UniProtKB - Q9P0S9 (TM14C_HUMAN)
Protein
Transmembrane protein 14C
Gene
TMEM14C
Organism
Homo sapiens (Human)
Status
Functioni
Required for normal heme biosynthesis.By similarity
GO - Biological processi
- erythrocyte differentiation Source: Ensembl
- heme biosynthetic process Source: UniProtKB-KW
- mitochondrial transport Source: GO_Central
- regulation of heme biosynthetic process Source: Ensembl
Keywordsi
Biological process | Heme biosynthesis |
Enzyme and pathway databases
PathwayCommonsi | Q9P0S9 |
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 14C |
Gene namesi | Name:TMEM14C Synonyms:C6orf53 ORF Names:HSPC194 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000111843.13 |
HGNCi | HGNC:20952, TMEM14C |
MIMi | 615318, gene |
neXtProti | NX_Q9P0S9 |
Subcellular locationi
Mitochondrion
- Mitochondrion membrane By similarity; Multi-pass membrane protein By similarity
Mitochondrion
- mitochondrial inner membrane Source: GO_Central
- mitochondrial membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 7 – 27 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 32 – 52 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 62 – 82 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 88 – 108 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, MitochondrionPathology & Biotechi
Organism-specific databases
DisGeNETi | 51522 |
OpenTargetsi | ENSG00000111843 |
PharmGKBi | PA134874746 |
Miscellaneous databases
Pharosi | Q9P0S9, Tdark |
Polymorphism and mutation databases
BioMutai | TMEM14C |
DMDMi | 27734405 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000221173 | 1 – 112 | Transmembrane protein 14CAdd BLAST | 112 |
Proteomic databases
EPDi | Q9P0S9 |
jPOSTi | Q9P0S9 |
MassIVEi | Q9P0S9 |
MaxQBi | Q9P0S9 |
PaxDbi | Q9P0S9 |
PeptideAtlasi | Q9P0S9 |
PRIDEi | Q9P0S9 |
ProteomicsDBi | 83594 |
TopDownProteomicsi | Q9P0S9 |
PTM databases
iPTMneti | Q9P0S9 |
PhosphoSitePlusi | Q9P0S9 |
SwissPalmi | Q9P0S9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000111843, Expressed in metanephros and 221 other tissues |
ExpressionAtlasi | Q9P0S9, baseline and differential |
Genevisiblei | Q9P0S9, HS |
Organism-specific databases
HPAi | ENSG00000111843, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ9P0S9
Protein-protein interaction databases
BioGRIDi | 119585, 50 interactors |
IntActi | Q9P0S9, 46 interactors |
MINTi | Q9P0S9 |
STRINGi | 9606.ENSP00000444561 |
Miscellaneous databases
RNActi | Q9P0S9, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | Q9P0S9 |
SMRi | Q9P0S9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the TMEM14 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4267, Eukaryota |
GeneTreei | ENSGT00940000154772 |
HOGENOMi | CLU_096652_4_0_1 |
InParanoidi | Q9P0S9 |
OMAi | NSWKFMP |
OrthoDBi | 1642026at2759 |
PhylomeDBi | Q9P0S9 |
TreeFami | TF323345 |
Family and domain databases
InterProi | View protein in InterPro IPR005349, TMEM14 |
PANTHERi | PTHR12668, PTHR12668, 1 hit |
Pfami | View protein in Pfam PF03647, Tmemb_14, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9P0S9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQDTGSVVPL HWFGFGYAAL VASGGIIGYV KAGSVPSLAA GLLFGSLAGL
60 70 80 90 100
GAYQLSQDPR NVWVFLATSG TLAGIMGMRF YHSGKFMPAG LIAGASLLMV
110
AKVGVSMFNR PH
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_046947 | 106 | S → R. Corresponds to variant dbSNP:rs1045961Ensembl. | 1 | |
Natural variantiVAR_046948 | 108 | F → L. Corresponds to variant dbSNP:rs1045964Ensembl. | 1 | |
Natural variantiVAR_046949 | 109 | N → I. Corresponds to variant dbSNP:rs1045967Ensembl. | 1 | |
