Translation: AAN15925.1
AB013909 mRNA Translation: BAB87799.1
AF151020 mRNA Translation: AAF36106.1
AL136600 mRNA Translation: CAB66535.1
AY359012 mRNA Translation: AAQ89371.1
AK054883 mRNA Translation: BAB70820.1
AK075335 mRNA Translation: BAC11554.1
AL139159 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91338.1
BC001106 mRNA Translation: AAH01106.1
CCDSiCCDS1408.1
RefSeqiNP_001275493.1, NM_001288564.1
NP_001275494.1, NM_001288565.1
NP_001275495.1, NM_001288566.1
NP_001275496.1, NM_001288567.1
NP_001275497.1, NM_001288568.1
NP_001275498.1, NM_001288569.1
NP_001275499.1, NM_001288570.1
NP_001275500.1, NM_001288571.1
NP_057540.1, NM_016456.4
XP_011507687.1, XM_011509385.1
XP_011507688.1, XM_011509386.2
XP_011507689.1, XM_011509387.2
UniGeneiHs.181444

Genome annotation databases

EnsembliENST00000367330; ENSP00000356299; ENSG00000116857
ENST00000367333; ENSP00000356302; ENSG00000116857
ENST00000367334; ENSP00000356303; ENSG00000116857
ENST00000485839; ENSP00000476893; ENSG00000116857
GeneIDi252839
KEGGihsa:252839
UCSCiuc001gvx.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY138587 mRNA Translation: AAN15925.1
AB013909 mRNA Translation: BAB87799.1
AF151020 mRNA Translation: AAF36106.1
AL136600 mRNA Translation: CAB66535.1
AY359012 mRNA Translation: AAQ89371.1
AK054883 mRNA Translation: BAB70820.1
AK075335 mRNA Translation: BAC11554.1
AL139159 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91338.1
BC001106 mRNA Translation: AAH01106.1
CCDSiCCDS1408.1
RefSeqiNP_001275493.1, NM_001288564.1
NP_001275494.1, NM_001288565.1
NP_001275495.1, NM_001288566.1
NP_001275496.1, NM_001288567.1
NP_001275497.1, NM_001288568.1
NP_001275498.1, NM_001288569.1
NP_001275499.1, NM_001288570.1
NP_001275500.1, NM_001288571.1
NP_057540.1, NM_016456.4
XP_011507687.1, XM_011509385.1
XP_011507688.1, XM_011509386.2
XP_011507689.1, XM_011509387.2
UniGeneiHs.181444

3D structure databases

ProteinModelPortaliQ9P0T7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128927, 98 interactors
IntActiQ9P0T7, 18 interactors
STRINGi9606.ENSP00000356298

PTM databases

GlyConnecti1857
iPTMnetiQ9P0T7
PhosphoSitePlusiQ9P0T7

Polymorphism and mutation databases

DMDMi20532090

Proteomic databases

EPDiQ9P0T7
MaxQBiQ9P0T7
PaxDbiQ9P0T7
PeptideAtlasiQ9P0T7
PRIDEiQ9P0T7
ProteomicsDBi83596

Protocols and materials databases

DNASUi252839
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367330; ENSP00000356299; ENSG00000116857
ENST00000367333; ENSP00000356302; ENSG00000116857
ENST00000367334; ENSP00000356303; ENSG00000116857
ENST00000485839; ENSP00000476893; ENSG00000116857
GeneIDi252839
KEGGihsa:252839
UCSCiuc001gvx.5 human

Organism-specific databases

CTDi252839
DisGeNETi252839
EuPathDBiHostDB:ENSG00000116857.16
GeneCardsiTMEM9
HGNCiHGNC:18823 TMEM9
MIMi616877 gene
neXtProtiNX_Q9P0T7
OpenTargetsiENSG00000116857
PharmGKBiPA38696
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4007 Eukaryota
ENOG4111KV2 LUCA
GeneTreeiENSGT00390000000819
HOVERGENiHBG050972
InParanoidiQ9P0T7
PhylomeDBiQ9P0T7
TreeFamiTF315146

Miscellaneous databases

ChiTaRSiTMEM9 human
GeneWikiiTMEM9
GenomeRNAii252839
PROiPR:Q9P0T7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116857 Expressed in 203 organ(s), highest expression level in hypothalamus
CleanExiHS_TMEM9
ExpressionAtlasiQ9P0T7 baseline and differential
GenevisibleiQ9P0T7 HS

Family and domain databases

InterProiView protein in InterPro
IPR008853 TMEM9
PANTHERiPTHR13064 PTHR13064, 1 hit
PfamiView protein in Pfam
PF05434 Tmemb_9, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMEM9_HUMAN
AccessioniPrimary (citable) accession number: Q9P0T7
Secondary accession number(s): B1ALM6, Q96NQ9, Q9BQF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: October 1, 2000
Last modified: October 10, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
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