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Protein

GSK3B-interacting protein

Gene

GSKIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets (PubMed:27484798, PubMed:25920809, PubMed:16981698). The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively (PubMed:27484798, PubMed:16981698). Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B (PubMed:25920809). During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (PubMed:19830702).4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei130Required for GSK3B interaction; contributes to a protective effect against H(2)O(2)-induced apoptosis3 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein kinase A binding Source: UniProtKB
  • protein kinase A regulatory subunit binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • protein kinase inhibitor activity Source: UniProtKB

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GSK3B-interacting proteinImported
Short name:
GSKIP1 Publication
Alternative name(s):
GSK3beta interaction proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GSKIP1 PublicationImported
Synonyms:C14orf129Imported
ORF Names:HSPC210
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000100744.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20343 GSKIP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616605 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9P0R6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi41 – 45VNDVL → PNDVP: Abolishes interaction with PRKAR2A and PRKAR2B. Abolishes acquired resistance against oxidative stress-induced apoptosis under activated cAMP signaling. Decreases PKA-mediated DNM1L phosphorylation. 1 Publication5
Mutagenesisi42N → I: Abolishes interaction with PRKAR2A. Prevents the Wnt-induced transcription. Does not alter the phosphorylation of CTNNB1 in the presence of Wnt. 1 Publication1
Mutagenesisi109S → A: No effect on GSK3B-mediated phosphorylation. Reduces to 30 % GSK3B-mediated phosphorylation; when associated with A-113. Reduces to 30 % GSK3B-mediated phosphorylation; when associated with A-113 and A-115. 1 Publication1
Mutagenesisi113T → A: No effect on GSK3B-mediated phosphorylation. Reduces to 30 % GSK3B-mediated phosphorylation; when associated with A-109.Reduces to 30 % GSK3B-mediated phosphorylation; when associated with A-113 and A-115. 1 Publication1
Mutagenesisi115S → A: No effect on GSK3B-mediated phosphorylation. Reduces to 30 % GSK3B-mediated phosphorylation; when associated with A-109.Reduces to 30 % GSK3B-mediated phosphorylation; when associated with A109 and A-113. 1 Publication1
Mutagenesisi130L → P: Loss of interaction with GSK3B. Abolishes GSK3B-mediated phosphorylation. Prevents beta-catenin accumulation in the cytoplasm and nucleus. Prevents the Wnt-induced transcription. Decreases PKA-mediated phosphorylation of GSK3B. Abolishes acquired resistance against oxidative stress-induced apoptosis under activated cAMP signaling. Decreases PKA-mediated DNM1L phosphorylation. 3 Publications1

Organism-specific databases

DisGeNET

More...
DisGeNETi
51527

Open Targets

More...
OpenTargetsi
ENSG00000100744

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134987554

Polymorphism and mutation databases

Domain mapping of disease mutations (DMDM)

More...
DMDMi
34582343

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002209511 – 139GSK3B-interacting proteinAdd BLAST139

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by GSK3B.1 Publication

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9P0R6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9P0R6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9P0R6

PeptideAtlas

More...
PeptideAtlasi
Q9P0R6

PRoteomics IDEntifications database

More...
PRIDEi
Q9P0R6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
83591

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in heart, brain, placenta, liver, skeletal muscle, kidney, testis, lung and pancreas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000100744 Expressed in 202 organ(s), highest expression level in secondary oocyte

CleanEx database of gene expression profiles

More...
CleanExi
HS_C14orf129

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9P0R6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9P0R6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043054
HPA046782

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a complex composed of PRKAR2A or PRKAR2B, GSK3B and GSKIP through GSKIP interaction; facilitates PKA-induced phosphorylation of GSK3B leading to GSK3B inactivation; recruits DNM1L through GSK3B for PKA-mediated phosphorylation of DNM1L; promotes beta-catenin degradation through GSK3B-induced phosphorylation of beta-catenin; stabilizes beta-catenin and enhances Wnt-induced signaling through PKA-induced phosphorylation of beta-catenin (PubMed:20007971, PubMed:25920809, PubMed:27484798). Interacts with GSK3B; induces GSK3B-mediated phosphorylation of GSKIP and inhibits GSK3B kinase activity (PubMed:16981698, PubMed:25920809).4 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119589, 7 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9P0R6

Protein interaction database and analysis system

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IntActi
Q9P0R6, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000412315

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1139
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9P0R6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9P0R6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9P0R6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni41 – 45Required for PRKAR2A interaction; contributes to a protective effect against H(2)O(2)-induced apoptosis1 Publication5
Regioni115 – 139Interaction with GSK3B and acts as GSK3B inhibitor1 PublicationAdd BLAST25

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GSKIP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3965 Eukaryota
ENOG4111QBG LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009517

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007951

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG051028

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9P0R6

Identification of Orthologs from Complete Genome Data

More...
OMAi
ETREGNR

Database of Orthologous Groups

More...
OrthoDBi
EOG091G15HV

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9P0R6

TreeFam database of animal gene trees

More...
TreeFami
TF313906

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.2280.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR037395 GSKIP
IPR007967 GSKIP_dom
IPR023231 GSKIP_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12490 PTHR12490, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05303 DUF727, 1 hit