Natural variantiVAR_046950 | 112 | H → D. Corresponds to variant dbSNP:rs1045986Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF151028 mRNA Translation: AAF36114.1 AL358777 Genomic DNA No translation available. CH471087 Genomic DNA Translation: EAW55271.1 BC002496 mRNA Translation: AAH02496.1 BC010086 mRNA Translation: AAH10086.1 |
CCDSi | CCDS4514.1 |
RefSeqi | NP_001158730.1, NM_001165258.1 NP_057546.1, NM_016462.3 |
Genome annotation databases
Ensembli | ENST00000229563; ENSP00000229563; ENSG00000111843 ENST00000541412; ENSP00000444561; ENSG00000111843 ENST00000642513; ENSP00000495127; ENSG00000284936 ENST00000643226; ENSP00000495742; ENSG00000284936 |
GeneIDi | 51522 |
KEGGi | hsa:51522 |
UCSCi | uc003mzh.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF151028 mRNA Translation: AAF36114.1 AL358777 Genomic DNA No translation available. CH471087 Genomic DNA Translation: EAW55271.1 BC002496 mRNA Translation: AAH02496.1 BC010086 mRNA Translation: AAH10086.1 |
CCDSi | CCDS4514.1 |
RefSeqi | NP_001158730.1, NM_001165258.1 NP_057546.1, NM_016462.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2LOS | NMR | - | A | 1-112 | [»] | |
BMRBi | Q9P0S9 | |||||
SMRi | Q9P0S9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119585, 50 interactors |
IntActi | Q9P0S9, 46 interactors |
MINTi | Q9P0S9 |
STRINGi | 9606.ENSP00000444561 |
PTM databases
iPTMneti | Q9P0S9 |
PhosphoSitePlusi | Q9P0S9 |
SwissPalmi | Q9P0S9 |
Polymorphism and mutation databases
BioMutai | TMEM14C |
DMDMi | 27734405 |
Proteomic databases
EPDi | Q9P0S9 |
jPOSTi | Q9P0S9 |
MassIVEi | Q9P0S9 |
MaxQBi | Q9P0S9 |
PaxDbi | Q9P0S9 |
PeptideAtlasi | Q9P0S9 |
PRIDEi | Q9P0S9 |
ProteomicsDBi | 83594 |
TopDownProteomicsi | Q9P0S9 |
Protocols and materials databases
DNASUi | 51522 |
Genome annotation databases
Ensembli | ENST00000229563; ENSP00000229563; ENSG00000111843 ENST00000541412; ENSP00000444561; ENSG00000111843 ENST00000642513; ENSP00000495127; ENSG00000284936 ENST00000643226; ENSP00000495742; ENSG00000284936 |
GeneIDi | 51522 |
KEGGi | hsa:51522 |
UCSCi | uc003mzh.4, human |
Organism-specific databases
CTDi | 51522 |
DisGeNETi | 51522 |
EuPathDBi | HostDB:ENSG00000111843.13 |
GeneCardsi | TMEM14C |
HGNCi | HGNC:20952, TMEM14C |
HPAi | ENSG00000111843, Low tissue specificity |
MIMi | 615318, gene |
neXtProti | NX_Q9P0S9 |
OpenTargetsi | ENSG00000111843 |
PharmGKBi | PA134874746 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4267, Eukaryota |
GeneTreei | ENSGT00940000154772 |
HOGENOMi | CLU_096652_4_0_1 |
InParanoidi | Q9P0S9 |
OMAi | NSWKFMP |
OrthoDBi | 1642026at2759 |
PhylomeDBi | Q9P0S9 |
TreeFami | TF323345 |
Enzyme and pathway databases
PathwayCommonsi | Q9P0S9 |
Miscellaneous databases
BioGRID-ORCSi | 51522, 3 hits in 826 CRISPR screens |
ChiTaRSi | TMEM14C, human |
GenomeRNAii | 51522 |
Pharosi | Q9P0S9, Tdark |
PROi | PR:Q9P0S9 |
RNActi | Q9P0S9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000111843, Expressed in metanephros and 221 other tissues |
ExpressionAtlasi | Q9P0S9, baseline and differential |
Genevisiblei | Q9P0S9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR005349, TMEM14 |
PANTHERi | PTHR12668, PTHR12668, 1 hit |
Pfami | View protein in Pfam PF03647, Tmemb_14, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TM14C_HUMAN | |
Accessioni | Q9P0S9Primary (citable) accession number: Q9P0S9 Secondary accession number(s): Q5T4I6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 10, 2003 |
Last sequence update: | October 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 148 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations