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UniProtKB - Q9P0S9 (TM14C_HUMAN)

Entry version 141 (16 Oct 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Transmembrane protein 14C

Gene

TMEM14C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for normal heme biosynthesis.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHeme biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 14C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM14C
Synonyms:C6orf53
ORF Names:HSPC194
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:20952 TMEM14C

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		615318 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9P0S9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		51522

Open Targets

More...OpenTargetsi		ENSG00000111843

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134874746

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9P0S9

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TMEM14C

Domain mapping of disease mutations (DMDM)

More...DMDMi		27734405

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002211731 – 112Transmembrane protein 14CAdd BLAST112

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9P0S9

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9P0S9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9P0S9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9P0S9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9P0S9

PeptideAtlas

More...PeptideAtlasi		Q9P0S9

PRoteomics IDEntifications database

More...PRIDEi		Q9P0S9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		83594

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q9P0S9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9P0S9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9P0S9

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9P0S9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000111843 Expressed in 209 organ(s), highest expression level in metanephros

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9P0S9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9P0S9 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC155Q8N6L03EBI-2339195,EBI-749265

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		119585, 10 interactors

Protein interaction database and analysis system

More...IntActi		Q9P0S9, 34 interactors

Molecular INTeraction database

More...MINTi		Q9P0S9

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000444561

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1112
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9P0S9

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM14 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4267 Eukaryota
ENOG4112205 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154772

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000211932

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9P0S9

Identification of Orthologs from Complete Genome Data

More...OMAi		NSKKAMP

Database of Orthologous Groups

More...OrthoDBi		1642026at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9P0S9

TreeFam database of animal gene trees

More...TreeFami		TF323345

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR005349 TMEM14

The PANTHER Classification System

More...PANTHERi		PTHR12668 PTHR12668, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03647 Tmemb_14, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9P0S9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQDTGSVVPL HWFGFGYAAL VASGGIIGYV KAGSVPSLAA GLLFGSLAGL 
        60         70         80         90        100
GAYQLSQDPR NVWVFLATSG TLAGIMGMRF YHSGKFMPAG LIAGASLLMV 
       110 
AKVGVSMFNR PH
Length:112
Mass (Da):11,565
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0C54AD12A50A96E0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_046947106S → R. Corresponds to variant dbSNP:rs1045961Ensembl.1
Natural variantiVAR_046948108F → L. Corresponds to variant dbSNP:rs1045964Ensembl.1
Natural variantiVAR_046949109N → I. Corresponds to variant dbSNP:rs1045967Ensembl.1
Natural variantiVAR_046950112H → D. Corresponds to variant dbSNP:rs1045986Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF151028 mRNA Translation: AAF36114.1
AL358777 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55271.1
BC002496 mRNA Translation: AAH02496.1
BC010086 mRNA Translation: AAH10086.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4514.1

NCBI Reference Sequences

More...RefSeqi		NP_001158730.1, NM_001165258.1
NP_057546.1, NM_016462.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000229563; ENSP00000229563; ENSG00000111843
ENST00000541412; ENSP00000444561; ENSG00000111843
ENST00000642513; ENSP00000495127; ENSG00000284936
ENST00000643226; ENSP00000495742; ENSG00000284936

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51522

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51522

UCSC genome browser

More...UCSCi		uc003mzh.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151028 mRNA Translation: AAF36114.1
AL358777 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55271.1
BC002496 mRNA Translation: AAH02496.1
BC010086 mRNA Translation: AAH10086.1
CCDSiCCDS4514.1
RefSeqiNP_001158730.1, NM_001165258.1
NP_057546.1, NM_016462.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LOSNMR-A1-112[»]
SMRiQ9P0S9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi119585, 10 interactors
IntActiQ9P0S9, 34 interactors
MINTiQ9P0S9
STRINGi9606.ENSP00000444561

PTM databases

iPTMnetiQ9P0S9
PhosphoSitePlusiQ9P0S9
SwissPalmiQ9P0S9

Polymorphism and mutation databases

BioMutaiTMEM14C
DMDMi27734405

Proteomic databases

EPDiQ9P0S9
jPOSTiQ9P0S9
MassIVEiQ9P0S9
MaxQBiQ9P0S9
PaxDbiQ9P0S9
PeptideAtlasiQ9P0S9
PRIDEiQ9P0S9
ProteomicsDBi83594
TopDownProteomicsiQ9P0S9

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		51522

Genome annotation databases

EnsembliENST00000229563; ENSP00000229563; ENSG00000111843
ENST00000541412; ENSP00000444561; ENSG00000111843
ENST00000642513; ENSP00000495127; ENSG00000284936
ENST00000643226; ENSP00000495742; ENSG00000284936
GeneIDi51522
KEGGihsa:51522
UCSCiuc003mzh.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51522
DisGeNETi51522

GeneCards: human genes, protein and diseases

More...GeneCardsi		TMEM14C
HGNCiHGNC:20952 TMEM14C
MIMi615318 gene
neXtProtiNX_Q9P0S9
OpenTargetsiENSG00000111843
PharmGKBiPA134874746

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4267 Eukaryota
ENOG4112205 LUCA
GeneTreeiENSGT00940000154772
HOGENOMiHOG000211932
InParanoidiQ9P0S9
OMAiNSKKAMP
OrthoDBi1642026at2759
PhylomeDBiQ9P0S9
TreeFamiTF323345

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TMEM14C human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51522
PharosiQ9P0S9

Protein Ontology

More...PROi		PR:Q9P0S9

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000111843 Expressed in 209 organ(s), highest expression level in metanephros
ExpressionAtlasiQ9P0S9 baseline and differential
GenevisibleiQ9P0S9 HS

Family and domain databases

InterProiView protein in InterPro
IPR005349 TMEM14
PANTHERiPTHR12668 PTHR12668, 1 hit
PfamiView protein in Pfam
PF03647 Tmemb_14, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM14C_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P0S9
Secondary accession number(s): Q5T4I6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: October 1, 2000
Last modified: October 16, 2019
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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