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Protein

Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial

Gene

COX16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase (PubMed:29355485, PubMed:29381136). Promotes the insertion of copper into the active site of cytochrome c oxidase subunit II (MT-CO2/COX2) (PubMed:29355485, PubMed:29381136). Interacts specifically with newly synthesized MT-CO2/COX and its copper center-forming metallochaperones SCO1, SCO2 and COA6 (PubMed:29381136). Probably facilitates MT-CO2/COX2 association with the MITRAC assembly intermediate containing MT-CO1/COX1, thereby participating in merging the MT-CO1/COX1 and MT-CO2/COX2 assembly lines (PubMed:29381136).2 Publications

Miscellaneous

No COX16 mutations have been detected in patients with cytochrome c oxidase (COX) deficiency.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • mitochondrial respiratory chain complex IV assembly Source: UniProtKB

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-611105 Respiratory electron transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.D.4.11.1 the proton-translocating cytochrome oxidase (cox) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome c oxidase assembly protein COX16 homolog, mitochondrialCurated
Short name:
hCOX161 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COX162 PublicationsImported
Synonyms:C14orf112Imported
ORF Names:HSPC2031 Publication, PTD0191 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000133983.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20213 COX16

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
618064 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9P0S2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 14Mitochondrial matrix2 PublicationsAdd BLAST14
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei15 – 37HelicalSequence analysisAdd BLAST23
Topological domaini38 – 106Mitochondrial intermembrane2 PublicationsAdd BLAST69

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
51241

Open Targets

More...
OpenTargetsi
ENSG00000133983

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162382755

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
COX16

Domain mapping of disease mutations (DMDM)

More...
DMDMi
68565330

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000195561 – 106Cytochrome c oxidase assembly protein COX16 homolog, mitochondrialAdd BLAST106

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9P0S2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9P0S2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9P0S2

PeptideAtlas

More...
PeptideAtlasi
Q9P0S2

PRoteomics IDEntifications database

More...
PRIDEi
Q9P0S2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
83592

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9P0S2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9P0S2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9P0S2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expressed at higher level in skeletal muscle, heart and liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000133983 Expressed in 200 organ(s), highest expression level in C1 segment of cervical spinal cord

CleanEx database of gene expression profiles

More...
CleanExi
HS_COX16

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9P0S2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9P0S2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA062659

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with the MITRAC complex (PubMed:29381136). Interacts with MT-CO2/COX; specifically interacts with newly synthesized MT-CO2/COX (PubMed:29355485, PubMed:29381136). Interacts with SCO1, SCO2 and COA6 (PubMed:29381136).2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119401, 17 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9P0S2

Protein interaction database and analysis system

More...
IntActi
Q9P0S2, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000374562

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9P0S2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the COX16 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J12X Eukaryota
ENOG411273P LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00520000055955

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000217274

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG105488

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9P0S2

KEGG Orthology (KO)

More...
KOi
K18182

Identification of Orthologs from Complete Genome Data

More...
OMAi
PRPWEEQ

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0G6P

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9P0S2

TreeFam database of animal gene trees

More...
TreeFami
TF324420

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020164 Cyt_c_Oxase_assmbl_COX16

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14138 COX16, 1 hit

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD076120 Cyt_c_Oxase_assmbl_COX16, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9P0S2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFAPAVMRAF RKNKTLGYGV PMLLLIVGGS FGLREFSQIR YDAVKSKMDP
60 70 80 90 100
ELEKKLKENK ISLESEYEKI KDSKFDDWKN IRGPRPWEDP DLLQGRNPES

LKTKTT
Length:106
Mass (Da):12,293
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEB84EE268DF62B07
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V2U5G3V2U5_HUMAN
Cytochrome c oxidase assembly prote...
COX16
25Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FJ460510 mRNA Translation: ACJ76681.1
FJ460511 mRNA Translation: ACJ76682.1
AF226729 mRNA Translation: AAG09730.1
AF151037 mRNA Translation: AAF36123.1
AK290743 mRNA Translation: BAF83432.1
CR457199 mRNA Translation: CAG33480.1
AL160191 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81031.1
BC001702 mRNA Translation: AAH01702.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9802.1

NCBI Reference Sequences

More...
RefSeqi
NP_001191019.1, NM_001204090.1
NP_057552.1, NM_016468.6

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.709581

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000389912; ENSP00000374562; ENSG00000133983

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
51241

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51241

UCSC genome browser

More...
UCSCi
uc001xmb.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ460510 mRNA Translation: ACJ76681.1
FJ460511 mRNA Translation: ACJ76682.1
AF226729 mRNA Translation: AAG09730.1
AF151037 mRNA Translation: AAF36123.1
AK290743 mRNA Translation: BAF83432.1
CR457199 mRNA Translation: CAG33480.1
AL160191 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81031.1
BC001702 mRNA Translation: AAH01702.1
CCDSiCCDS9802.1
RefSeqiNP_001191019.1, NM_001204090.1
NP_057552.1, NM_016468.6
UniGeneiHs.709581

3D structure databases

ProteinModelPortaliQ9P0S2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119401, 17 interactors
CORUMiQ9P0S2
IntActiQ9P0S2, 2 interactors
STRINGi9606.ENSP00000374562

Protein family/group databases

TCDBi3.D.4.11.1 the proton-translocating cytochrome oxidase (cox) superfamily

PTM databases

iPTMnetiQ9P0S2
PhosphoSitePlusiQ9P0S2

Polymorphism and mutation databases

BioMutaiCOX16
DMDMi68565330

Proteomic databases

EPDiQ9P0S2
MaxQBiQ9P0S2
PaxDbiQ9P0S2
PeptideAtlasiQ9P0S2
PRIDEiQ9P0S2
ProteomicsDBi83592
TopDownProteomicsiQ9P0S2

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
51241
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389912; ENSP00000374562; ENSG00000133983
GeneIDi51241
KEGGihsa:51241
UCSCiuc001xmb.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51241
DisGeNETi51241
EuPathDBiHostDB:ENSG00000133983.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
COX16
HGNCiHGNC:20213 COX16
HPAiHPA062659
MIMi618064 gene
neXtProtiNX_Q9P0S2
OpenTargetsiENSG00000133983
PharmGKBiPA162382755

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J12X Eukaryota
ENOG411273P LUCA
GeneTreeiENSGT00520000055955
HOGENOMiHOG000217274
HOVERGENiHBG105488
InParanoidiQ9P0S2
KOiK18182
OMAiPRPWEEQ
OrthoDBiEOG091G0G6P
PhylomeDBiQ9P0S2
TreeFamiTF324420

Enzyme and pathway databases

ReactomeiR-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-611105 Respiratory electron transport

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
COX16 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51241

Protein Ontology

More...
PROi
PR:Q9P0S2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000133983 Expressed in 200 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_COX16
ExpressionAtlasiQ9P0S2 baseline and differential
GenevisibleiQ9P0S2 HS

Family and domain databases

InterProiView protein in InterPro
IPR020164 Cyt_c_Oxase_assmbl_COX16
PfamiView protein in Pfam
PF14138 COX16, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD076120 Cyt_c_Oxase_assmbl_COX16, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOX16_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P0S2
Secondary accession number(s): A6NDT5, A8K3X8, B8XYC5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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