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD080843 DUF727, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9P0R6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METDCNPMEL SSMSGFEEGS ELNGFEGTDM KDMRLEAEAV VNDVLFAVNN
60 70 80 90 100
MFVSKSLRCA DDVAYINVET KERNRYCLEL TEAGLKVVGY AFDQVDDHLQ
110 120 130
TPYHETVYSL LDTLSPAYRE AFGNALLQRL EALKRDGQS
Length:139
Mass (Da):15,648
Last modified:September 9, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA2D8BAF4B458B316
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V368G3V368_HUMAN
GSK3B-interacting protein
GSKIP
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V4I5G3V4I5_HUMAN
GSK3B-interacting protein
GSKIP
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF36130 differs from that shown. Reason: Frameshift at position 132.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti46F → S in BAA91380 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF151044 mRNA Translation: AAF36130.1 Frameshift.
AK000796 mRNA Translation: BAA91380.1
AK094654 mRNA Translation: BAG52902.1
AL359240 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81634.1
BC004818 mRNA Translation: AAH04818.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32153.1

NCBI Reference Sequences

More...
RefSeqi
NP_001258833.1, NM_001271904.1
NP_001258834.1, NM_001271905.1
NP_001258835.1, NM_001271906.1
NP_057556.2, NM_016472.4
XP_016876854.1, XM_017021365.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.4104
Hs.745067

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000438650; ENSP00000412315; ENSG00000100744
ENST00000554182; ENSP00000451384; ENSG00000100744
ENST00000555181; ENSP00000450420; ENSG00000100744
ENST00000556095; ENSP00000451188; ENSG00000100744

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
51527

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51527

UCSC genome browser

More...
UCSCi
uc001yfj.6 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151044 mRNA Translation: AAF36130.1 Frameshift.
AK000796 mRNA Translation: BAA91380.1
AK094654 mRNA Translation: BAG52902.1
AL359240 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81634.1
BC004818 mRNA Translation: AAH04818.1
CCDSiCCDS32153.1
RefSeqiNP_001258833.1, NM_001271904.1
NP_001258834.1, NM_001271905.1
NP_001258835.1, NM_001271906.1
NP_057556.2, NM_016472.4
XP_016876854.1, XM_017021365.1
UniGeneiHs.4104
Hs.745067

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SGONMR-A1-139[»]
ProteinModelPortaliQ9P0R6
SMRiQ9P0R6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119589, 7 interactors
CORUMiQ9P0R6
IntActiQ9P0R6, 4 interactors
STRINGi9606.ENSP00000412315

Polymorphism and mutation databases

DMDMi34582343

Proteomic databases

EPDiQ9P0R6
MaxQBiQ9P0R6
PaxDbiQ9P0R6
PeptideAtlasiQ9P0R6
PRIDEiQ9P0R6
ProteomicsDBi83591

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000438650; ENSP00000412315; ENSG00000100744
ENST00000554182; ENSP00000451384; ENSG00000100744
ENST00000555181; ENSP00000450420; ENSG00000100744
ENST00000556095; ENSP00000451188; ENSG00000100744
GeneIDi51527
KEGGihsa:51527
UCSCiuc001yfj.6 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51527
DisGeNETi51527
EuPathDBiHostDB:ENSG00000100744.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GSKIP

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0011950
HGNCiHGNC:20343 GSKIP
HPAiHPA043054
HPA046782
MIMi616605 gene
neXtProtiNX_Q9P0R6
OpenTargetsiENSG00000100744
PharmGKBiPA134987554

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3965 Eukaryota
ENOG4111QBG LUCA
GeneTreeiENSGT00390000009517
HOGENOMiHOG000007951
HOVERGENiHBG051028
InParanoidiQ9P0R6
OMAiETREGNR
OrthoDBiEOG091G15HV
PhylomeDBiQ9P0R6
TreeFamiTF313906

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GSKIP human
EvolutionaryTraceiQ9P0R6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51527

Protein Ontology

More...
PROi
PR:Q9P0R6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
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Gene expression databases

BgeeiENSG00000100744 Expressed in 202 organ(s), highest expression level in secondary oocyte
CleanExiHS_C14orf129
ExpressionAtlasiQ9P0R6 baseline and differential
GenevisibleiQ9P0R6 HS

Family and domain databases

Gene3Di3.30.2280.10, 1 hit
InterProiView protein in InterPro
IPR037395 GSKIP
IPR007967 GSKIP_dom
IPR023231 GSKIP_dom_sf
PANTHERiPTHR12490 PTHR12490, 1 hit
PfamiView protein in Pfam
PF05303 DUF727, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD080843 DUF727, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGSKIP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P0R6
Secondary accession number(s): B3KSZ0, Q9BST1, Q9NWK0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 9, 2003
Last sequence update: September 9, 2003
Last modified: December 5, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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